• Natural Product Sciences
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• 제13권2호
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• pp.169-173
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• 2007

Luteolin is a major flavonoid of Lonicera japonica and has anti-inflammatory effect. The activation of proteinase-activated receptor (PAR)-2 and -4 by trypsin appears to play a role in inflammation, In the present study, we examined the inhibitory effects of luteolin on activation of trypsin-induced human leukemic mast cells (HMC-1). HMC-1 cells were stimulated with trypsin, PAR-2 and PAR-4 agonist, in the presence or absence of luteolin. The level of TNF-${\alpha}$ secretion was measured by enzyme-linked immunosorbent assay (ELISA). The expression of tryptase and phosphorylated-extracellular signal-regulated kinase (ERK) were assessed by Westem blot analysis. Moreover, trypsin activity was measured by the substrate Bz-DL-Arg-p-nitroanilide (BAPNA). TNF-${\alpha}$ secretion and Tryptase expression in trypsin-stimulated HMC-1 cells were markedly inhibited by pretreatment of luteolin. Furthermore, the pretreatment of luteolin resulted in the reduction of ERK phosphorylation and trypsin activity. These results suggest that luteolin might has the inhibitory effects on the PAR-2 and -4-dependent inflammation.

• Journal of Microbiology
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• 제43권5호
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• pp.391-397
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• 2005

Escherichia coli is a common inhabitant of the intestinal tracts of animals and humans. The intestines of animals also represent an ideal environment for the selection and transfer of antimicrobial resistance genes. The aim of this study was to investigate the resistance of E. coli isolated from chicken fecal samples to fluoroquinolones and to analyze the characterization of mutations in its gyrA and parC gene related resistance. One hundred and twenty-eight E. coil isolates showed a high resistance to ciprofloxacin (CIP; $60.2\%$), enrofloxacin (ENO; $73.4\%$) and norfloxacin (NOR; $60.2\%$). Missense mutation in gyrA was only found in the amino acid codons of Ser-83 or Asp-87. A high percentage of isolates ($60.2\%$) showed mutations at both amino acid codons. Missense mutation in parC was found in the amino acid codon of Ser-80 or Glu-84, and seven isolates showed mutations at both amino acid codons. Isolates with a single mutation in gyrA showed minimal inhibitory concentrations (MIC) for CIP (${\le}0.5\;to\;0.75{\mu}g/ml$), ENO (1 to $4{\mu}g/ml$) and NOR (0.75 to $4{\mu}g/ml$). These MIC were level compared to isolates with two mutations, one in gyrA and one in parC, and three mutations, one in gyrA and two in parC (CIP, ${\le}0.5\;to\;3{\mu}g/ml;\;ENO,\;2\;to\;32<{\mu}g/ml;\;NOR,\;1.5\;to\;6\;{\mu}g/ml$). However, the isolates with two mutation in gyrA regardless of whether there was a mutation in parC showed high MIC for the three fluoroquinolones (CIP, 0.75 to $32{\le}{\mu}g/ml;\;ENO,\;3\;to\;32{\le}{\mu}g/ml;\;NOR,\;3\;to\;32{\le}{\mu}g/ml$). Interestingly, although the E. coil used in this study was isolated from normal flora of chicken, not clinical specimens, a high percentage of isolates showed resistance to fluoroquinolones and possessed mutations at gyrA and parC associated with fluoroquinolone resistance.

• 한국약용작물학회지
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• 제10권2호
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• pp.82-87
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• 2002

차광 및 광 강도별 맥문동의 광합성속도, 기공전도도 및 증산작용과 그 관련형질간의 상호연관성을 구명하였던 바는 다음과 같다. 맥문동의 광합성속도는 광 강도가 증가함에 따라 증가하였고 PAR $700-1000{\mu}mol/m^2/s$에서 최고치를 나타내었으며 차광에 의해 증가되는 경향이었다. 기공전도도는 광 강도가 증가함에 따라 증가되었고, 광합성속도, 증산작용 및 기공전도도의 일변화는 비슷한 경향의 양상을 띄었다. 광합성속도와 기공전도도와의 관계는 1차직선회귀관계로 고도의 정(正)의 상관이 인정되었으나 대조구와 차광구가 각각 다른 1차회귀직선을 보여 동일한 기공전도도에서 차광구의 광합성속도가 대조구보다 높은 경향으로 나타났다. 증산작용과 기공전도도 및 광합성속도와 증산작용의 관계는 양자간에 모두 1차회귀식의 정(正)의 상관관계가 인정되었다.

