• Bulletin of the Korean Chemical Society
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• 제34권8호
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• pp.2446-2450
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• 2013

Oxindole dimers have been used as intermediates in the synthesis of various cyclotryptamine alkaloids. An efficient direct synthesis of oxindole dimers has been carried out from 3-substituted oxindoles via an oxidative dimerization using manganese(III) acetate or copper acetate/silver acetate system.

• 약학회지
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• 제18권1호
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• pp.74-76
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• 1974

Oh heating isatin with aromatic monocarboxylic acids having .alpha.-hydrogen atoms such as p-nitrophenylacetic acid, p-methoxyphenyl acetic acid and .alpha.-naphthylacetic acid in the presence of anhydrous sodium acetate functioning as a catalyst, p-nitrobenzylidene-3-oxindole, p-methoxybenzylidene-3-oxindole and ${\alpha}$-naphthobenzylidene-3-oxindole are obtained, respectively. The results of these experiments show that isatin may be used as the carbonyl component in the condensation reaction.

• 한국산업융합학회 논문집
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• 제6권2호
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• pp.123-129
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• 2003

Oxindoles(6a-g) are obtained by rhodium(II)-catalyzed Wolff rearrangement of diazoquinolinediones in moderate yields. Treatment of 6a-g oxindole derivatives reacted with CAN in acetonitrile at room temperature to gave 7a-g isatins in good yields. The structures of these compound were identified by MP, IR and NMR-spectra.

• Bulletin of the Korean Chemical Society
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• 제34권8호
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• pp.2431-2435
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• 2013

A simple and efficient method for the synthesis of spiro[4H-pyran-oxindole] derivatives by means of three-component reactions between isatins, malononitrile or ethyl cyano-acetate, and 1,3-dicarbonyl compounds in the presence of catalytic amount of magnesium perchlorate in 50% aqueous ethanol medium has been described.

• 약학회지
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• 제25권3호
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• pp.83-87
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• 1981

Reaction of 3-chloroindolenine with acetic acid gives oxindole and acetoxyindole. Similar treatment of 3-bromoindolenine affords 6-bromoindole. Reaction of 3-chloro-and 3-bromoindolenine with methanolic sodium hydroxide gives 3-methoxyindolenine, 2-methoxyindolenine and oxindole. Thermal reaction of 3-bromoindolenine in 1, 1', 2, 2'-tetrachloroethane gives 6-bromoindole but no reaction is occurred in 3-chloroindolenine. Photolysis of 3-chloroindolenine gives indole, 4-, 5- and 7-chloroindole.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3171-3172
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• 2012

• 한국응용곤충학회지
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• 제54권2호
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• pp.55-62
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• 2015

비티 포자와 Xenorhabdus nematophila (Xn)의 배양액을 혼합하여 비티플러스가 개발되었다. 높은 살충력에도 불구하고 비티플러스는 다양한 해충에 대한 넓은 살충범위를 보이지 않는 한계가 있다. 본 연구에서는 Xn 대사물질 첨가를 통한 파밤나방과 같은 비감수성 해충에 대한 비티플러스의 살충력 향상에 초점을 맞추었다. Xn의 주요 대사물질인 oxindole (OI)과 benzylideneacetone (BZA)는 비티의 살충력을 향상시킨다고 보고되었다. 본 연구에서 OI 또는 BZA의 첨가는 비티플러스의 살충력을 향상시켰다. 그러나 동결건조된 Xn 배양액의 첨가는 보다 낮은 농도의 OI 또는 BZA로도 충분히 비피플러스의 살충력을 상승시켰다. HPLC 분석에서 Xn 배양액에 최소 12개의 대사물질이 포함되어 있는 것을 확인하였다. 이러한 결과는 OI와 BZA 외에도 Xn 대사물질에 생리활성물질이 존재하는 것을 제시한다.

• Animal cells and systems
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• 제1권4호
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• pp.583-587
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• 1997

Incubation of an NADPH-dependent succinic semialdehyde reductase from bovine brain with N-bromosuccinimide (NBS) resulted in a time-dependent loss of enzyme activity. The inactivation followed pseudo-first-order kinetics with the second-order rate constant of $6.8\times{10}^3$ $M^-1$ $min^{-1}$. The inactivation was prevented by preincubation of the enzyme with substrate succinic semialdehyde, but not with coenzyme NADPH. There was a linear relation-ship between oxindole formation and the loss of enzyme activity. Spectro-photometric studies indicated that about one oxindole group per molecule of the enzyme was formed following complete loss of enzymatic activity. It is suggested that the catalytic function of succinic semialdehyde reductase is modulated by binding of NBS to a specific tryptophan residue at or near the substrate binding site of the enzyme.

• Journal of Microbiology and Biotechnology
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• 제24권4호
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• pp.507-521
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• 2014

A phase variation has been reported in an entomopathogenic bacterium, Xenorhabdus nematophila. Compared with a wild-type primary form, a secondary form usually loses several physiological and biochemical characters. This study showed that the phase variation of X. nematophila caused a significant alteration in its immunosuppressive activity and subsequent entomopathogenicity. A secondary form of X. nematophila was detected in laboratory colonies and exhibited significant differences in dye absorption and entomopathogenicity. In addition, the secondary form was different in its production of eicosanoid-biosynthesis inhibitors (EBIs) compared with the primary form of X. nematophila. Production of oxindole and p-hydroxypropionic acid was significantly reduced in the culture broth of the secondary form of X. nematophila. The reduced EBI production resulted in significant suppression in the inhibitory effects on cellular nodule formation and phenoloxidase activity. Culture broth of the primary form of X. nematophila enhanced the pathogenicity of Bacillus thuringiensis ( Bt) significantly more than the culture broth of the secondary form. Furthermore, this study developed a highly efficient "Dual Bt-Plus: to control both lepidopteran insect pests Plutella xylostella and Spodoptera exigua, by mixing two effective Bt strains along with the addition of potent bacterial metabolites or 100-fold concentrated X. nematophila culture broth.

• Journal of Microbiology and Biotechnology
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• 제32권3호
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• pp.302-306
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• 2022

A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and High-resolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.