• Journal of Neurogastroenterology and Motility
• /
• v.24 no.4
• /
• pp.669-675
• /
• 2018

Background/Aims Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing diarrhea-dominant IBS, however its effect on overlap syndrome (OS) patients has not been reported. Therefore, we investigated the effect of trimebutine on the model of OS in guinea pigs. Methods Male guinea pigs were used to evaluate the effects of trimebutine in corticotropin-releasing factor (CRF) induced OS model. Different doses (3, 10, and 30 mg/kg) of trimebutine were administered orally and incubated for 1 hour. The next treatment of $10{\mu}g/kg$ of CRF was intraperitoneally injected and stabilized for 30 minutes. Subsequently, intragastric 3 mL charcoal mix was administered, incubated for 10 minutes and the upper GI transit analyzed. Colonic transits were assessed after the same order and concentrations of trimebutine and CRF treatment by fecal pellet output assay. Results Different concentrations (1, 3, and $10{\mu}g/kg$) of rat/human CRF peptides was tested to establish the OS model in guinea pigs. CRF $10{\mu}g/kg$ was the most effective dose in the experimental OS model of guinea pigs. Trimebutine (3, 10, and 30 mg/kg) treatment significantly reversed the upper and lower GI transit of CRF induced OS model. Trimebutine significantly increased upper GI transit while it reduced fecal pellet output in the CRF induced OS model. Conclusions Trimebutine has been demonstrated to be effective on both upper and lower GI motor function in peripheral CRF induced OS model. Therefore, trimebutine might be an effective drug for the treatment of OS between FD and IBS patients.

• Molecules and Cells
• /
• v.41 no.7
• /
• pp.665-675
• /
• 2018

Rice is a facultative short-day (SD) plant in which flowering is induced under SD conditions or by other environmental factors and internal genetic programs. Overexpression of Histone Deacetylase 701 (HDT701) accelerates flowering in hybrid rice. In this study, mutants defective in HDT701 flowered late under both SD and long-day conditions. Expression levels of florigens Heading date 3a (Hd3a) and Rice Flowering Locus T1 (RFT1), and their immediate upstream floral activator Early heading date 1 (Ehd1), were significantly decreased in the hdt701 mutants, indicating that HDT701 functions upstream of Ehd1 in controlling flowering time. Transcript levels of OsINDETERMINATE SPIKELET 1 (OsIDS1), an upstream repressor of Ehd1, were significantly increased in the mutants while those of OsGI and Hd1 were reduced. Chromatin-immunoprecipitation assays revealed that HDT701 directly binds to the promoter region of OsIDS1. These results suggest that HDT701 induces flowering by suppressing OsIDS1.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2016.10a
• /
• pp.246-249
• /
• 2016

크롬 OS는 온라인에 연결된 상태라면 시간과 장소의 제약 없이 인터넷에 연결해서 사용자 중심의 개인 환경을 제공하는 웹 OS이다. 크롬 OS의 특징이라면 구글 계정으로 접속하여 원하는 APP 설치나 다양한 구글의 온라인 서비스를 자유롭게 이용할 수 있다는 점을 꼽을 수 있다. 특히 기존의 윈도우나 리눅스와는 달리 사용자가 OS 전반에 걸친 설정을 직접 제어할 필요가 없다는 점이 획기적이다. 하지만 웹 OS 임에도 불구하고 이에 대한 보안 대비책이 전혀 마련되어 있지 않다. 따라서 이같은 보안 위협에 대비하기 위해 본 논문은 취약점 분석 쉘 스크립트 구현을 통해 취약점 탐지와 보안 강화를 통한 성능 개선 방안을 제안한다.

• Journal of Gastric Cancer
• /
• v.17 no.1
• /
• pp.63-73
• /
• 2017

Purpose: Data on operable gastric cancer from India is sparse. The purpose of this study was to investigate the clinical details, histopathological demographics, and 5-year overall survival (OS) and disease free survival (DFS) associated with operable, non-metastatic gastric cancer in a dedicated upper gastrointestinal (GI) surgical unit in India. Materials and Methods: Data for patients diagnosed with operable gastric cancer between January 2006 and December 2014 were retrospectively analyzed. Data were collected from electronic hospital records in addition to mail and telephonic interviews when possible. Results: A total of 427 patients were included. The tumor was located in the pyloro-antral region in 263 patients (61.7%). Subtotal gastrectomy was performed in 291 patients and total gastrectomy in 136 patients. Tumor stage classification revealed 43 patients (10.0%) with stage I, 40 patients (9.4%) with stage IIA, 59 patients (13.9%) with stage IIB, 76 patients (17.8%) with stage IIIA, 96 patients (22.5%) with stage IIIB, and 113 patients (26.4%) with stage IIIC disease. Follow-up data were available for 71.6% of the patients with a mean duration of 32.4 months. Five-year DFS and OS were 39% and 59%, respectively. Conclusions: Despite presenting at an advanced stage, the 5-year DFS and OS of patients with operable gastric cancer treated at a dedicated upper GI unit of a tertiary care center in India was good.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2017.04a
• /
• pp.319-322
• /
• 2017

