• BMB Reports
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• v.53 no.3
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• pp.148-153
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• 2020

Erythropoietin and iron have individually shown beneficial effects on early-phase liver regeneration following partial hepatectomy (PHx); however, there are limited data on the combined effect on late-phase liver regeneration after PHx. Here we examined combined effects of recombinant human erythropoietin (rhEPO, 3,000 IU/kg) and iron isomaltoside (IIM, 40 mg/kg) on late-phase liver regeneration following PHx and investigated the possible underlying mechanism. Rats administrated with rhEPO showed significantly higher liver mass restoration, interleukin-6 (IL-6, a hepatocyte mitogen) levels, and Ki-67-positive hepatocytes on day 7 after PHx than saline-treated controls. These beneficial effects were further enhanced on days 7 and 14 by co-treatment with IIM. This combination also significantly improved liver function indices, such as increased albumin production and decreased bilirubin levels, but did not alter serum levels of toxic parameters, such as aspartate transaminase and alanine transaminase. This study demonstrates that the combination of rhEPO and IIM synergistically improves late-phase liver regeneration and function after PHx, probably by promoting IL-6-mediated hepatocyte proliferation without adverse effects. Thus, this combination treatment can be a potential therapeutic strategy for patients undergoing resection for hepatic malignancies.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.18 no.7
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• pp.596-602
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• 2006

Ice adhesion and blockage problems have been issued in continuous ice slurry making process. So we composed continuous ice slurry making device using a commercial small plate heat exchanger (PHX), and investigated character of ice formation. An experiment of ice formation was peformed with an aqueous solution of ethylene glycol 7 mass%. In the experiment, the effect of the pressurization on ice slurry formation during the cooling process was investigated. The pressurization test for the aqueous solution was performed by setting valves at the PHX inlet and outlet. At the results, the time of continuous ice formation increased as the pressure of the plate heat exchanger increased for cooling temperature of $-5^{\circ}C$. Also continuous ice formation at the cooling temperature of $-7^{\circ}C$ showed a possibility. It was found that the pressurization may contribute to suppress the dissolution of supercooled aqueous solution in the PHX.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.9
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• pp.647-653
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• 2007

In dynamic ice storage system(DISS), ice slurry is formed not only from solution freezing by mechanical removing parts but also supercooled solution. However, in order to perform continuous ice formation in the system without mechanical moving parts, supercooled aqueous solution should be formed stable through cooling heat exchanger and be dissolved uniformly in storage tank. In previous study, the time of ice slurry increased as the pressure of the cooling heat exchanger(PHX) increased. In this study, a cooling experiment of an ethylene glycol 7mass% solution was performed with various inlet temperature of the PHX, which has constant brine inlet temperature of $-7^{\circ}C$. The temperature in the storage tank maintained to freezing point of the solution. At results, the time of ice slurry formation increased as the supercooling degree decreased and the cooling rate increased.

• Proceedings of the SAREK Conference
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• 2006.06a
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• pp.138-143
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• 2006

The peculiarity of ice slurry, such as liquidity, high heat transfer rate and easy storage can also find to supercooled type dynamic ice storage system(DISS) which is one of the DISS. However, in order to accomplish continuous ice formation in the system without mechanical moving parts, supercooled aqueous solutionshould be formed stable through cooling heat exchanger and be dissoluted in storage tank. In previous research, the time of ice slurry increased as the pressure of the cooling heat exchanger(PHX) increased. In this study, a cooling experiment of an ethylene glycol 7mass% solution was performed with various inlet temperature of the PHX, which has constant brine inlet temperature of $-7^{\circ}C$. The temperature in the storage tank maintained to freezing point of the solution. At results, the time of ice slurry formation increased as the supercooling degree decreased and the cooling rate increased.

• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.419-424
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• 2008

Heat transfer and pressure drop characteristics of welded plate heat exchanger are studied to apply it for the solution heat exchanger of 210RT absorption system. This study quantifies the effect of mass flow rate and strong solution concentration on the heat transfer coefficient and pressure drop in the plate heat exchanger. The concentration of weak solution is fixed at 55% and the strong solution varies 55%, 57%, and 59% in mass. The results show that the overall heat transfer coefficient and pressure drop increase linearly with increasing Reynolds number. It is also found that the heat transfer coefficient of hot side increases with increasing the concentration of strong solution while the strong solution concentration has no effect on heat transfer coefficient of cold side.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.20 no.1
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• pp.49-56
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• 2008

When the outdoor air temperature decreased less than the freezing temperature, frost forms at the surface of heat exchangers and it makes the performance degradation of a heat pump system. In this study, a heat pump system has been developed which has a refrigerant heating device as an auxiliarly heating equipment. To reduce power consumptions of the system, a liquid pump, rather than a compressor, was used to drive refrigerant in the heat pump cycle. Ratio of refrigerant mass flow between a refrigerant heating heat exchanger(GHX) and a outdoor plate heat exchanger(PHX) was varied and the system performance was measured and analyzed. As results, when the refrigerant flow rate to the GHX was decreased, the system performance is decreased due to heat absorption capability restriction of the GHX and small variation of the power consumption in the compressor. The effect on the evaporating and condensing pressure by the distribution ratio of the refrigerant to the each heat exchanger is small compare to the effect by the frequency change in the compressor. When the compressor was replaced by the liquid pump, the capacity of the system decreased a little, however the power consumption decrease approximately 80% compare with the power used in the compressor.