• Title/Summary/Keyword: PANDAS

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A CASE OF PANDAS WITH CHILDHOOD DISINTEGRATIVE DISORDER (소아기 붕괴성 장애의 양상을 보이는 PANDAS 1례)

  • Cho, Soo-Churl;Seong, Deock-Kyu
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.12 no.1
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    • pp.149-156
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    • 2001
  • After the fact that obsessive-compulsive symptoms or tic symptoms are common in Sydenham's chorea which is a sequale of rheumatic fever produced by group A beta-hemolytic streptococcus was reported, the association between group A beta-hemolytic streptococcus and a subgroup of obsessivecompulsive disorder(OCD) or tic disorder has been attentioned. This subgroup shared a unique clinical course, characterized by an abrupt onset of symptoms and/or dramatic exacerbations. And this subgroup was distinguished by pre-pubertal onset of symptoms, neurological abnormalities(choreiform movements and a unique pattern of motoric hyperactivity), as well as by relapsing and remitting symptom course. Acronym PANDAS(pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) was used to denote a subgroup of OCD or tic disorder patients with these clinical characteristics. Then, there was a report suggesting that PANDAS category include some of attention-deficit/hyperactivity disorder(ADHD) and were two case reports of anorexia nervosa and body dysmorphic disorder with characteristics of PANDAS. This case is a patient who developed normally until age of 7, but after pharyngeal inflammation with high fever, he showed disturbance of cognition, social relationship, and language and communication, as well as tic symtoms and abnormal movement on face, hand, and foot. We report this case with review of literatures, because we think that this case belongs to the PANDAS category. Based on this observation, we suggest that PANDAS category include some of childhood disintegrative disorder as well as OCD, tic disorder, and ADHD.

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Proposal For Improving Data Processing Performance Using Python (파이썬 활용한 데이터 처리 성능 향상방법 제안)

  • Kim, Hyo-Kwan;Hwang, Won-Yong
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.13 no.4
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    • pp.306-311
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    • 2020
  • This paper deals with how to improve the performance of Python language with various libraries when developing a model using big data. The Python language uses the Pandas library for processing spreadsheet-format data such as Excel. In processing data, Python operates on an in-memory basis. There is no performance issue when processing small scale of data. However, performance issues occur when processing large scale of data. Therefore, this paper introduces a method for distributed processing of execution tasks in a single cluster and multiple clusters by using a Dask library that can be used with Pandas when processing data. The experiment compares the speed of processing a simple exponential model using only Pandas on the same specification hardware and the speed of processing using a dask together. This paper presents a method to develop a model by distributing a large scale of data by CPU cores in terms of performance while maintaining that python's advantage of using various libraries is easy.

A PRELIMINARY STUDY OF B LYMPHOCYTE ANTIGEN D8/17 IN TOURETTE SYNDROME CHILDREN WHO SUGGESTED PANDAS (PANDAS가 의심되는 뚜렛장애 아동에서의 B 임파항원 D8/17에 관한 예비연구)

  • Joung Yoo-Sook;Lee Young-Sik
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.17 no.1
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    • pp.27-31
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    • 2006
  • Objectives : We examined whether D8/17 expression in Tourette syndrome children who suggested PANDAS were higher than comparison group, and there was my clinical difference by D8/l7 expression. Methods : Nine Tourette's syndrome children suggested PANDAS and two ADHD children without tic disorder were evaluated far percentage of D8/17 expression-positive B cells by immunofluorescence flow cytometric assay and anti-streptolysin O titer. Results : The frequency of D8/17 positive B lymphocyte rate was significantly higher in Tourette's syndrome than ADHD, whose average rate were 77.9 and 24.8, respectively. Among 9 TD patients,4 patients showed above 90% D8/l7 expression. There was high concordance expression rate between mother (98.4%) and daughter (99.0%) The significant relation between percentage of D8/17 expression and tic severity were not detected. The significant relation between percentage of D8/17 expression and anti-streptolysin O titer were not detected, however in 66.7% TD patients showed above 100IU/ml. Conclusion : We concluded that subgroup of TD children are streptococcal infected tic disorder, so called PANDAS.

