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Enhanced Recovery after Surgery for Gastric Cancer Patients Improves Clinical Outcomes at a US Cancer Center

  • Desiderio, Jacopo;Stewart, Camille L.;Sun, Virginia;Melstrom, Laleh;Warner, Susanne;Lee, Byrne;Schoellhammer, Hans F.;Trisal, Vijay;Paz, Benjamin;Fong, Yuman;Woo, Yanghee
    • Journal of Gastric Cancer
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    • 제18권3호
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    • pp.230-241
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    • 2018
  • Purpose: Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GCERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERAS protocol at a National Comprehensive Cancer Center in the United States. Materials and Methods: We reviewed medical records of patients surgically treated for gastric cancer with curative intent from January 2012 to October 2016 and compared the GC-ERAS group (November 1, 2015-October 1, 2016) with the historical control (HC) group (January 1, 2012-October 31, 2015). Propensity score matching was used to adjust for age, sex, number of comorbidities, body mass index, stage of disease, and distal versus total gastrectomy. Results: Of a total of 95 identified patients, matching analysis resulted in 20 and 40 patients in the GC-ERAS and HC groups, respectively. Lower rates of nasogastric tube (35% vs. 100%, P<0.001) and intraabdominal drain placement (25% vs. 85%, P<0.001), faster advancement of diet (P<0.001), and shorter length of hospital stay (5.5 vs. 7.8 days, P=0.01) were observed in the GC-ERAS group than in the HC group. The GC-ERAS group showed a trend toward increased use of minimally invasive surgery (P=0.06). There were similar complication and 30-day readmission rates between the two groups (P=0.57 and P=0.66, respectively). Conclusions: The implementation of a GC-ERAS protocol significantly improved perioperative outcomes in a western cancer center. This finding warrants further prospective investigation.

Breast Cancer Knowledge and Screening Behavior among Female School Teachers in Gaza City

  • Abu-Shammala, Bissan Ismail;Abed, Yehia
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권17호
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    • pp.7707-7711
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    • 2015
  • A cross-sectional survey of 370 female teachers working at Governmental schools in Gaza city was conducted. Twenty four schools were selected randomly of all female schools of the city that included primary, preparatory and secondary. In each school all-female teachers aged 35-45 year were invited to fill out a self-administered questionnaire to investigate knowledge and behavior toward breast cancer screening. The survey revealed that more than 75% of women had never undergone clinical breast examination and 60% had never undergone mammography, whereas 62% performed breast self-examination (BSE). Women who performed BSE had significantly higher knowledge about breast cancer screening (P=0.001). Women attending CBE and mammography screening also had significantly higher knowledge (P=0.001). There were significant associations between the practices and presence of positive breast cancer family history (P=0.002) and the level of education of husbands (P=0.024). The oldest women demonstrated higher performance rates of screening methods than the youngest (P=0.001). Lack of breast screening knowledge was identified among more than one third of the women, and 24.6% of women did not know any screening method. About a half of women harboured misconceptions about breast cancer screening, including the belief that breast cancer not treatable. Women residing in Gaza city (P=0.00) and with husbands less educated were more likely to have a high level of misconceptions (P=0.01).

Human Recombinant Endostatin Combined with Cisplatin Based Doublets in Treating Patients with Advanced NSCLC and Evaluation by CT Perfusion Imaging

  • Zhang, Feng-Lin;Gao, Er-Yun;Shu, Rong-Bao;Wang, Hui;Zhang, Yan;Sun, Peng;Li, Min;Tang, Wei;Jiang, Bang-Qin;Chen, Shuang-Qi;Cui, Fang-Bo
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권15호
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    • pp.6765-6768
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    • 2015
  • Aims: To study the effectiveness of human recombinant endostatin injection (Endostar(R)) combined with cisplatin doublets in treating advanced non-small cell lung cancer (NSCLC), and to evaluate outcome by CT perfusion imaging. Methods: From April 2011 to September 2014, 76 patients with advanced NSCLC who were treated with platinum-based doublets were divided into group A (36 patients) and group B (40 patients). Endostar(R) 15mg/day was administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A, and combined with chemotherapy from the first day in Group B. Endostar(R) in the two groups was injected intravenously for 14 days. Results: Treatment effectiveness in the two groups differed with statistical significance (p<0.05). Effectiveness evaluated by CT perfusion imaging, BF, BV, MTT and PS also demonstrated significant differences (all p<0.05). Adverse reactions in the two groups did not significantly vary (p> 0.05). Conclusions: The response rate with Endostar(R) administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A was better than Endostar(R) combined with chemotherapy from the first day, and CT perfusion imaging could be a reasonable method for evaluation of patient outcomes.

