• Bulletin of the Korean Chemical Society
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• v.10 no.2
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• pp.132-133
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• 1989

To probe the geometrical effects of cyclopropyl moiety on the stabilization of an adjacent cation center, chemical shift of 2-p-fluorophenyl-8,9-dehydro-2-adamantyl cation (3) was compared with that of 5-p-fluorophenyl-2,4-dehydro-5-homoadamantyl cation (4). Difference between the chemical shift of 8,9-dehydro-2-adamantyl cation 3 and that of 2,4-dehydro-5-adamantyl cation 4 is 5.1 ppm (${\Delta}{\Delta}{\delta}$). We conclude, therefore, that ion 3 is about 3.82 kcal more stadble than ion 4 of which rigid carbon skeleton requires significant distortion of the cyclopropane ring from the ideal bisected conformation. The energy difference between these cations can be calculated by Taft-Relationship$^8$ on the basis of chemical shift.

• Applied Chemistry for Engineering
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• v.5 no.5
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• pp.836-842
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• 1994

The optimum design conditions of gas sparger pipe and the effects of operating variables on $SO_2$ removal efficiency have been examined in Jet Bubbling Reactor. Geometry of gas sparser pipe of Jet Bubbling Reactor is a very important factor to obtain a effective gas-liquid contact. Test results revealed that Reynolds numbers at sparger and slot have to be kept greater than 12,000 identically at a given gas velocity. $SO_2$ removal efficiency was a function of ${\Delta}P$, pH, inlet $SO_2$ concentration and particle size of limestone and was more sensitive to the change of ${\Delta}P$ than to the changes of others. The ${\Delta}P$ of at least 230mmAq must be maintained to acheive the above 90% $SO_2$ removal at pH of 4.0 which is considered as adequate operating pH. Higher $SO_2$ removal efficiency was obtained even at lower pH ranges, which resulted from the complete oxidation of the absorbed $SO_2$ to sulfates by adding air and consequently from the reduction of $SO_2$ equillibrium partial pressure in the gas-liquid interface The 99.5% of the limestone utilization was attained in pH range from 3.0 to 5.0 with regardless to the particle size of limestone employed.

• The Journal of Korean Medicine
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• v.20 no.2
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• pp.63-74
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• 1999

We demonstrated the moxibution on CV5(Serk-Moon) and CV3(Chung-Guk), as we have known contraceptive acupuncture point and pregnancy acupuncture point in oriental medcine, effected on concentration of progesteron and estrogen. As the reports, $3{\beta}-hydroxysteroid\;dehydrogenase/{\Delta}5-{\Delta}4$ isomerase $(3{\beta}-HSD)$ is an enzyme that has catalytic oxidation and isomerase reaction on steroidhormon synthase including progesteron and estrogen. So we observated the concentration and mass of $(3{\beta}-HSD)$ by immuno-chemicalstain, western blot and Enzyme-Linked Immunosorbent Assay in rat ovary. In results, we detected that the mass of $(3{\beta}-HSD)$ decreased significantly in moxibution treated group on CV5($p{\leq}0.05$) in rat ovary and proposed that the moxibution of CV5 make possible to contraception because of blocking estrogen synthesis by $(3{\beta}-HSD)$ decrease. But we didn't know moxibution effects exactly whether is biochemical reaction or thermal reaction on acupuncture point.

• The Journal of Korean Physical Therapy
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• v.23 no.2
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• pp.53-59
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• 2011

Purpose: This study was designed to compare the effects of transcutaneous electrical nerve stimulation (TENS) and silver spike point (SSP) therapy on current perception threshold (CPT) and mechanical pain threshold (MPT). Methods: Forty-five healthy adult male and female subjects were studied. Fourteen of them were males and twenty-one were females. Subject were randomly assigned to receive; (1) TENS (80/120 Hz alternating frequency), (2) SSP (3 Hz), or (3) no treatment (control group). Electric stimulation was applied over LI4 and LI11 on acupuncture points of the left forearm for 30 minutes. CPT and MPT were recorded before and after electrical stimulation. The data were analyzed using linear mixed models, with group treated as a between subject factor and time a within-subject factor. Results: At 30 minutes after cessation of electrical stimulation the CPT of C fibers and A${\delta}$fibers was reduced in the TENS group that of C fibers was reduced in the SSP group (p<0.05). After cessation of electrical stimulation, the MPT of C fibers and A${\delta}$fibers increased in the TENS group, and that of A${\delta}$fibers increased in the SSP group (p<0.05). Conclusion: After TENS and SSP stimulation, MPT of C fibers and A${\delta}$fibers were selectively increased. In particular, the TENS group showed increases in both C and A${\delta}$fibers, while the SSP group showed increases only in A${\delta}$fibers.