• 대한치과교정학회지
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• 제46권1호
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• pp.27-35
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• 2016

Objective: The aims of our study were to verify the validity of the T-Scan III system (Tekscan) as an objective occlusal evaluation tool, and to assess the differences between two occlusal indexes - the peer assessment rating (PAR) index and the American Board of Orthodontics objective grading system (OGS) - by comparing the scores derived from the T-Scan III system with the two occlusal indexes and analyzing the correlations between them. Methods: The final study sample included 48 adult volunteers (39 men and 9 women, mean age $24.14{\pm}3.16years$), after excluding 29 volunteers whose occlusion could not be evaluated by the T-Scan III system due to severe skeletal or occlusal problems. PAR index and OGS scores were assessed using dental study models, and measurements of centric occlusion, protrusive movement, and lateral excursion movement were obtained via the T-Scan III system. The results were analyzed to determine correlations. Results: Occlusal analysis by the T-Scan III system was clinically reliable (p < 0.05), and the PAR index and OGS scores were significantly correlated with several measurements obtained with the T-Scan III system (p < 0.05). Conclusions: The T-Scan III system is a quantitative and reliable method for occlusal evaluation, and represents a potential substitute for occlusal indexes. Compared to the PAR index, the OGS scores of more variables were significantly correlated with the T-Scan measurements.

• 한국음향학회지
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• 제14권1호
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• pp.40-47
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• 1995

본 논문은 redundancy를 제거함으로 해서 데이타의 축약을 할 수 있는 새로운 방법론 즉, 병렬 컴퓨터인 MasPar 머쉰에 적합한 새로운 데이타 구조를 제시하고자 하는데 그 주된 목적이 있다. 이것을 실제로 구현한 결과, 본 논문에 제시된 방법인 PDOCM (Parallel Dynamic Octal Compact Mapping)은 기존의 방법중 가장 효율이 좋은 것으로 나타난 Huffman 코드와 비교할때는 평균적으로 $30\%$정도, bit-mapping방법과 비교할때는 평균적으로 $40\%$ 정도의 우수성을 보였다. 그리고 10 백만개의 영문자를 이용해서 MasPar 기계에서 64개의 프로세서를 이용하여 구현시킨 결과 54.188의 가속화율을 얻으므로서 우수한 방법임을 알 수가 있었다.

• 응용통계연구
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• 제29권1호
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• pp.133-144
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• 2016

본 논문에서는 주기적 자기회귀(periodic autoregressive) 모형에서 모수의 수를 줄이기 위한 모수 절약 주기적 자기회귀 모형을 연구하였다. 제안된 모수 절약 모형은 실증분석에서 실업률을 이용하여 기존의 계절 시계열 모형과 비교를 통하여 그 성능을 평가하였다. 모수 절약 구조를 부여하기 위하여 계절성에서 공통된 패턴을 찾아내는 방법을 사용하였으며 기존 주기적 자기회귀 모형과의 통계적 차이 유무는 LR 검정을 통해 확인하였다. 그 결과, 중장기적으로 주기적 자기회귀 모형이 기존의 계절시계열 모형보다 우수한 예측성능을 보였으며, 특히 모수 절약 주기적 자기 회귀 모형의 사용은 기존의 주기적 자기회귀 모형보다 우수한 예측성능을 나타내는 것을 확인하였다.