Laparoscopic Versus Open Radical Cystectomy for Patients Older than 75 Years: a Single-Center Comparative Analysis

  • Yasui, Takahiro;Tozawa, Keiichi;Ando, Ryosuke;Hamakawa, Takashi;Iwatsuki, Shoichiro;Taguchi, Kazumi;Kobayashi, Daichi;Naiki, Taku;Mizuno, Kentaro;Okada, Atsushi;Umemoto, Yukihiro;Kawai, Noriyasu;Sasaki, Shoichi;Hayashi, Yutaro;Kohri, Kenjiro
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권15호
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    • pp.6353-6358
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    • 2015
  • Background: To explore the safety, efficacy, and oncological outcome of 3-port laparoscopic radical cystectomy (LRC) compared to open radical cystectomy (ORC) in patients older than 75 years. Materials and Methods: From June 2010 to July 2014, we analyzed 16 radical cystectomies in patients older than 75 years (LRC group=8; ORC group=8). Demographic parameters, operative variables, and perioperative outcome in the 2 groups were retrospectively collected, analyzed, and compared. Results: Patients in both groups had comparable preoperative characteristics. A significantly longer operating time (476 vs. 303 min, P=0.0002) and less estimated blood loss (627 vs. 2,106 mL, P=0.021) were observed in the LRC group compared to the ORC group. Infection and ileus were the most common early complications after surgery. Patients who underwent ORC suffered from more postoperative infection (22.2% vs. 0.0%, P=0.054) and ileus (25.0% vs. 12.5%, P=0.521) than the LRC group, but the difference was not significant. Conclusions: Judging from this initial trial, 3-port LRC can be safely carried out in elderly patients. We suggest 3-port LRC as the primary intervention to treat muscle-invasive or high-risk nonmuscle-invasive bladder cancer in elderly patients with an otherwise relatively long life expectancy.

우리나라 중 고등학교 학생들의 패스트푸드 및 탄산음료 섭취에 관한 지역별 비교연구 (A Comparison of Fast foods and Soft drink Consumption among Korean Adolescents by Geographical Regions)

  • 이규영;하영미;김성희
    • 한국학교보건학회지
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    • 제21권2호
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    • pp.47-60
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    • 2008
  • Objectives: The purpose of this study was to compare Fast foods and Soft drinks consumption of Korean adolescents in a large city, a medium city, and a rural area. Methods: This was a descriptive comparative survey using a convenience sample of 2,261 8th and 11th grade students. The data were analyzed by X2-test and ANOVA using SPSS 10.0 statistical program. Results: For fast food consumptions, the higher in a large city than in a medium city and a rural area(p=.000). For soft drinks in a school, cafeteria or vending machines was higher in a large city and a medium city then in a rural area(p=.000). For eating snacks including cookies and popcorns was higher among students in a rural area than those in a medium city and large city(p=.008). Conclusions: 1. Overall, the health information among rural students is lower than those among other areas, as well as taking a health education course among rural students is also lower. Thus, the health inequality by regional differences should be considered. To decrease health inequality among different regions, health professionals who can systematically teach a health education course for middle and high school students and undertake students' health are needed. 2. Soft drinks sold in schools are higher in a large city and medium city than in a rural area. Therefore, there is a need of strong regulations and policies about the restriction of soft drinks sold in vending machines or school cafeterias.

경기도 성남시, 인천시, 강원도 강릉시, 충북 청원군 강수의 화학적 성분에 관한 비교 연구 (A Comparative Study on the Chemical Compositions of Precipitations in Sungnam City of Kyunggi Province, Inchon City, Kangneung City of Kangwon Province, and Chongwon-gun of Chungbuk Province)

  • 박국태;문경언
    • 한국환경과학회지
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    • 제4권3호
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    • pp.285-294
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    • 1995
  • A comparative study on the chemical compositions of precipitations from February 1993 to April 1993 in Sungnam city of Kyunggi province, Inchon city, Kangneung city of Kangwon province, and Chongwon-gun of Chungbuk province has been performed. The metal cation and anion concentrations were measured by atomic absorption spectrometer and ion liquid chromatography, respectively. pH/Ion meter and direct nesslerization method were used for the concentration measurements of $H^+$ and $NH^{4+}$ ions, respectively. The quantitative orders of the cation and anion average concentrations, correlation coefficients between the ion concentrations, and pH values are used for chemical analysis on the environmental pollution and pollutant sources in the urban, surburban, seaside, and rural areas of the Korean Peninsula.

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일부지역 노인의 구강건강영향지수 비교 연구 (A comparative study on the oral health impact profile in two urban area)

  • 김설희;박인숙
    • 한국치위생학회지
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    • 제9권2호
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    • pp.221-228
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    • 2009
  • The purpose of this study was to evaluate the impact of oral health impact profile in two urban area The respondents enrolled in this study were elderly people aged 65years from Gwang-ju city, Sunchon city. A total of 371 participants(Gwang-ju city 161, Sunchon city 210) analyzed. The contents of the research were social demographic characteristics, self perceived need for dental care, attributes related to denture, dental visiting pattern, the perceptions regarding dental health condition, and OHIP-14. 1. In the comparison Two urban area, the perceptions regarding dental health condition, self perceived need for dental care, dental visiting pattern was statistically significant difference(p<0.05). 2. Among the 7 OHIP-14 subscales, the mean scores of physical disability were significantly higher in two urban area(p<0.05). 3. The Social demographic characteristics, OHIP-14 represented a statistically significant difference related to gender, age and denture use(p<0.05). Through this research, Both Gwang-ju city and Sunchon city was found that elderly people was more negative impact of physical disability on oral health related quality of life. Therefore need to oral health program for improving oral health in the elderly people.

