• Journal of Powder Materials
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• v.29 no.4
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• pp.291-296
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• 2022

The green body of WC-Co cemented carbides containing polymeric binders such as paraffin, polyethylene glycol (PEG), and polyvinyl acetate (PVA) are prepared. The green density of the WC-Co cemented carbides increases with the addition of binders, with the exception of PVA, which is known to be a polar polymeric substance. The green strength of the WC-Co cemented carbides improves with the addition of paraffin and a mixture of PEG400 and PEG4000. In contrast, the green strength of the WC-Co does not increase when PEG400 and PEG4000 is added individually. The compressive strength of the green body increases to 14 MPa, and the machinability of the green body improves when more than 4-6 wt% paraffin and a mixture of PEG400 and PEG4000 is used. Simultaneously, the sintered density of WC-Co is as high as 99% relative density, similar to a low binder addition of 1-2 wt%.

• Journal of the Korean Wood Science and Technology
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• v.37 no.6
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• pp.497-504
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• 2009

The characteristic changes in weight, moisture content, and dimension at the early adsorptiondesorption stage of PEG-treated Korean pine (Pinus koraiensis), Japanese larch (Larix kaempferi), mongolian oak (Quercus mongolica) and sargent cherry (Prunus sargentii) woods were investigated. The wood samples were treated with PEG 1000, 2000 and 4000, and conditioned at the relative 98%, 65% and 20% for humidities of one week. The weight of Korean pine, Japanese larch and sargent cherry woods treated with PEG 1000 and 2000 during the adsorption-desorption was significantly changed, but mongolian oak was slightly changed. Moisture content was highly Moisture content was highly fluctuated by the change of relative humidity in the three species except oak wood. Although the weight of PEG-treated wood; however, changes in dimension could be prevented by PEG treatment in all species tested.

• Korean Journal of Materials Research
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• v.7 no.1
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• pp.15-20
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• 1997

목재의 건조 균열방지를 위한 진공흡입기술의 새로운 목재처리방법에 대해 연구를 수행하였다. 목재의 건조균열 방지를 위해 사용된 ployetylene grycogen(PEG) 처리재들은 PEG-1540, PEG-2000, PEG-4000, PEG-10000이었으며, 진공펌프의 감압정도는 85kPa과 39kPa 이었다. 시험결과, 진공흡입처리에 의한 PEG액의 흡입은 방사단면에 걸쳐 고르게 이루워졌음을 확인 할 수 있었다. 또한 PEG의 분자량이 증가할수록 단위시간당 PEG의 분자량이 증가할수록 단위시간당 PEG의 흡입량과 처리전.후의 함수률의 차인$\Delta$ M.C 는 PEG-2000을 변곡점으로 하여 감소하였다. 그리고 리기다 소나무의 건조균열 방지를 위한 약제 흡입처리에 있어 최적의 PEG 분자량과 농도 그리고 감압력의 조건은 각각 PEG-2000과 30%(wt.)그리고 85kPa임을 알 수 있었다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.177-177
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• 1994

좌제중에서 OMZ의 분해는 1차 반응적이었으며, 안정화제로서는 arginine이 가장 좋아서 arginine을 10 mg 첨가한 Witepsol H15 좌약과 PEG 4000좌약의 분해속도 상수는 각각. 3.89$\times$10-3day$^{-1}$, 8.67$\times$$10^{-3}$ day$^{-1}$이어서, arginine 비첨가 Witepsol Hl5기제 (k = 00.11 day$^{-1}$, PEG 4000기제( k = 0.48 day$^{-1}$)의 경우보다 훨씬 양호하였으며, 35$^{\circ}C$, 75%RH에서 장기보존시험 결과 Witepsol H15 좌제와 PEG 4000 기제는 각각 k = 3.63$\times$$10^{-4}$ day$^{-1}$, t190% = 291 8 days와 k = 3.69$\times$$10^{-4}$ day$^{-1}$ 및 t90% = 282.1 days이었으며, 좌제로부터 약물의 용출에 미치는 영향은 arginine의 첨가, 원료약품 입자의 미세화, 적절한 계면활성제의 첨가 그리고 지용성 기제량의 감소등으로서 이들은 약물의 용출을 증가시켰다. 실험한 좌약의 bioavailability는 경구용 캅셀이 17%, 지용성좌제 44.9%, 수용성좌제 41.0%로서 좌제가 유의성 있게 높았으며(p<0.01), 지용성좌제에 SLS나 EDTA를 첨가하였을 때에는 각각 29.7%, 32.7%로서 이들을 첨가하지 않았을 때 보다 유의성 있게 낮았다(p<0.01). 또한 직장점막 자극시험결과 부작용을 관찰할 수 없었으며 간초회통과 회피율은 수용좌제에서 28.9%, 지용성좌제에서 33.6%로 나타나서 OMZ의 투여경로는 직장좌제가 유용한 한가지 투여방법이 될 것임을 시사하였다.

