• Annals of Clinical Neurophysiology
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• v.7 no.2
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• pp.80-82
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• 2005

Background: Idiopathic Parkinson's disease (IPD) is closely related to Lewy body pathology. Pathological changes in medullar oblongata and pontine tegmentum have been reported in patients with subclinical motor symptom. Vestibular evoked myogenic potential (VEMP) is mediated by vestibular nuclei in lower brainstem and reflects the function of lower brainstem. The purpose of our study is to estimate the lower brainstem function in IPD patients. Methods: Ten patients with idiopathic Parkinson's disease underwent VEMP test. The patients were divided into Hohn-Yahr (H-Y) stage I (unilateral motor involvement) group and H-Y stage II or more severe (bilateral motor involvement) group. VEMP results were compared between groups using Mann-Whitney U test. Results: Among patients, 6 patients showed abnormal VEMP (unilateral abnormality 2, bilateral abnormalities 4). Between H-Y stage I group and H-Y II,III group, there was no statistical difference in the results of VEMP. Conclusions: We concluded that the lower brainstem dysfunction reflected in VEMP could occur in IPD regardless of the progression of the disease.

• Journal of Sasang Constitutional Medicine
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• v.14 no.3
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• pp.153-159
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• 2002

Parkinson's disease(PD) is characterized by chronic progress of mesencephalic dopaminergic neuronal death. Diagnostic criteria for PD require at least two of three motor sign: tremor, rigidity, or bradykinesia. Levodopa and the dopamine agonists are considerd first-line drug therapy. In the book ‘dongyi soose bowon(東醫壽世保元)’, Soyangin Gihwangbeakho-tang(地黃白虎湯) is used at Soyangin Interior-overheated-disease. This case is patient who is 69 years old lady, suffered by the tremor of jaw and a slight rigidity, bradykinesia etc. This patient was classified as Soyangin by features, somatotype and emotional patterns. She improved in the tremor of jaw and others with Gihwangbeakho-tang for 67days. The result revealed that Soyangin-Gihwangbeakho-tang was effected on the tremor of jaw and others with Parkinson's disease patient.

• Journal of muscle and joint health
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• v.19 no.3
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• pp.350-361
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• 2012

Purpose: The purpose of this study is to explore the level of bone mineral densities of the femur neck and to identify factors affecting bone mineral density of the femur in Parkinson's disease (PD) patients. Methods: Participants were 121 PD patients visiting the outpatient clinic of D University Hospital in B City. Bone mineral density was measured at the femur neck by using a dual-energy x-ray absorptiometry. The serum vitamin D level, the amounts of milk intake, caffeine intake, cigaret smoking, and alcohol consumption, and the number of steps taken daily were measured. Past and present disease history, the medication history, and duration of the disease were also collected. The level of disability was obtained by neurologists using the Hoehn and Yahr stage and the Unified Parkinson's Disease Rating Scale. Results: Among PD patients, 57% had osteopenia and 15.7% had osteoporosis. The bone mineral density of the femur was associated with weight, serum vitamin D level, age, and working status. Conclusion: The identification of weight and serum vitamin D level as important predictive factors emphasizes the importance of balanced nutrition for PD patients.

• PNF and Movement
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• v.17 no.2
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• pp.189-197
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• 2019

Purpose: The aim of our study was to evaluate the therapeutic effects of walking and turning plus treadmill training on the functional balance and walking ability of individuals with Parkinson's disease (PD). Methods: Twenty-four participants with Stage 1 to 3 ($2.13{\pm}0.64$) PD based on the Hoehn and Yahr scale were randomly allocated to the experimental group (EG) and control group (CG), with 12 participants in each group. The measured outcomes included the motor subscale of the unified Parkinson's disease rating scale (UPDRS-M), the Berg balance scale (BBS), the Timed Up and Go (TUG) test, the 10-meter walk test (10MWT), and the 6-minute walk test (6MWT). Results: Pre-to-post intervention improvements were noted for all the outcome measures for both groups (p < 0.05). Post intervention, there was a significant improvement in the EG compared to the CG for the following measured outcomes (p < 0.05): UPDRS-M (p = 0.021; 95% CI, 0.081-6.519), BBS (p = 0.042; 95% CI, 1.375-4.541), TUG (p = 0.034; 95% CI, -3.315--0.143), 10MWT (p = 0.011; 95% CI, -2.032--0.289), and 6MWT (p = 0.002; 95% CI, 24.39-91.273). Conclusion: Our study suggests that walking and turning plus treadmill training improves balance and walking compared to treadmill training only in patients with PD.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.283-284
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• 2019

