• Journal of the Korean Applied Science and Technology
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• v.1 no.1
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• pp.3-9
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• 1984

Interaction of dietary Magnesium, Calcium and Polyunsaturated fatty acid(vegetable oils)on 3-Hydroxy-3-Methylglutaryl Co-A reductase activity was studied for a period of 30 days using isocalories and isonitrogenous as a basal diet . The subject rabbits were divided into 18 feeding groups. The results are summarized as follows: 1. The ratio of ${\alpha}_1-lipoprotein$ par lipalbumin is 0.34 for control group, 0.38 the highest group fed 0.1 Mg(II) 10ml plus perilla oil and basal diet, the lowest 0.25 group fed 0.1M Mg(II) 5ml plus sesame oil and basal diet. 2. The ratio ratio of ${\alpha}_2-lipoprotein$ per lipalbumin is 0.64 for control group. 0.95 as the highest for the group fed 0.1M Ca(II) 15ml plus sesame oil and basal diet, 0.1M Ca(II) 5ml plus perilla oil and basal diet. 3. The ratio of ${\beta}-lipoprotein$ per lipalbumin is 0.71 for control group, the highest 0.81 for the groups fed 0.1M Mg(II) 10ml plus sesame oil and basal diet, the lowest 0.37 for the group fed 0.1M Mg(II) 15ml plus soybean oil and basal diet. 4. In serum triglyceride, control group was 129.5mg%, the highest 155.4mg% for the group fed 0.1M Ca(II) 5ml plus sesame oil and basal diet, the lowest 85.7mg% for the group fed 0.1M Mg(II) 10ml plus soybean oil and basal diet. 5. In serum cholesterol, control group was 96.7mg%, the highest 152.5mg% for the group fed 0.1M Ca(II) 10ml plus sesame oil and basal diet, the lowest 80.5mg% for the group fed 0.1M Mg(II) 15ml plus soybean oil and basal diet. 6. In case of HMG-CoA reductase activity, control group was 0.95, the highest 0.98 for the group fed 0.1M Ca(II) plus soybean oil and basal diet. 7. Interaction between metal(II) ions and polyunsaturated fatty acid(vegetable oil) are soybean oil>sesame oil>perilla oil, for Mg(II). soybean oil>perilla oil>sesame oil, for Ca(II). Therefore, it is invetigated that the interaction between metal ion and polyunsaturated fatty acid is the higher, the cholesterol level is the lower, and HMG-CoA reductase activity is increased.

• Journal of Korean Society of Transportation
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• v.31 no.2
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• pp.60-68
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• 2013

This study developed plural gravity models and their application method in order to increase the accuracy of trip distribution estimation. The developed method initially involves utilizing the coefficient of determination ($R^2$) to set the target level. Afterwards, the gravity model is created, and if the gravity model's coefficient of determination is satisfactory in regards to the target level, the model creation is complete and future trip distribution estimation is calculated. If the coefficient of determination is not on par with the target level, the zone pair with the largest standardized residual is removed from the model until the target level is obtained. In respect to the model, the removed zone pairs are divided into positive(+) and negative(-) sides. In each of these sides, gravity models are made until the target level is reached. If there are no more zone pairs to remove, the model making process concludes, and future trip distribution estimation is calculated. The newly developed plural gravity model and application method was adopted for 42 zone pairs as a case study. The existing method of utilizing only one gravity model exhibited a coefficient of determination value ($R^2$) of 51.3%, however, the newly developed method produced three gravity models, and exhibited a coefficient of determination value ($R^2$) of over 90%. Also, the accuracy of the future trip distribution estimation was found to be higher than the existing method.

• Economic and Environmental Geology
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• v.34 no.6
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• pp.617-625
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• 2001

The Skaergaard intrusion is widely considered a type example of a strongly fractionated, layered intrusion that has undergone extensive in situ igneous differentiation. The Intrusion, therefore, should be a good locality for modeling trace element vriation in a closed system. Previous studios (Haskin and Haskin, 1968; Faster et al., 1974), however, have suggested thats the rare earth elements in whole rocks and mineeral separates from the Intrusion did not fellow the expected trend for closed system crystatllization. Trace element modeling using published distribution coefficients, modal abundances of the coexisting minerals, and the concentration of trace elements In whole rocks and mineral separates from the Skaergaard Intrusion, reveals that the rare earth elements were significantly Influenced by the crystallization of abundant apatite in the Layered Series suring the final stages of crystallization. The results of trace element modeling also suggcsts that apatite, which appears sporadically in the UBS, is not a primary liquidus phase in these samples as previously suggested (Naslund, 1984) but an interstitial phase that (lid not directly effect trace element abundances In the evolving magma As the Skaergaard magma coaled convection, or convected as small Isolated cells during the final stages of differentiation, an elebated $P_{H2O}$ Induced by accumulation of volatile elements near the roof of the magma chamber ingibited or delayed the precipitation of primary apatite in the UBS If the Skaergaard differentiation Is modeler assuming primary apatite crystallization In the upper par of the LS where abundant modal apatite is present, and only late stage crystallization of apatite In the UBS where apatite Is less abundant, rare earth elements abundances follow a closed system variation trend. These results rule but any differentiation model for the Skaergaard Intrusion that Includesvolumetrically significant injections or discharges of magma Into or out of the chamber during the final 20% of the crystallization history.

