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The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo

  • Jiang, Wei;Huang, Yong;Wang, Jing-Peng;Yu, Xiao-Yun;Zhang, Lin-Yi
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권8호
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    • pp.4615-4619
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    • 2013
  • Background: Artesunate, extracted from Artemisia annua, has been proven to have anti-cancer potential. Allicin, diallyl thiosulfinate, the main biologically active compound derived from garlic, is also of interest in cancer treatment research. This object of this report was to document synergistic effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo. Methods: After treatment with artesunate and allicin at various concentrations, the viability of osteosarcoma cells was analyzed by MTT method, with assessment of invasion and motility, colony formation and apoptosis. Western Blotting was performed to determine the expression of caspase-3/9, and activity was also detected after drug treatment. Moreover, in a nude mouse model established with orthotopic xenograft tumors, tumor weight and volume were monitored after drug administration via the intraperitoneal (i.p.) route. Results: The viability of osteosarcoma cells in the combination group was significantly decreased in a concentration and time dependent manner; moreover, invasion, motility and colony formation ability were significantly suppressed and the apoptotic rate was significantly increased through caspase-3/9 expression and activity enhancement in the combination group. Furthermore, suppression of tumor growth was evident in vivo. Conclusion: Our results indicated that artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis.

From Excluded Ghettos to Exclusionary Enclaves: A Private Sector Initiative in Guangzhou, China

  • Chen, Huiwei;Chan, Roger C.K.;He, Qicong
    • 토지주택연구
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    • 제4권3호
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    • pp.211-223
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    • 2013
  • Massive migration is underway in rapidly urbanizing Guangzhou, the south gate of P. R. China. Over half the migrants choose to rent in "villages-in-the-city" in the downtown area because of the low-cost and prime location. The overpopulation and resulting poor environment and high crime-rate turn villages-in-the-city into de facto ghettos. As a result, these ghettos are undergoing a manner of demolition-development, leaving migrants' housing needs unmet. A private-sector initiative-the Tulou Commune-intends to address this considerable market potential. Targeting low-income groups, the Tulou Commune creates a socio-spatially exclusionary enclave. This paper analyzes the Tulou Commune and the implications if more low-income migrants shifting from village-in-the-city (excluded ghetto) to Tulou Commune (exclusionary enclave). This study argues that the intervention of the private sector causes the demographic, social, and spatial similarities and differences of the two living arrangements. Socioeconomic and institutional factors also affect the initiative. This study also provides more empirical evidence in the field of low-cost housing and socio-spatial development in transitional Chinese cities. As the first project of its kind, the analysis of the case can suggest how to improve strategies for accommodating migrants in the future.

대학생의 자아존중감과 스트레스에 미치는 영향 요인 (Factors affecting the Self-esteem and Stress of University Students)

  • 정연옥;심규범;이명선;남철현
    • 한국학교ㆍ지역보건교육학회지
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    • 제16권3호
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    • pp.65-78
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    • 2015
  • Objectives: The purpose of this study was to investigate self esteem and stress of students at their universities for the development of a program related to school life and guidance. Methods: The survey were carried out in 5 universities located in Gyounggi Do, Gyungbuk Do, Busan city and Daegu city from 2014. October 1. to November 30. Out of a total of 500 Questionnaires answered by 500 students, 489 Questionnaires, were analyzed with SPSS version 12.0. Results: The total mean of the self esteem point of college student's school living was $3.41{\pm}0.44$ points. The total mean of the general stress point of college students was $2.67{\pm}0.52$ points. Affecting factors of the self-esteem of subjects(multiple regression analysis) were important things of school living(p<0.05), human and friendship(p<0.05), protector's job(p<0.001), home economic states(p<0.001), and friendship(p<0.001). Based on multiple regression analysis, affecting factors of the stress of subjects were important things of school living(p<0.05), human and friendship(p<0.05), religion(p<0.001), protector's job(p<0.001), friendship(p<0.001), and arbeit job(p<0.05). Conclusions: The results of this study help to provide a basis for development of a strategy to improve the self-esteem and solve problems of stress for university students. Also relevant programs should be developed and provided by related authorities and universities.