• Journal of the Korean Chemical Society
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• v.19 no.3
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• pp.156-162
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• 1975

Rates of reactions of methanesulfonyl chloride with various substituted anilines have been measured in methanol. Substituent effects in aniline are found to be linearly correlated with pKa(Bronsted relation with ${\beta}$ = 0.84) and ${\rho}$(Hammett equation with ${\rho}$ = -2.46) respectively. The results are interpreted in terms of degree of bond-formation at the transition state, which was found to have progressed relatively further. The rates for o-methylaniline deviated from the Bronsted plot established by meta and para substituted anilines because of a steric effect of ortho position in aniline. Activation parameters, ${\Delta}H^{\neq}$ and ${\Delta}S^{\neq}$ have also been determined. The enthalpy of activation showed a regular variation in that electron donating substituents in the p-substituted aniline decrease ${\Delta}H^{\neq}$ and increase the negative value of ${\Delta}S^{\neq}$.

• Journal of the Korean Chemical Society
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• v.38 no.8
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• pp.539-546
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• 1994

The critical micelle concentration(CMC) and the counterion binding $constant(\beta)$ at the CMC of cetyltrimethylammonium bromide(CTAB) in a series of aqueous solutions containing medium chain-length n-alcohols(Propanol, Butanol, Pentanol and Hexanol) have been determined from the concentration dependence of electrical conductance at serveral temperature from $17^{\circ}C\;to\;41^{\circ}C.$ Thermodynamic parameters $({\Delta}G^o_m,\;{\Delta}H^o_m,\;{\Delta}S^o_m,\;and\;{\Delta}C_p)$ associated with micelle formation of CTAB have been also estimated from the temperature dependence of CMC and $\beta$ values, and the significance of these parameters and their relation to the theory of micelle formation have been considered. The results show that an enthalpy-entropy compensation effect is usually observed for the micellization of CTAB. The effects of n-alcohols on the micellar properties (CMC and $\beta$) of CTAB solutions have been also investigated. The addition of n-alcohol to the CTAB solution in a small quantity decreases the CMC value and the counterion binding constant $(\beta)$ at the CMC, but the addition of n-alcohol in an excessive quantity increases the CMC values on the conterary. These results have been explained in terms of the effect of the micelle-solubilized alcohol on the micellar surface charge density.

• Journal of Korean Society of Steel Construction
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• v.12 no.1 s.44
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• pp.1-8
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• 2000

In this study, the effect of semi-rigid connections on the structural behavior of 20-story braced steel structure has been investigated utilizing the second-order elastic structural analysis program in which nonlinear behavior of beam-column connections and geometric nonlinearity have been considered. Global effects such as P-delta effect and sway at the top have been studied, as well as distribution of member force and combined stress in structural members as local effects. When the structure subjected to horizontal load and vertical load is equipped with lateral-load resisting system such as braces, replacement of shear connection with semi-rigid connection has not caused any problem in P-delta effect and top lateral displacement. Distribution of member forces resulted in reduction in member size for economic structural design.

• Molecules and Cells
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• v.28 no.1
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• pp.49-55
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• 2009

Hepatitis delta virus (HDV) infection causes fulminant hepatitis and liver cirrhosis. To elucidate the molecular mechanism of HDV pathogenesis, we examined the effects of HDV viral proteins, the small hepatitis delta antigen (SHDAg) and the large hepatitis delta antigen (LHDAg), on $NF-{\kappa}B$ signaling pathway. In this study, we demonstrated that $TNF-{\alpha}-induced$ $NF-{\kappa}B$ transcriptional activation was increased by LHDAg but not by SHDAg in both HEK293 and Huh7 cells. Furthermore, LHDAg promoted TRAF2-induced $NF-{\kappa}B$ activation. Using coimmunoprecipitation assays, we demonstrated that both SHDAg and LHDAg interacted with TRAF2 protein. We showed that isoprenylation of LHDAg was not required for the increase of $NF-{\kappa}B$ activity. We further showed that only LHDAg but not SHDAg increased the $TNF-{\alpha}-mediated$ nuclear translocation of p65. This was accomplished by activation of $I{\kappa}B_{\alpha}$ degradation by LHDAg. Finally, we demonstrated that LHDAg augmented the COX-2 expression level in Huh7 cells. These data suggest that LHDAg modulates $NF-{\kappa}B$ signaling pathway and may contribute to HDV pathogenesis.

