• Title/Summary/Keyword: PGI

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THE CONCENTRATIONS OF PROSTAGLANDIN E2, 6-KETO-PROSTAGLANDIN F1α, AND LEUKOTRIENE B4 IN PULPAL AND PERIAPICAL LESIONS (치수 및 치근단병소에서 Prostaglandin E2, 6-keto-Prostaglandin F1α, Leukotriene B4의 분포에 관한 연구)

  • Shon, Won-Jun;Baek, Seung-Ho;Lim, Sung-Sam
    • Restorative Dentistry and Endodontics
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    • v.25 no.2
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    • pp.193-201
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    • 2000
  • Prostaglandins (PGs) and Leukotrienes (LTs) have been implicated in the genesis of pulpal and periapical inflammation. In this study, the relationships among $PGE_2$, 6-keto-PG $F_1{\alpha}$ (a stable metabolite of $PGI_2$) and $LTB_4$ concentrations in inflamed pulp and periapical lesions were discussed. Pulp tissue were obtained in routine endodontic treatment and periapical lesions in periapical surgery after clinical diagnoses were made. These specimens were divided into four groups as normal pulp group (Control group), acute pulpitis group, chronic pulpitis group, and periapical lesion group. Pulp tissue and periapical lesions were stored in liquid nitrogen. The concentration of $PGE_2$, $PGI_2$ and $LTB_4$ were measured with ELISA. The data were analyzed by one-way ANOVA. Significantly higher levels of $PGE_2$, 6-keto-PG $F_1{\alpha}$ a and $LTB_4$ were found in acute pulpitis group than chronic pulpitis group and periapical lesion group(p<0.05). Periapical lesion group showed significantly higher mean concentrations of $PGE_2$ and $LTB_4$ than chronic pulpitis group. In control and chronic pulpitis group, significant higher levels of $PGI_2$ than $PGE_2$ and $LTB_4$ were found. These results suggested that the high levels of $PGE_2$ and $LTB_4$ in periapical lesions may be due to rich endothelium., fibroblast and lymphocyte known as the main producers of $PGE_2$ and $LTB_4$. $PGI_2$ may be thought to one of the most abundant PGs in normal pulp tissue.

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The Variation of Isoenzymes and Morphological Characteristics of Needle, Cone and Seed According to Resin Duct Index in Pinus densiflora and Pinus thunbergii (소나무 및 곰솔의 수지구지수(樹脂溝脂數)에 따른 침엽(針葉), 구과(毬果) 및 종자(種子)의 형태적(形態的) 특성(特性)과 동위효소(同位酵素)의 변이(變異))

  • Son, Doo Sik;Park, Sang Jun;Hwang, Jae Woo
    • Journal of Korean Society of Forest Science
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    • v.79 no.4
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    • pp.424-430
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    • 1990
  • The variation of needle, cone and seed characteristics and of allelic frequency in isoenzyme, ADH, ME and PGI, according to different resin duct index in Pinus densiflora, Pinus thunbergii and their hybrids was analyzed. The results obtained were as follows : 1. With increase of number of resin ducts, morphological characteristics such as needle length, needle sheath length, cone size, seed size, seed wing size, 1000 seeds weight, etc. tended to he increased, while number of stomata row in needle to be decreased. 2. As the results of discriminant analysis for the morphological characteristics of needle, cone and seed, most individuals are generally coincided with number of resin duct mostly in Pinus densiflora were not. 3. According to the canonical discriminant function obtained from the morphological characteristics in Pinus densiflora, Pinus thunbergii and their hybrids including introgressive hybrid, the resin duct index, 1000 seeds weight, cone size and neelde sheath length characterized fairly their species. 4. With increase of resin duct index, hybrid index tended to be higher. The results obtained from the discriminant analysis and the hybrid index were nearly same each other. 5. With increase of number of resin duct, the allelic frequencies for isoenzyme, ADH-$B_2$, ME-$A_2$ and PGI-$B_1$. $B_2$ tended to increase but those of ADH-$B_3$, ME-$A_4$, and PGI-$B_3$, to decrease. It is thought that this increase of frequency for the former four isoenzymes was resulted in introgressive gene flow from Pinus thunbergii to Pines densiflora and accordingly the frequency of latter three isoenzymes tended to decrease.

