• Journal of Positioning, Navigation, and Timing
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• v.12 no.3
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• pp.215-228
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• 2023

The State Space Representation (SSR) method provides individual corrections for each Global Navigation Satellite System (GNSS) error components. This method can lead to less bandwidth for transmission and allows selective use of each correction. Precise Point Positioning (PPP) - Real-Time Kinematic (RTK) is one of the carrier-based precise positioning techniques using SSR correction. This technique enables high-precision positioning with a fast convergence time by providing atmospheric correction as well as satellite orbit and clock correction. Currently, the positioning service that supports PPP-RTK technology is the Quazi-Zenith Satellite System Centimeter Level Augmentation System (QZSS CLAS) in Japan. A system that provides correction for each GNSS error component, such as QZSS CLAS, requires monitoring of each error component to provide reliable correction and integrity information to the user. In this study, we conducted an analysis of the performance of residual error bounding for each error component. To assess this performance, we utilized the correction and quality indicators provided by QZSS CLAS. Performance analyses included the range domain, dispersive part, non-dispersive part, and satellite orbit/clock part. The residual root mean square (RMS) of CLAS correction for the range domain approximated 0.0369 m, and the residual RMS for both dispersive and non-dispersive components is around 0.0363 m. It has also been confirmed that the residual errors are properly bounded by the integrity parameters. However, the satellite orbit and clock part have a larger residual of about 0.6508 m, and it was confirmed that this residual was not bounded by the integrity parameters. Users who rely solely on satellite orbit and clock correction, particularly maritime users, thus should exercise caution when utilizing QZSS CLAS.

• BMB Reports
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• v.52 no.9
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• pp.548-553
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• 2019

Ets-1 is a prototype of the ETS protein family. Members of the ETS protein family contain a unique ETS domain. Ets-1 is associated with cancer progression and metastasis in many types of cancer. Many studies have shown a link between elevated expression of Ets-1 in cancer biopsies and poor survival. CCR7 is a chemokine that binds to specific ligand CCL21/CCL19. CCR7 expression is associated with tumor metastasis and infiltration into lymph nodes. The objective of this study was to test whether Ets-1 could regulate CCR7 expression and enhance tumor metastasis. Our data showed that CCR7 expression was downregulated in Ets-1-deficient T cells upon T-cell stimulation. Overexpression of Ets-1 increased CCR7 expression in breast cancer cell lines. In contrast, knockdown of Ets-1 reduced CCR7 expression. Ets-1 could directly bind to CCR7 promoter and mediate CCR7 expression in luciferase reporter assays and chromatin immunoprecipitation assays. Transactivation activity of Ets-1 was independent of the Pointed domain of Ets-1. Ets-1 could also enhance $NF-{\kappa}B$ and CBP transactivation of CCR7 promoter. Our results also showed that Ets-1 could modulate cancer cell transmigration by altering CCR7 expression in transwell assay and wound healing assay. Taken together, our data suggest that Ets-1 can enhance CCR7 expression and contribute to tumor cell migration.