• Journal of the Korean Society of Safety
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• v.33 no.5
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• pp.120-126
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• 2018

The traffic accident types are largely classified into vehicle to vehicle accident, vehicle-to-person accident and single-vehicle. Especially, the single-vehicle accident types are severe when the vehicle crashed into road facilities such as bridge, piers, utility poles. The severity of single-vehicle accidents are ten times higher than that of all other accidents types. It is needed to consider to reduce accident severity. This study was conducted to develop crash worthy safety design facility to ensure the vehicle occupant safety. The simulation and the crash tests were conducted for assessment of the safety performance to check the criteria of CC2(Crash Cushion 2) level. THIV(Theoretical Head Impact Velocity) and PHD(Post-impact Head Deceleration) were used to assess occupant impact severity for crashes. The non-redirection collision test conditions for 900 kg and 1,300 kg-head on crash tests, 900 kg-1/4 offset crash tests, 1,300 kg-head on crash test with $15^{\circ}$angle were conducted. The simulation and experiment test result showed that THIV values were below 44 km/h criterion, PHD values were below the 20G. The development non-redirective crash cushion is expected to be used for the fixed object such as bridge piers for assuring occupant safety.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.10
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• pp.21-29
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• 2013

This paper proposed the architecture of the authentication and the transmission for high reliable emergency data management based on U-healthcare wireless mesh networks. In U-healthcare monitoring service, the high reliable bio data management as well as the data transmission are required because the monitoring emergency bio data is related linked to life. More specifically, the technologies of the identity authentication of the measuring bio data, the personalized emergency status diagnosis who is authenticated the bio data and the emergency data transmission are important first of all. To do this, this paper presents the structure and protocol of the identity authentication management with using the extended IEEE 11073 PHD, the structure of policy-based management of the emergency bio data for the highly reliable management and the resilient routing protocol based on wireless mesh network for the reliable data transmission.

• Toxicological Research
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• v.24 no.2
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• pp.101-107
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• 2008

Studies on hypoxia-signaling pathways have revealed novel Fe(II) and $\alpha$-ketoglutarate-dependent dioxygenases that hydroxylate prolyl or asparaginyl residues of a transactivator, Hypoxia-Inducible $Factor-\alpha(HIF-\alpha)$ protein. The recognition of these unprecedented dioxygenases has led to open a new paradigm that the hydroxylation mediates an instant post-translational modification of a protein in response to the changes in cellular concentrations of oxygen, reducing agents, or $\alpha$-ketoglutarate. Activity of $HIF-\alpha$ is repressed by two hydroxylases. One is $HIF-\alpha$ specific prolyl-hydroxylases, referred as prolyl-hydroxylase domain(PHD). The other is $HIF-\alpha$ specific asparaginyl-hydroxylase, referred as factor-inhibiting HIF-1(FIH-1). The facts (i) that many dioxygenases commonly use molecular oxygen and reducing agents during detoxification of xenobiotics, (ii) that detoxification reaction produces radicals and reactive oxygen species, and (iii) that activities of both PHD and FIH-1 are regulated by the changes in the balance between oxygen species and reducing agents, imply the possibility that the activity of $HIF-\alpha$ can be increased during detoxification process. The importance of $HIF-\alpha$ in cancer and ischemic diseases has been emphasized since its target genes mediate various hypoxic responses including angiogenesis, erythropoiesis, glycolysis, pH balance, metastasis, invasion and cell survival. Therefore, activators of PHDs and FIH-1 can be potential anticancer drugs which could reduce the activity of HIF, whereas inhibitors, for preventing ischemic diseases. This review highlights these novel dioxygenases, PHDs and FIH-1 as specific target against not only cancers but also ischemic diseases.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.3
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• pp.179-186
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• 2016

A study is to research crash barriers for vehicles that prevent road breakaway of vehicles and protect car passengers and pedestrians as absorbing impulse. Protection performance tests on vehicle passengers were simulated by using a LS-DYNA program. Through repetitive simulation on various speed and angles, passenger protection performance according to different impact condition was contemplated. Variable setting for the simulation was calculated as the mean weight of domestic car sales. By analyzing NASS (National Automotive Sampling System) of NHTSA (National Highway Traffic Safety Administration) of the U.S., the actual speed and collision angle section of accidents were computed. As a result, we confirmed that THIV (Theoretical Head Impact Velocity) and PHD (Post-impact Head Deceleration) are increased according to the impact speed and angle. Also, when the vehicle hit the guardrail post, we could be confirmed that the passenger protection performance greatly decreased.

• International Journal of Oral Biology
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• v.33 no.4
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• pp.125-129
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• 2008

Inositol 1,4,5-trisphosphate ($IP_3$) plays an important role in the release of $Ca^{2+}$ from intracellular stores into the cytoplasm in a variety of cell types. $IP_3$ translocation dynamics have been studied in response to many types of cell signals. However, the dynamics of cytosolic $IP_3$ in salivary acinar cells are unclear. A green fluorescent protein (GFP)-tagged pleckstrin homology domain (PHD) was constructed and introduced into a phospholipase C ${\delta}1$ (PLC ${\delta}1$) transgenic mouse, and then the salivary acinar cells were isolated. GFP-PHD was heterogeneously localized at the plasma membrane and intracellular organelles in submandibular gland and parotid gland cells. Application of trypsin, a G protein-coupled receptor activator, to the two types of cells caused an increase in GFP fluorescence in the cell cytoplasm. The observed time course of trypsin-evoked $IP_3$ movement in acinar cells was independent of cell polarity, and the fluorescent label showed an immediate increase throughout the cells. These results suggest that GFP-PHD in many tissues of transgenic mice, including non-cultured primary cells, can be used as a model for examination of $IP_3$ intracellular dynamics.

