• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2321-2323
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• 2016

Background: Inflammatory hematological parameters like the neutrophil/lymphocyte (N/L) ratio have been investigated in many cancer types and significant relationships found with prognosis, for example. The aim of this present study was to investigate the impact of hematological parameters notably on N/L ratio and mean platelet volume (MPV) in papillary thyroid cancer cases. Materials and Methods: A total of 79 patients who underwent a thyroidectomy operation in Findikli, Goiter Research and Treatment Center during 2011-2015 period were enrolled in the study, 41 with papillary thyroid cancer and 38 with benign goiter confirmed by pathological examination. We collected clinical and laboratory data for the patients from hospital records retrospectively. Blood samples taken at admission were assessed for parameters compared between the groups. Results: No significant differences between papillary thyroid cancer and benign goiter groups were apparent in terms of age, the N/L ratio, MPV, white blood cell count (WBC), red blood cell count (RBC), hemoglobin, hematocrit, platelet, neutrophil, lymphocyte, red blood cell distribution width (RDW) and platelet crit (PCT) levels (p>0.05). Only the level of platelet distribution width (PDW) significantly differed, being lower in the papillary cancer group (p<0.05). Conclusions: No significant relationship between papillary thyroid cancer and inflammatory hematological parameters including in particular the N/L ratio and MPV. The relevance of the PDW values remains unclear.

• Journal of Acupuncture Research
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• v.20 no.3
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• pp.45-62
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• 2003

Objective : To examine the effects of Beevenom on the cell proliferation of human breast carcinoma cell line MCF-7, we performed various experiments such as does-dependent effect of Beevenom on cell proliferation and viability, morphological changes, and alterations of apoptosis/cell cycle-regulatory gene products. Methods : Beevenom induced cell viability and proliferation of MCF-7 cells in a concentration-dependent manner. The anti-proliferative effect by Beevenom treatment in MCF-7 cells was associated with morphological changes such as membrance shrinking and cell rounding up. Results : Beevenom induced apoptotic cell death in a concentration-dependent manager, which was associated with degradation of ${\beta}$-catenin, an apoptotic target protein. Beevenom induced the Bax expressions, a pro-apoptotic gene, both in protein and mRNA levels, however, the levels of Bcl-$X_{S/L}$ expression, an anti-apoptotic gene, were down-regulated in Beevenom-treated cells. Western blot analysis and RT-PCT data revealed that the levels of cyclin of B1 protein and cyclin E mRNA were reduced by Beevenom treatment in MCF-7 cells, respectively, where as the expression of tumor suppressor p53 and cyclin dependent kinase inhibitor p21 mRNA were markedly increased in a concentration-dependent fashion. Conclusions : Taken together, these findings suggest that Beevenom induced inhibition of human breast cancer cell proliferation is associated with the induction of apoptotic cell death and Beevenom may have therapeutic potential in human breast cancer.

• Environmental and Resource Economics Review
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• v.23 no.1
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• pp.67-89
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• 2014

This paper uses patent data of OECD countries in order to investigate if there is converging tendency in renewable energy area. We used the concepts of sigma convergence and beta convergence to measure the convergence. GINI coefficient, HH index are also borrowed from other area of economics. The results show that technology level does not seem to have been converging in this area. Even though the number of patent in relatively less advanced countries has been increased a lot, we could find no evidence that there is the tendency that the gap among the countries have been narrowed. This is quite different from the results of IT industry or other industry since we could find the converging tendency in the data of those industries. Instead, it seems that there is the convergence club among most advance countries in renewable energy area.

• Applied Chemistry for Engineering
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• v.18 no.4
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• pp.386-390
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• 2007

In this study, polyurethane prepolymers were synthesized from polycaprolactonediol (PCDs. M.W. 530, 830, 1000, 1250, and 2000) and polycaprolactonetriol (PCTs. M.W. 300 and 900), and hexamethylenediisocyanate (HMDI). Polyurethane beads was prepared from the different prepolymers by a two-step suspension polymerization. The particle size of polyurethane beads was investigated by particle size analyzer. The beads were $10{\sim}30{\mu}m$ in size. The structure of beads was confirmed by FT-IR spectrometer. Their thermal properties were analyzed by TGA. Glass transition temperatures ($T_g$) of the beads were in the range of $-23{\sim}-53^{\circ}C$ and decreased with the increase of the PCD molecular weight. In order to prevention the cohesion of beads, the beads were coated with tetraethoxysilane (TEOS).

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.11
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• pp.1415-1421
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• 2013

Recently, to resolve problems regarding legal liability for accidents and disasters, various simulation techniques such as F.E.M. and F.V.M. have been used in the field of forensic engineering. In this study, we performed mechanical structure analysis using ADINA to investigate the cause of bridge collapse accidents. Such accidents occurred owing to modified and missing processes in comparison with the original design while filling with concrete. Modified and missing processes cause buckling of the upper plate and twisting of the main girder. Through this study, we determine the exact cause of bridge collapse by comparing the evaluation of the structure stability of the original design with the evaluation of the structure stability of the modified and missing process using ADINA structure analysis. Hence, this result indicates that buckling prediction through FEA is the most effective method.

