• 환경위생공학
• /
• 제19권1호
• /
• pp.8-16
• /
• 2004

Ground water samples were collected from residential, green" industrial, landfill and mining area and analyzed for 23 inorganics from March to October in 2002. The results are as follows; 1. The detection frequencies of inorganic materials such as As, Ba, B, Mo, Ca, Mg, Al, Cu, Fe, Mn, Zn, Na, K were 7.2∼77.1% which showed that these inorganics were detected in many ground waters. 2. The detection frequencies of 7 inorganics(Cd, Cr, Ph, Se, Sb, Be, Tl) were commonly low at ranging from 0.42 to 2.5%. These inorganics were contained in ground water partially. 3. Three inorganics such as Hg, Ni, Ag were not detected in any ground-water samples. 4. Compared to the other areas, ground water samples from landfill area contained greater concentration in many inorgainics and then showed higher levels in industral, residential, mining and green area in order. 5. Compared to noted concentrations of bottled water, inorganic minerals including Ca, Mg, Na, K related to taste were fluent in target samples. The results showed that the average concentrations of Mg, Na, K were 4.0 mg/l, 14.7 mg/l, 1.5 mg/l respectively. 6. The concentrations of inorganics such as Sb, Ba, Mo, Be, Tl, K in some ground water samples exceeded the water quality standards of WHO, the US and UK. Especially, Ba, Mo, K also showed relatively high detection frequencies so these inorganics need to be considered as analytes in Korea Drinking Water Regulation in further study.

• 생명과학회지
• /
• 제12권2호
• /
• pp.129-135
• /
• 2002

여러 종류의 호열성, 호기성 간균(Bacillus genus)군, 중금속 leaching 미생물군(Thiobacillus, T. ferooxidans), 그리고 여러 가지 난분해성 물질을 분해하는 미생물군 (Pseudomonas genus)을 활용하여 퇴비화의 조건을 연구하고 이를 이용하여 축산폐기물의 퇴비화에 미치는 효과를 연구하였다. 35∼40의 C/N비, 50∼65%의 함수율 범위에서 실험실용 회전드럼형 반응조에서의 퇴비화는 온도상승이 수동식 반응조보다 낮으며 느리게 일어났다. 퇴비화 후 성분분석에서 높은 수준의 광물질을 함유하는 것으로 화학비료 대체효과를 보여주며 퇴비화 전후 중금속 분석에서 As는 모든 퇴비에서, Cr은 돈분, ph은 축분, Hg은 계분, 그리고 Cu는 축분퇴비에서 규제값 이하를 보여주었다. 여러 가지 부숙도 분석에서 퇴비의 숙성도를 나타내었다. SS 또는 EMB agar plate을 이용한 살모넬라균과 대장균의 검사에서 병원균에 대한 퇴비의 안전성이 확인되었다. 이러한 결과는 금속 및 다른 난분해성 물질을 생분해하는 미생물을 투입하여 퇴비의 중금속감소와 퇴비화 속도증가의 가능성을 시사한다.

• 동아시아식생활학회지
• /
• 제15권4호
• /
• pp.465-474
• /
• 2005

This study was conducted to estimate the contents of heavy metals 'mercury(Hg), cadmium(Cd), lead(Pb), arsenic(As), zinc(Zn), copper(Cu), chrome(Cr) and manganese(Mn)' in root vegetables which were produced in Korea. The levels of heavy metals were determined using a mercury analyzer, an ICP(inductively coupled plasma spectrometer) and an AAS(atomic absorption spectrophotometer) after wet digestion. The values of heavy metals 'mean(minimum-maximum)' mg/kg(ppm) in root vegetables (radish, turnip, carrot, ginger, edible burdock, taro, Chinese yam, east indian lotus) were as follows ; Hg : 0.0019(0.0002${\~}$0.0062), Cd : 0.0088(ND${\~}$0.0402), Pb : 0.021(ND${\~}$0.1070), As : 0.0401(ND${\~}$0.1732), Zn : 1.865(0.4186${\~}$6.9319), Cu : 0.648 (0.1826${\~}$4.0172), Cr : 0.121(0.0132${\~}$1.2030), and Mn : 2.730(0.0477${\~}$10.0468) mg/kg. These results showed that Hg were generally similar to and Cd was lower but Ph, As, Zn, Co, Mn were little higher than the levels of those reported contents in root vegetables on retail markets in Korea. Although the tolerable limit of Cd and Hg is not set in a regulation of WHO/FAO, the tested mean levels(Pb, As, Zn, Cu) were lower than the regulated ones of WHO/FAO, Pb '0.1-2.0', As '1.0', Zn '5.0', and Cu 0.1${\~}$50 mg/kg from vegetables. Therefore, root vegetables sold in the retail markets were evaluated as safe in terns of the heavy metal contents.