In the last decades patient's suffering with Parkinson's disease is increasing at a rapid rate and as per prediction it will grow more rapidly as old age population is increasing at a rapid rate through out the world. As the performance of wearable sensor based approach reached to a new height as well as powerful machine learning technique provides more accurate result these combination has been widely used for assessment of various neurological diseases. ON state is the state where the effect of medicine is present and OFF state the effect of medicine is reduced or not present at all. Classification of ON/OFF state for the Parkinson's disease is important because the patients could injure them self due to freezing of gait and gait related problems in the OFF state. in this paper wearable sensor based approach has been used to collect the data in ON and OFF state and machine learning techniques are used to automate the classification based on the gait pattern. Supervised machine learning techniques able to provide 97.6% accuracy while classifying the ON/OFF state.

• Research in Community and Public Health Nursing
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• v.33 no.1
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• pp.105-113
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• 2022

Purpose: The purpose of this study is to explore the roles and function of family in mediating the relationship between depression and quality of life of patients with Parkinson's disease (PD). Most studies have found that depression is particularly common in patients with PD and further associated with poor quality of life. Family function, as a mediator, is based on a strength orientation perspective that emphasizes not only their responsibilities and risks but also recuperative powers and growth potential. Methods: Overall 157 adults with idiopathic Parkinson's disease were enrolled in this study via outpatient clinic and completed a set of assessment to measure depression using BDI, family APGAR questionnaire, and patients' quality of life using PDQ-8. Hierarchical multiple regression analysis was conducted to examine the mediating role of family APGAR score in the relationship between BDI and PDQ-8. Results: Patients' depression, gait disturbance, duration of illness, and family function were statistically significant on quality of life. These factors accounted for 60% of the variance in quality of life. Family function has a partial mediating effect on the relationship between depression and quality of life. Conclusion: Findings from the study suggest that although PD patients' depression impacts their quality of life, by having strong family function, the extent to which depression impacts the quality of life can be favorably mitigated. Additionally, these outcomes have important implications for future model development regarding PD patients.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.01a
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• pp.169-171
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• 2023

Wolff Parkinson White Syndrome(WPW)은 일반인과는 다르게 선천적으로 심방과 심실 사이에 부전도로(Accessory Pathway)가 존재하여 정상 전도와 비교하였을 때, 빠른 속도로 심실을 자극하여 부정맥을 일으키는 것을 의미한다. WPW는 부정맥이 주된 증상이기는 하나, 평소에는 무증상인 경우가 많고, 성인이 되어 갑작스럽게 발생하는 경우가 존재하기 때문에 인지하지 못하고 살아가는 환자들이 많다는 것이 특징이다. 이러한 특징은 갑작스러운 건강 악화가 타인의 생명에 악영향을 줄 수 있는 트럭 운전기사나 의사와 같은 직업군 등의 경우 WPW를 조기에 발견하고 치료해 위험을 사전에 방지하는 것이 매우 중요하다. 따라서, 본 논문에서는 Electrocardiogram(ECG) 데이터를 기반으로 WPW를 자동으로 분류하기 위한 Feature Ensemble 기반 심층 학습 프레임워크를 제안한다. 제안된 기법의 경우 단일 1D-CNN과 GRU를 이용한 기법 대비 F1-Score, Accuracy 기준의 성능 향상을 달성하였기에 본 Task에 적합함을 보여준다.

