• 한국강구조학회 논문집
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• 제19권6호
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• pp.575-585
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• 2007

본 논문은 55 MPa 이하 강도의 콘크리트를 사용한 CFT 기둥에 대한 P-M 상관곡선을 제안한 선행연구의 후속연구로서, 2005 AISC에서 새롭게 포함된 55 MPa 이상의 고강도 콘크리트를 사용한 정방형 CFT 기둥의 P-M 설계식을 제안하였다. 선행연구에서 제안한 개념을 적용하여 고강도 콘크리트를 사용한 CFT에서의 최대모멘트와 최대모멘트시의 압축력을 구하기 위해 강관의 폭두께비(b/t)와 강관의 항복강도에 대한 콘크리트의 상대강도(fck/Fy)를 중요 변수로 총 36개의 대상단면을 선정하여 Fiber Analysis를 통한 변수해석을 수행하였다. 강관의 응력-변형율 관계는 완전탄소성으로 가정하였고 콘크리트는 고강도 콘크리트에 적용가능한 Sakino의 모델을 이용하였다. 변수해석으로부터 얻어진 결과로부터 상기의 두 변수를 이용하여 고강도 콘크리트를 사용한 각형 CFT 기둥의 설계에 쉽게 사용할 수 있는 설계식을 제안하였다. 기존의 실험결과와 비교한 결과 본 논문에서 제시하는 방법은, 2005 AISC에서 제시하는 방법에 비해 보다 더 쉽고 간단하게 사용될 수 있는 것으로 나타났다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2003년도 가을 학술발표회 논문집
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• pp.452-461
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• 2003

The effect of initial combined load on the lateral free vibration of arches is investigated. For the analysis, P-M interaction own for the arches are obtained. The arches are circular arches which have constant cross-section and simply supported. Also, the arches are subjected both radial uniform distributed load which results in an axial compression on the cross-section and end moments that cause uniform bending action at the same time. All analysis are performed by finite element method based on Kang and Yoo's curved beam theory.

• 콘크리트학회논문집
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• 제14권5호
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• pp.677-688
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• 2002

철근콘크리트 기둥의 비선형 이축모멘트-곡률 관계를 추적할 수 있는 이론모델을 개발하였다. 개발된 모델은 피복콘크리트 박리나 또는 최대하중 후 나타날 수 있는 기둥의 모멘트 저항능력의 취성적인 감소도 모사할 수 있다. 개발된 모델을 이용 기둥의 구성재료 특성과 철근의 기하학적 배치가 PM 상관도와 모멘트-곡률에 미치는 영향에 대하여 변수영향을 고찰하고 철근콘크리트 기둥의 연성은 축하중의 크기, 횡방향 철근의 간격 또는 체적에 가장 큰 영향을 받음이 이론적으로 고찰된 ACI PM-상관도와 비교하여 ACI 내진설계 기준에 따라 횡방향 철근이 배근된 기둥의 경우, 축하중과 모멘트에 대한 : (square root of sum of squares)값이 약 10% 증가하였으며 최대 축하중은 약 20% 정도 증가하였다.

• Geomechanics and Engineering
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• 제5권5호
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• pp.379-399
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• 2013

In practice, analysis of laterally loaded piles is carried out using beams on non-linear Winkler springs model (often known as p-y method) due to its simplicity, low computational cost and the ability to model layered soils. In this approach, soil-pile interaction along the depth is characterized by a set of discrete non-linear springs represented by p-y curves where p is the pressure on the soil that causes a relative deformation of y. p-y curves are usually constructed based on semi-empirical correlations. In order to construct API/DNV proposed p-y curve for clay, one needs two values from the monotonic stress-strain test results i.e., undrained strength ($s_u$) and the strain at 50% yield stress (${\varepsilon}_{50}$). This approach may ignore various features for a particular soil which may lead to un-conservative or over-conservative design as not all the data points in the stress-strain relation are used. However, with the increasing ability to simulate soil-structure interaction problems using highly developed computers, the trend has shifted towards a more theoretically sound basis. In this paper, principles of Mobilized Strength Design (MSD) concept is used to construct a continuous p-y curves from experimentally obtained stress-strain relationship of the soil. In the method, the stress-strain graph is scaled by two coefficient $N_C$ (for stress) and $M_C$ (for strain) to obtain the p-y curves. $M_C$ and $N_C$ are derived based on Semi-Analytical Finite Element approach exploiting the axial symmetry where a pile is modelled as a series of embedded discs. An example is considered to show the application of the methodology.