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Possible Application of Animal Reproductive Researches to the Restoration of Endangered and/or Extinct Wild Animals - Review -

  • Fujihara, N.;Xi, Y.M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.13 no.7
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    • pp.1026-1034
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    • 2000
  • As described here, most recently developed methods for improving reproduction performance of domesticated animals such as cattle, swine and chicken have been considered to be also usable for restoring some sorts of endangered and/or extinct wild animals in the very near future. Especially, the techniques for in vitro storage of gametes obtained from dead animals shortly after the death, probably 24 h following the sacrifice are also available for obtaining some of experimental specimens. In case of the endangered animals, nobody will be allowed to use any tissues from the living animals, therefore, e.g., the use of skin tissues from these bodies is another possibility of restoring the living animals. Regarding the use of skin tissues, the most highly usable tools must be the cloning techniques for reviving rare cells from the living body. Most possible techniques for cloning cells is nuclear transfer from rare species to highly relative species, and this is the case of germ cells, e.g., primordial germ cells (PGCs) of avian species. One of the possibilities is the nuclear transfer of Crested Ibis (Nipponia nippon) to the PGCs of chicken, resulting in the PGCs with transferred nucleus from the ibis. In mammalian species, the same procedure as in the case of birds would be successful, e.g., the removed nucleus from Giant Pandas will be transferred to the cell, such as somatic cells or germ cells from black bears or lesser pandas, leading to the production of transnucleared cells in the body of female black bears. These two cases are most promising techniques for reviving endangered animals in the world, particularly in Asian countries, mainly in China. As a conclusion, possible production of cloned animals carrying transnucleared cells from endangered animals, such as Giant Pandas and Crested Ibis, may be reproduced gradually in the near future. Scientists are, therefore, required to convert the paradigm from domestic animals to wild animals, including endangered and/or extinct animals on the earth.

THERAPEUTIC APPROACHES FOR TREATMENT RESISTANT OBSESSIVE-COMPULSIVE DISORDER IN CHILDREN AND ADOLESCENTS (소아청소년기 치료저항성 강박장애의 치료적 접근)

  • Suh, Hyun-Ju;Kim, Boong-Nyun
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.14 no.1
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    • pp.64-80
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    • 2003
  • Although obsessive-compulsive disorder(OCD) affects children, adolescents, and adults whether its juvenile(dhild and adolescent) and adult forms are different subtype of a disorder remains unknown. But there are increasing findings that suggest that juvenile OCD may be unique subtype of the disorder. One proposed subtype is the childhood OCD associated with high comorbidity of tic disorder and increased familial loading for OCD or tic disorder. The other proposed subtype is the childhood OCD and/or tic disorder occuring in association with streptococcal infection(PANDAS). These two subtypes of OCD are unlikely to respond to SSRI due to possible different pathphysiological mechanism. So this paper reviews the characteristics of OCD and therapeutic approaches for treatment resistant OCD in childhood and adolescence. Considering the likely heterogeneity of OCD, the possibility that juvenild OCD may be a variant of the disorder can have important clinical and scientific implications because it may further our understanding of this disorder, its etiology, and perhaps its treatment.

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TIC DISORDER AND OBSESSIVE COMPULSIVE DISORDER IN CHILDHOOD (틱 장애 및 소아기 발병 강박 장애)

  • Hong, Hyun-Ju;Song, Dong-Ho
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.16 no.2
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    • pp.183-191
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    • 2005
  • Tic disorder including Tourette's disorder is a neurodevelopmental disorder that appears in childhood and characterized by the presence of motor and vocal tics. Childhood-onset obsessive-compulsive disorder (OCD) is suggested to be a phenomenologically and etiologically distinct subtype of OCD, bearing a close genetic relationship to tic-disorders. Tourette's disorder and OCD are comorbid in $40-75\%$ of patients initially diagnosed with either disorder. Basal ganglia and cortico-striato-thalamic circuits are implicated in the pathophysiology of both disorders and these disorders have similar clinical features. Over the past decades, the progress in research on Tourette's disorder and OCD has been extraordinary. This review describes some of important insights from these work, involving these areas : 1) clinical implication 2) genetics and epidemiology 3) brain imaging study 4) neuroche-mistry 5) pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS).

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Interspecies comparative morphological evaluation of the corneal epithelial stem cell niche: a pilot observational study

  • Popova, Petya;Malalana, Fernando;Biddolph, Simon;Ramos, Tiago;Parekh, Mohit;Chantrey, Julian;Ahmad, Sajjad
    • Journal of Veterinary Science
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    • v.23 no.4
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    • pp.62.1-62.10
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    • 2022
  • Background: The corneal and limbal morphology relevant to corneal epithelial maintenance in ten different species was examined using histological methods. Objectives: The presence of a Bowman's layer, limbal epithelial cell, and superficial stromal morphology was examined in the following species to evaluate the differences in corneal thickness and epithelium: Java sparrows, frogs, macaws, spoonbills, red pandas, penguins, horses, Dobermans, orangutans, and humans. Methods: Corneal sections (4 ㎛) were obtained from ten ocular globes from three different animal classes: Aves, Amphibia, and Mammalia. All sections were stained with hematoxylin and eosin and periodic acid-Schiff reaction. After microscopy, all stained slides were photographed and analyzed. Results: Significant morphological differences in the corneal and limbal epithelia and their underlying stroma between species were observed. The number of corneal epithelial cell layers and the overall corneal epithelial thickness varied significantly among the species. The presence of a Bowman's layer was only observed in primates (orangutans and humans). Presumed supranuclear melanin caps were noted in four species (orangutans, macaws, red pandas, and horses) in the limbal basal epithelial layer (putative site of corneal epithelial stem cells). The melanin granules covered the apex of the cell nucleus. Conclusions: Supranuclear melanin capping has been described as a process within the epidermis to reduce the concentration of ultraviolet-induced DNA photoproducts. Similarly, there may be a relationship between limbal stem cell melanin capping as a protective mechanism against ultra-violet radiation.

