• 한국융합학회논문지
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• 제9권1호
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• pp.441-463
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• 2018

본 연구에서는 위와 같은 선행연구의 한계점을 극복하기 위해 영성, 영성적 안녕, 직장 내 영성, 영성과 종교 등 영성과 관련된 개념에 대해 구체적으로 구분하고 이를 검토하고자 한다. 특히, 영성교육의 영향을 살펴보고자 하였다. 조직에서 수행하는 영성 교육의 구성원들의 성과에 어떠한 영향을 미치는지 살펴보는 것은 매우 중요한 학문적 그리고 실무적 함의를 제공할 수 있을 것으로 판단된다. 이를 위해 본 연구에서는 제안모형을 제시함에 있어서 영성의 모든 차원을 반영하기 위해 개인, 집단, 조직적 관점을 모두 반영하였다. 또한 본 연구에서는 직업성격유형과 직업 환경 이론을 기반으로 제안모형을 구성하고 이를 실증적으로 분석하였다. 실증분석결과 비업무 몰입은 영성교육의 중요성 인식에 부정적 영향을 미치는 것으로 나타났다. 반면에 업무 적정성과 경영진의 관심은 영성교육의 인식에 긍정적 영향을 미치는 것으로 나타났다. 또한 영성교육의 인식은 영성교육의 만족에 긍정적 영향을 미치는 것으로 나타났다. 마지막으로 영성교육의 중요성 인식은 영성교육의 만족에 긍정적 영향을 미치는 것으로 나타났다.

• 생물정신의학
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• 제22권1호
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• pp.1-6
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• 2015

Suicide, the fourth leading cause of death in Korea, is a serious national problem. The Korea National Suicide Survey (KNSS) is the result of the first legislation to address this issue, "Article 11 of THE ACT FOR THE PREVENTION OF SUICIDE AND THE CREATION OF A CULTURE OF RESPECT FOR LIFE" (the "Act for the Prevention of Suicide"). To overcome the limitations of previous studies, the KNSS was designed by collaborators from a variety of fields : psychology, epidemiology, social welfare, and psychiatry. The KNSS was composed of four substudies that addressed the multifaceted process involved in suicide-related behavior over time, exploring general attitudes toward suicide and suicidal ideation, suicide planning, suicide attempts, and completed suicides. Study 1 examined the risk factors for suicide based on data regarding completed suicides ; Study 2 adopted the approach of a psychological autopsy ; Study 3 focused on suicide attempters ; and Study 4 explored attitudes toward suicide in the general population. The KNSS was designed to provide a comprehensive understanding of suicide from a longitudinal, multifaceted perspective to serve as a basis for policies aimed at suicide prevention.

• 대한한의학회지
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• 제35권1호
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• pp.114-123
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• 2014

Objectives: Evidence-based medicine(EBM) advocates the use of up-to-date "best" scientific evidence from health care research as the basis for making medical decisions. EBM also has been applied to traditional Korean medicine(TKM), especially in the field of safety. Recently, the standard prescription for TKM by Korea Institute of Oriental Medicine was published based on toxic index from various toxicity tests. However, there are some limitations when the results from the study based on EBM are applied in clinics. To overcome these imitations, the term "evidence-based practical medicine" was developed and defined as clinically applicable results from the study based on EBM. And safety classification for TKM was suggested as an example of evidence-based practical medicine. Methods: For safety classification for TKM, the data for $LD_{50}$(50% lethal dose), which was transformed to theoretical $LD_1$(1% lethal dose), was analyzed as one of tools for EMB study and divided by maximum dose used in clinics. Results and Conclusions: As a result, human equivalent dose(HED)-based MOS(margin of safety) for korean traditional medicine was calculated and used for safety classification with 5 categories. These categories would be helpful for oriental medicine clinicians to decide the increase and decrease of dosage according to various factors such as patient's sensitivity, potential toxicity of herbal medicines, clinician's experience for better cure. Thus, this safety classification provides some evidences enough that evidence-based practical medicine should be not the same with EBM and defined differently from EBM.