• Journal of Life Science
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• v.27 no.5
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• pp.524-529
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• 2017

This study was aimed to produce a transgenic zebrafish expressing the human KCNE1 gene. Initially, the entire CDS of the human KCNE1 gene was amplified from a human genomic DNA sample by polymerase chain reaction using a primer set engineered with restriction enzyme sites (EcoRI, BamHI) at the 5' end of each primer. The resultant 402 bp KCNE1 amplicon flanked by EcoR1 and BamH1 was obtained and subsequently cloned into a plasmid vector pPB-CMVp-EF1-GreenPuro. The integrity of the cloned CDS sequence was confirmed by DNA sequencing analysis. Next, the recombinant vector containing the human KCNE1 (pPB-CMVp-hKCNE1-EF1-GreenPuro) was introduced into fertilized eggs of zebrafish by microinjection. Successful expression of the recombinant vector in the eggs was confirmed by the expression of the fluorescence protein encoded in the vector. Finally, in order to assure that the stable expression of the human KCNE1 gene occurred in the transgenic animal, RNAs were extracted from the animal and the presence of KCNE1 transcripts was confirmed by RT-PCT as well as DNA sequencing analysis. The study provides a methodology to construct a useful transgenic animal model applicable to the development of diagnostic technologies for gene therapy of LQTS (Long QT Syndrome) as well as tools for cloning of useful genes in fish.

• Transactions of the Korean hydrogen and new energy society
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• v.18 no.1
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• pp.26-31
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• 2007

Hydrogen has a high potential to be a renewable substitute for fossil fuels, because of its high gravimetric energy density and environment friendliness. In particular, Magnesium have attracted much interest since their hydrogen capacity exceeds that of known metal hydrides. One of the approaches to improve the kinetic is addition of metal oxide. In this paper, the effect of $Fe_2O_3$ concentration on the kinetics of Mg hydrogen absorption reaction was investigated. $MgH_x-Fe_2O_3$ composites have been synthesized by hydrogen induced mechanical alloying. The powder synthesized was characterized by XRD, SEM and simultaneous TG, DSC analysis. The hydrogenation behaviors were evaluated by using a sievert's type automatic PCT apparatus. Absorption and desorption kinetics of Mg catalyzed with 5,10 mass% $Fe_2O_3$ are determined at 423, 473, 523, 573, 623K.

• Korean Journal of Materials Research
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• v.20 no.10
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• pp.543-549
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• 2010

The hydrogen energy had recognized clean and high efficiency energy source. The research field of hydrogen energy was production, storage, application and transport. The commercial storage method was using high pressure tanks but it was not safety. However metal hydride was very safety due to high chemical stability. Mg and Mg alloys are attractive as hydrogen storage materials because of their lightweight and high absorption capacity (about 7.6 wt%). Their range of applications could be further extended if their hydrogenation properties and degradation behavior could be improved. The main emphasis of this study was to find an economical manufacturing method for Mg-Ti-Ni-H systems, and to investigate their hydrogenation properties. In order to examine their hydrogenation behavior, a Sievert's type automatic pressure-compositionisotherm (PCI) apparatus was used and experiments were performed at 423, 473, 523, 573, 623 and 673 K. The results of the thermogravimetric analysis (TGA) revealed that the absorbed hydrogen contents were around 2.5wt.% for (Mg8Ti2)-10 wt.%Ni. With an increasing Ni content, the absorbed hydrogen content decreased to 1.7 wt%, whereas the dehydriding starting temperatures were lowered by some 70-100 K. The results of PCI on (Mg8Ti2)-20 wt.%Ni showed that its hydrogen capacity was around 5.5 wt% and its reversible capacity and plateau pressure were also excellent at 623 K and 673 K.

• Korean Journal of Veterinary Service
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• v.31 no.1
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• pp.101-111
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• 2008

The purpose of this study was to investigate the protective effects against porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) in suckling piglets by oral administration of IgY. Twenty piglets were divided into two groups with the same number: group I (treated with IgY) and group II (not treated). Group I was administerd orally with IgY for three days from one-day-old and experimentally challenged with PEDV and TGEV at four-day-old. The other was administered with saline solution and challenged with PEDV and TGEV at four-day-old. Serum antibody titers against PEDV and TGEV were examined by enzyme-linked immunosorbent assay (ELISA) and the detection of PEDV or TGEV antigen from feces and small intestines was performed by reverse transcription-polymerase chain reaction (RT-PCR) and indirect immunofluorescence (IFA). The antibody titers of the group I was higher than that of the other, and lasted at the end of experiment. In the detection tests of both virus from feces and small intestine, the rate of the group I was lower. Based on these results, oral administration of IgY may be effective to prevent the diarrhea caused by PEDV and TGEV.

• Transactions of the Korean hydrogen and new energy society
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• v.22 no.6
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• pp.780-786
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• 2011

Mg hydride had high hydrogen capacity (7.6%), lightweight and low cost materials and it was promising hydrogen storage material at high temperature. However, commercial applications of the Mg hydride are currently hindered by its high absorption/desorption temperature, and very slow reaction kinetics. one of the approaches to improve the kinetic is $MgH_x$ intermixed with carbon. And it shows that carbon and carbon allotropes have a beneficial effect on hydrogen sorption in Mg. The graphene is a kind of carbon allotropes which is easily desorbed reaction at low temperatures because its reaction is exothermic. In this work, the effect of graphene concentration on the kinetics of Mg hydrogen absorption reaction was investigated. The $MgH_x$-Graphene composites has been prepared by hydrogen induced mechanical alloy (HIMA). The synthesized powder was characterized by XRD and simultaneous TG, DSC analysis. The hydrogenation behaviors were evaluated by using a sievert's type automatic PCT apparatus. In this research, results of kinetic profiles exhibit hydrogen absorption rate of $MgH_x$-5wt.% and 10wt.% graphene composite, as 1.25wt.%/ms, 10.33wt.%/ms against 0.88wt.%/ms for $MgH_x$ alone at 473K.