• YAKHAK HOEJI
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• v.44 no.6
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• pp.578-587
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• 2000

The purpose of the present study was to design and prepare the optimum formulation for the oral administration of titrated extract of the unsaponifiable fraction of Zea mays L. (ETIZM). For this purpose, we simulated the blood concentration of ETIZM after its oral administration, changing the dissolution rate constants $(0.05{\sim}20\;hr^{-1})$. In vivo parameters, such as absorption rate constant $(k_a)$, elimination rate constant (k) and volume of distribution (Vd), were incorporated in the simulation on the basis of the experiments and literatures. When the dissolution rate constant $(k_r)$ is over $5\;hr^{-1}$, the absorption process appears to be the rate limiting step for the transport of ETIZM from the G.I. ract to the blood circulation. While less than $5\;hr^{-1}$, the dissolution rate considered to be the rate limiting step. Moreover, the optimum blood concentration was shown in the range from 1 to $5\;hr^{-1}$ of $k_r$ in the simulation. To design and prepare the tablets on the basis of the above results, 7 formula containing HPMC, PEG 4000 and PEG 6000 (1-5%, respectively) were prepared and evaluated. The tablets containing PEG 4000 (1%), PEG 6000 (1%) or PEG 4000 (5%) satisfy the optimum $k_r$ range ($1-5\;hr^{-1}$). These formulations, therefore, will be able to show the more effective blood concentration, compared with the commercial products after the oral administration.

• YAKHAK HOEJI
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• v.37 no.4
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• pp.370-382
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• 1993

In order for formulation of rectal containing OMZ, the OMZ suppositories were prepared using water-soluble base, PEG 4000 base and oil-soluble base, Witepsol H 15. Chemical stability of OMZ in suppositories was increased when Witepsol H 15 was used as a suppository base and arginine was added as a stabilizer. The decomposition of OMZ in suppository bases followed the first-order kinetics and their rate constants were 0.11 day $^{1}(t_{1/2}$=/6.25 days) for Witepsol H 15 suppository and 0.48 day $^{1}(t_{1/2}$=/1.43 days) for PEG 4000 suppository, respectively. On the other hand, the decomposition rate constants of Witepsol suppository and PEG suppository stabilized with arginine were 3.89$\times$10$^{-3}$(t$_{1/2}$=171.1 days) and 8.76$\times$10$^{-3}$ day $^{1}(t_{1/2}=79.9 days), respectively. Shelf-lives of the Witepsol and PEG suppositories stabilized with arginine were t$_{90%}$=291.8 days and t$_{90%}$=282.1 days at $35^{\circ}C$ and 75% RH, respectively. The dissolution test of OMZ suppositories was performed by rotating dialysis cell(RDC) method and the release rate constant was calculated by the simplified Higuchi's equation, Q'=K' t$^{1/2}$. Dissolution of OMZ from suppositories was augmented as arginine was added, particle size of OMZ was reduced and a suitable surfactant such as SLS was added. RDC method was more appropriate and available than Paddle method to evaluate the dissolution rate of lipophilic-base suppositoies. Arginine was found to be a very useful exipient for the enhancement of stability and dissolution of OMZ in suppositories.

• Fisheries and Aquatic Sciences
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• v.19 no.5
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• pp.25.1-25.8
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• 2016

The fractionation of serine protease inhibitor (SPI) from fish roe extracts was carried out using polyethylene glycol-4000 (PEG4000) precipitation. The protease inhibitory activity of extracts and PEG fractions from Alaska pollock (AP), bastard halibut (BH), skipjack tuna (ST), and yellowfin tuna (YT) roes were determined against target proteases. All of the roe extracts showed inhibitory activity toward bromelain (BR), chymotrypsin (CH), trypsin (TR), papain-EDTA (PED), and alcalase (AL) as target proteases. PEG fractions, which have positive inhibitory activity and high recovery (%), were the PEG1 fraction (0-5 %, w/v) against cysteine proteases (BR and PA) and the PEG4 fraction (20-40 %, w/v) against serine proteases (CH and TR). The strongest specific inhibitory activity toward CH and TR of PEG4 fractions was AP (9278 and 1170 U/mg) followed by ST (6687 and 2064 U/mg), YT (3951 and 1536 U/mg), and BH (538 and 98 U/mg). The inhibitory activity of serine protease in extracts and PEG fractions from fish roe was stronger than that of cysteine protease toward common casein substrate. Therefore, SPI is mainly distributed in fish roe and PEG fractionation effectively isolated the SPI from fish roes.

