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Feasibility and Effectiveness of a Ring-Type Blood Pressure Measurement Device Compared With 24-Hour Ambulatory Blood Pressure Monitoring Device

  • Huijin Lee;Sungjoon Park;Hyuktae Kwon;Belong Cho;Jin Ho Park;Hae-Young Lee
    • Korean Circulation Journal
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    • v.54 no.2
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    • pp.93-104
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    • 2024
  • Backgrounds and Objectives: This study aimed to evaluate the applicability and precision of a ring-type cuffless blood pressure (BP) measurement device, CART-I Plus, compared to conventional 24-hour ambulatory BP monitoring (ABPM). Methods: Forty patients were recruited, and 33 participants were included in the final analysis. Each participant wore both CART-I Plus and ABPM devices on the same arm for approximately 24 hours. BP estimation from CART-I Plus, derived from photoplethysmography (PPG) signals, were compared with the corresponding ABPM measurements. Results: The CART-I Plus recorded systolic blood pressure (SBP)/diastolic blood pressure (DBP) values of 131.4±14.1/81.1±12.0, 132.7±13.9/81.9±11.9, and 128.7±14.6/79.3±12.2 mmHg for 24-hour, daytime, and nighttime periods respectively, compared to ABPM values of 129.7±11.7/84.4±11.2, 131.9±11.6/86.3±11.1, and 124.5±13.6/80.0±12.2 mmHg. Mean differences in SBP/DBP between the two devices were 1.74±6.69/-3.24±6.51 mmHg, 0.75±7.44/-4.41±7.42 mmHg, and 4.15±6.15/-0.67±5.23 mmHg for 24-hour, daytime, and nighttime periods respectively. Strong correlations were also observed between the devices, with r=0.725 and r=0.750 for transitions in SBP and DBP from daytime to nighttime, respectively (both p<0.001). Conclusions: The CART-I Plus device, with its unique ring-type design, shows promising accuracy in BP estimation and offers a potential avenue for continuous BP monitoring in clinical practice.

Interaction of dietary Mg(II), Ca(II) and polyunsaturated fatty acids on 3-Hydroxy-3-Methylalutaryl Co-A reductase activity (불포화 지방산과 마그네슘, 칼슘과의 상호작용이 3-Hydroxy-3-Methylglutaryl Co-A reductase 활성에 미치는 영향)

  • Nam, Hyun-Keun
    • Journal of the Korean Applied Science and Technology
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    • v.1 no.1
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    • pp.3-9
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    • 1984
  • Interaction of dietary Magnesium, Calcium and Polyunsaturated fatty acid(vegetable oils)on 3-Hydroxy-3-Methylglutaryl Co-A reductase activity was studied for a period of 30 days using isocalories and isonitrogenous as a basal diet . The subject rabbits were divided into 18 feeding groups. The results are summarized as follows: 1. The ratio of ${\alpha}_1-lipoprotein$ par lipalbumin is 0.34 for control group, 0.38 the highest group fed 0.1 Mg(II) 10ml plus perilla oil and basal diet, the lowest 0.25 group fed 0.1M Mg(II) 5ml plus sesame oil and basal diet. 2. The ratio ratio of ${\alpha}_2-lipoprotein$ per lipalbumin is 0.64 for control group. 0.95 as the highest for the group fed 0.1M Ca(II) 15ml plus sesame oil and basal diet, 0.1M Ca(II) 5ml plus perilla oil and basal diet. 3. The ratio of ${\beta}-lipoprotein$ per lipalbumin is 0.71 for control group, the highest 0.81 for the groups fed 0.1M Mg(II) 10ml plus sesame oil and basal diet, the lowest 0.37 for the group fed 0.1M Mg(II) 15ml plus soybean oil and basal diet. 4. In serum triglyceride, control group was 129.5mg%, the highest 155.4mg% for the group fed 0.1M Ca(II) 5ml plus sesame oil and basal diet, the lowest 85.7mg% for the group fed 0.1M Mg(II) 10ml plus soybean oil and basal diet. 5. In serum cholesterol, control group was 96.7mg%, the highest 152.5mg% for the group fed 0.1M Ca(II) 10ml plus sesame oil and basal diet, the lowest 80.5mg% for the group fed 0.1M Mg(II) 15ml plus soybean oil and basal diet. 6. In case of HMG-CoA reductase activity, control group was 0.95, the highest 0.98 for the group fed 0.1M Ca(II) plus soybean oil and basal diet. 7. Interaction between metal(II) ions and polyunsaturated fatty acid(vegetable oil) are soybean oil>sesame oil>perilla oil, for Mg(II). soybean oil>perilla oil>sesame oil, for Ca(II). Therefore, it is invetigated that the interaction between metal ion and polyunsaturated fatty acid is the higher, the cholesterol level is the lower, and HMG-CoA reductase activity is increased.