• Korean Journal of Acupuncture
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• v.27 no.2
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• pp.141-157
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• 2010

Objectives : The aim of this study is to examine the effects of acupuncture at PC7(Daereung) on normal human EEG using power spectral analysis. Methods : EEG power spectrum exhibits site-specific and state-related differences in specific frequency bands. In this study, power spectrum was used as a measure of complexity. 30 subjects (16 males and 14 females; averaged age = 23.4 years) were engaged with thirty channel EEG study. Results : In $\alpha$(alpha) band, the power values at Fp1, Fp2, F7, F8 channels(p<0.05) during PC7 treatment were significantly decreased. But, the power values at Fz channel(p<0.05) during non-acupoint treatment was significantly decreased. In $\beta$(beta) band, the power values at Fp1, Fp2 channels(p<0.05) during PC7 treatment were significantly decreased. But, the power values at Fz channel(p<0.05) during non-acupoint treatment was significantly decreased and at F8, TCP2 channels(p<0.05) during non-acupoint treatment were increased. In $\theta$(theta) band, the power values at Fp1, Fp2, F7, F8 channels(p<0.05) during PC7 treatment were significantly decreased. But, the power values at Fz channel(p<0.05) during non-acupoint treatment was significantly decreased. In $\delta$(delta) band, the power values at Fp1, Fp2, F7, Fz, F8 channels (p<0.05) during PC7 treatment were significantly decreased. But, the power values at Fz channel (p<0.05) during non-acupoint treatment was significantly decreased. $\alpha/\beta$ values during PC7 treatment were decreased. $\beta/\theta$ values during PC7 treatment were decreased. Conclusion : These results suggest that acupuncture at PC7 induce the change on $\alpha$(alpha), $\beta$(beta), $\theta$ (theta), $\delta$(delta) wave values being decreased and and bothe $\alpha/\beta$ and $\beta/\theta$ values being decreased respectively. This is considered that acupuncture at PC7 affects the activity of cerebral cortex and endocrine system.

• Korean Journal of Veterinary Research
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• v.37 no.3
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• pp.669-685
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• 1997

The present study was performed to evaluate the effects of xylazine and tiletamine + zolazepam on echocardiograms before and after experimental myocardial infarctions in clinically normal dogs taken preliminary examinations related to cardiac function. The results are as follows. With xylazine administration, left ventricle end-diastolic dimension, left ventricle end-systolic dimension, left atrium/aorta, ejection time and velocity of circumferential fiber shortening increased and mitral valve CD slope, % delta D decreased(p<0.01). In tiletamine+zolazepam administered group, interventricular septum amplitude(p<0.01), mitral valve DE slope(p<0.05) and ejection time(p<0.01) decreased and left atrium/aorta, ejection time also decreased compared with xylazine group(p<0.01). In 48 hours after experimental myocardial infarction group, anterior aortic wall amplitude decreased compared with control, xylazine, tiletamine + zolazepam group, respectively(p<0.01). Posterior aortic wall amplitude decreased compared with control(p<0.01). Left ventricle end systolic dimension increased compared with control and tiletamine + zolazepam group, respectively(p<0.01). Left ventricular posterior wall end systolic dimension decreased compared with control(p<0.01). Left ventricular posterior wall amplitude decreased compared with control and tiletamine+zolazepam group(p<0.01). Left atrium/aorta decreased compared with xylazine group(p<0.01). % thickening left ventricular posterior wall decreased compared with control(p<0.05). % delta D decreased compared with control and tiletamine+zolazepam group(p<0.01). Ejection time decreased compared with xylazine(p<0.01). Velocity of circumferential fiber shortening increased compared with control and tiletamine + zolazepam group(p<0.01). With xylazine administration 48 hours after experimental myocardial infarction, anterior aortic wall amplitude, posterior aortic wall amplitude decreased compared with control(p<0.01). Left ventricle end-diastolic dimension increased compared with control(p<0.01). Left ventricle end-systolic dimension increased compared with control and tiletamine + zolazepam group, respectively(p<0.01). Left ventricular posterior wall end-systolic dimension and left ventricular posterior wall end-diastolic dimension decreased compared with control(p<0.01). Left atrium/aorta decreased compared with xylazine group(p<0.01). % thickening left ventricular posterior. wall(p<0.05) and % delta D(p<0.01) decreased compared with control. Velocity of circumferential fiber shortening increased compared with tiletamine + zolazepam group(p<0.01). With tiletamine + zolazepam administration 48 hours after experimental myocardial infarction, anterior aortic wall amplitude decreased compared with control, xylazine and tiletamine+zolazepam group, respectively(p<0.01). Posterior aortic wall amplitude decreased compared with control(p<0.01). Left ventricle end-systolic dimension increased compared with control and tiletamine+zolazepam group(p<0.01). Left ventricular posterior wall end-systolic dimension, left ventricular posterior wall end-diastolic dimension and interventricular septum amplitude decreased compared with control(p<0.01). Left atrium/aorta decreased compared with xylazine group(p<0.01). % delta D decreased compared with control and tiletamine + zolazepam group(p<0.01). Ejection time decreased compared with xylazine group and velocity of circumferential fiber shortening increased compared withtiletamine+zolazepam group(p<0.01). Conclusively, echocardiography was proved to be a useful, diagnostic, non-invasive and simple method for establishing the diagnosis of myocardial infarction and evaluating the effects of drug on cardiac function before and after myocardial infarction.