• Economic and Environmental Geology
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• v.34 no.6
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• pp.555-571
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• 2001

The dynamic evolution of the Chugaryeong fault valley is studied by paleomagnetic works on 163 samples at 16 sites from Late Cretaceous and Quaternary volcanic rocks in the valley. Conglomerate test and stepwised thermal/alternating field demagnetization indicate that all the characteristic directions are of primary origin. Paleomagnetic pole ponsition(216.8$^{\circ}$E/7l .6$^{\circ}$N; dp=7.1$^{\circ}$, dm=10.0$^{\circ}$) for the upper par of the Jijangbong Volcanic Complex Is indistinguishable from the coeval retference pole position from the Gyeongsang Basin, which further substanciates the reliability of the Paleomagnetic data. This indicates the study area has not undergone any tectonic rotation since Late Cretaceous by uy significant reactivation of the Chugaryeong fault valley. The Quaternary pole position (134.2$^{\circ}$E/86.5$^{\circ}$N; $A_{95}$=7.1 $^{\circ}$) from the Jeongog Basalt reflects the present geocentric axial dipole field for the area, supporting the above conclusion. Unlike the upper part, paleomasnelic directions of the lower part of the Jijangbong Volcanic Complex show random distrinution between sites. We interpret that the early stage of the volcanic activity was created by sinistral strike slip motion of the Chugaryeong fault during early Late Cretaceous. The creation and evolution of the Chugaryeong fault valley emphasize the significance of the kinematic FR (folding ruler) model in east Asia.

• Korean Journal of Agricultural and Forest Meteorology
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• v.21 no.4
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• pp.358-365
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• 2019

An agrivoltaic systems (AVS) is mixed systems associating photovoltaic panels (PVPs) and crop cultivation at the same time on the given land area. It is receiving attention to improve rural economy. However, it is likely that, the crop yield should be decreased due to the reduced absorption of solar radiation by leaves. Thus, before popularizing the AVS, it is necessary to comprehend the degree of shading by PVPs in AVS. In this study, the change of radiation condition under AVS mimic shading net was investigated. The minimum and maximum of difference of photosynthetically active radiation (PAR) between under and outside shading net were 3.03 mol/㎡/day on a cloudy day and 17.08 mol/㎡/day on a sunny day. This difference decreased when the ratio of diffuse irradiance to global irradiance increased. Such a shading effect resulted in the increase of rice height and decrease of rice tillering.

• Journal of Life Science
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• v.23 no.3
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• pp.462-469
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• 2013

Withaferin A is a steroidal lactone purified from the Indian medicinal plant Withania somnifera. It exhibits a wide variety of activities, including anti-tumor, anti-inflammation, and immunomodulation properties. In this review, we focused on the anti-cancer effects of withaferin A. Withaferin A inhibits cell proliferation, metastasis, invasion, and angiogenesis in cancer cells. Furthermore, it sensitized irradiation, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-, and doxorubicin-mediated apoptosis. The results showed that multiple mechanisms were involved in withaferin A-mediated anti-cancer effects. First, withaferin A increased intracellular reactive oxygen species (ROS) production and induced ER stress- and mitochondria-mediated apoptosis. Second, withaferin A inhibited the signaling pathways (Jak/STAT, Akt, Notch, and c-Met), which are important in cell survival, proliferation, and metastasis. Third, it induced apoptosis and inhibited cancer cell migration through the up-regulation of prostate apoptosis protein-4 (Par-4). Finally, withaferin A up-regulated pro-apoptotic protein expression levels through the inhibition of proteasome activity. Our findings suggested that withaferin A is a potential, potent therapeutic agent.