Postmetacercarial changes in Echinostoma caproni maintained in a defined medium plus calf serum

  • Fried, Bernard;Reddy, Aditya
    • Parasites, Hosts and Diseases
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    • v.38 no.3
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    • pp.173-175
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    • 2000
  • The present study examined postmetacercarial changes in the excysted metacercariae of Echinostoma caproni maintained in the defined medium Mixture 199 plus 20% calf serum for 7 days at $41^{\circ}C$. The gas phase was atmospheric air. Each culture was inoculated with 25 excysted metacerariae. Cultures were maintained upright in closed 15 ml plastic centrifuge tubes each containing 10 ml of medium plus 200 units of penicillin/ml and $200{\;}\mu\textrm{g}$ of streptomycin/ml. By 4 days in culture, most metacercariae had voided their excretory concretions. Organisms were clumped or solitary at the bottom of the cultures. Many organisms showed flaring of the oral collar and extension of both the collar and tegumentary spines. By 4 days in culture, posterior protuberances or bumps were noted on many of the organisms and some organisms showed abnormal vesicular growths or blebs at their posterior ends. Some mortality was noted in culture by day 5, but most organisms were still alive when the cultures were terminated on day 7.

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Effective Herbicides for Control of Sulfonylurea-Resistant Monochoria vaginalis in Paddy Field

  • Kuk, Yong-In;Kwon, Oh-Do
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.48 no.4
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    • pp.286-291
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    • 2003
  • Monochoria vaginalis is one of the most troublesome resistant weeds in Korean rice culture. Thus, the objectives of this study were to evaluate the response of M. vaginalis resistant to sulfonylurea(SU) herbicides and to determine alternative herbicides for the control of resistant M. vaginalis in direct seeded and transplanted rice culture in Korea. In greenhouse studies, the resistant biotype was 31-, 38-, 3172-, and 7-fold more resistant to ben-sulfuron-methyl, cyclosulfamuron, imazosulfuron, and pyrazosulfuron-ethyl, respectively, than the susceptible biotype, indicating cross-resistance to the SU herbicides used in this study. Non-SU herbicides, butachlor, carfentrazone-ethyl, mefenacet, pretilachlor, pyrazolate, and thiobencarb, several SU herbicide-based mixtures, ethoxysulfuron plus fentrazamide, pyrazosulfuron-ethyl plus pyrazolate plus simetryn, and non-SU herbicide-based mixtures, pyrazolate plus butachlor, pyrazolate plus pretilachlor, simetryn plus molinate, carfentrazone-ethyl plus butachlor, and carfentrazone-ethyl plus thiobencarb can be used to control both the resistant and susceptible biotypes of M. vaginalis when applied before the second leaf stage. In the field experiment, the resistant biotype of M. vaginalis that survived from the paddy fields treated with a SU herbicide-based mixture could effectively be controlled by using mixtures of bentazone plus MCPA, bentazone plus mecoprop-P, and bentazone plus 2,4-D when applied at 2 or 4 main leaves. Our results suggest that the SU-resistant M. vaginalis had not developed multiple resistances to herbicides with different modes of action. In particular, bentazone plus MCPA and bentazone plus mecoprop-P were effective control measures after failure to control resistant M. vaginalis in Korean rice culture.

