• Journal of Dental Anesthesia and Pain Medicine
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• 제22권5호
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• pp.323-338
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• 2022

Burning mouth syndrome (BMS) is a chronic oral disorder of unknown etiology which presents therapeutic challenges. Alpha-lipoic acid (ALA) has been studied as a potential treatment for BMS. The objective of this systematic review and meta-analysis was to evaluate the effectiveness of ALA compared to that of placebo or other interventions in individuals with BMS. Randomized controlled trials (RCT) using ALA to treat BMS were identified from MEDLINE, Cochrane Library, EMBASE, and Web of Science up to February 3, 2021. The assessment of the risk of bias in the included studies was based on the Cochrane guidelines. The primary outcome evaluated was the visual analog scale (VAS) pain intensity. ALA was compared with placebo, clonazepam, gabapentin, pregabalin, ALA plus gabapentin, capsaicin, Biotène^®, and laser therapy. Altogether, 137 records were scanned for inclusion/exclusion, and nine RCTs (two unclear and seven at high risk of bias) were included in the qualitative and quantitative analyses, with a total of 594 patients with BMS included in this review. All studies reported an improvement in VAS pain scores ranging from -0.72 to -2.77. Meta-analysis results showed a non-significant reduction in pain intensity for ALA (P = 0.616) compared to that of placebo on a VAS of 0-10. Patients taking ALA were 1.923 times more likely to show an improvement in self-reported BMS symptoms (P = 0.031) than those in the placebo group. Clonazepam and pregabalin showed a significant VAS pain reduction of 4.08 and 4.68 (P < 0.001), respectively, compared to that with ALA. Although ALA intervention provided a non-significant improvement in the pain score and was more likely to produce a reduction in BMS symptoms, the evidence was of low quality. Further research is needed to establish clear guidelines for the use of ALA for BMS treatment.

• 한방비만학회지
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• 제22권2호
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• pp.125-135
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• 2022

Objectives: A restrospective chart review were conducted to investigate the overall weight loss effect of the integrated Korean medicine treatment on obese patients (body mass index [BMI] ≥25 kg/m²) in Korean medicine clinic and analyze the difference in the effect according to lifestyle behaviors. Methods: The medical records of 43 obese patients were retrospectively analyzed including body weight, BMI, waist circumference, hip circumference, and body composition who received integrated Korean medicine treatment for 4 weeks at 24 Korean medicine clinics in Daejeon metropolitan city. All outcome measures were evaluated again 8 weeks after the end of treatment at week 12 for follow-up. EuroQol-5D (EQ-5D), the Korean version of the obesity-related quality of life scale (KOQOL) and patient's satisfaction were also evaluated. The analysis was divided according to the treatment period and observation period, and subgroup analysis was performed according to drinking and exercise habits. Results: Body weight, body fat, waist circumference, hip circumference, body fat were significantly reduced at week 4 and week 12. Theses weight reduction effects were significantly greater within treatment period (0 to 4 week) than observation period (4 to 12 week). Especially in the non-exercise group, the changes in body fat mass and body fat percent showed a significant difference between the treatment period and the observation period. KOQOL were also significantly improved at 12 week, but not in EQ-5D. No severe adverse events were observed. Conclusions: The integrated Korean medicine treatment could be effective to treat obesity including weight loss. It is necessary to prevent additional weight regain through regular exercise even after Korean medicine treatment.

• 한국컴퓨터정보학회논문지
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• 제14권11호
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• pp.53-60
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• 2009

본 논문은 MMORPG 게임에서 캐릭터 대비 통로의 적절한 크기를 유추하고 이를 기존 게임에 대비하여 역 산출함으로써 데이터의 객관성을 높임과 동시에 통로의 기능에 따라 다양하게 표현되고 있는 실내 내부의 크기에 관한 연구이다. 이 연구를 위하여 데이터를 객관화 시키는 작업부터 하였으며, 던전이라는 특성화 된 기능을 지니는 통로의 규정을 이동을 위한 목적 및 소규모로 진행되는 전투 기능까지의 범위로 한정시켜 실험을 진행하였다. 그리고 게임의 장르에 따른 게임그래픽의 종류를 MMORPG로 한정시켜 실험의 결과 값을 정형화하였으며 캐릭터의 크기의 객관성을 위해 실사풍의 RPG 게임으로 한정시키고 그래픽디자이너의 성향에 따라 크기의 차이를 얼굴의 크기에 맞추어 신체크기 값을 통일 시켰다. 캐릭터의 크기 중 어깨넓이, 팔 길이 등 이동성 던젼의 넓이의 특징 점으로 찾았으며, 이를 분석하여 MMORPG 게임의 메인캐릭터의 상체의 크기를 이용하여 이동성 던젼의 크기를 재구성 하여 4개의 실험데이터를 게임전문가 200명에게 적절한 게임 던젼의 크기를 선택하도록 인지 실험을 하였다. 이에 캐릭터와 이동성 던젼의 비례관계를 감성적인지 관점에서 허용범위의 평균값을 얻을 수 있는 산출 공식을 만들 수 있었다.

