• Molecules and Cells
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• v.37 no.12
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• pp.865-872
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• 2014

Premature ovarian failure (POF) is a long-term adverse effect of chemotherapy treatment. However, current available treatment regimens are not optimal. Emerging evidence suggests that bone marrow-derived mesenchymal stem cells (BMSCs) could restore the structure and function of injured tissues, but the homing and restorative effects of BMSCs on chemotherapy injured ovaries are still not clear. In this study, we found that granulosa cell (GC) apoptosis induced by cisplatin was reduced when BMSCs were migrated to granulosa cells (GCs) in vitro. Chemotherapy-induced POF was induced by intraperitoneal injection of cisplatin in rats. BMSCs labeled with enhanced green fluorescent protein (EGFP) were injected into the rats via the tail vein to investigate the homing and distribution of BMSCs in vivo. The number of BMSCs in the ovarian hilum and medulla was greater than in the cortex, but no BMSCs were found in the follicles and corpus lutea. In addition, the BMSCs treatment group's antral follicle count and estradiol levels increased after 30 days, compared with the POF group. Hence, our study demonstrates that intravenously delivered BMSCs can home to the ovaries, and restore its structure and function in POF model rats.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.241-244
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• 2012

In this paper, three types of optical receivers are designed using a $0.35-{\mu}m$ standard CMOS technology for plastic optical fiber (POF) applications. Basic common-source transimpedance amplifier (CS-TIA), common-gate TIA (CG-TIA), and regulated-cascode TIA (RGC-TIA) are optimally designed, and their transimpedance gain (TZ gain), 3-dB bandwidth, and noise characteristics are compared and analyzed. As a result of simulations, the RGC-TIA indicates better TZ gain and 3-dB bandwidth than other topologies, and CS-TIA has the best noise performance. Each optical receiver occupies area of $0.35mm^2$.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.10
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• pp.1291-1296
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• 2013

Risk-based inspection (RBI) is a well-known method that is used to optimize inspection activities based on risk analysis in order to identify the high-risk components of major facilities such as power plants. RBI, when implemented and maintained properly, improves plant reliability and safety while reducing unplanned outages and repair costs. Risk is given by the product of the probability of failure (POF) and the consequence of failure (COF). A semi-quantitative method is generally used for risk assessment. Semi-quantitative risk assessment complements the low accuracy of qualitative risk assessment and the high expense and long calculation time of quantitative risk assessment. The first step of RBI is to identify important failure modes and causes in the equipment. Once these are defined, the POF and COF can be assessed for each failure. During POF and COF assessment, an effective inspection method and range can be easily found. In this paper, the calculation of the POF is improved for accurate risk assessment. A modified semi-quantitative risk assessment was carried out for boiler facilities of thermal power plants, and the next maintenance schedules for the equipment were decided.

• Smart Structures and Systems
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• v.26 no.4
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• pp.507-520
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• 2020

In order to achieve effective corrosion monitoring of buried metal pipelines, a Novel nondestructive Testing (NDT) methodology using ultra-long (250 mm) Polymer Optical Fiber (POF) sensors coated with the Fe-C alloy film is proposed in this study. The theoretical principle is investigated to clarify the monitoring mechanism of this method, and the detailed fabrication process of this novel POF sensor is presented. To validate the feasibility of this novel POF sensor, exploratory research of the proposed method was performed using simulated corrosion tests. For simplicity, the geometric shape of the buried pipeline was simulated as a round hot-rolled plain steel bar. A thin nickel layer was applied as the inner plated layer, and the Fe-C alloy film was coated using an electroless plating technique to precisely control the thickness of the alloy film. In the end, systematic sensitivity analysis on corrosion severity was further performed with experimental studies on three sensors fabricated with different metal layer thicknesses of 25 ㎛, 30 ㎛ and 35 ㎛. The experimental observation demonstrated that the sensor coated with 25 ㎛ Fe-C alloy film presented the highest effectiveness with the corrosion sensitivity of 0.3364 mV/g at Δm = 9.32 × 10^-4 g in Stage I and 0.0121 mV/g in Stage III. The research findings indicate that the detection accuracy of the novel POF sensor proposed in this study is satisfying. Moreover, the simple fabrication of the high-sensitivity sensor makes it cost-effective and suitable for the on-site corrosion monitoring of buried metal pipelines.