CBP7 Interferes with the Multicellular Development of Dictyostelium Cells by Inhibiting Chemoattractant-Mediated Cell Aggregation

  • Park, Byeonggyu;Shin, Dong-Yeop;Jeon, Taeck Joong
    • Molecules and Cells
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    • v.41 no.2
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    • pp.103-109
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    • 2018
  • Calcium ions are involved in the regulation of diverse cellular processes. Fourteen genes encoding calcium binding proteins have been identified in Dictyostelium. CBP7, one of the 14 CBPs, is composed of 169 amino acids and contains four EF-hand motifs. Here, we investigated the roles of CBP7 in the development and cell migration of Dictyostelium cells and found that high levels of CBP7 exerted a negative effect on cells aggregation during development, possibly by inhibiting chemoattractant-directed cell migration. While cells lacking CBP7 exhibited normal development and chemotaxis similar that of wild-type cells, CBP7 overexpressing cells completely lost their chemotactic abilities to move toward increasing cAMP concentrations. This resulted in inhibition of cellular aggregation, a process required for forming multicellular organisms during development. Low levels of cytosolic free calcium were observed in CBP7 overexpressing cells, which was likely the underlying cause of their lack of chemotaxis. Our results demonstrate that CBP7 plays an important role in cell spreading and cell-substrate adhesion. cbp7 null cells showed decreased cell size and cell-substrate adhesion. The present study contributes to further understanding the role of calcium signaling in regulation of cell migration and development.

Studies on Population of Rumen Ciliates as Affected by Feeding (사료급여후(飼料給與後) 시간경과(時間經過)에 따른 젖소의 제일위내(弟一胃內) 섬모충류(纖毛蟲類)의 동태(動態))

  • Rhee, Jae Ku;Lee, Ho Il;Lee, Sang Bork;Baek, Byeong Kirl
    • Korean Journal of Veterinary Research
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    • v.19 no.2
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    • pp.143-147
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    • 1979
  • Eight Holstein cows weighing 419-673kg with 2 to 10 years of age were allocated into two groups, four animals each, to study the effect of feeding urea and urea plus Zeolite on rumen pH and the population of rumen ciliates. Rumen fluid samples were taken after morning feed for 7 times at one hour intervals. Experimental results obtained were as follows; 1. Rumen pH was gradually dropped from 7.272 to 7.163 by 3.01 hour and from 7.18 to 7.07 by 2.87 hour and reached 7.352 and 7.29 at 7 hour after feeding, respectively on urea and urea plus Zeolite feeding group. 2. Total ciliate numbers decreased from 209,540 to 113,755 by 4.311 hour and from 381,430 to 203.125 by 4.406 hour and gradually increased to 151,030 and 265,230 by 7 hour after feeding, respectively on urea and urea plus Zeolite feeding group. 3. Population of ruminal ciliates was not changed and Entodinium simplex was the major ciliate population for both treatments. It was from 81.21 to 89.12% on urea feeding group and from 84.6 to 88.3% of total number of ciliates on urea plus Zeolite feeding group.

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Biochemical Characterization of Alkaliphilic Cyclodextran Glucanotransferase from an Alkaliphilic Bacterium, Paenibacillus daejeonensis

  • Yang, So-Jin;Ko, Jin-A;Kim, Hae-Soo;Jo, Min-Ho;Lee, Ha-Nul;Park, Bo-Ram;Kim, Young-Min
    • Journal of Microbiology and Biotechnology
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    • v.28 no.12
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    • pp.2029-2035
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    • 2018
  • Cycloisomaltooligosaccharide glucanotransferase (CITase) was isolated from alkaliphilic Paenibacillus daejeonensis via an amino acid homology search for the reported CITase. The recombinant alkaliphilic CITase (PDCITase) from P. daejeonensis was expressed in an Escherichia coli expression system and purified as a single protein band of 111 kDa. PDCITase showed optimum activity at pH 8.0 and retained 100% of activity within a broad pH range (7.0-11.5) after 18 h, indicating alkaliphilic or alkalistable CITase properties. In addition, PDCITase produced CI-7 to CI-17, CI-18, and CI-19, which are relatively large cycloisomaltooligosaccharides yet to be reported. Therefore, these large cycloisomaltooligosaccharides can be applied to the improvement of water solubility of pharmaceutical biomaterials.