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대청호 주원천 인공습지의 오염물질 정화효율 평가 (Evaluation of treatment efficiencies of pollutants in daecheong lake juwon stream constructed wetlands)

  • 김태훈;성기은;하덕호;김동희;허순욱;최충식
    • 상하수도학회지
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    • 제29권2호
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    • pp.211-222
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    • 2015
  • This study focused on evaluating the efficiency of the removal of non-point source pollution by Daecheong Lake Juwon Stream constructed wetlands. The constructed wetland system is a surface flow type designed in the year 2007 for purifying eutrophic water of Daecheong Lake Juwon Stream. The value of conductivity, suspended solids(SS), chemical oxygen demand using a potassium permanganate($COD_{Mn}$), five-day biochemical oxygen demand($BOD_5$), total nitrogen(T-N), total phosphorous(T-P), and pH in inflow averaged 220.2, 2.46, 3.33, 1.34, 2.00, 0.04 mg/L and 7.24, respectively and in outflow averaged 227.9, 1.12, 3.34, 0.87, 1.16, 0.02 mg/L and 7.45, respectively. The average removal efficiency of constructed wetlands was 30 % for SS, 22 % for $BOD_5$, 45 % for T-N and 31 % for T-P. The removal rates of SS, $BOD_5$ and T-N in the spring, summer and autumn were higher than those in winter. The removal rate of T-P was not significant different in all seasons. The amounts of pollutants removal in the constructed wetlands were higher in the order of $3^{rd}$ < $2^{nd}$ < $1^{st}$ wetland for SS and T-P, $2^{nd}$ < $3^{rd}$ < $1^{st}$ wetland for $BOD_5$ and T-N. Therefore, our findings suggest that the constructed wetlands could well treat the eutrophic Daecheong Lake Juwon Stream waters.

농어촌(農漁村)과 시설거주(施設居住) 아동(兒童)의 영양상태(營養狀態)에 관(關)한 연구(硏究) -제2보(第2報) : 혈액성장(血液性狀)을 중심(中心)으로- (A Study on the Nutritional Status of Children Living in Rural Area and City Orphan Asylum -II. Hematological view-)

  • 박복희
    • 한국식품영양과학회지
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    • 제14권2호
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    • pp.108-116
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    • 1985
  • This study was designed to investigate the nutritional anemic state and hematological findings of children, aged 11 and 12 years, living in Haenam Koon (living at home) and in Mokpo City (living in an orphan asylum) located in Chonnam. The mean red blood cell number of male was higher than female in both groups of living in the rural area and in the city orphan asylum (p<0.01), but the white blood cell count was not significantly different. The levels of average hemoglobin, hematocrit and mean corpuscular hemoglobin concentration of the children in both groups were similar, and 19.8% of children living at home in the rural area and 32.1% of children living in the city orphan asylum were anemic. The mean levels of serum total protein, albumin and A/G ratio in children of both group were not statistically different, and 18.4% of children living at home in the rural area and 13.2% of children living in the city orphan asylum were insufficient in the serum total protein value. The average serum cholesterol level of children living at home in the rural area was higher than that of children living in the city orphan asylum(p<0.01), and that of female living at home was higher than that of male (p<0.05). The mean levels of serum iron, total iron binding capacity and transferrin saturation of children living at home in the rural area were significantly higher than those of children living in the city orphan asylum (p<0.01).

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해항도시의 해양환경 관리실태 분석 - 부산광역시와 인천광역시를 중심으로 - (A Study on the Status of Marine Environment Management of Sea Port Cities - Focused on Busan Metropolitan City and Incheon metropolitan city -)

  • 김상구
    • 한국항해항만학회지
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    • 제35권3호
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    • pp.259-263
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    • 2011
  • 본 연구는 우리나라의 대표적인 해항도시이며, 우리나라의 해양수도 및 동북아 관문항을 지향하는 부산광역시와 인천광역시의 해양환경 관리실태를 비교 분석하고 이의 제고방안을 모색하고자 하였다. 이러한 연구목적을 달성하기 위해 본 연구는 해양환경지표로서 수온(C), 염분(‰), 수소이온농도(PH), 용존산소(DO: mg/l), 화학적 산소요구량(COD: mg/l), 용존무기질소(DIN: mg/l), 총질소(T-N: mg/l), 용존무기인(DIP: mg/l), 총인(T-P: mgp/ml), 규산규소(Sio2-Si), 부유물질(mg/l), 클로로필(Chi-a: ${\mu}g/l$) 등의 총 12개 지표들을 사용하였다. 연구의 결과, 부산광역시와 인천광역시의 경우 2000년도부터 2003년도까지는 해양환경상태가 악화되는 것으로 나타났다. 또한 부산광역시 및 인천광역시의 해양환경상태를 악화시키고 있는 해양환경지표는 총질소, 용존무기인, 총인 등으로 나타났고, 이들 해양환경지표들은 해가 갈수록 악화되고 있는 것으로 분석되었다.