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Production of Prostaglandin $E_2$ and $I_2$ is Coupled with Cyclooxygenase-2 in Human Follicular Dendritic Cells

  • Cho, Wha-Jung;Kim, Jin-I;Cho, Kyu-Bong;Choe, Jong-Seon
    • IMMUNE NETWORK
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    • v.11 no.6
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    • pp.364-367
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    • 2011
  • Background: Prostaglandins (PGs) play pathogenic and protective roles in inflammatory diseases. The novel concept of PGs as immune modulators is being documented by several investigators. By establishing an in vitro experimental model containing human follicular dendritic cell-like cells, HK cells, we reported that HK cells produce prostaglandin $E_2$ ($PGE_2$) and prostaglandin $I_2$ ($PGI_2$) and that these PGs regulate biological functions of T and B cells. Methods: To investigate the respective contribution of cyclooxygenase-1 (COX-1) and COX-2 to $PGE_2$ and $PGI_2$ production in HK cells, we performed siRNA technology to knock down COX enzymes and examined the effect on PG production. Results: Both $PGE_2$ and $PGI_2$ productions were almost completely inhibited by the depletion of COX-2. In contrast, COX-1 knockdown did not significantly affect PG production induced by lipopolysaccharide (LPS). Conclusion: The current results suggest that mPGES-1 and PGIS are coupled with COX-2 but not with COX-1 in human follicular dendritic cell (FDC) and may help understand the potential effects of selective COX inhibitors on the humoral immunity.

Effect of Austempering Treatment on Dynamic Characteristics of Brake Drums (오스템퍼링 처리가 브레이크 드럼의 동적 특성에 미치는 영향)

  • Yim, K.B.
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.19 no.1
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    • pp.65-70
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    • 2010
  • The effect of austempering treatment on the dynamic properties of a brake drum was investigated to primarily evaluate the potential damping advantage of an AGI (austempered gray iron) drum over a PGI (pearlitic gray iron) drum. This investigation provides valuable information for brake noise reduction since the brake drum is most often the outstanding component that generates the noise of the brake assembly. Test results show that the AGI drum provided slightly larger damping values than the PGI drum for the first few major resonances observed. A finite element model of a drum was also developed to aid in studying its dynamic behavior. A good correlation was obtained between the analytical results and the actual measurement data.

Electrophoretic Study of Semisulcospira gottschei in Korea (한국산(韓國産) Semisulcospira gottschei의 전기영동적(電氣泳動的) 연구(硏究))

  • Kim, Chang Han
    • The Korean Journal of Malacology
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    • v.2 no.1
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    • pp.30-34
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    • 1986
  • Genetic variations of Semisulcospjra gottschei in Korea were investigated by means of starch gel-electrophoresis. The results are as follows; 1) Eight loci of ${\alpha}$-Gpd, Mdh-2, Pept-1, Pgm-2, Gp-1, Gp-2, Gp-3 and Gp-4 were monomorphic, and 8 loci of Mpi, Mdh-1, Pgi, Got, Pept-2, Pept-3, Pgm-1 and Sdh showed genetic variations. 2) Means of allele per locus ($\bar{A}$) and polymorphism (P) were revealed 0.64 and 0.44, respectively. The value of heterozygosity ($H_G$) showed a little more than heterozygosity $H_D$. ($H_D$=0.09, $H_G$=0.13) 3) Genetic variation appears to be due to loci of Got, Pept, Pgi, and Sdh, all of which of the $H_D$ values are high.

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Effect of Acidic Polysaccharides of Korean White Ginseng on Lipolytic Action of Toxohormone-L from Cancerous Ascites Fluid (암독소 호르몬-L이 유발하는 체지방분해에 고려백삼 산성다당체 성분이 미치는 영향)

  • 이성동
    • The Korean Journal of Food And Nutrition
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    • v.4 no.2
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    • pp.149-154
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    • 1991
  • This study was devised to observe the inhibitory effect of 7 kinds of the acidic polysaccharide fraction(PGI, PGa, PG3, PGa, PGs, PG6 and PG7) from Korean white ginseng on a lipolytic action of Toxohormone-L. Toxohormone-L is a lipolytic factor, found in ascites fluid of .sarcoma -180 bearing mice and of patients with hepatoma. A substace that inhibited the lipolytic action of Toxohormone-L was isolated from white ginseng powder. This substance was an acidic polysaccharides. In vitro test showed that the inhibitory effect of PGs fraction of the lipolysis by Toxohormone-L was highest percent among other treatments at concentration of 50, 10, 200, 500 and 1,000 Ug/ml of reaction mixture. And total inhibitory activity(units) of PGI and PG4 was highest among other treatments at the same concentration and that of 10 Ug/ml.