Transplantation and Production of OPU Derived Hanwoo IVP Embryos (OPU 유래 한우 수정란 생산 및 이식)

  • Jin, Jong-In;Choi, Byung-Hyun;Kim, Seong-Su;Jo, Hyun-Tae;Sun, Du-Won;Lim, Hyun-Tae;Lee, Jung-Gyu;Min, Chan-Sik;Kong, Il-Keun
    • Journal of Embryo Transfer
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    • v.29 no.3
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    • pp.273-281
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    • 2014
  • This study was carried out to establish the system of OPU derived embryo production, management of recipients as well as offspring production. OPU derived embryo production system was carried out of aspiration of immature oocytes 2 times per week, total 24 times for 3 months by an ultrasonographic guided follicular aspiration system and then produced in vitro-produced blastocysts by in vitro maturation, fertilization and culture system. This work was collected total 13,866 oocytes, average $8.2{\pm}4.5$ oocytes per session and 8,170 G1 + G2 grade oocytes, average 4.8 oocytes per session by 1,692 times session of total 71 donors for 4 years from 2010 to 2013. The rate of cleavage and blastocyst developmental competence were obtained 11,825 (85.3%) and 5,032 (36.3%) that was $7.0{\pm}3.8$ cleaved embryos and $3.0{\pm}2.5$ blastocysts per session. OPU derived embryo transfer were taken place in 2, 4, 6 and 7 local governments at 2010, 2011, 2012 and 2013 for 4 years and pregnancy rate were obtained 41.2, 43.9, 46.5 and 49.7% in each years. It means that pregnancy rate was continuously improved according of every year for 4 years. Pregnancy rate was significantly different according to individual local government in which was 62.7% in B, but 24.2% in F at 2012. Paternity identification was carried out total 26 offspring in C local government of 2012 and then confirmed 100% agreement of its analysis. In conclusion, the results obtained the possibility of mass production of elite cow embryos as well as offspring by OPU derived embryo production system, of which could be decreased the required time of genetic improvement.

A comparative study on iPhone 6 Plus and Samsung Galaxy Note 4 from Vietnamese consumer perception

  • Le, Huong Van;Park, Hyun Woo
    • Asia Pacific Journal of Business Review
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    • v.2 no.1
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    • pp.53-68
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    • 2017
  • The objective of this research is to analyze the product innovation aspect in two comparable smartphones and partly illustrate perception and preference of Vietnamese consumers of two smartphone lines of Apple - iPhone 6 Plus and Samsung - Samsung Galaxy Note 4. The research tries to clarify which innovative features in two smartphones are more preferable to a group of consumer in Vietnam. The reason why the research studies iPhone 6 Plus and Samsung Galaxy Note 4 when iPhone 7 and Samsung Galaxy Note 7 have just released is that passing more than one year is enough time for consumers to totally experience both 2 smartphone lines to give the most precise and truthful evaluation for their preferences. Moreover, iPhone 6 Plus launch signed one of the most historical memorable landmark in the development process of iPhone products when it introduced larger-screen iPhone model for the first time. It is such an important change of iPhone which could open a new continuing successful era for Apple and iPhone. The first phase of this study involves analyzing strengths and weaknesses existed considering the opportunities and threats from the competitive market, then a competitive advantage analysis is implemented for each product. The second phase conducts a survey with Vietnamese participants from different backgrounds, by which a Mann-Whitney U test will be executed to check the significant difference in opinions in different respondent groups by age and by gender to several features of two smartphones. By conducting the survey, some interesting facts revealed with the winner seemingly falling into iPhone 6 Plus. However, it still reveals some significant difference among respondent groups by age and by gender to both iPhone 6 Plus and Samsung Galaxy Note 4 in several comparing features.