• PNF and Movement
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• 제19권3호
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• pp.311-319
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• 2021

Purpose: The study examined the effects of the proprioceptive neuromuscular facilitation pattern exercise and protein intake on balance, gait ability, and lower extremity muscular strength for sarcopenia in the elderly. Methods: A total of 30 elderly people (65~74years) with sarcopenia were recruited and randomized to Group I (n=10), Group II (n=10), and Group III (n=10). Their balance ability was measured using the functional reach test. Group I performed the proprioceptive neuromuscular facilitation pattern exercise and protein intake. Group II performed the proprioceptive neuromuscular facilitation pattern exercise. Group III performed protein intake. Their gait ability was measured using the Timed Up and Go test. Lower extremity muscular strength was measured using the Five Times Sit to Stand test. Results: As a result of comparison within groups, Group I and Group II showed a significant difference in balance, gait, and lower extremity muscular strength after the experiment (p<0.05), and Group I showed a more effectively significant difference than either Group II or Group III in balance, gait, and lower extremity muscular strength before and after the experiment (p<0.05). Conclusion: This study showed that the proprioceptive neuromuscular facilitation patterns exercise and protein intake was effective in balance, gait ability, and lower extremity muscular strength for sarcopenia in the elderly.

• 한방재활의학과학회지
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• 제20권1호
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• pp.1-12
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• 2010

Objectives : Cool Pharmacopuncture for static blood is a famous pharmacopuncture treatment that treated disease caused by static blood. Hyolhae(Sp10) is also a famous point of acupuncture that treated that. This study was designed to evaluate the effects of Cool Pharmacopuncture for static blood into Hyolhae(Sp10) on BAX and BCL-2 expression in the experimental traumatic brain injury(TBI) rats. Methods : Male rats were divided into 3 groups. I was no treatment after TBI. II was treatment with needle-prick acupuncture after TBI. III was treatment with Cool Pharmacopuncture for static blood into Hyolhae(Sp10) after TBI. The author carried out neurological motor behavioral test, histological assessment test. Neurological motor behavior tests consist of rotarod test, beam-walking test and postural reflex test. In the histological assessment test, BAX and BCL-2 expression, hematoxylin & eosin staining were experimented. Results : In neurological motor behavior tests, motor and cognitive function recovery was significantly increased in the II, III as compared with I (p<0.05). Especially III was significantly increased as compared with II (p<0.05). BAX expression was significantly decresed in order of the III, II, I after 7 and 14 days later. BCL-2 expression was investigated in the III, II as compared with I. Especially Most incresed expression was experimented in the III. Conclusions : According to the above results, Cool Pharmacopuncture for static blood can inhibit apoptosis of cells after TBI in rats by contol of BAX and BCL expression.

• Natural Product Sciences
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• 제15권3호
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• pp.115-120
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• 2009

Woohwangcheongsimwon (WHCSW) is a traditional oriental medicinal fomula which has been clinically used for treating strokes, palpitation, loss of consciousness and anxiety. The purpose of this study was to characterize the putative anxiolytic properties of WHCSW using an elevated plus-maze (EPM) and hole-board test. Control mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). In the EPM test, WHCSW significantly increased the percentage of time-spent in the open arms (200 mg/kg, P < 0.05) and the percentage of open arm entries (200 and 400 mg/kg, P < 0.05). WHCSW also significantly increased the number of head-dips in the hole-board test (200 mg/kg, P < 0.05). In addition, the anxiolytic properties of WHCSW examined in the EPM test were inhibited by flumazenil (10 mg/kg, i.p.), a GABA$_A$ antagonist. However, no changes in spontaneous locomotor activity or myorelaxant effects were observed versus 10% Tween 80 controls. These results suggested that WHCSW is an effective anxiolytic agent, and that its anxiolytic effects are mediated via GABA$_A$ receptors.

• 대한간호학회지
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• 제23권1호
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• pp.107-117
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• 1993