• Archives of Pharmacal Research
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• 제27권9호
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• pp.901-905
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• 2004

A rapid, sensitive and selective hydrophilic interaction liquid chromatography-tandem mass spectrometric(HILIC-MS/MS) method for the determination of tiapride in human plasma was developed. Tiapride and internal standard, metoclopramide were extracted from human plasma with dichloromethane at basic pH and analyzed on an Atlantis HILIC silica column with the mobile phase of acetonitrile-ammonium formate (190 mM, pH 3.0) (94：6, v/v). The ana-Iytes were detected using an electrospray ionization tandem mass spectrometry in the multi-ple-reaction-monitoring mode. The standard curve was linear (r＝0.999) over the concentration range of 1.00-200 ng/mL. The coefficient of variation and relative error for intra- and inter-assay at three QC levels were 6.4∼8.8％ and -2.0∼3.6％, respectively. The recoveries of tiapride ranged from 96.3 to 97.4％, with that of metoclopramide (internal standard) being 94.2％. The lower limit of quantification for tiapride was 1.00 ng/mL using 1 00 $\mu$L of plasma sample.

• Archives of Pharmacal Research
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• 제14권2호
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• pp.181-187
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• 1991

The muscarinic antagonist 1-[benzilic 4, 4'-$[^3H]$ QUINUCLIDINYL BENZILATE $([^3H]$ QNB) bound to a single class of muscarinic receptors with high affinity in rabbit ileal membranes. The $K_D\;and\;B_{ max}$ values for $([^3H]$ QNB calculated from analysis of saturation isotherms were 52.5 pM AND 154 fmol/mg, respectively. Chlopheniramine (CHP), histamine $H_1$ blocker, increased $K_D$ vlue for $([^3H]$QNB without affecting the binding site concentrations and Hill coefficient. The $K_i$ value of CHP for inhibition of $([^3H]$QNB binding in ileal membranes was 1.44\mu{M}$ and the pseudo-Hill coefficient for CHP was close to unit. In the functional assay carbachol, muscarinic agonist, increased the contractile force of ileum with $ED_{50}$ value of $0.11\mu{M}$. CHP caused the rightward shift of the dose-response curve to carbachol. The $pA_2$ value of CHP determined from Schild analysis of carbacholinduced contraction was 5.77 and the slope was unity indicating competitive antagonism with carbachol. The dissociation constant $(K_i)$ of CHP obtained in competitive experiments with $([^3H]$ QNB was similar to the $K_A$ value (1.69 \mu{M)}$ of CHP as inhibitor of carbachol induced contraction in rabbit ileum. This result suggest that the binding of $H_i$ blocker. CHP, vs $([^3H]$QNB to muscarinic receptors in ileal membranes represents an interaction with a receptor of physiological relevance.

• 콘크리트학회논문집
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• 제29권4호
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• pp.353-360
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• 2017

PHC말뚝을 보강한 CFP말뚝의 P-M 상관도를 통한 휨 모멘트 예측과 휨 실험 결과를 통해 P-M 계산법의 타당성과 CFP말뚝의 휨 성능을 평가한 실험 연구이다. 시험체는 PHC말뚝과 링형 합성 전단연결재 그리고 속채움 콘크리트를 기본으로 한 CFP말뚝과 1차 보강(말뚝 보강철근 H13-8ea), 2차 보강(내부 보강철근 H19-8ea)으로 제작된 시험체의 휨 실험 결과 CFP-N-N 시험체 대비 최고 하중이 46.4%, 103.9% 증대되었으며, 보강 철근량에 따른 연성능력 증대가 이루어졌다. 또한 CFP말뚝 설계법의 극한한계상태 예측값과 실험 결과값을 비교해 볼 때, 각 보강 단계별 1.23, 1.40배의 안전율을 확보하여 본 연구에서 제시한 설계법이 합리적인 것으로 판단된다.