• Molecules and Cells
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• 제40권11호
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• pp.871-879
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• 2017

Levels of maturation-promoting factor (MPF) in oocytes decline after vitrification, and this decline has been suggested as one of the main causes of low developmental competence resulting from cryoinjury. Here, we evaluated MPF activity in vitrified mouse eggs following treatment with caffeine, a known stimulator of MPF activity, and/or the proteasome inhibitor MG132. Collected MII oocytes were vitrified and divided into four groups: untreated, 10 mM caffeine (CA), $10{\mu}M$ MG132 (MG), and 10 mM caffeine + $10{\mu}M$ MG132 (CA+MG). After warming, the MPF activity of oocytes and their blastocyst formation and implantation rates in the CA, MG, and CA+MG groups were much higher than those in the untreated group. However, the cell numbers in blastocysts did not differ among groups. Analysis of the effectiveness of caffeine and MG132 for improving somatic cell nuclear transfer (SCNT) technology using cryopreserved eggs showed that supplementation did not improve the blastocyst formation rate of cloned mouse eggs. These results suggest that maintaining MPF activity after cryopreservation may have a positive effect on further embryonic development, but is unable to fully overcome cryoinjury. Thus, intrinsic factors governing the developmental potential that diminish during oocyte cryopreservation should be explored.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.138-140
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• 2002

The spinal cord dose is the one of the limiting factor for the radiation treatment of the head & neck (H&N) or the thorax region. Due to the fact that the cord is the elongated shaped structure, it is not an easy task to maintain the cord dose within the clinically acceptable dose range. To overcome this problem, the spinal cord partial block technique (PBT) with the dynamic Multi-Leaf Collimator (dMLC) has been developed. Three dimension (3D) conformal beam directions, which minimize the coverage of the normal organs such as the lung and the parotid gland, were chosen. The PBT field shape for each field was designed to shield the spinal cord with the dMLC. The transmission factors were determined by the forward calculation method. The plan comparisons between the conventional 3D conformal therapy plan and the PTB plan were performed to evaluate the validity of this technique. The conformity index (CI) and the dose volume histogram (DVH) were used as the plan comparison indices. A series of quality assurance (QA) was performed to guarantee the reliable treatment. The QA consisted of the film dosimetry for the verification of the dose distribution and the point measurements. The PBT plan always generated better results than the conventional 3D conformal plan. The PBT was proved to be useful for the H&N and thorax region.

• 한국인터넷방송통신학회논문지
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• 제18권2호
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• pp.197-207
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• 2018

다품종 소량생산체제인 중소기업 제조공장은 고객의 니즈를 대응하기 위해 제품을 대량생산하여 판매하는 형태이다. 이는 기업이 재고 부족에 따른 손실을 줄이기 위해 과도한 양의 자재 수급을 의미하고 높은 재고 유지비용이 발생한다. 그리고 수요 대응에 실패한 제품은 관리 창고에 쌓여 있어 재고 보관비용이 발생하는 현실이다. 본 논문은 이러한 문제를 보완하기 위해 시계열 분석 기법인 ARIMA모형을 이용하여 계절적 요인과 같은 시간적인 변동성을 찾아 수요를 예측하고 이를 통해 경제적 주문량 모형 기반의 수요예측 모델을 개발하여 재고 부족 위험을 예방한다. 또한 시뮬레이션을 수행하여 개발 모델의 효용성 평가하고 향후 중소기업에 적용하여 개발 모델의 효과를 입증한다.

• 대한조선학회논문집
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• 제54권5호
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• pp.387-392
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• 2017

There is a constant demand for hull variation related to ship design. Various input variables are generally given to achieve the objective functions assigned by each variation process. When dealing with geometric shapes accompanied by nonlinear operations during the variation process, vague relationships or uncertainties among input variables are commonly observed. Therefore, it is strongly recommended to identify those uncertainty factors in advance. A method to modify the shape of a closed hull form with a new area and a centroid had been introduced as a new process of hull variation. Since uncertainty between input variables still existed in the method, however, it was not easy for the user to enter the area and the corresponding centroid. To overcome this problem, a method is presented in this paper to provide the feasible region of centroids for a given area. By utilizing the concept and techniques used in the statistics such as the number of samples, probability, margin error, and level of confidence, this method generates the distribution of possible centroids along the regression curve. The result shows that the method helps the user to choose an appropriate input value following his or her design intention.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.605-613
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• 2007