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Pitching grade index in Korean pro-baseball (한국프로야구에서의 투수평가지표)

  • Lee, Jang Taek
    • Journal of the Korean Data and Information Science Society
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    • v.25 no.3
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    • pp.485-492
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    • 2014
  • In baseball, the traditional measure of pitchers are wins and ERA. But these statistics are influenced by luck or team power. So sabermetrician proposes a number of indicators that predict future performance. We determine a new measure, which we call pitching grade index (PGI) that efficiently summarizes a pitcher's performance on a numerical scale using principal components analysis. The PGI statistic can often be useful to assessing a pitcher's individual contribution. Also K-means clustering algorithm are used for segmentation of players into groups.

Power-Gen International(PGI) 2008 참관기(1)

  • Kim, In-Cheol
    • JOURNAL OF ELECTRICAL WORLD
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    • s.385
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    • pp.48-50
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    • 2009
  • 2008년 11월 29일부터 12월 6일까지 미국 폴로리다주 올랜도에서 열린 세계적인 발전설비 전시회(Power-Gen International 2008)를 대한전기협회가 주관하여 전력산업계 실무자들이 직접 체험하는 행사를 마련했다. 여기에 참석한 실무자들의 경험담을 게재한다.

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Inheritance of Isoenzymes in Root Tips of Trembling Aspen (Populus tremuloides Michx.) (북미(北美)사시나무 trembling aspen (Populus tremuloides Michx.) 근단조직내(根端組織內)의 동위효소들의 유전)

  • Hyun, Jung Oh
    • Journal of Korean Society of Forest Science
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    • v.64 no.1
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    • pp.20-25
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    • 1984
  • The inheritance of isoenzymes in young coat tissues of trembling aspen (Populus tremuloides Michx.) was studied by electrophoretically analysing five parental clones and their full-sib progenies obtained by crossing one female clone to four male clones. The distal 2cm section of vigorous young roots of 70 seedlings per family were subjected to horizontal starch gel electrophoresis. The resulting gels were tested for activity of 7 enzyme systems. Evidences for the inheritance of isoenzymes observed indicated that the isoenzyme variants of every isoenzyme zone were under control of codominant alleles at a single locus. Chi-square test of joint segregation data of the two loci, 6-PGD-2 and PGI-2, indicated that the pair of loci was not linked.

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Pedigree Indexing of Imported American Brahman Breeder Cattle in the Philippines

  • Bondac, O.L.;Mercado, C.M.;Vera Cruz, N.C.;Palou, R.N.;Jr, J.S.Server
    • Asian-Australasian Journal of Animal Sciences
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    • v.10 no.6
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    • pp.614-620
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    • 1997
  • Pedigree data were used to predict the performance of 1,166 imported Americas Brahman breeder cattle, composed of 104 bulls and 1,062 heifers with an average age of 24.4 months (range of 17 to 40 months). A total of 13 full sib, 10 maternal half sib, and 228 paternal half sib groups were identified, each with average group size of 2.08, 2.00, and 4.49, respectively. Only 758 (64.9% of total) imported cattle were found to have at least one ancestor with expected progeny differences (EPDs) reported in the Spring 1995 Brahman Sire Summary. Moderate average accuracy values of .71, .69, .52, and .52 for birth weight, weaning weight, yearling weight, and maternal milk, respectively, were noted for EPDs of the ancestors. Prediction equations were derived by multiple regression analysis of available EPDs of sire, paternal grand sire, and maternal grand sire. Based on pedigree indexes that involve various combinations of available ancestral information, the average predicted EPDs (lbs) for imported cattle were $1.76{\pm}0.54$, $14.93{\pm}4.86$, $25.10{\pm}9.50$, and $5.86{\pm}2.08$ for birth weight, weaning weight, yearling weight, and maternal milk, respectively. Significant correlations (p < .05) were also found between sire and son EPDs (+.27) for yearling weight; and between sire and paternal grand sire EPDs for birth weight (+.34), weaning weight (+.51), yearling weight (+.49), and maternal milk (+.55).