• Journal of Pharmaceutical Investigation
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• v.25 no.1
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• pp.31-36
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• 1995

Solid dispersions and inclusion complex were prepared for the enhancement of solubility and dissolution rate of poorly water-soluble ibuprofen(IPF) as a model drug. Polyethylene glycol 4000(PEG4000) and polyvinylpyrrolidone(PVP) were used for the preparation of solid dispersion. $2-Hydroxypropyl-{\beta}-cyclodextrin(2-HP{\beta}CD)$ was also used for the preparation of inclusion complex. The solubility of IPF increased as the concentration of PEG4000, PVP and $2-HP{\beta}CD$ increased. Solubilization capacity of $2-HP{\beta}CD$ was increased about 10 times when compared to PEG 4000 and PVP. The dissolution rate of drug from solid dispersions and inclusion complex in the simulated gastric fluid was enhanced when compared to pure IPF and commercial $BR4^{\circledR}$ tablet as a result of improvement of solubility. In case of solid dispersions, dissolution rate of drug was proportional to polymer concentration in the formulation. The marked enhancement of dissolution rate of drug by inclusion complexation with $2-HP{\beta}CD$ was noted. However, dissolution rate of drug from solid dispersions and inclusion complex in the simulated intestinal fluid was not significant because IPF was readily soluble in that condition. From these findings, water-soluble polymers and cyclodextrin were useful to improve solubility and dissolution rate of poorly water-soluble drugs. However, easiness and reliability of preparation method, scale-up and cost of raw materials must be considered for the practical application of solid dispersion and inclusion complex in pharmaceutical industry.

• Journal of Pharmaceutical Investigation
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• v.6 no.3
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• pp.48-57
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• 1976

An enhancement in the dissolution rate of the drug should facilitate its GI absorption if the absorption process is dissolution rate limited. One of the need for the techniques that can potentially enhance the dissolution rate and extent of absorption of hydrophobic drugs is the formation of coprecipitates with pharmacologically inert, polymeric materials. The physicochemical modification offers the advantage of possibly enabling one to administer the drug orally in a form from which it is most available for GI absorption. Several $investigation^{1-15)}$ demonstrated that the formation of solid dispersions or coprecipitates of relatively water-insoluble drugs with various pharmacologically inert carriers can increase singnificantly their in vitro dissolution rates. However, little information is available in the literature related to the dissolution rate patterns of furosemide, a water-insoluble diurectices, with respect to the sort of copolymer and the ratio of coprecipitates as a function of time, respectively. The purpose of the present investigation was to ascertain, the general applicability of the copolymers to use fore more fast, enhanced dissolution techniques of furosemide. To accomplish the need for enhancement in the dissolution rate of furosemide, varying ratio coprecipitates with different water-soluble polymers, such as polyvinylpyrrolidone (PVP), polyethylene glycol 4000(PEG 4000), and polyethylene glycol 6000 (PEG 6000), were quantitatively studied by comparing their dissolution characteristics of furosemide. The dissolution patterns of pure furosemide, varying ratio furosemide-PVP coprecipitates, (1:2, 1:5, and 1:9(w/w)), furosemide-PEG 4000 coprecipitates (1:4, 1:9, and 1:19(w/w), furosemide-PEG 6000 coprecipitates(1:4, 1:9, and 1:19(w/w)), and the same ratio physical mixtures, respectively, were compared by the amount dissolved as a function of time.

• 보존과학연구
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• s.34
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• pp.50-61
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• 2013

The Grave encapsulated by lime soil mixture were excavated with clothing and hemp shoes from the Choseon Dynasty in Gooam, Sacheon. Hemp shoes have wood in the center and their surroundings were made of complex materials including herbaceous ones but the front part was lost or became very fragile. We analyzed the hemp shoes and pre-test of consolidant for conservation treatment of hemp shoes. As a result of analyzing, three kinds of plants were identified. For hemp shoes, Oryza spp, hemp, and one kind of dicotyledones were used and it was analyzed that fabrics attached to the back of Dogaengi was cotton. Conservation methods for pre-test of consolidant, Polyethylene Glycol, Paraloid-B72, Dammar gum, Methyl Cellulose and Silicone resin was selected. The solution was sprayed twice in a 24-hour duration. Properties of consolidant was measured; color difference, glossiness difference, folding streangth and tensile streangth. By comparing the results, PEG was confirmed to the most suitable as consolidant. For the conservation treatment, cleaning and strengthening was conducted. For strengthening treatment, PEG 4000 was selected given that the shoes were made of complex materials. The PEG impregnation method was applied with the PEG 4000 concentration gradually changing from 5% to 80% for reinforcement. Then humidity- controlled drying in order to avoid any rapid environment change.