The Research Regarding of Visitors' Perception of Animal Elements in Landscape Architecture

  • Shen, Ning;Bae, Jung Nam;Zhang, Li-Qin;Piao, Yong-Ji
    • Journal of Environmental Science International
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    • v.22 no.6
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    • pp.679-686
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    • 2013
  • Based on the survey of East Lake Park, South Lake Park and Tian Waicun in Tai'an by questionnaire survey, on-the-spot investigation and in-depth interview, the paper analyzes the tendencies of visitors to the animal elements and animal landscape in landscape architecture from three terms: primary attributes, the cognition of animal elements and animal elements landscape preferences. We have drawn several conclusions: the landscapes of animal elements are in urgent demand by the public ; The animal elements having lovely image, auspicious meaning and local characteristics are the most popular application types of animal elements landscapes ; The most favorite types of animals and animal elements are: doves, cranes monkeys, pandas, butterflies, dragonflies, fold fish, dolphins, dragons and cartoon animals ; The popular landscaping techniques of animal elements are the methods of combining with plants, buildings and garden ornaments.

The Correlation Of Weather And Hanhwa Eagles (날씨와 한화 이글스의 상관관계)

  • Heo, Tai-Sung;Kang, Ha-Ram
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2021.07a
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    • pp.237-238
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    • 2021
  • 야구는 데이터 스포츠라 불릴 만큼 경기마다 많은 데이터가 생성되며, 이를 바탕으로 경기를 진행한다. 본 연구는 한국 프로야구 구단인 한화 이글스의 승률 및 타자의 성적과 날씨 사이의 상관관계를 분석하였다. 이를 위하여 한화 이글스의 승률과 타자의 성적을 한국프로야구(KBO) 공식 홈페이지 및 야구 기록 통계사이트 스탯티즈(statiz)에서 수집하였으며, 날씨 데이터는 온도와 습도를 고려한 불쾌지수 데이터를 기상청으로 부터 수집하였다. 파이선의 pandas 라이브러리를 사용하여 데이터 전처리를 실행하였다. 이후 파이선의 matplotlib 라이브러리를 이용하여 데이터 분석 및 시각화를 진행하였다. 본 연구의 분석 결과로는 불쾌지수가 보통일 때 승률이 가장 크고 높음일 때 가장 낮음을 확인할 수 있었다. 또한, 타자들의 평균 성적을 분석한 결과 보통과 매우 높음은 전체적인 타격 지수가 비슷하나 높음일 때 부진한 것으로 나왔다.

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A Machine Learning-Based Encryption Behavior Cognitive Technique for Ransomware Detection (랜섬웨어 탐지를 위한 머신러닝 기반 암호화 행위 감지 기법)

  • Yoon-Cheol Hwang
    • Journal of Industrial Convergence
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    • v.21 no.12
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    • pp.55-62
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    • 2023
  • Recent ransomware attacks employ various techniques and pathways, posing significant challenges in early detection and defense. Consequently, the scale of damage is continually growing. This paper introduces a machine learning-based approach for effective ransomware detection by focusing on file encryption and encryption patterns, which are pivotal functionalities utilized by ransomware. Ransomware is identified by analyzing password behavior and encryption patterns, making it possible to detect specific ransomware variants and new types of ransomware, thereby mitigating ransomware attacks effectively. The proposed machine learning-based encryption behavior detection technique extracts encryption and encryption pattern characteristics and trains them using a machine learning classifier. The final outcome is an ensemble of results from two classifiers. The classifier plays a key role in determining the presence or absence of ransomware, leading to enhanced accuracy. The proposed technique is implemented using the numpy, pandas, and Python's Scikit-Learn library. Evaluation indicators reveal an average accuracy of 94%, precision of 95%, recall rate of 93%, and an F1 score of 95%. These performance results validate the feasibility of ransomware detection through encryption behavior analysis, and further research is encouraged to enhance the technique for proactive ransomware detection.