• Applied Biological Chemistry
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• v.38 no.5
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• pp.382-386
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• 1995

The potato proteinase inhibitor II (PI-II) protein contains chymotrypsin and trypsin inhibitory site. Among several PI-II genes isolated from genomic library, amino acid sequence deduced from PI-IIT gene has 84% identity with that of the polypeptide chymotrypsin inhibitor (PCI). Therefore a gene fragment having homology with the PCI was cloned into a vector using polymerase chain reaction(PCR) from the potato proteinase inhibitor IIT gene. Two different primers were utilized for cloning; primer A contains NdeI restriction site and 30 nucleotides, which has AUG N-terminal methionine codon, primer B contains BclI restriction site and 28 nucleotides, which has TAG translation stop codon. After PCR, about 160 bp-long DNA fragment was cloned into pRT146, derivative of pUC118, and sequenced. The sequenced NdeI/BclI fragment was moved to pET3a, containing bacteriophage T7 promoter and terminator. The expressed proteins in E. coli BL2l(DE3) were determined on a polyacrylamide gel containing sodium dodecyl sulfate. The expected size of protein deduced from the sequenced gene fragment is about 6,500 dalton whose size was similar to the IPTG-induced protein (6,000 dalton) on a gel. However the expression level was much lower than expected.

• The Journal of the Korea Contents Association
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• v.19 no.12
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• pp.279-288
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• 2019

The purpose of this study was to compare the health behaviors and health indices according to whether a percutaneous coronary intervention(PCI) was performed due to chest pain. This is a secondary data analysis study of nursing information questionnaires and electronic medical records of 247 chest pain patients in a hospital from January 2010 to December 2017. The participants were divided into non-PCI and PCI groups, and the health behaviors, blood pressure, and blood lipid levels were collected at the first hospital admission and re-admission. Collected data were analyzed using SPSS 24.0. As a result of the study, smoking and lipid levels were significantly healthier than the participants in PCI group during re-hospitalization. Non-PCI group had a high risk of smoking despite the high risk of coronary artery stenosis. It was found that continuous integrated management to promote health behavior is needed. The significance of this study was to identify the importance of health behavior in patients with the risk of cardiovascular disease.

• Tuberculosis and Respiratory Diseases
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• v.49 no.3
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• pp.323-331
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• 2000

Purpose: Brain metastases are present in approximately 10-16% of small cell lung cancer patients at diagnosis. Brain metastasis is an important clinical problem associated with increasing the survival rate, with a cumulative incidence of up to 80% in patients surviving 2 years. Prophylactic cranial irradiation(PCI) reduces the incidence of brain matastasis and may prolong survival in patients with limited small-cell lung cancer who achieved complete remission. This study was performed to analyze the incidence of brain metastasis, survival and clinical aspects after PCI in patients with limited small-cell lung cancer who achieved complete remission. Methods : Between 1989 and 1999, forty-two patients with limited small-cell lung cancer who achived achieved complete remission after therapy were enrolled into this study retrospectively. All patients received etoposide and cisplatin(VPP) alternating with cytoxan, adriamycin, and vincristine(CAV) every 3 weeks for at least 6 cycles initially. All patients received thoracic radiotherapy: concurrent(38.1%) and sequential(61.9%). All patients received late PCI. Results : Most patients(88.1%) were men, and the median age was 58 years. The median follow-up duration was 18.1 months. During the follow-up period, 57.1% of the patients developed relapse. The most frequent site of relapse was chest(35.7%), followed by brain(14.3%), liver(11.9%), adrenal gland(44%), and bone(2.2%). With the Kaplan-Meier method, the average disease-free interval was 1,090 days(median 305 days). The average time to development of brain relapse after PCI and other sites relapse(except brain) were 2,548 days and 1,395 days(median 460 days), respectively. The average overall survival was 1,233 days(median 634 days, 21.1 months), and 2-year survival rates was 41.7%. The average overall survival in the relapse group was 642 days(median 489 days) and in the no relapse group was 2,622 days(p<0.001). The average overall survival in the brain relapse group was 928 days(median 822 days) and in the no brain relapse group was 1,308 days(median 634 days)(p=0.772). In most patients(85.7%), relapse(except brain) or systemic disease was the usual cause of death. Brain matastasis was the cause of death in 14.3% of the cases. Conclusions : We may conclude that PCI reduces and delays brain metastasis in patients with limited small cell lung cancer who achieved complete remission. We found decreased survival in relapse group but, no significant survival difference was noted according to brain matastasis. And relapse(except brain) or systemic disease was the usual cause of death. In order to increase survival, new treatment strategies for control methods for relapse and systemic disease are required.