• The Korean Journal of Pain
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• 제27권4호
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• pp.345-352
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• 2014

Background: Epidural administration of dexamethasone has been suggested for pain control after minor orthopedic surgery. This study was conducted to assess its efficacy after such surgery, combined or not to IV dipyrone, IV parecoxibe or their combination. Methods: 91 patients were randomly assigned to seven groups. Patients were submitted to spinal bupivacaine anesthesia combined to epidural administration of either 10 ml saline or 10 mg dexamethasone diluted to 10-ml volume. Patients also received 10 ml IV saline or 1 gr dipyrone and/or 40 mg parecoxibe diluted to 10 ml with saline. Control group (CG) received epidural and IV saline. Dexamethasone group (DexG) received epidural dexamethasone and IV saline. Dipyrone group (DipG) received epidural saline and IV dipyrone. Dex-Dip G received epidural dexamethasone and IV dipyrone. Parecoxibe group (ParG) received epidural saline and IV parecoxibe. Dex-ParG received epidural dexamethasone and IV parecoxibe. Finally, Dex-Dip-ParG received epidural dexamethasone and IV dipyrone plus IV parecoxibe. Results: The CG expressed 4h of analgesia and sooner requested pain killer. DexG was similar to DipG or ParG or Dex-ParG (7-hours), and they requested less ketoprofen compared to the CG (P < 0.05). However, the Dex-DipG and the Dex-Dip-ParG resulted in longer time to demand pain killer (17-hours) and less ketoprofen consumption in 24-hours (P < 0.002). Adverse effects were similar among groups. Conclusions: The analgesia secondary to epidural dexamethasone was enhanced by IV dipyrone, while no effects were observed by the addition of IV parecoxibe.

• 한국식품영양과학회지
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• 제40권10호
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• pp.1488-1492
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• 2011

Hydrocolloids로 arabic gum, carboxymethylcellulose, pectin 등을 밀가루 대비 각각 0.2와 0.5% 첨가하여 제조한 par baked 바게트를 냉동저장(-18oC)하면서 1주일 간격으로 해동 후 구워 비용적, 수분함량, 경도 및 관능검사 등을 분석하였다. 비용적은 3주 저장 시 CMC을 0.2% 첨가한 것이 3.20 cc/g로 가장 높았고, 수분함량은 대조구와 시험구간에 변화가 거의 없었으며, 경도는 3주 저장 시 pectin을 0.2% 첨가한 것이 가장 낮아 부드러운 것으로 나타났다. 관능검사에서 저장 3주에 pectin을 0.2% 첨가한 것의 전체적인 기호도가 가장 높은 점수를 얻었다. 이상의 연구에서 par baked바게트를 냉동저장 시 pectin을 0.2% 첨가한 제품의 특성이 가장 좋은 것으로 나타났다.

• 한국해양공학회지
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• 제11권1호
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• pp.55-64
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• 1997

A wing operating in close proximity to the ground exhibits a reduction in induced drag, which increase the lift/drag ratio. The poert-augmented ram (RAR) phenomenon involves directiing the efflux from forward mounted propulsion ststem under the wings, with the efflux nearly stagnated under the wings. In the present paper, 3 dimentional PAR was numerically studied by solving the Navier-Stokes equations. Pressure distribution and velocity vectors are calculated around the wing surface and the ground. Through the numerical simulation, Cp values and lift/drag ratio are carefully reviewed by changing the height/chord; 0.05, 0.1, 0.3 and 0.8. The shape of model is NACA 0012 with a span/chord ratio of 3.0. According to the numerical results, the relationship between lift/drag and height/chord is fairly reasonable.

• 동의생리병리학회지
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• 제18권1호
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• pp.110-113
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• 2004

The Baenong-san has long been used for treatment of inflammatory in Korea. In this study, the anti-inflammatory effects of Baenong-san water extract (BWX) were investigated in proteinase-activated receptor-2 (PAR2)-mediated rat paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH₂ (to-NH₂) into hindpaw of rats. BWX (10, 50, 100 and 200mg/kg) was orally administered 1 h before induction of inflammation. At doses of 50, 100 and 200 mg/kg, BWX showed significant inhibition of both change in paw volume and vascular permeability. BWX(100mg/kg) significantly also inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity in paw tissue. This study demonstrated that BWX has an anti-inflammatory action for PAR2-mediated paw edema.