• International Journal of Oral Biology
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• v.33 no.4
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• pp.143-147
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• 2008

The sodium bicarbonate cotransporter (NBC) protein is functionally expressed in salivary glands. In this experiment, we examined the role of NBC in $HCO_3^-$ formation in human parotid gland acinar cells. Intracellular pH (pHi) was measured in 2'-7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF)-loaded cells. Acetazolamide (0.1 mM) and 4,4'-diisothio cyanatostilbene-2,2'-disulphonic acid (DIDS, 0.5 mM) were used as specific inhibitors of carbonic anhydrase and NBC, respectively. The degree of inhibition was assessed by measuring the pHi recovery rate (${\Delta}pHi$/min) after cell acidification using an ammonium prepulse technique. In control experiments, ${\Delta}pHi$/min was $1.40{\pm}0.06$. Treatment of cells with 0.5 mM DIDS or 0.1 mM acetazolamide significantly reduced ${\Delta}pHi$/min to $1.14{\pm}0.14$ and $0.74{\pm}0.15$, respectively. Simultaneous application of DIDS and acetazolamide further reduced ${\Delta}pHi$/min to $0.47{\pm}0.10$. Therefore, DIDS and acetazolamide reduced ${\Delta}pHi$/min by 19% and 47%, respectively, while simultaneous application of both DIDS and acetazolamide caused a reduction in ${\Delta}pHi$/min of 67%. These results suggest that in addition to carbonic anhydrase, NBC also partially contributes to $HCO_3^-$ formation in human parotid gland acinar cells.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.3
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• pp.331-341
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• 2018

The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male Sprague-Dawley rats using chronic constriction injury of the infraorbital nerve (CCI-ION) and perineural application of 2% QX-314 to the infraorbital nerve. CCI-ION produced severe mechanical allodynia, which was maintained until postoperative day (POD) 30. An immediate single application of 2% QX-314 to the infraorbital nerve following CCI-ION significantly reduced neuropathic mechanical allodynia. Immediate double application of QX-314 produced a greater attenuation of mechanical allodynia than a single application of QX-314. Immediate double application of 2% QX-314 reduced the CCI-ION-induced upregulation of GFAP and p-p38 expression in the trigeminal ganglion. The upregulated p-p38 expression was co-localized with NeuN, a neuronal cell marker. We also investigated the role of voltage-gated sodium channels (Navs) in the antinociception produced by preemptive application of QX-314 through analysis of the changes in Nav expression in the trigeminal ganglion following CCI-ION. Preemptive application of QX-314 significantly reduced the upregulation of Nav1.3, 1.7, and 1.9 produced by CCI-ION. These results suggest that long-lasting blockade of the transmission of pain signaling inhibits the development of neuropathic pain through the regulation of Nav isoform expression in the trigeminal ganglion. Importantly, these results provide a potential preemptive therapeutic strategy for the treatment of neuropathic pain after nerve injury.

• Korean Journal of Soil Science and Fertilizer
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• v.3 no.1
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• pp.35-41
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• 1970