• The Journal of the Korea Contents Association
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• v.8 no.11
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• pp.33-40
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• 2008

The application of OCR moves from traditional formatted documents to the web document and natural scene images. It is usual that the new applications use not only standard fonts of Myungjo and Godic but also various fonts. The conventional databases which have mainly been constructed with standard fonts have limitations in applying to the new applications. In this paper, we generate 243 image samples for each of 2350 Hangul character classes which differs in font size, quality, and resolution. Additionally each sample was varied according to binarization threshold and rotational transformation. Through this process 2187 samples were generated for each character class. Totally 5,139,450 samples constitutes the printed Hangul character database called the PHD08. In addition, we present the characteristics and recognition performance by an commercial OCR software.

• Journal of Information Processing Systems
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• v.14 no.1
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• pp.205-217
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• 2018

Deep learning using convolutional neural networks (CNNs) is being studied in various fields of image recognition and these studies show excellent performance. In this paper, we compare the performance of CNN architectures, KCR-AlexNet and KCR-GoogLeNet. The experimental data used in this paper is obtained from PHD08, a large-scale Korean character database. It has 2,187 samples of each Korean character with 2,350 Korean character classes for a total of 5,139,450 data samples. In the training results, KCR-AlexNet showed an accuracy of over 98% for the top-1 test and KCR-GoogLeNet showed an accuracy of over 99% for the top-1 test after the final training iteration. We made an additional Korean character dataset with fonts that were not in PHD08 to compare the classification success rate with commercial optical character recognition (OCR) programs and ensure the objectivity of the experiment. While the commercial OCR programs showed 66.95% to 83.16% classification success rates, KCR-AlexNet and KCR-GoogLeNet showed average classification success rates of 90.12% and 89.14%, respectively, which are higher than the commercial OCR programs' rates. Considering the time factor, KCR-AlexNet was faster than KCR-GoogLeNet when they were trained using PHD08; otherwise, KCR-GoogLeNet had a faster classification speed.

• Journal of Nutrition and Health
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• v.49 no.6
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• pp.459-470
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• 2016

Purpose: The purpose of the present study is to identify the relationship between practicing healthy diet and metabolic syndrome indicators in Koreans. Methods: This research is a cross-sectional study based on the 2013~2014 Korea National Health and Nutritional Examination Survey. This study investigated 6,748 adults aged 19 to 64 yr (19~49 yr: n = 4,230, 50~64 yr: n = 2,518) to examine practice of healthy diet and metabolic syndrome indicators. In this study, according to practicing healthy diet, we classified subjects into the "Practicing healthy diet (PHD)" group (19~49 yr: n = 1,782, 50~64 yr: n = 937) and "Non-practicing healthy diet (NPHD)" group (19~49 yr: n = 2,448, 50~64 yr: n = 1,581). PHD score was determined by adding the number of practicing factors: adequate fat intake, sodium intake ${\leq}2,000mg/day$, fruit & vegetable intake ${\geq}500g/day$, and using nutrition label information in food selection. Results: Female adults had a larger proportion of subjects who practiced a healthy diet compared to male adults (p < 0.001), and the percentages of 19~49 yr and 50~64 yr were 40.46% and 37.07%, respectively. The PHD group consumed significantly more calcium, vitamin $B_1$, $B_2$, and vitamin C density compared to the NPHD group. In 50~64 yr females, the subjects practicing healthy diet (PHD score ${\geq}2$) was inversely associated with risk of abdominal obesity (OR: 0.71, 95% CI: 0.54~0.93, p value = 0.0131) and metabolic syndrome (OR: 0.70, 95% CI: 0.52~0.94, p value = 0.0166) after adjustments for multiple confounding factors, compared with the lower PHD score (PHD score ${\leq}1$). Conclusion: Good dietary practice such as adequate fat intake, sodium intake ${\leq}2,000mg/day$, sufficient fruit & vegetable intake, and using nutrition label information in food selection could be useful in decreasing metabolic syndrome risk of Korean adults.

• The Korean Journal of Ecology
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• v.28 no.5
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• pp.295-303
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• 2005

The sexual dimorphism and intra sexual dimorphism in males of Rhinogobius brunneus were investigated at Jiam stream, a tributary of the Bukhan river from May, 2005. The frequency distributions in standard length were similar for the females and maleLs, but maleSs were smaller than the females and maleLs. The ratio of MaleL (N=79) to males (N=79) was 1 : 0.46. The comparison between female (N=79) and maleL (N=79) gave significant differences (P<0.05) in 18 morphometric characteristics (SNL, AHD, PHD, ML, DL, MW, AHW, IFW, PHW, ED, HL, FDFL, SDFB, CFL, AFB, VFL, PFL, PFB) and 12 characteristics (SNL, AHD, ML, DL, MW, AHW, IFW, PHW, HL, FDFI, CFL, PFB) (P<0.001). Eight morphometric characteristics (SNL, ML, DL, MW, HL, CFL, VFL, PFL) in female (N=36) and males (N=36) had significant differences (P<0.05) and three characteristics (ML, DL, HL) had very significant differences (P<0.001). Eleven characteristics (SNL, AHD, PHD, ML, DL, MW, AHW, IFW, PHW, HL, FDFL) were significantly different in maleL (N=36) and males (N=36) (P<0.05) and six (ML, DL, MW, AHW, HL, FDFL) were very significantly different (P<0.001).

• Proceedings of the Korea Society of Design Studies Conference
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• 2005.10a
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• pp.82-83
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• 2005