• Journal of Menopausal Medicine
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• v.24 no.3
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• pp.196-203
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• 2018

Objectives: This study was aimed to establish the most effective premature ovarian failure (POF) mouse model using Cyclophosphamide (CTX), busulfan (Bu), and cisplatin considering treatment duration of anticancer drugs and natural recovery time. Methods: POF was induced by intraperitoneally injecting CTX (120 mg/kg)/Bu (12 mg/kg) for 1 to 4 weeks or cisplatin (2 mg/kg) for 3 to 14 days to C57BL/6 female mice aged 6 to 8 weeks. Controls were injected with equal volume of saline for the same periods. Body weight was measured every week, and ovarian and uterine weights were measured after the last injection of anticancer drug. To assess ovarian function, POF-induced mice were superovulated with pregnant mare serum gonadotropin and human chorionic gonadotropin, and then mated with male. After 18 hours, zygotes were retrieved and cultured for 4 days. Finally, the mice were left untreated for a period of times after the final injection of anticancer drug, and the time for natural recovery of ovarian function was evaluated. Results: After 2 weeks of CTX/Bu injection, ovarian and uterine weights, and ovarian function were decreased sharply. Cisplatin treatment for 10 days resulted in a significant decrease in ovarian and uterine weight, and ovarian function. When POF was induced for at least 2 weeks for CTX/Bu and for at least 10 days for cisplatin, ovarian function did not recover naturally for 2 weeks and 1 week, respectively. Conclusions: These results suggest that CTX/Bu should be treated for at least 2 weeks and cisplatin for at least 10 days to establish the most effective primary ovarian insufficiency mouse model.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.4 no.3
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• pp.199-203
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• 2003

In this study plastic optical fibers (POFs) were considered as light-transmitting media and substrates for the potential use in photocatalytic environmental purification system. After the characteristics of POFs in terms of light transmittance and absorption were determined at the beginning, the further investigation was performed through the photocatalytic degradation of trichloroethylene (TCE), iso-propanol and etc. with TiO$_2$-coated optical fiber reactor systems (POFR). It is concluded that the use of POFs is preferred to quartz optical fibers (QOFs) since the advantages such as ease of handling, lower cost, relatively reasonable light attenuation at the wavelength of near 400nm can be obtained. Various geometrical reactor shapes have been constructed and applied for the last one and half years. For the use of POF in water phase treatment, however, more detailed scientific and engineering aspects should be envisaged. This case requires a suitable mixture to obtain more stable and innocuous immobilization of photocatalyst on POF. To overcome this disadvantage, metal-organic chemical vapor deposition (MOCVD) was conducted in a fluidized bed to deposit thin films of titania on glass and alumina beads. Those can be used as photocatalysis for the removal of pollutants especially in liquid phases.

• Current Optics and Photonics
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• v.1 no.5
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• pp.468-473
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• 2017

We determined the feasibility of a fishing camera system using an optical fiber as the fishing line by testing a power-over-fiber (POF) module and multimode optical fiber. Operation of the remote camera module (RCM) without the battery was preferred because the removal of the charging or battery replacement section enabled a waterproof single-body type design. The average efficiency of the photovoltaic power converter (PPC) in the tested POF module was 32.6% at 820 nm, and thus, a high-power laser of at least 1.27 W was required for operating the developed RCM with an electrical dissipation of 413 mW. Because the optical fiber was wound on a fishing reel, composite loss composed of bending and tensile loss occurred. To mitigate the composite loss, we employed a simple holder that showed an improvement in the composite loss of 0.38 dB to 0.8 dB, which was considerably better than the losses without the holder.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.6
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• pp.415-422
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• 2010

Development of the reliability-based design program in the GUI environment is inadequate for engineers familiar with the deterministic design to deal with the international design criterion based on the probabilistic design. In this study, the design program based on the GUI environment is developed in order to more efficiently input the design factor and more easily carry out the design works. The GUI environment is the GUIDE (Graphic User Interface Development Environment) tool supported by the latest MATALB version 7.1. In order to test the model reliability, the probabilities of failure (POF) on the breakwater armor block (AB) and gravity quay-wall (QW) in the sliding mode are computed using the model in the Level II and Level III. The POF are 55.4~55.7% for breakwater AB and 0.0006~0.0007% for gravity QW. A non-GUI environment program results of the POF are 55.6% for breakwater AB and 0.0018% for gravity QW. In comparison, the POF difference is negligible for breakwater AB because the exact input design parameters are available, whereas the large POF difference, but within the same order, for gravity QW can be explained by the difference of the input design factors because of the poor input data information.

• Polymer Science and Technology
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• v.13 no.2
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• pp.180-186
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• 2002

• Polymer Science and Technology
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• v.13 no.2
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• pp.195-201
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• 2002