The experiment was conducted at the salt concentration of 0.5% and 1% end of April, respectively, in low and high-salty and the non-salty areas of silt loam with the Nongkwang, rice variety. The factorial design with confounding blocks of 3 levels each of 10, 15 and 20 kg of N, 8, 12 and 16kg of phosphate and potash, respectively, per 10a was applied. 1. N applications increased by 1.5 and 2 times with the fixed amount of $P_2O_5$ and $K_2O$ (8kg/10a each) increased the proportion absorbed to the applications of N in both non salty and low-salty areas. It was observed that the absorption of Ca and Si was inhibited by either an increased treatment of N alone or combination with the other nutrients in the salty area. 2. In the non-salty area, an increased applications of standard amount of N, $P_2O_5$ and $K_2O$ respectively did not increased the yields. Doubling the application of $K_2O$ resulted in a decreased yield. 3. Applications of additional of 1.5 and 2 times the 10 kg of N per 10a increased the rice yields 12% and 21% respectively, in the low-salty area. An increased application of $P_2O_5$ and $K_2O$ failed to bring about an increased yield. 4. Increasing the application of N gave a significant increased in the yield of rice grain and 1.5 times of N applications were seemed profitable on the high-salty area. Although an increased applications $P_2O_5$ and $K_2O$ seemed to increase the yields of grain, no significant increase was observed. 5. An increased application of N increased the number of panicles up to 1.5 times the standard amount in the non-salty area, but no further increase resulted by doubling the application. The number of panicles was increased in proportion to the increased application of N in both low and high-salty areas. An increased application of $P_2O_5$ increase the number of panicles per unit area in each experimental plot while that of $K_2O$ had no effect but rather decreased the number. 6. The effect of an increased application of N decreased the weight of panicle in the non-salty area, but when the application was increased to 1.5 times or more an increased weight of panicle resulted in both salty areas. Doubling the application had approximately the same effect as 1.5 times the application. Increasing the applications of $P_2O_5$ and $K_2O$ had no effect on the panicle weight in the experimental plots. Increasing the applications of N, $P_2O_5$ and $K_2O$ did not effect the weight of 1,000 grains produced in the non-salty and salty areas. Increasing the application of N decreased the number of grains per panicle in the non-salty area but increased the number of grains per panicle in either salty areas. 7. The ratio of matured grains was highest in the low-salty area and the lowest in the high-salty area. An increased N applications decreased the ratio of matured grains in the non-salty area. No effect was observed in both low and high-salty areas. Increased the $P_2O_5$ and $K_2O$ application showed no effect on the ratio of matured grains in the experimental plots. 8. Increased applications of N, $P_2O_5$ and $K_2O$ was observed not to change the percentage of milling recovery in any experimental plots. Broken rice was increased equally by an increased application of N in the non-salty and salty areas but more remarkably so in the former. 9. Increased applications of N increased the straw production equally in the non-salty, low and high-salty areas. However, no increased production was observed from heavier applications of $P_2O_5$ and $K_2O$. Additional N applications reduced the rate of rough grain weight v.s. straw weight in the non-salty area but increased the ratios in both low and high-salty areas. Additional $P_2O_5$ and $K_2O$ had no effect with the ratio.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.3
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• pp.575-580
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• 2017

In these days, the big-size and high resolution multimedia file is widely used through networks. To transfer and service effectively, the internet network technology is necessary to substitute broadcasting. Normally Content Delivery Network(CDN) is widely used in conventional internet for multimedia services. But it has a small bandwidth to service. So to solve this problems, many researchers have suggest the protocol for download, content distribution/saving, server synchronization, caching, pushing rate, and streaming etc. But all of these has some defects like low resolution, packets loss and delay, real application implementations etc. So, this paper suggests a new method of network protocol based on P2P collaboration and user's content using information. And it evaluated the performance of suggested method. As the results, it showed the effectiveness of 4 performances indices : download speed, decreasing rate of connected user in same time, adaptive hit ratio, traffic decreasing rate.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.11a
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• pp.523-524
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• 2009

Peer-to-Peer(P2P) 시스템은 분산된 대용량 데이터를 효율적으로 공유하게 하여 사용자들에게 제공되는 killer application 으로 최근까지 여러 분야에서 연구가 되고 있다. 하지만 P2P 네트워크에서 피어가 소유한 데이터나 공통 관심사 또는 사회적인 관계를 고려하지 않고 무작위로 오버레이가 구성되기 때문에 검색 결과의 제약이 발생한다. 따라서 본 논문에서는 P2P 오버레이상의 효율적인 데이터 검색을 위해서 각 피어가 가지고 있는 데이터와 공통의 관심사를 기반으로 유사성을 측정하여 semantic overlay를 구성하는 기법을 제안한다. 그리고 피어들 간의 semantic proximity는 데이터 요약 기법을 사용하여 측정되며 측정 과정상에서 popular content을 고려하여 semantic proximity의 왜곡현상을 방지하여 semantic link quality의 향상을 가져오는 방안을 도입한다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.2
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• pp.545-548
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• 2005

Recently, the computing environment of P2P come out to solve the excessive load of the server in the computing environment of the client/server. Currently, operated computing environment of P2P is mainly spreading out P2P system of read name or anonymity base about a publisher, sender and receiver of the file. But, to the current file protection there is three problem. The first problem is to a host become attack target. The second is to received file loose attack of Brute Force. The third is to define target of attack of DOS. To solve the this problem. it divide file into block unit. Each block is safely scattered peers. This paper propose the distribution P2P system of file division. Both proposing system solve the this problem and promote efficiency of file application.