단동, 중국, 북한의 경제 및 무역협력에 관한 연구 (Economy and Trade Cooperation between Dandong, China and D. P. R. Korea)

  • Li, Tie-Li;Jiang, Huai-Yu;Gao, Feng
    • 대한지리학회지
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    • 제37권5호
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    • pp.551-558
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    • 2002
  • 요동반도 경제 개방 지역의 동쪽 길계에 위치한 단동시(Dandong city)는 한반도 중국, 유라시아 대륙을 연결하는 주요한 관문이다. 단동시는 중국과 북한의 경제 및 무역에서 항상 중요한 역할을 담당했는데, 최근 중국의 개방 정책이 수행되고 동북아 지역에서 경제 협력이 강화되면서 더욱 중요성이 커졌다. 한반도에서 평화가 정착되고 북한의 개방이 진행됨에 따라 단동과 북한의 경제 및 무역 협력이 보다 큰 진전을 이룰 것으로 예상된다.

간호대학생의 기본심폐소생술 수행능력 관련 요인 (Factors Influencing Cardiopulmonary Resuscitation Skills in Nursing Students)

  • 심환희;태영숙
    • 한국학교ㆍ지역보건교육학회지
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    • 제16권2호
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    • pp.1-15
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    • 2015
  • Objectives: This study purposed to identify the factors influencing cardiopulmonary resuscitation(CPR) skills in nursing students. Methods: The research design was descriptive study. Data were collected through structured questionnaires. The participants of this study were 202 nursing students in B & U metropolitan city, and C city. Data were collected from November 15 to November 30, 2013. The data were analyzed using t-test, ANOVA, Scheffe's test, Pearson's correlation coefficients, and Multiple stepwise regression with SPSS WIN v 20.0. Results: CPR knowledge(r=0.51, p<0.001), critical thinking disposition(r=0.43, p<0.001), CPR attitude(r=0.56, p<0.001). self efficacy(r=0.74, p<0.001), and CPR skills were significantly correlated with each other. Predictors of CPR skills were self efficacy, CPR knowledge, critical thinking disposition, grade, and CPR attitude. These variables explained 60% of CPR skills. Multiple regression analysis showed that most powerful factors influencing CPR skills among nursing students was self efficacy. Conclusions: Based on this study, it is required to develop nursing education program to improve self efficacy of nursing students for increasing CPR skills.

폐슬러지와 폐굴껍질의 중금속 흡착특성 (Adsorption Characteristics of Heavy Metals for Waste Sludge and Oyster Shell)

  • 전대영;이경심;신현무;오광중
    • 한국환경과학회지
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    • 제15권11호
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    • pp.1053-1059
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    • 2006
  • This study was performed to investigate the possible uses of waste sludge for the removal of heavy metal ions. The adsorption experiments were conducted with wastes such as sewage treatment sludge, water treatment sludge and oyster shell to evaluate their sorption characteristics. Heavy metals selected were cadmium, copper and lead. in the sorption experiments on the sewage treatment sludge, water treatment sludge, oyster shell and soil, sorption occurred in the beginning and it reached equilibrium after 40 minutes on the oyster shell and 4 hour on the sewage treatment sludge and water treatment sludge. Results of Freundlich isotherms indicated that sewage treatment sludge could be properly used as an adsorbent for heavy metals and sorption strength of heavy metals was in the order of Pb > Cu > Cd. In the influence of pH on the adsorbents, sorption rate was more than 80% in pH 4 and most of heavy metals were adsorbed in pH 9. Adsorption rate of Cd decreased with decreasing pH and then adsorption rate of Cu was lower in soil.

일 도시 간호대학생의 소수집단에 대한 사회적 거리감 (A Study on Social Distance of Nursing Students toward Minority Groups in a Metropolitan City)

  • 강혜영;한석영
    • 한국보건간호학회지
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    • 제27권1호
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    • pp.166-178
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    • 2013
  • Purpose: To survey the social distance of nursing students toward minority groups (immigrants, foreign workers, Saeteomins, and foreign students) and compare them according to general and multicultural characteristics. Methods: The subjects were 409 students from two nursing schools at G metropolitan city. Data were collected with self-reported questionnaires from April 2012 to June 2012, and analyzed by descriptive statistics (t-test, analysis of variance (ANOVA) and Scheffe test) using the SPSS/WIN 17.0 program. Results: The mean scores of social distance were $1.90{\pm}0.57$ (out of 4 points) and scores significantly differed according to religion (t=3.095, p=.002), tourist experiences in foreign countries (t=-2.651, p=.008), and for Asian background of minority groups. There were also differences according to the number of foreign friends(F=4.924, p=.008) and duration of friendships(F=3.913, p=.021). Conclusion: The level of social distance of nursing students was lower than average but needs to be reduced. We suggest further studies on the social distance toward each minority group and the development of valid scales for social distance and its related variables.

