• Journal of Community Nutrition
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• v.8 no.4
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• pp.207-213
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• 2006

The present study was conducted to investigate the effect of oolong tea extract on blood glucose level and antioxidant system in diabetic rats. The Sprague-Dawley rats were fed on AIN-76 based experimental diets containing 1 % oolong tea extract for 6 weeks. They were induced to be diabetic by receiving streptozotocin (45mg/kg BW) intramuscularly. Blood glucose, blood and hepatic concentration of vitamins A and E, and antioxidant enzyme activities were measured. Oolong tea extract feeding decreased the plasma glucose in diabetic rats. Dietary supplementation of oolong tea extract did not affect antioxidative enzyme activities such as superoxide dismutase, glutathione peroxidase and catalase in diabetic rats. The plasma level of retinol was increased in diabetic rats by feeding oolong tea extract. Plasma and hepatic levels of ${\alpha}$-tocopherol were higher in diabetic rats fed oolong tea extract. In conclusion, these results suggest that oolong tea extract consumption might reduce the plasma glucose in diabetic rats and protect the oxidative damage from diabetic stress to some extent.

• Environmental Analysis Health and Toxicology
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• v.20 no.3 s.50
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• pp.205-208
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• 2005

대표적 간장해 유발 물질인 사염화탄소로 유도된 급성 간독성에 미치는 한국산 부추(Alluim tuberosum) 에탄을 추출물의 효과를 관찰하였다. 사염화탄소 투여로 혈청 AST (aspartate transaminale), ALT (alanine tranlaminase)와 ALP(alkaline phosphatase)활성이 현저히 증가하였으며,부추 에탄을 추출물의 투여(50, 100, 200mg/kg)로 특히 CCl$_{4}$에 의해 유도된 AST와 ALT의 활성이 농도 의존적으로 회복되었다. 사염화탄소 투여로 감소된 SOD (superoxide dismutase)와 catalase 활성은 부추의 에탄을 추출물 투여로 유의성 있는 활성 증가를 나타내어 간장해로 인한 산화적 스트레스가 부추의 항산화작용에 의해 완화되었음을 시사하였다. 결과적으로 부추 ethanol 추출물의 간보호 및 항산화작용으로 사염화탄소로부터의 간장해를 개선시키는 것으로 사료된다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.22-25
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• 2010

Hyangsapyeongwi-san has been used for various gastrointestinal diseases in Oriental medicine. Nevertheless, there is little known to scientific evidence for its efficacy and mechanism. This study was aimed to investigate effects of Hyangsapyeongwi-san in gastrointestinal diseases through the analysis of articles. A total of 15 articles were selected from PubMed, KTKP, and Weipu. The selected articles were analyzed according to three aspects of study types, target diseases and its efficacy, and results of clinical studies. Hyangsapyeongwi-san has positive effects in gastrointestinal disorders, such as prevent gastric mucosal injury, improve hyperacidity and dyspepsia, protect oxidative damage, and antitumor effects and enhance both cellular and humoral immunity. However, it proved insufficient to confirm its efficacy owing to lack of clinical studies of high quality. So, we need well designed studies to verify clinical efficacy of Hyangsapyeongwi-san hereafter.

• Proceedings of the KAIS Fall Conference
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• 2005.05a
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• pp.290-291
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• 2005

본 연구에서는 음극전리수가 paraquat에 의한 사람 임파구 DNA의 손상에 미치는 영향을 alkaline comet assay를 사용하여 조사하였다. 또한 음극전리수가 plasmid DNA 손상에 미치는 효과도 조사하였다. 사람 임파구에 다양한 농도의 paraquat을 처리한 후, 음극전리수를 첨가하여 반응시킨 결과 paraquat에 의한 임파구 DNA의 손상은 paraquat 농도증가에 의존적으로 증가하였다. 그러나 음극전리수를 처리한 결과 DNA의 산화적 손상이 paraquat 미처리 대조군 수준으로 거의 다 복구되었다.

• Fibers and Polymers
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• v.7 no.2
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• pp.105-111
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• 2006

Coating the fibre surface by in situ oxidative chemical polymerisation of polypyrrole (using $FeCl_3$ as oxidant) is a readily industrial applicable way to give electrical properties to wool with good ageing stability [1], although pre-treatments are required to avoid damage of the cuticle surface due to the acidic condition of the process. FT-IR and EDX analysis reveal that organic sulphonates and sulphates, used as dopants, are absorbed by wool, while chlorine ions are preferably embedded on the polypyrrole layer. The resulting electrical conductivity seems mainly due to the presence of chlorine as counter-ion of polypyrrole; nevertheless, the presence of arylsulphonate in the polymerisation bath increases the electrical conductivity of the coating layer.

• Archives of Pharmacal Research
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• v.13 no.2
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• pp.121-125
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• 1990

The present study examined the alterations in endogenous oxy-radical scaverging system of pancreatic tissue associated with the dose of 45 mg/kg steptozotocin (STZ) alone or with various combinations. The activities of pancreatic Min-superoxide dismutase (SOD) and catalase were no apparent changes in the other groups except for the Cu(II) 4 mg/kg pretreated group. The presence of 4 mg/kg of Cu(II) with or without 125 mg /kg of diethylenetriaminepentaacetic acid (DTPA) markedly attenuated the fall in activity of Cu, Zn-Sod by STZ stress. In particular, STZ-induced superoxide generation was dramatically abolished by prior administration of Cu(II) 4 mg/kg. Conculsively, We suggested the possible involvement that copper may enhance the defence mechanism of pancreatic oxidative damage by STZ challenge.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2001.10b
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• pp.116-117
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• 2001

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.05a
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• pp.44-44
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• 2002

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2001.10b
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• pp.121-122
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• 2001

• Preventive Nutrition and Food Science
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• v.12 no.1
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• pp.7-10
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• 2007

Theaflavins (TF) and thearubigins (TR) were separated from Korean microbially fermented tea leaves. Contents of TF (74.4 $\mu$M/g) and TR (37.2%) were higher than reported for black tea fermented by oxidase. Antioxidant activities of TF, TR and EGCG were analyzed and protective effects of COS-7 cells against copper and cadmium-induced toxicity were investigated. TF and TR exhibited good inhibition rates of about 85$\sim$90% for antioxidant and scavenging activities of free radicals and protected COS-7 cells against apoptosis or damage caused by stress, such as cadmium and copper-oxidative injury, free radicals etc. These results indicate that TF, TR and EGCG have antioxidant and scavenging activities against free radicals and protect COS-7 cells from Cu, Cd induced injury.