• 한국콘텐츠학회논문지
• /
• 제22권3호
• /
• pp.261-272
• /
• 2022

본 연구는 탐색적 요인분석 등을 통해 한국 청소년들이 경험하는 분노유발요인 측정을 위한 척도개발을 목적으로 한다. 이를 검증하기 위해 국내외 청소년대상 분노유발요인 척도를 분석하여 130문항을 추출하고, 이를 연구팀이(관련교수 2명, 박사과정생 2명) 적절성, 시기적/문화적 타당성, 중복성 등을 점검하여 총 54개 예비문항을 구성하였다. 이후 청소년 252명을 대상으로 개발된 예비문항을 설문조사하여 탐색적 요인분석을 실시하였다. 낮은 요인부하량을 나타낸 12개 항목을 제거하고, 7개요인(자존감을 위협당할 때, 통제할 수 없는 상황, 소유물에 대한 침해, 제지당했을 때, 규범이 지켜지지 않을 때, 부당한 일을 당했을 때, 차별(무시)당할 때) 총 42개 항목이 추출되었다. 분석 결과 청소년대상 분노유발요인 척도의 내적합치도, 타당도 결과가 적절한 것으로 나타났다. 특성분노와 공격행동척도와의 상관관계도 통계적으로 유의미하게 나타나 적절한 수렴타당도를 나타냈다. 개발된 척도의 확인적 요인분석를 추가적으로 실행하고 그 결과를 제시하였다. 본 연구결과는 국내 청소년들이 분노하는 상황요인에 대한 이해를 돕고 궁극적으로 분노를 완화하는 대안제시를 위한 기초자료로 활용될 것으로 기대된다.

• 생명과학회지
• /
• 제30권9호
• /
• pp.826-833
• /
• 2020

Phospholipase C gamma (PLCγ)는 phosphatidylinositol을 가수분해하여 신호전달 과정에 참여하는 PLC의 주요한 isotype으로 γ-specific array의 특징적인 구조를 바탕으로 receptor tyrosine kinases 및 non-receptor tyrosine kinase 신호를 주로 매개한다. PLCγ1과 PLCγ2의 두 isozyme이 존재하며 다양한 세포에서 발현하여 cell proliferation, migration 및 differentiation 등 여러 세포작용을 조절하고 있다. 최근의 연구들에서 PLCγ 돌연변이가 cancer와 immune disease 및 brain disorder 등에 연관된다는 것이 밝혀지고 있으며 genetic model을 통해 PLCγ의 생리적·병리적 기능이 제시되었다. 본 리뷰에서는 최신의 연구 결과들을 바탕으로 PLCγ의 구조와 활성 조절 기전에 대해 기술하고 나아가 여러 질병의 발병과 진행에서 보고된 PLCγ의 돌연변이와 knockout 마우스를 활용한 연구 결과를 바탕으로 생리적·병리적 관점에서 PLCγ의 역할에 대해 고찰하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권19호
• /
• pp.8377-8382
• /
• 2014

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting p53 profile in an OSCC rat model. Methods: In this study, 120 male rats were divided into 8 groups of 15 animals each. The new formulated DOX-MTX NP and free doxorubicin were IV and orally given to rats with 4-nitroquinoline-1-oxide induced OSCC. Results: Results showed that both DOX and DOX-MTX-NP caused significant increase in mRNA levels of P53 compared to the untreated group (p<0.000). With both DOX and DOX-MTX NP, the IV mode was more effective than the oral (gavage) route (p<0.000). Surprisingly, in oral mode, p53 mRNA was not affected in DOX treated groups (p>0.05), Nonetheless, both IV and oral administration of MTX-DOX NP showed superior activity (~3 fold) over free DOX in reactivation of p53 in OSCC (p<0.000). The effectiveness of oral route in group treated with nanodrug accounts for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Moreover, in treated groups, tumor stage was markedly related to the amount of p53 mRNA (p<0.05). Conclusion: Both oral and IV application of our novel nanodrug possesses superior activity over free DOX-in up-regulation of p53 in a OSCC model and this increase in p53 level associated with less aggressive tumors in our study. Although, impressive results obtained with IV form of nanodrug (-21 fold increase in p53 mRNA level) but both forms of nanodrug are effective in OSCC, with less toxicity normal cells.

• 동서간호학연구지
• /
• 제5권1호
• /
• pp.120-126
• /
• 2000

This study was intended to grasp the history of nursing education from the beginning to the present in Korea, and grip and look-out current diversified systems of nursing education on basis of February, 2000 through literatural review and investigation by close telephone interviews. The basic nursing educational institutions in the whole country were total 113, namely, 3 years course, 65 junior colleges of nursing, and 4 years course, 48 colleges of nursing. And there were 3 types of continuing nursing educational system: two of three were transferring to another college for gain bachelor's degree in nursing; RN-BSN programs and university of broadcasting, and the other was the system of independent learning and then examination for BSN. Total nursing graduates from junior college of nursing courses and college of nursing courses were 7,564 on February, 1999. In general graduate school, the number of master courses were 21 and Ph.D courses were 13. And the number of special graduate schools were 21, i.e., graduate school of education were 7, graduate school of administration were 2, graduate school of public health were 11 and graduate school of industry was 1. As the perspective on nursing education, we overviewed changing nursing organizational environment, increasing the system of continuing education, making standards in nursing education and systemization of nursing educational accreditation, specialization of nursing, information system in nursing education and education of graduate school. The summary of the above overviewed subjects were as follows; Every nursing educational institution needed to educate by educational criteria and standard and characteristically run BSN and graduate courses. Specialization in nursing has to develop more and more, therefore advanced education and law should be prepared appropriately. According to the age's and social needs, we have to establish counter-plan for fundamental educational environment. We have to sensitive to rapidly changing information in the era of globalization. In the level of university education, each university needs characterization of educational objectives, goals and contents, and has to replace the shortage of the number of professor. And the regulation of thesis and dissertation examinations need to be reinforced. Education in nursing should consists with specialization. Collaboration among universities will bring efficiency in the nursing education.