• 대한족부족관절학회지
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• 제26권1호
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• pp.40-47
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• 2022

Purpose: The modified Broström repair (BR) technique has yielded good outcomes in patients with chronic ankle instability. This study compared clinical and radiological outcomes between two groups of patients who underwent modified BR or lateral ligament augmentation using suture tapes (ST). Materials and Methods: Seventy-seven patients (ST group [n=47], BR group [n=30]; body mass index <26.61 kg/m²; mean age, 30.7±11.0 years [range, 17~39 years]; mean follow-up, 34.0±12.0 months [range, 24~59 months]) were retrospectively reviewed between January 2014 and July 2017. The Foot and Ankle Outcome Score (FAOS), American Orthopedic Foot and Ankle Score (AOFAS), Foot and Ankle Ability Measure (FAAM), visual analogue scale (VAS) score, and Sefton grading system were used for clinical assessment. The talar tilt angle and anterior talar translation were measured using the Telos stress device (Telos GmbH, Marburg, Germany) at 150 N for radiological evaluation. Results: FAOS, AOFAS, FAAM, and VAS scores improved in both groups at final follow-up (ST, 91.1±5.2, 93±2, 88.1±4.5, 1.5±0.7 vs. BR, 91.3±5.4, 93±3, 83.3±4.8, 1.2±0.7, respectively; p=0.854, 0.971, <0.001, 0.04, respectively). According to the FAOS, mean sports activity scores for the ST and BR groups at the final follow-up were 90.3±3.2 and 76.6±4.2, respectively, reflecting superior outcomes in the ST group (p<0.001). Sefton grading revealed satisfactory functional outcomes (ST, 91.5% vs. BR, 90.0%). There was significant improvement in the talar tilt angle and anterior talar translation in both the ST and BR groups (7.6°±1.2°, 10.5±1.8 mm vs. 4.9°±1.1°, 7.9±1.5 mm, respectively; p<0.001). Conclusion: The ST group demonstrated comparable clinical but better improvement in mechanical stability and FAOS sports scores than the BR group.

• 대한토목학회논문집
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• 제28권6D호
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• pp.775-789
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• 2008

2006년 9월 국무조정실이 수립한 교통사고 잦은 곳 개선 종합대책에 의하면 전방신호기 설치가 교차로 교통사고에 괄목할만한 효과라고 판단하여, 교통사고 잦은 곳 개선사업에 우선적으로 전방신호등을 설치를 권장하고 있다. 하지만 전방 신호등의 효과에 대한 검증 없이 국무조정실이 수립한 종합대책을 토대로 전방신호등 개선사업을 시행한다면 오히려 교통안전측면에서 더 큰 시행착오를 범할 수 있다. 이에 본 연구는 전방신호등의 설치가 과연 얼마만큼의 효과가 있는지, 또한 전방신호기의 설치에 따른 교통사고 유형의 변화 및 전방신호기의 설치가 적합한 교차로 유형에 대한 분석결과를 제시하고자한다. 이를 위해 Hauer가 개발한 비교그룹방법(Comparison-Group, C.G Method)을 활용하여 분석한 결과, 전방신호등 설치로 인한 전체 교통사고 감소효과에는 긍정적인 결과로 나타났으나 교차로의 규모별, 교통사고 유형별 효과분석에서는 각기 상이한 결과를 나타내기도 하였다. 소규모 교차로에서는 교통사고 유형별로 모두 전방신호등 설치로 인한 감소효과가 나타났지만, 대규모 교차로의 경우 정면충돌 및 측면직각 교통사고 유형에서는 오히려 전방신호등 설치로 인하여 교통사고가 증가하여 교통안전측면에서는 부정적인 결과를 초래하였다. 따라서 대규모 교차로에 전방신호기를 설치 할 경우에는 교통운영 및 교통시설, Human Factor 등 다각적인 측면에 대한 개선안을 신중하게 고려하여 시행 할 것을 권장하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제66권6호
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• pp.652-663
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• 2023