• 약학회지
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• 제34권4호
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• pp.224-237
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• 1990

A single uniform population of specific, saturable, high affinity binding site of $[^3H]QNB$ guinuclidinyl benzilate(QNB) was identified in the rat cerebral microsomes. The Kd value(37.2 pM) for $[^3H]QNB$ calculated from the kinetically derived rate constants was in agreement with the Kd value(48.9 pM) determined by analysis of saturation isotherms at various receptor concentrations. Dimenhydrinate(DMH), histamine $H_1-blocker$, increased Kd value for $[^3H]QNB$ QNB without affecting the binding site concentrations and this effect resulted from the ability of DMH to slow $[^3H]QNB-receptor$ association. Pirenzepine inhibition curve of $[^3H]QNB$ binding was shallow(nH = 0.52) indicating the presence of two receptor subtypes with high ($M_1-site$) and low($M_2-site$) affinity for pirenzepine. Analysis of these inhibition curves yielded that 68% of the total receptor populations were of the $M_1-subtype$ and the remaining 32% of the $M_2-subtype$. Ki values for the $M_1-$ and $M_2-subtypes$ were 2.42 nM and 629.3 nM, respectively. Ki values for $H_1-blockers$ that inhibited $[^3H]QNB$ binding varied with a wide range ($0.02-2.5\;{\mu}M$). The Pseudo-Hill coefficients for inhibition of $[^3H]QNB$ binding by most of $H_1-blockers$ examined except for oxomemazine inhibition of $[^3H]QNB$ binding were close to one. The inhibition curve for oxomemazine in competition with $[^3H]QNB$ was shallow(nH = 0.74) indicating the presence of two receptor populations with different affinities for this drug. The proportion of high and low affinity was 33:67. The Ki values for oxomemazine were $0.045{\pm}0.016\;{\mu}M$ for high affinity and $1.145{\pm}0.232\;{\mu}M$ for low affinity sites. These data indicate that muscarinic receptor blocking potency of $H_1-blockers$ varies widely between different drugs and that most of $H_1-blockers$ examined are nonselective antagonist for the muscarinic receptor subtypes, whereas oxomemazine might be capable of distinguishing between subclasses of muscarinic receptor.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 춘계학술발표회 논문집(I)
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• pp.62-65
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• 2006

This study investigated the behavior of R/C column confined with headed crossties subjected to eccentric loading. The 16 specimens are designed to have adequate confinement steel, determined by ACI seismic design. The variables studied in this research test are eccentricity to depth ratios, spacing of lateral steel and the anchor type of end of crossties. From the test results, all columns showed similar behavior up to the peak load but those columns laterally confined with head presented more ductile behavior after the peak load. The comparisons indicate that the flexural behavior of confined-concrete columns can be computed resonable accurately by P-M interaction curve.

• Bulletin of the Korean Chemical Society
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• 제33권2호
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• pp.553-558
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• 2012

A simple new method was developed for the determination of betaine in Fructus Lycii using hydrophilic interaction liquid chromatography with evaporative light scattering detection (HILIC-ELSD). Good chromatographic separation and reasonable betaine retention was achieved on a Kinetex HILIC column ($2.1{\times}100mm$, $2.6{\mu}m$) packed with fused-core particle. The mobile phase consisted of (A) acetonitrile and (B) 10 mM ammonium formate (pH 3.0)/acetonitrile (90/10, v/v). It was used with gradient elution at a flow rate of 0.7 mL/min. The column temperature was set at $27.5^{\circ}C$ and the injection volume was $10{\mu}L$. The ELSD drift tube temperature was $50^{\circ}C$ and the nebulizing gas (nitrogen) pressure was 3.0 bar. Stachydrine, a zwitterionic compound, was used as an internal standard. Calibration curve over $10-250{\mu}g/mL$ showed good linearity ($R^2$ > 0.9992) and betaine in the 70% methanol extract of Fructus Lycii was well separated from other peaks. Intraand inter-day precision ranged from 1.1 to 3.0% and from 2.4 to 5.3%, respectively, while intra- and inter-day accuracy ranged from 100.0 to 107.0% and from 94.3 to 103.9%, respectively. The limit of quantification (LOQ) was $10{\mu}g/mL$ and the recoveries were in the range of 98.2-102.7%. The developed HILIC-ELSD method was successfully applied to quantitatively determine the amount of betaine in fourteen Fructus Lycii samples from different locations, demonstrating that this method is simple, rapid, and suitable for the quality control of Fructus Lycii.