Comparative study on body shape satisfaction and body weight control between Korean and Chinese female high school students

  • Ro, Yoo-Na;Hyun, Wha-Jin
    • Nutrition Research and Practice
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    • 제6권4호
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    • pp.334-339
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    • 2012
  • This study was conducted to compare body shape satisfaction, body image perception, weight control status, and dietary habits of Korean and Chinese female high school students in order to provide information for proper body image perception of adolescents. 221 students in Yongin, a city in Korea, and 227 students in Weihai, a city in China, were surveyed using questionnaires. Body shape satisfaction was significantly higher in Chinese students (P < 0.001) compared to Korean students. 76.2% of Korean students and 72.7% of Chinese students wanted a thinner body shape than their present body shapes. Experiences of weight control, laxative or diuretics uses, eating during weight control, and vomiting after eating were significantly higher in Korean students (P < 0.05-P < 0.001) compared to Chinese students. The score for dietary habits was significantly higher in Chinese students (P < 0.001) compared to Korean students, suggesting a more desirable dietary habit among Chinese students. Students of both countries showed a significantly positive correlation between body shape satisfaction and dietary habits, suggesting that as body shape satisfaction increases, dietary habits become more desirable. In conclusion, Korean female students showed a more distorted body image perception and had more poor dietary habits than Chinese students. Nutritional education for the establishment of normal body weight, proper body image perception, and healthy dietary habits are needed.

중 .소도시 소비자의 비거주지 의류구매행동에 관한 연구 (A Study on the Outbuying Behavior of Clothing Products of the Consumers in Local Retail Areas.)

  • 장윤화;정명선
    • 한국가정과학회지
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    • 제3권2호
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    • pp.120-134
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    • 2000
  • The purpose of this study was to investigate the factors influence the outbuying behavior of the consumers reside in middle sized cities adjacent to Kwangju. a metropolitan city of Korea. Data were collected by using questionnaire from 570 female consumers in Suncheon and Yeosu city from 8 September to 16. 1999. Data from 513 respondents were analyzed. Factor analysis. t-text. $x^2$test and cross analysis were used. Respondents were divided by two groups, outbuying group/resident purchasing group, based on the frequency of purchasing and intention of purchasing in local stores. and the differences between two groups were analyzed. The results were as follows : 1. There were significant differences in the residence. levels of education and Income. age. job. automobile possession, numbers of children, clothing expenditure Per month between outbuying group and resident purchasing group(p<.001, respectively) . 2. Outbuying group had significant higher tendency toward pursuing fashionability and pleasure, and symbolism in clothing than resident purchasing group(p<.001. respectively) 3. Outbuying group considered store services. assortments. shopping convenience significantly more important than resident purchasing group(p<.001. respectively) 4. Outbuying group obtained information from media sources and non-media sources significantly more often than resident purchasing group(p<.001, respectively) .

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G광역시 N유치원의 라돈 농도 (Radon Concentration at N-Kindergarten in G-City)

  • 박윤;김원준
    • 한국방사선학회논문지
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    • 제9권6호
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    • pp.421-424
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    • 2015
  • 본 연구는 G광역시 N유치원을 대상으로 창문을 닫고 열은 상태에서 라돈 가스를 측정하였다. 측정 결과 라돈가스를 측정한 N유치원의 실내 평균 라돈농도는 창문을 닫았을 때 2.9pCi, 창문을 열었을 때 0.8pCi로 미국 일반인 공기 중 라돈가스 최대허용농도 기준치인 4pCi 이하의 값으로 나타났다. 이러한 결과는 N유치원에서 라돈 가스에 대한 피폭은 문제가 되지 않으나 라돈 가스가 폐에 축척이 되면 폐암과 같은 피해를 입을 수 있다. 따라서 방어적 측면에서 유치원 내의 창문을 자주 열어 환기를 하는 것이 매우 중요함을 알 수 있었다.