• Journal of Korea Water Resources Association
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• v.45 no.5
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• pp.445-454
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• 2012

The present study aims to investigate the long-term channel morphological changes derived from channelization, embankment and levee construction works in unregulated fluvial channel of the Jiseock River. Analyses of aerial photographs taken past (Year 1966) and recent (Year 2002) showed the temporally remarkable changes in channel planform such as channel shape, bar migration, vegetation encroachment in bar. During the period, the natural single threading changed into braided types together with decreasing sinuosity by 9.2%, increasing vegetation occupied bar ranged 97% of total bars area. Because such channel morphological changes are closely similar to those in dam downstream channels, we assume that both/either flow regime alteration and/or sediment transport discontinuity may be critical for the fixed channel and spread of vegetated bars even in unregulated river without dam reservoir upstream. We found more reduced frequency and magnitude of flooding water level comparing with past, but no significant alteration of inter annual water level variation. Bed material has been coarsened by 4~5 times and the riverbed has been degraded in overall channel but aggraded locally in conjunction reach of tributaries. The results indicates that reduced sediment dynamics in fluvial channel which derived by bed material coarsening, river bed degradation and unbalanced sediment transport capacity between tributary and mainstem can be a causal factor to trigger channel morphological changes even in unregulated rivers.

• Journal of Korean Neurosurgical Society
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• v.57 no.2
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• pp.88-93
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• 2015

Objective : Elevated cellular retinoic acid binding protein-I (CRABP-I) is thought to be related to the abnormal proliferation and migration of smooth muscle cells (SMCs). Accordingly, a higher CRABP-I level could cause disorganized vessel walls by causing immature SMC phenotypes and altering extracellular matrix proteins which could result in vulnerable arterial walls with inadequate responses to hemodynamic stress. We hypothesized that elevated CRABP-I level in the cerebrospinal fluid (CSF) could be related to subarachnoid hemorrhage (SAH). Moreover, we also extended this hypothesis in patients with vascular malformation according to the presence of hemorrhage. Methods : We investigated the CSF of 26 patients : SAH, n=7; unruptured intracranial aneurysm (UIA), n=7; arteriovenous malformation (AVM), n=4; cavernous malformation (CM), n=3; control group, n=5. The optical density of CRABP-I was confirmed by Western blotting and presented as mean${\pm}$standard error of the measurement. Results : CRABP-I in SAH ($0.33{\pm}0.09$) was significantly higher than that in the UIA ($0.12{\pm}0.01$, p=0.033) or control group ($0.10{\pm}0.01$, p=0.012). Hemorrhage presenting AVM (mean 0.45, ranged 0.30-0.59) had a higher CRABP-I level than that in AVM without hemorrhage presentation (mean 0.16, ranged 0.14-0.17). The CRABP-I intensity in CM with hemorrhage was 0.21 and 0.31, and for CM without hemorrhage 0.14. Overall, the hemorrhage presenting group (n=11, $0.34{\pm}0.06$) showed a significantly higher CRABP-I intensity than that of the non-hemorrhage presenting group (n= 10, $0.13{\pm}0.01$, p=0.001). Conclusion : The results suggest that elevated CRABP-I in the CSF could be related with aneurysm rupture. Additionally, a higher CRABP-I level seems to be associated with hemorrhage development in vascular malformation.

• BMB Reports
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• v.38 no.6
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• pp.755-762
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• 2005

Epstein-Barr virus (EBV) infects more than 90% of the world's population and has a potential oncogenic nature. A histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), has shown potential ability in cancer chemoprevention and treatment, but its effect on EBV-infected Akata cells has not been examined. This study investigated the effect of TSA on the proliferation and apoptosis of the cells. TSA inhibited cell growth and induced cytotoxicity in the EBV infected Akata cells. TSA treatment sensitively induced apoptosis in the cell, which was demonstrated by the increased number of positively stained cells in the TUNEL assay, the migration of many cells to the sub-$G_0/G_1$ phase in flow cytometric analysis, and the ladder formation of genomic DNA. Western blot analysis showed that caspase-dependent pathways are involved in the TSA-induced apoptosis of EBV-infected Akata cells. Overall, this study shows that EBV-infected B lymphomas are quite sensitive to TSA-provoked apoptosis.