This study was a clinical Quasi-experiment to examine the effects of the range of motion exercise on powerlessness and life satisfaction among the E-Institutionalized elderly in Pusan. The purpose was to test the effect of the range of motion exercises on powerlessness and life satis-faction, and to examine the correlation between powerlessness and life satisfaction. The subjects for this study were 54 elderly people, both were over 60 and residing at I-Institution in Pusan. The research samples of 54 elderly were divided into an experimental and control group by matching randomized assignment. The instruments for this study were the Assessment Tool of Powerlessness in the elderly developed by Miller, Life satisfaction developed by Yoon Jin, and the Active-Passive Range of Motion Exercise Program which was developed and utilized by Shin, Jae-Shin. The data were collected from December 15, 1990 to November 1991. The paired t-test, t-test and ANCOVA were used to test hypothesis I and II, related to the Effect of the Range of Motion Exercises to powerlessness and life satisfaction. To identify the relationship of the range of motion exercises to powerlessness and life satisfaction, path analysis was done through multiple regression. The interrelationship of the variables was analyzed using t-test paired t-test. The results of the three hypothesis can be summarized as follows : 1. Hypothesis I -the experimental group which participated in the Range of Motion Exercise gets lower powerlessness score than that of the control group-was accepted by t-test (t = -3.40, p = .001) but not accepted by ANCOVA (F = .1, p =.96). 2. Hypothesis II - the experimental group which participated in the Range of Motion Exercise gets a higher Life Satisfaction Score than that of the control group-was not supported by t-test(t = 1.01, p = .316) but was accepted by ANCOVA (F = 4.39, p = .006). 3. Hypothesis III - if the powerlessness Score becomes higher, the Life Satisfaction Score will be-come lower - was accepted by Pearson Correlation Coefficient (pre-exercise : r : -.34, p=.006), (post exercise : r = -.06, p=.32) . The relation-ship between the score of powerlessness and life satisfaction was negatively correlated. The results obtained clearly showed that the effects of the range of motion exercises on powerlessness and life satisfaction are beneficial to the elderly The relation between the scores of powerlessness and life satisfaction was negatively correlated and the range of motion exercise had a direct influence to powerlessness. Therefore, it is concluded that the relationship between powerlessness and life satis-faction was not a causal one. Also it is concluded that the range of motion exercises can be applied as a nursing intervention to reduce powerlessness and to improve life satisfaction in the elderly.

• Journal of Periodontal and Implant Science
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• 제51권4호
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• pp.276-284
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• 2021

Purpose: The aim of this randomized clinical trial was to assess whether chemical cleansing using a sulfonic/sulfuric acid gel solution (HBX) as an adjunct to scaling and root planing (SRP) resulted in a decrease in residual plaque and calculus in deep periodontal pockets compared to SRP alone. Methods: Fifty-six patients with 56 hopeless posterior teeth, scheduled for extraction due to severe periodontitis, were enrolled in this study. Each tooth was randomly assigned to 1 of the 2 experimental procedures. The test teeth were subjected to the irrigation of the subgingival area with HBX for 2 minutes, followed by SRP with hand and ultrasonic instruments for 14 minutes, and then extracted. The control teeth received only mechanical instrumentation before extraction. Residual biofilm was evaluated on photographs and measured as total area and percentage of root surface covered by remaining plaque (RP) or calculus (RC) after treatment. Results: The initial pocket depth (PD) and total subgingival root surface area were similar between the 2 treatment groups. After treatment, the total subgingival root area covered by RP and RC was statistically significantly larger (P<0.001) in the control group than in the test group. The test teeth showed a lower percentage of RP, but a higher percentage of RC than the control teeth (both P<0.001). Complete calculus removal was achieved in 42% of the control teeth surfaces and in 25% of the test teeth surfaces for a PD of 4 mm. Conclusions: The additional chemical cleansing with HBX resulted in a statistically significant improvement in bacterial plaque removal during SRP of deep pockets, but it was not effective in reducing calculus deposits.

• PNF and Movement
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• 제15권2호
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• pp.141-148
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• 2017

Purpose: This study attempts to identify the effects of abdominal strength training using proprioceptive neuromuscular facilitation (PNF) on the balance ability and pain level of patients with chronic lower back pain. Methods: A total of 30 patients with chronic lower back pain were randomly divided into either experimental group I (n=10), who received abdominal strength training using PNF, experimental group II (n=10), who received abdominal strengthening training, or the control group (n=10), who received conventional physiotherapy. The interventions were applied three times a week for six weeks. We measured Berg's balance scale (BBS) in order to investigate the change in balance ability, while we measured the visible analogue scale (VAS) to determine the severity of pain. We conducted a paired t-test to compare the within-group change before and after the intervention. For the comparison of the between-group difference, we used a one-way ANOVA test. Tukey's test was used as a post hoc test. The statistical significance level was set at ${\alpha}=0.05$ for all the variables. Results: Experimental group I and experimental group II showed a significant within-group change in BBS (p<0.01). A statistically significant between-group difference was observed in terms of the change in BBS (p<0.01). According to the results of the post hoc Tukey test, experimental group I and experimental group II showed a more effective change in BBS than the control group. Experimental group I, experimental group II, and the control group all showed a significant within-group change in the VAS (p<0.01). There was a statistically significant between-group difference in terms of the change in the VAS (p<0.01). According to the results of the post hoc Tukey test, the change in the VAS was more effective in experimental group I than in experimental group II and the control group. Conclusion: In this study, the application of abdominal strength training using PNF for subjects who complained of chronic lower back pain proved effective in improving their balance ability and reducing pain. We therefore believe that this training method could be applied as a useful program for patients with chronic lower back pain.