• Molecules and Cells
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• v.19 no.3
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• pp.375-381
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• 2005

Phospholipase C-${\beta}$ (PLC-${\beta}$) hydrolyses phosphatidylinositol 4,5-bisphosphate and generates inositol 1,4,5-trisphosphate in response to activation of various G protein-coupled receptors (GPCRs). Using glial cells from knock-out mice lacking either PLC-${\beta}1$ [PLC-${\beta}1$ (-/-)] or PLC-${\beta}3$ [PLC-${\beta}3$ (-/-)], we examined which isotype of PLC-${\beta}$ participated in the cellular signaling events triggered by thrombin. Generation of inositol phosphates (IPs) was enhanced by thrombin in PLC-${\beta}1$ (-/-) cells, but was negligible in PLC-${\beta}3$ (-/-) cells. Expression of PLC-${\beta}3$ in PLC-${\beta}3$ (-/-) cells resulted in an increase in pertussis toxin (PTx)-sensitive IPs in response to thrombin as well as to PAR1-specific peptide, while expression of PLC-${\beta}1$ in PLC-${\beta}1$ (-/-) cells did not have any effect on IP generation. The thrombin-induced $[Ca^{2+}]_i$ increase was delayed and attenuated in PLC-${\beta}3$ (-/-) cells, but normal in PLC-${\beta}1$ (-/-) cells. Pertussis toxin evoked a delayed $[Ca^{2+}]_i$ increase in PLC-${\beta}3$ (-/-) cells as well as in PLC-${\beta}1$ (-/-) cells. These results suggest that activation of PLC-${\beta}3$ by pertussis toxin-sensitive G proteins is responsible for the transient $[Ca^{2+}]_i$ increase in response to thrombin, whereas the delayed $[Ca^{2+}]_i$ increase may be due to activation of some other PLC, such as PLC-${\beta}4$, acting via PTx-insensitive G proteins.

• Molecules and Cells
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• v.38 no.11
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• pp.991-997
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• 2015

Tristetraprolin (TTP) is an AU-rich elements (AREs)-binding protein, which regulates the decay of ARE-scontaining mRNAs such as proto-oncogenes, anti-apoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3' untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.5
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• pp.491-498
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• 2005

J sewage treatment plant (WWTP) in Busan has used methanol as an external carbon source for the biological denitrification process. Methanol is widely used. but rather expensive and very dangerous in handling. Therefore, it has been required that the economic alternative carbon source must be developed. By-product from a fine chemical industry can be Purified by removing high molecular weight substances using the ultrafilter membrane separation process and RBDCOD fraction becomes $98{\sim}99%$ of COD substances in the purified by-product. The purified by-product containing three types of alcohols, methanol, prophylenglycol and methoxypropanol; showed similar chemical characteristics to the methanol, a main external carbon source, in biodegradation pathway. Shown above, the compatibility between main and alternative carbon sources has been achieved. Also very short or no adaptation period is necessary in the case of exchanging these carbon sources. The compatibility between external carbon sources is an essential element for stabilizing WWTP operations. During the full-scale application test of the by-product, the alternative carbon source line got on par with the treatment efficiency of the methanol line. With the test result, J-WWTP changed methanol to a fine chemical by-product, in two out of three J-WWTP lines. Moreover, it is expected that 55.4% of the external carbon source cost reduction can be achieved in the alternative carbon source applied lines.

• Biomedical Science Letters
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• v.18 no.1
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• pp.79-82
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• 2012

Acinetobacter infections are of great concern in clinical settings because of multi-drug resistance (MDR) and high mortality of the infected patients. The MDR Acinetobacter baumannii has emerged as a significant infectious agent in hospitals worldwide. The purpose of this study was to determine for molecular characterization of MDR A. baumannii clinical isolates obtained from the Wonju Christian Hospital in Gangwon province of Korea. A total of seventy nonduplicate A. baumannii isolates were collected from the Wonju Christian Hospital in Korea from March to April in 2011. All of the MDR A. baumannii isolates were encoded by $bla_{OXA-23-like}$ gene and all isolates with the $bla_{OXA-23-like}$ gene had the upstream element ISAba1 to promote increased gene expression and subsequent resistance to carbapenem. 16S rRNA methylase gene (armA) was detected in 44 clinical isolates which were resistant to amikacin, and phosphotransferase genes encoding aac(3)-Ia and aac(6')-Ib were the most prevalent. A combination of 16S rRNA methylase and aminoglycoside-modifying enzyme genes (armA, aac(3)-Ia, aac(6')-Ib, and aph(3')-Ia) were found in 31 isolates. The sequencing results for the quinolone resistance-determining region (QRDR) of gyrA and parC revealed the presence of Ser (TCA) 83 Leu (TTA) and Ser (TCG) 80 Leu (TTG) substitutions in the respective enzymes for all MDR. Molecular typing for MDR A. baumannii could be helpful in confirming the identification of a common source or cross-contamination. This is an important step in enabling epidemiological tracing of these strains.