• The Korean Journal of Petroleum Geology
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• v.11 no.1 s.12
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• pp.27-41
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• 2005

The hydrocarbon source rock potential of the Eocene units in the southern Oregon Coast Range was evaluated by using the Rock-Eval pyrolysis. Most Eocene units in southern Oregon Coast Range are thermally immature and contain lean, gas-prone Type III kerogen. However, some beds(coals) are sufficiently organic-rich to be sources of biogenic and thermogenic methane discovered in numerous seeps. The overall hydrocarbon source rock potential of the southern Oregon Coast Range is moderately low. Several requirements for commercial accumulations of hydrocarbon, however, probably exist locally within and adjacent areas. Three speculative petroleum systems are identified. The first includes the southern part of the Oregon Coast Range near the border with the Mesozoic Klamath Mountains and is related to a proposed subduction zone maturation mechanism along thrust faults. The second is centered in the northern part of the range and may be associated with basin-centered gas in an over-pressured zone. The third occurs near the eastern border of the range where maturation is related heating by sills and migration of hydrothermal fluids associated with mid-Tertiary volcanism in the Western cascade arc.

• Korean journal of applied entomology
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• v.47 no.1
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• pp.37-44
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• 2008

Oriental fruit moth, Grapholita molesta, is a serious pest on apples. To control this pest in an environmentally friendly method, mating disruption strategy using sex pheromone has been developed. Area-wide application of mating disruption has been needed to be effective, with little understanding on how much size of apple cultivating area should be treated in one time application of the mating disruption technique. On this matter, we needed to determine a minimal mating active zone of G. molesta that should be applied with mating disrupters to be effective. Molecular markers to discriminate a specific population should be developed to trace population migration for reproductive behaviors. Here we developed two effective molecular markers using random amplified polymorphic DNA (RAPD) technique. Different field populations of G. molesta, based on locations and seasons, were analyzed with these markers. In a specific location, G. molesta populations varied in genetic composition with different seasons. Different local populations showed differential variation according to their relative distances among apple orchards. In overall, genetic variation among different populations became lessen with progression of seasons.

• Advances in Traditional Medicine
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• v.1 no.1
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• pp.8-27
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• 2000

Components of extracellular matrix and the matrix-degrading enzymes are some of the key regulators of tumor metastasis and angiogenesis. Hyaluronic acid (HA), a matrix glycosaminoglycan, is known to promote tumor adhesion and migration, and its small fragments are angiogenic. Until now, we have compared levels of hyaluronidase, an enzyme that degrade HA, in normal adult prostate, benign prostate hyperplasia and prostate cancer tissues and in conditioned media from epithelial explant cultures, using a substrate (HA)-gel assay and ELISA-like assay (Kim et al., unpublished results). The present review described an overall characterization of hyaluronidases and its application to human diseases. The hyaluronidases are a family of enzymes that have, until recently, deed thorough explication. The substrate for these enzymes, hyaluronan, is becoming increasingly important, recognized now as a major participant in basic processes such as cell motility, wound healing, embryogenesis, and implicated in cancer progression. And in those lower life forms that torment human beings, hyaluronidase is associated with mechanisms of entry and spread, e.g. as a virulence factor for bacteria, for tissue dissection in gas gangrene, as a means of treponema spread in syphilis, and for penetration of skin and gut by nematode parasites. Hyaluronidase also comprises a component of the venom of a wide variety of organisms, including bees, wasps, hornets, spiders, scorpions, sh, snakes and lizards. Of particular interest is the homology between some of these venom hyaluronidases and the enzyme found in the plasma membrane of mammalian spermatozoa, attesting to the ancient nature of the conserved sequence, a 36% identity in a 300 amino acid stretch of the enzyme protein. Clearly, hyaluronidase is of biological interest, being involved in the pathophysiology of so many important' human disorders. Greater effort should be made in studying this family of enzymes that have, until recently, been overlooked. Also, oriental medical application of the hyaluronidase will be discussed with respect to inhibition and suppression of inflammation and malignacy.

• Korea journal of population studies
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• v.24 no.2
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• pp.207-234
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• 2001

Even though the number of Korean Americans has dramatically increased over the last 20 years, there have been very few studies that have examined the health of this population. This paper investigates the contemporary health status of Korean Americans in comparison to Koreans, employing mortality related health measures: life expectance, age-specific death rates, and leading cause of death. Overall, we find that Korean American adults enjoy longer life expectancy and lower age-specific death rates than do their Korean counterparts, suggesting superior health status of the former as compared to the latter. Comparison of leading causes of death indicates that Korean American adults (age of 25-64) are more likely to die from neoplasms than are their Korean counterparts, while Koreans show a dramatically higher probability of death from liver-related diseases than Korean Americans. When these two cause of death are regressed on various demographic and socioeconomic factors, the difference in prevalence of neoplasms between the two populations disappeared, while that of liver-related diseases remains unaffected. Based on the outcomes from this research, we suggest that Korean Americans are a self-selected group in terms of health and socioeconomic status, and they adopt healthy behaviors after immigration. This has resulted in the relatively superior health of Korean Americans as compared to Koreans.