Objective : This study compared the quality of recovery (QoR) after minicraniotomy for clipping of unruptured intracranial aneurysms (UIAs) between patients with and without scalp nerve block (SNB). Methods : Patients were randomly assigned to the SNB (SNB using ropivacaine with epinephrine, n=27) and control (SNB using normal saline, n=25) groups. SNB was performed at the end of surgery. To assess postoperative QoR, the QoR-40, a patient-reported questionnaire, was used. The QoR-40 scores were measured preoperatively, 1-3 days postoperatively, at hospital discharge, and 1 month postoperatively. Pain and intravenous patient-controlled analgesia (IV-PCA) consumption were evaluated 3, 6, 9, and 12 hours and 1-3 days postoperatively. Results : All QoR-40 scores, including those measured 1 day postoperatively (primary outcome measure; 155.0 [141.0-176.0] vs. 161.0 [140.5-179.5], p=0.464), did not significantly differ between the SNB and control groups. The SNB group had significantly less severe pain 3 (numeric rating scale [NRS]; 3.0 [2.0-4.0] vs. 5.0 [3.5-5.5], p=0.029), 9 (NRS; 3.0 [2.0-4.0] vs. 4.0 [3.0-5.0], p=0.048), and 12 (NRS; 3.0 [2.0-4.0] vs. 4.0 [3.0-5.0], p=0.035) hours postoperatively. The total amount of IV-PCA consumed was significantly less 3 hours postoperatively in the SNB group (2.0 [1.0-4.0] vs. 4.0 [2.0-5.0] mL, p=0.044). Conclusion : After minicraniotomy for clipping of UIAs, SNB reduced pain and IV-PCA consumption in the early postoperative period but did not improve the QoR-40 scores.

• Journal of Korean Neurosurgical Society
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• 제66권6호
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• pp.672-680
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• 2023

Objective : We evaluated the diagnosis, treatment, and long-term results of patients with dural arteriovenous fistula (dAVF), which is a very rare cause of posterior fossa hemorrhage. Methods : This study included 15 patients who underwent endovascular, surgical, combined, or Gamma Knife treatments between 2012 and 2020. Demographics and clinical features, angiographic features, treatment modalities, and outcomes were analyzed. Results : The mean age of the patients was 40±17 years (range, 17-68), and 68% were men (11/15). Seven of the patients (46.6%) were in the age group of 50 years and older. While the mean Glasgow coma scale was 11.5±3.9 (range, 4-15), 46.3% presented with headache and 53.7% had stupor/coma. Four patients (26.6%) had only cerebellar hematoma and headache. All dAVFs had cortical venous drainage. In 11 patients (73.3%), the fistula was located in the tentorium and was the most common localization. Three patients (20%) had transverse and sigmoid sinus localizations, while one patient (6.7%) had dAVF located in the foramen magnum. Eighteen sessions were performed on the patients during endovascular treatment. Sixteen sessions (88.8%) were performed with the transarterial (TA) route, one session (5.5%) with the transvenous (TV) route, and one session (5.5%) with the TA+TV route. Surgery was performed in two patients (14.2%). One patient (7.1%) passed away. While there were nine patients (64.2%) with a Rankin score between 0 and 2, the total closure rate was 69.2% in the first year of control angiograms. Conclusion : In the differential diagnosis of posterior fossa hemorrhages, the differential diagnosis of dAVFs, which is a very rare entity, should be considered, even in the middle and elderly age groups, in patients presenting with good clinical status and pure hematoma. The treatment of such patients can be done safely and effectively in a multidisciplinary manner with a good understanding of pathological vascular anatomy and appropriate endovascular treatment approaches.

• 문화기술의 융합
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• 제9권6호
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• pp.1173-1178
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• 2023