• The Journal of the Korea Contents Association
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• v.14 no.5
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• pp.251-261
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• 2014

Primary percutaneous coronary intervention (PCI) has been found to be superior, in terms of hospital mortality and long-term outcome, compared with thrombolytic therapy in patients with acute myocardial infarction (AMI). However, the clinical benefits of primary PCI have not been precisely evaluated in elderly patients.1,974 patients (Group I: n=1,018, $age{\geq}65years$, $73.8{\pm}5.99years$; Group II: n=956, age<65years, $52.8{\pm}7.96years$) who underwent primary PCI for AMI at Chonnam National University Hospital between 2006 and 2010 were analyzed according to their clinical, angiographic characteristics for hospital and one-year survival. Group I had a higher percentage of women, diabetes mellitus, hypertension, multi-vessel disease and lower prevalence of current smoking, hyperlipidemia, familial history than Group II. Culprit lesions were at the left anterior descending artery, left circumflex artery, right coronary artery and left main artery in 42.8% vs. 45.0%, 34.1% vs. 29.6%, 14.6% vs 14.6, 2.7% vs. 1.6%, respectively (p=0.007). Stent diameter was smaller in group I ($3.17{\pm}0.39$ vs. $3.29{\pm}0.42mm$, p=0.001). In-hospital mortality was higher in group I (8.4 vs. 1.9%, p<0.001). There were significant differences in the rates of major adverse cardiac events between the two groups during one-year clinical follow-up (20.1 vs.14.0%, p<0.001). On multiple logistic regression analysis, systolic blood pressure<100mmHg, serum $creatinine{\geq}1.3mg/dL$, Killip class> I, multivessel disease, left ventricular ejection fraction <40% and cerebro vascular disease were independent predictors of one-year motality in patients over 65 years after PCI.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 1992.06a
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• pp.125-128
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• 1992

• Review of Korean Society for Internet Information
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• v.16 no.2
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• pp.41-55
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• 2015

• Magazine of the Korea Concrete Institute
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• v.10 no.5
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• pp.58-66
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• 1998

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.2
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• pp.171-177
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• 2004

Many instrumentations have been used to acquire the performance data of military systems fer many years. But they could not satisfy environmental specifications(vibration, shock, temperature) and processing speed to apply for the performance test of military systems because of having developed as common vehicles/fixed installation equipments. Thus a new rugged embedded measurement system is required to process large data in high processing speed(Maximum sample rate:1.25Mhz/ch) with rugged environmental specifications. We have developed embedded measurement systems by using PXI(PCI extension for Instrumentation)bus interface composed of a stand alone controller and versatile data acquisition boards(analog, digital, vision, temperature and small signal conditioner) on PC-based environment to solve these problems. Operation programs have been developed using Lab_View and the performances have been validated experimentally.

• Proceedings of the IEEK Conference
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• 2000.09a
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• pp.105-108
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• 2000

CTI[1]의 응용 영역 중에서 인터넷 폰이 최근 뜨거운 관심의 대상으로 떠오르고 있다. 인터넷을 이용한 음성전달 기술은 인터넷의 성장 보급과 더불어 나날이발전 하고 있는데, 이러한 음성전달기술을 이용해 개발된 소프트 웨어를 통칭해서 인터넷 폰이라고 부르고 있다. 이러한 변화 속에서 비용의 절감과 비디오 전화, 영상회의와 같은 응용에 적용할 수 있는, 본 개발은 One Encoder One Decoder 지원의 VoIP(Voice over Internet Protocol) Phone에 관한 것으로, 특히 압축하여 인터넷 망에 접속시켜 사용할 수 있는 PC 장착형 One Board 형태의 시스템을 구현하였다. 이 Board에 사용 된 칩셋은 국내 회사인 C&S Technology 사의SEAGUL723이며, PC인터페이스는 PCI(Peripheral Component Interconnect) 버스 방식을 이용하였다. 주요 연구내용에 있어서 하드웨어 부분은 내선제어모듈,PCI 모듈, 칩셋을 이용한 음성신호처리 모듈, Board제어 모듈 등이 있으며, 소프트 웨어 설계 부분에 있어서는 하드웨어 구동을 위한 시스템 드라이브, Application과 인터넷 상의 VoIP 통신을 위한 소프트웨어, 사용자를 위한 User Interface 소프트 웨어 등이 있다.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.2
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• pp.57.1-57.1
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• 2015

VLBI에서 관측 대역폭이 n배 증가될 경우 관측감도는 sqrt(n)만큼 향상되고, 이는 관측 연구 측면에서 기존에는 불가능하던 천체에 대한 연구 수행이 가능함을 의미한다. 관측 대역폭의 확대는 관측 데이터의 용량 증가를 의미하며 여기서 해당 데이터의 처리를 위한 초고속 데이터 기록시스템은 핵심적 역할을 한다. 이에 따라 현재 KVN에서는 미국 MIT Haystack 천문대에서 개발된 초고속 기록시스템인 Mark5B/B+와 Mark6를 운용 중에 있다. 하지만 이들 시스템의 경우 사실상 VLBI연구를 위한 목표로 특수 개발되었기에 유지 및 운영 측면에서 여러 불편이 있고, 성능에 있어서도 단일 스트림 기준으로 8Gbps를 넘지 못하는 한계를 안고 있다. 본 발표에서는 기존 시스템을 대체할 수 있는 기술로서 PCI 익스프레스 기반의 데이터 처리를 소개하고자 한다. 나아가 실제 관측 데이터에 대한 입출력 및 기존 시스템과의 성능 비교를 통해 광대역 관측 연구에 최적화된 기록 시스템을 제안하고자 한다.