• Journal of Korean Medicine Rehabilitation
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• v.33 no.4
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• pp.95-107
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• 2023

Objectives The purpose of this study is to help find the future prospects by analyzing the trends of scalp acupuncture treatment for Parkinson's disease (PD) by searching the China National Knowledge Infrastructure (CNKI) and PubMed. Methods We searched clinical studies adopting scalp acupuncture treatment as a main intervention for PD through the searching the database of CNKI and PubMed. We analyzed the characteristics of selected studies especially according to study design, publication year, sample size, treatment period, treatment methods, outcomes criteria and adverse events. Results Twelve randomized controlled trials studies published from January 1, 2012 to July 1, 2023 were selected. In these studies, two types of scalp acupuncture treatments were performed and the most common treatment was Jiao shunfa's scalp acupuncture with fine needles. The most commonly used acupoints were "Chorea tremor control area", 風池 (GB20), 四神聰 (EX-HN1) and 百會 (GV20). The most commonly used outcome measures were effective rate, unified Parkinson disease rating scale (UPDRS) and UPDRS-III. Conclusions Through these results, we found that the Chinese review literature positively reported the effects of scalp acupuncture on PD. However, more high-quality evaluation using the well-designed studies including more objective outcomes should be required.

• Journal of Acupuncture Research
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• v.34 no.3
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• pp.13-21
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• 2017

Objectives : The purpose of this study was to investigate the effect of acupuncture treatment (AT) in the tendency of increase of the need for AT for the treatment of Parkinson's disease (PD) worldwide and to investigate the advancements in AT research in Korea and the future directions of research on this topic. Methods : Until May 2017, the PubMed, Scopus, Medline, and four Korean databases were searched. The searched keywords were "Parkinson's disease", "Acupuncture", and "Intervention study". The intervention groups from all screened original studies were analyzed and the methods used to determine the effect of AT on PD were examined. Results : A total of 17 studies were grouped by country on the basis of the first author's position, of which 10 studies were conducted in China, four in the United States, two in Korea, and one in Brazil. The most common type of intervention was electroacupuncture (nine studies), followed by AT (six studies), and a combination of AT and bee venom AT (two studies). The most frequently used acupoints in AT were Baihui (GV20), Taichong (LR3), Zusanli (ST36), Sanyinjiao (SP6), and Yanglingquan (GB34). The most commonly used tool for evaluation of PD was the Unified Parkinson's Disease Rating Scale III, which assesses motor functions. Conclusion : The screened studies reported that there were no adverse effects of AT on drug therapy, and AT reduced the dose of drugs used in PD treatment. Future studies on PD treatment with AT should use the acupoints GV20, LR3, ST36, SP6, and GB34, and the meridians Gallbladder meridian and Governor Vessel. Clinical studies on PD should use CONSORT or STRICTA to ensure the quality of national studies and allow the development of new tools for the assessment of the effect of AT on PD using the above criteria.

• Journal of Preventive Medicine and Public Health
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• v.43 no.1
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• pp.9-17
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• 2010

Objectives: Parkinson's disease is one of the most common neurodegenerative diseases in the elderly population. In order to estimate the prevalence of Parkinson's disease in the community, the application of a good screening tool is essential. We evaluated the validity and reliability of a Parkinson's disease screening questionnaire and propose an alternative measure to improve its validity for use in community surveys. Methods: We designed the study in a three-phase approach consisting of a screening questionnaire, neurologic examination, and confirmatory examination. A repeated survey was administered to patients with disease detected in the community and on 150 subjects. We examined internal consistency using Cronbach's alpha test, test-retest reliability using the kappa statistic, and validity using sensitivity, specificity, and ROC curves. Unadjusted odds ratios were utilized for the estimation of weights for each questionnaire item. Results: The Cronbach's alpha of the questionnaire was 0.708. The kappa statistic for test-retest reliability was good to generally fair in most of the items. When newly proposed weighting scores were used, the optimum cut-off value was 7/8. When cut-off value was 5/6 for surveying prevalence in a community, the sensitivity was 0.98, and the specificity was 0.61, with simultaneous improvement in reliability. Conclusions: We recommend 5/6 as the ideal cut-off value for the survey of PD prevalence in community. This questionnaire designed for the Korean community could help future epidemiologic studies of PD.