현대 사회에서는 효율성을 강조하여 조직 내 팀 프로젝트와 개인 업무를 세부 계획으로 이끄는 경향이 있다. 24시간 일상에서 시간을 효과적으로 활용하는 능력은 성실함의 지표로 여겨지며, 사람들은 계획적이고 조직적인 사람들을 모방하고 다양한 시스템을 활용하여 일상을 관리하려고 노력한다. 주어진 업무를 효율적으로 수행하려는 이유는 정해진 기간 내에 작업을 완료함으로써 프로젝트의 성패에 영향을 미치기 때문이다. 프로젝트 일정을 소홀히 할 경우, 성공적인 결과를 위협하는 큰 위험으로 여겨집니다. 이는 조직의 대형 프로젝트뿐 아니라 개인의 생활에서도 같이 적용되며, 시간 기반의 효율적인 관리를 강조하는 다양한 일정 관리 도구를 활용한다. 프로젝트 관리에서는 단순히 '오늘'을 기준으로 하는 것이 아니라 세부 업무 진행 상황을 주의 깊게 파악하는 것이 필요하다. 본 논문에서는 우리는 사용자가 속한 프로젝트에 날짜가 아닌 업무 단위로 접근하여 일정을 관리할 수 있는 안드로이드 애플리케이션을 제안하고 그 구현 내용을 소개한다. 본 논문에서 우리가 구현한 애플리케이션은 사용자가 속한 프로젝트를 등록하여 프로젝트의 목표 및 일정을 관리할 수 있다. 더불어, 프로젝트 전체 또는 개별 목표 진행률을 가시화하여 업무에 효율적으로 접근할 수 있는 기능을 제공한다. 이로써 사용자들은 본 논문에서 우리가 제안하는 애플리케이션을 활용하여 본인이 속한 프로젝트에 전념하며 업무 단위로 일정을 관리함으로써 프로젝트의 전반적인 효율을 향상할 수 있다.

• 한방재활의학과학회지
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• 제33권4호
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• pp.45-59
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• 2023

Objectives The aim of this study was to analyze the trends of researches on oriental medicine treatments for supraspinatus tendinopathy. Methods We used five databases for searching researches; Korean studies Information Service System, Oriental Medicine Advanced Searching Integrated System, Research Information Sharing Service, PubMed, and China National Knowledge Infrastructure. Only randomized controlled trials suitable for the subject were selected. The methodological quality of included randomized controlled trials (RCTs) was assessed by the Cochrane risk of bias tool. Results Twenty randomized controlled trials were analyzed. There were 9 types of treatment interventions; acupuncture, acupotomy, pharmacopuncture, electroacupuncture, fire needling, warming needle, catgut-embedding therapy, herbal medicine, cupping. The most frequently used treatment intervention was acupuncture and acupotomy. There were 9 outcome measurements including visual analog scale (VAS), Constant-Murley Score (CMS), and range of motion. The most used measurement was VAS. As a result of meta-analysis, acupuncture was more effective than control group in VAS. Additionally, acupotomy was clinically significant compared to control groups in VAS and CMS. Conclusions In this review, we analyzed researches on effectiveness of oriental medicine for supraspinatus tendinopathy. A provisional conclusion can be produced that acupuncture and acupotomy showed beneficial effect to supraspinatus tendinopathy. Although there were some RCT studies, many of them had a high risk of bias, so it is hard to conclude that our study can include overall clinical status. Further well-designed trials are needed.

• 산업융합연구
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• 제21권12호
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• pp.55-62
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• 2023

최근 등장하는 랜섬웨어들은 다양한 공격 기법과 다양한 경로를 통해 공격을 수행하고 있어 조기 탐지와 방어에 많은 어려움을 겪고 있으며, 그 피해 규모도 날로 증가하고 있다. 따라서 본 논문에서는 효과적인 랜섬웨어 탐지를 위하여 파일 암호화와 암호화 패턴을 머신러닝 기반으로 하는 감지 기법을 제안한다. 파일 암호화는 랜섬웨어가 공격하는데 필수적으로 사용하는 기능으로 암호 행위와 암호화 패턴을 분석함으로써 랜섬웨어를 탐지하고 랜섬웨어의 특정 변종이나 새로운 유형의 랜섬웨어를 탐지할 수 있기 때문에 랜섬웨어 공격을 식별하고 차단하는 데 매우 효과적이다. 제안한 머신러닝 기반의 암호화 행위 감지 기법은 암호화 특성과 암호화 패턴 특성을 추출하여 머신러닝 기반의 분류기를 통해 각각 학습을 시켜 해당 행위에 대한 탐지를 진행하고 최종 결과는 두 분류기의 평가 결과를 기반으로 앙상블 분류기에서 랜섬웨어 유무를 판별하여 좀 더 정확도를 높였다. 또한, 제안한 기법을 numpy와 pandas, 파이썬의 사이킷런 라이브러리를 사용하여 구현하여 평가지표를 사용한 성능를 평가한 결과 평균적으로 94%,의 정확도와 95%의 정밀도, 93%의 재현률과 95%의 F1 스코어가 산출되었다. 성능 평가 결과를 보면 암호화 행위 감지를 통해 랜섬웨어 탐지가 가능하다는 것을 확인할 수 있었고 랜섬웨어의 사전 탐지를 위해 제안한 기법의 성능을 높이기 위한 연구도 계속해서 진행되어야 한다.