• Journal of the Korean association of regional geographers
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• v.13 no.3
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• pp.321-340
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• 2007

In this thesis we have examined the concrete forms and periodic tendency changes of eup-settlements, local administrative town, locations within 91 districts in 71 counties of Gyeongsang province. First of all, we have analyzed the overall conditions of eup-settlement locations in Joseon Dynasty under the criterion of topography, feng-shui, and scenery image of the mountains at the back. Then we looked into alterations of location forms mainly of the eup-settlement in which the exact time of migration can be identified and cities which have the evident dates of construction. To sum up, the result is as follows. Firstly, the concrete form of eup-settlement locations in Joseon Dynasty are usually built up in traditional ways, however, quite a few unconventional ones also existed. Secondly, the town castles constructed at the end of Goryeo Dynasty period and before 1430's are hardly related to the traditional location format of Joseon Dynasty, yet the ones constructed after 1430's were mostly in the typical location format. Thirdly, the old eup-settlements established before 1425 are scarcely in the typical location form of Joseon dynasty, but the new eup-settlement established after 1425 were mostly in the typical location forms.

• Journal of Life Science
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• v.16 no.5
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• pp.812-827
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• 2006

To investigate the population structure and geographic distance among anchovies (Engraulis japonicus) in Korea, we compared and analyzed the mitochondrial DNA control region sequences (227 bp) of anchovies from 12 localities in inshore and offshore waters. The sequence analysis of 84 individuals showed 29 haplotypes, ranging in sequence divergence by pairwise comparisons from 0.3% to 3.5% (1 bp-12 bp). E9 haplotype of anchovies were found largely in inshore waters and also in offshore waters, which was regarded as the major source in Korean waters (58.3%). However, E26, E27, E28, and E29 haplotypes were found in westsouthern (locality 10, four among 7). Phylogenetic analysis using PHYLIP was divided into two clades (clade A and B). Most of the haplotypes, excluding E26, E27, E28, and E29, were strongly supported by bootstrap analysis (>75%), whereas the relationship between clade A and B was weakly supported by bootstrap analysis (51%). High levels of genetic diversity were found; haplotype diversity (H)=0.75-1.00, and nucleotide diversity $({\pi})=0.015-0.0244$. Analysis of $F_{ST}$ between populations in inshore waters ranged in 0.01-0.05, whereas those of offshore waters ranged in 0.01-0.58. A high gene flow occurred in inshore (Nm=22.61-34.22) and offshore (Nm=11.57-45.67) populations. The distribution of mitochondrial DNA haplotypes between westsouthern and other populations was suggestive of significantly different differentiation ($F_{ST}$=0.20-0.59, p<0.05; d=0.52, p=0.00; ${\phi}=0.02-0.41$, p＜0.05). These results suggested that the overall anchovy population in the Korean peninsula caused considerable migration due to the mitochondrial gene flow between inshore and offshore populations to form a genetically homogenous and panmictic structure, although a heterogeneous population was found in this study.

• Korean Journal of Environment and Ecology
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• v.31 no.5
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• pp.472-478
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• 2017

The feeding habits of Coreoperca herzi were investigated from specimens collected in the Geum River, from March to December 2016. The specimens were separated into groups of 38~70 mm, 71~109 mm, and over 110 mm in total length. The live foods of C. herzi included Ephemeroptera, Odonata, Plecoptera, Coleoptera, Diptera, Trichoptera, and fishes. The Korean aucha perches fed mostly on aquatic insects which took up 98.8% of food regarding the number, 55.8% regarding the biomass, and 97.1% in terms of iregarding the index of relative importance. They were carnivorous in diet and predators (stalker) in food intake characteristics and forms when applying Keenleyside's classification. The main food sources of C. herzi were Ephemeroptera, Diptera, and Trichoptera while Odonata, Plecoptera, Coleoptera, and fishes were rare. A food migration was observed since less Ephemeroptera was found and more Trichoptera and fishes were found in the biomass of the feed consumed by larger species. The amount of Coleoptera and Diptera did not change much with the size of the species. The overall composition of live food was not seasonal. The result of the study indicates that, when restoring the streams to be the habitat for the natural population increase of Coreoperca herzi, the environment should be inhabitable to Ephemeroptera, Diptera, and Trichoptera which are the main foods.