• 한국임상약학회지
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• 제32권1호
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• pp.13-19
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• 2022

Background: The use of combination therapy and fixed-dose combination therapy is increasing for the treatment of type 2 diabetes. Sodium glucose cotransporter-2 inhibitor (SGLT2i) is a drug class used in combination with metformin. Methods: Type 2 diabetes patients on SGLT2i/metformin combination therapy were extracted from the 2019 Health Insurance Review & Assessment Service-National Patients Sample. On July 1, 2019, SGLT2i and metformin fixed-dose combination (SGLT2i/metformin FDC) and two-pill combination (TPC) groups were identified, and a chi-square test and multiple logistic regression were performed. Results: Of total 2,992 patients, 1,077 (36%) were prescribed SGLT2i/metformin FDC and 1,915 (64%) were prescribed TPC. We found that the most common comorbidities were in the order of dyslipidemia, gastrointestinal disease, and hypertension. Multiple logistic regression analysis showed that the use of SGLT2i/metformin FDC was lower than TPC in patients with diabetic neuropathy (OR=0.76, p=0.008). Clinic (OR=2.09, p<0.001) and general hospital (OR=1.40, p=0.019) showed higher tendency to prescribe SGLT2i/metformin FDC compared to tertiary hospital. The tendency of prescribing SGLT2i/metformin FDC was lower in Kyeonggi (OR=0.79, p=0.037), Gyeongsang (OR=0.77, p=0.025) and Chungcheong (OR=0.68, p=0.007) than Seoul. Conclusion: Factors related to the use of SGLT2i/metformin FDC in patients with type 2 diabetes were complication, medical institution and region. The tendency to prescribe SGLT2i/metformin FDC was relatively higher in clinics than in tertiary general hospitals and in Seoul than in other regions.

• 한국미생물·생명공학회지
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• 제25권2호
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• pp.137-143
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• 1997

Porcine transforming growth factor-$\beta$1 (TGF-$\beta$1) was expressed in Escherichia coli using cDNA of TGF-$\beta$1 and glutathione S-transferase (GST) fusion vector pGEX-1$\lambda$T. An ApoI-Tth111I fragment of cDNA which correspond to the amino acid residues from 123 to 390 of the precursor TGF-$\beta$1 was inserted into EcoRI-Tth111I digested pGEM#-l$\lambda$T and the recombined plasmid was named pGET-12. Gene products from the cloned regions of the recombinant plasmids pGET-12 was not detected in soluble fraction of cell free extract but detected in insoluble fraction. The solubilization of insoluble gene product was achieved by the treatment of N-laurylsarcosine. Molecular weight of partially purified proteins determined by electrophoresis was same as expected from cloned fragment. The ELISA test results of the purified proteins showed that immunologically detectable epitope was preserved in recombinant protein.

• Corrosion Science and Technology
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• 제2권2호
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• pp.93-97
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• 2003

Fatigue crack growth test or low alloy steel was performed in high temperature water. Test parameters were dissolved oxygen content. loading frequency and R-ratio ($P_{min}/P_{max}$). Since the sulfur content or the steel was low, there were no environmentally assisted cracks (EAC) in low dissolved oxygen(DO) water. At high DO, the crack growth rate at R = 0.5 tests was much increased due to environmental effects and the crack growth rate depended on loading frequency and maximized at a critical frequency. On the other hand, R = 0.7 test results showed an anomalous decrease of the crack growth rate as much different behavior from the R = 0.5. The main reason of the decrease may be related to the crack tip closure effect. All the data could be qualitatively understood by effects of oxide rupture and anion activity at crack tip.

• 생약학회지
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• 제24권3호
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• pp.231-234
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• 1993

Neuropharmacological profile of Humulus lupulus (hop) extract was studied in mice. At doses above 100 mg/kg(i.p.), it decreased spontaneous locomotor activity and raised the nociceptive threshold in the hot-plate test. At doses above 250 mg/kg (i.p.), it increased pentobarbital-induced sleeping time and produced muscle relaxant effect. At the dose of 500 mg/kg, anticonvulsive effect against pentylenetetrazole-induced convulsion and hypothermic effect was observed.