위험 분석을 위한 방법론은 결정론적 정성적 접근과 확률론적 정량적 접근으로 대별될 수 있는데, 보다 현실적으로 다양한 요인을 적극적으로 고려할 수 있는 정량적 방법론은 효율성이 높으나 모델의 복잡성과 자료수집의 어려움을 극복하는 것이 필요하다. 본 연구에서는 복잡한 모델링을 체계적으로 수행하여 철도 건널목에서의 사고로 인한 위험도를 정량적으로 평가하기 위한 방법론을 도출하고 기본적인 적용성 연구를 통해, 정량평가 방법론의 유용성을 입증하고 추후 철도 통합 위험도 평가 시스템의 개발에 반영하는 목적으로 수행되었다. 제안된 위험도 평가를 위한 방법론은 다음과 같이 요약될 수 있다. 먼저 Preliminary Hazard Analysis 결과로부터 철도 사고에 대한 위험요인 목록을 작성하고 사건수목(Event Tree)을 이용하여 위험요인별로 사고 시나리오를 전개한다. 사건수목중 사건수목 분기확률을 정량화하기위해 보조논리를 필요로 하는 경우에 대해서 고장수목(Fault Tree)을 작성한다. 작성된 사건수목과 고장수목에 정량화를 위해 필요한 평가 자료를 입력하고 통합 정량화 방법론을 적용하여 최종 정량화를 수행한다. 정량화된 결과에 사고 상황을 고려한 해석을 수행하고 필요하다면 민감도 분석이나 불확실성 분석이 수행한다. 본 연구에서는 이러한 분석 방법론을 전국 철도건널목 사고 분석에 시범 적용하였다. 또한 2005년 국내 철도 건널목에서 발생한 사고자료를 이용하여 시범적인 정량화를 수행하여 그 적용성을 보였다.

• Journal of Ginseng Research
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• 제35권4호
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• pp.462-470
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• 2011

Myeloid-derived suppressor cells (MDSCs) actively suppress immune cells and have been considered as an impediment to successful cancer immunotherapy. Many approaches have been made to overcome such immunosuppressive factors and to exert effective anti-tumor effects, but the possibility of using medicinal plants for this purpose has been overlooked. Korean red ginseng (KRG) is widely known to possess a variety of pharmacological properties, including immunoboosting and anti-tumor activities. However, little has been done to assess the anti-tumor activity of KRG on MDSCs. Therefore, we examined the effects of KRG on MDSCs in tumor-bearing mice and evaluated immunostimulatory and anti-tumor activities of KRG through MDSC modulation. The data show that intraperitoneal administration of KRG compromises MDSC function and induces T cell proliferation and the secretion of IL-2 and IFN-${\gamma}$, while it does not exhibit direct cytotoxicity on tumor cells and reduced MDSC accumulation. MDSCs isolated from KRG-treated mice also express significantly lower levels of inducible nitric oxide synthase and IL-10 accompanied by a decrease in nitric oxide production compared with control. Taken together, the present study demonstrates that KRG enhances T cell function by inhibiting the immunosuppressive activity of MDSCs and suggests that although KRG alone does not exhibit direct anti-tumor effects, the use of KRG together with conventional chemo- or immunotherapy may provide better outcomes to cancer patients through MDSC modulation.

• 감성과학
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• 제5권1호
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• pp.49-60
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• 2002

The aims of the study are first, in other to meet the demand for a new product design process, to review the prototype theory and to find out the conceptual structure of product aesthetics, which is another properly thought to be as important as the typical pattern in an effort to patch up the theory second to help designers overcome the limits of idea generation and create consumer oriented designs with a high success rate by setting up a new product design process that is established through the application of the aesthetically influential factor 'proportion'based on the preceeding studies that tested product aesthetics measuring devices. In other words, this study tries to find out product categories, making use of the prototype theory to introduce an ideal proportion for product design, recognizing the importance of proportion by conducting product pattern analysis: to create a differentiated method that can product consumer oriented designs, even if it only manipulate proportion and to establish a new design process that can systematically explain the methodology for various form generation that applies proportion. This study reviews the theoretical aspects of concepts pertaining to the above … and, based on them, empirically tests them by patting to use the programs, for proportion manipulation. This study was conducted in the following way: To begin with, this study takes out proportion out of some aesthetically influential factors that has a great impact on the way consumers prefer certain product designs and tries to see how proportion affects the consumer preference when consumers select a product. In addition, we could analyze the difference between the ideal proportion that consumers prefer and the traditional golden proportion produced through theoretical studies. The correlations between preferred proportion and ideal proportion, and preferred proportion and golden proportion could be shown. In order that we may create form variations through more detailed proportion manipulation on the basis of the ideal proportion verified as preferable, we again applied the proportion factor to the process utilizing PDS(proportion Distortion System). In the way the restraint of form generation could be pursued. All in all, this study makes an attempt to set up a design process to create new product forms through the application of Proportion.