• Korean Journal of Soil Science and Fertilizer
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• v.43 no.6
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• pp.852-857
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• 2010

This study was performed to explore the effect of the clay mineral illite on the improvement of bed soil and plant growth. Red pepper (Capsicum annuum L.) was used as a model vegetable crop. The experiment was performed during the whole six weeks in the glass house of the Chungbuk National University. Its seedlings were cultivated in the bed soil normally used for horticultural purpose. Of the seedlings cultured, the healthy and regular size of seed were selected and cultivated in the pots. They were treated with two forms of illite, particulate (PA) and powder (PW), at the following application rates: standard application[P1 (PA1, PW1), 1:20 (w/w)], two times[P2 (PA2, PW2), 1:10 (w/w)], and four times[P4 (PA4, PW4), 1:5 (w/w)] of standard application. Untreatment (P0) was used as a control pot. At six weeks of cultivation, their growth lengths were correspondingly increased as the application rate was increased ranging from P0, P1, P2, and to P4. Their growth length was a little greater on the application of powder illite (PW) than on the particulate illite (PA). Based on the plant analysis for the root, leaf, stem of red pepper, the uptake amounts of K, Ca, and Mg, were correspondingly increased, as the application rate was increased ranging from P0, P1, P2, and to P4, respectively. At the same application rate, their amounts taken up in the respective parts were higher on the application of PW illite than on the PA one. Especially the amounts of Ca and Mg were higher in the stem, leaf than root. Consequently, it appears that the illite treatment, especially, PW form of illite, enhance the growth of red pepper in the glass house during the whole six weeks of experiment.

• Journal of the Korea Society of Computer and Information
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• v.10 no.2 s.34
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• pp.69-78
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• 2005

As the study and use of P2P systems are diversified, the effect of excessive amount of traffic, which occurs in searching peers' resource and is considered as a network bandwidth Problem, cannot let the matter Pass without making a protest. In case P2P application doesn't reduce network traffic, it can be much effected to use bandwidth smoothly in the internet environment where various network applications lie scattered and there will be inconvenience when many network users makes use of related applications . In this Paper, we propose a pure P2P model based-broadcasting technique for producing successful hit ratio and traffic amount in the weakly connected environment based-P2P system where situation of peers' connection and exit is ambiguous . The proposed searching technique is designed/implemented to improve a resident problem in the related system and we have estimated the performance of the proposed searching technique comparing our technique with the existing broadcasting based-searching technique .

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.389.2-389.2
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• 2016

The flexible solid state device has been widely studied as portable and wearable device applications such as display, sensor and curved circuits. A zero-bias operation without any external power consumption is a highly-demanding feature of semiconductor devices, including optical communication, environment monitoring and digital imaging applications. Moreover, the flexibility of device would give the degree of freedom of transparent electronics. Functional and transparent abrupt p/n junction device has been realized by combining of p-type NiO and n-type ZnO metal oxide semiconductors. The use of a plastic polyethylene terephthalate (PET) film substrate spontaneously allows the flexible feature of the devices. The functional design of p-NiO/n-ZnO metal oxide device provides a high rectifying ratio of 189 to ensure the quality junction quality. This all transparent metal oxide device can be operated without external power supply. The flexible p-NiO/n-ZnO device exhibit substantial photodetection performances of quick response time of $68{\mu}s$. We may suggest an efficient design scheme of flexible and functional metal oxide-based transparent electronics.

• Journal of Internet Computing and Services
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• v.7 no.3
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• pp.53-60
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• 2006

As it has been continuously increased the volume of traffic over Internet, it is hard for a network traffic monitoring system to analysis every packet in a real-time manner. While it is increased usage of applications which are dynamically allocated port number such as peer-to-peer(P2P), steaming media, messengers, users want to analyze traffic data generated from them. This high level analysis of each packet needs more processing time. This paper proposes to introduce load shedder for limiting the number of packets. After it determines what application generates a selected packet, the packet is analyzed with a defined application protocol.