크롬비트는 크롬 OS를 기반으로 하여 사용자 맞춤형 클라우드 서비스를 제공하는 스틱 PC이다. 기존의 크롬북이 이동성을 강조한 외부 인터넷 환경에 특화된 기기라고 할 때, 크롬비트는 스마트 TV구축 등을 비롯한 내부 인터넷 환경에 특화된 기기라고 볼 수 있다. 이처럼 크롬 OS를 실내와 실외에서 사용 가능하다는 것을 감안한다면 클라우드와 사물인터넷 등을 매개로 하는 4차 산업 혁명에 가장 근접한 OS 임에 틀림이 없다. 그럼에도 불구하고 현재 이 운영체제의 개발 속도와 더불어 보안 취약점 분석을 위한 방안은 전혀 마련되어 있지 않다. 그래서 본 논문에서는 취약점 분석 쉘 스크립트 실행을 통한 성능 향상 방안 마련과 크롬 OS의 보안 성능 개선 여부 확인을 살펴보고자 한다.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.110-110
• /
• 2017

Stomata are the main gateways for water and air transport between leaves and the environment. Inward-rectifying potassium channels regulate photo-induced stomatal opening. Rice contains three inward rectifying shaker-like potassium channel proteins, OsKAT1, OsKAT2 and OsKAT3. Among these, only OsKAT2 is specifically expressed in guard cells. Here, we investigated the functions of OsKAT2 in stomatal regulation using three dominant negative mutant proteins, OsKAT2(T235R), OsKAT2(T285A) and OsKAT2(T285D), which are altered in amino acids in the channel pore and at a phosphorylation site. Yeast complementation and patch clamp assays showed that all three mutant proteins lost channel activity. However, among plants overexpressing these mutant proteins, only plants overexpressing OsKAT2(T235R) showed significantly less water loss than the control. Moreover, overexpression of this mutant protein led to delayed photo-induced stomatal opening and increased drought tolerance. Our results indicate that OsKAT2 is an inward-rectifying shaker-like potassium channel that mainly functions in stomatal opening. Interestingly, overexpression of OsKAT2(T235R) did not cause serious defects in growth or yield in rice, suggesting that OsKAT2 is a potential target for engineering plants with improved drought tolerance without yield penalty.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2016.04a
• /
• pp.18-21
• /
• 2016

크롬 OS는 구글에서 개발한 운영체제로서 리눅스와 HTML5 기술 등을 도입해 빠른 부팅과 안정적인 프로그램 실행 등을 통해서 윈도우로 대표되어왔던 기존 컴퓨터 운영체제들의 불편함을 개선한 것이 가장 큰 특징이다. 그러나 클라이언트용 OS라는 점을 감안하였을 때 사용자층이 점차 늘어나고 있는 그래픽이나 암호화, 복호화 같은 보다 세분화된 다양한 데이터 처리를 하는데 있어 요구사항을 만족 시키기에는 부족한 부분이 많았다. 이 같은 문제점들은 운영체제 최적화를 통해 해결할 수 있으며, 이 논문에서는 크롬 OS의 가상메모리 설정 변수의 최적화 수치를 찾아 개선하는 방안을 제안한다.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.90-90
• /
• 2017

Regulation of seed dormancy is important in many grains to prevent pre-harvest sprouting. To identify and understand the gene related to seed dormancy regulation, we have screened for viviparous phenotypes of rice mutant lines generated by insertion of Ds transposon in a Korean Japonica cultivar (Dongjin) background. One of the mutants, which represented viviparous phenotype, was selected for further seed dormancy regulation studies and designated dor1. The dor1 mutant has single Ds insertion in the second exon of OsDor1 gene encoding glycine-rich protein. The seeds of dor1 mutant showed a higher germination potential and reduced abscisic acid (ABA) sensitivity compared to wild type Dongjin. Over-expression of Dor1 complements the viviparous phenotype of dor1 mutant, indicating that Dor1 function in seed dormancy regulation. Subcellular localization assay of Dor1-GFP fusion protein revealed that the OsDor1 protein mainly localized to membrane and the localization of OsDOR1 was influenced by presence of a giberelin (GA) receptor OsGID1. Further bimolecular fluorescence complementation (BiFC) analysis indicated that OsDOR1 interact with OsGID1. The combined results suggested that OsDOR1 regulates seed dormancy by interacting with OsGID1 in GA response. Additionally, expression of OsDOR1 partially complemented the cold sensitivity of Escherichia coli BX04 mutant lacking four cold shock proteins, indicating that OsDOR1 possessed RNA chaperone activity.

• Journal of KIISE:Computer Systems and Theory
• /
• v.32 no.3
• /
• pp.107-114
• /
• 2005

In this paper. we propose an architecture of IEEE1394 device driver for RTLinux. The device driver has two interfaces for applications running on the RTLinux kernel and Linux kernel. With the interfaces, the device driver simultaneously supports RT-Thread of RTLinux kernel and user level process of Linux kernel. This architecture could be a reference for designing other device driver on the dual kernel platform.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2008.05a
• /
• pp.386-389
• /
• 2008

낮은 처리속도와 기억용량을 가진 임베디드 센서 네트워크의 소프트웨어를 개발할 때 Tiny OS는 컴포넌트방식의 nesC 언어를 이용하여 효율적인 설계를 돕는다. 컴포넌트 방식을 이용하기 때문에 여러가지 소프트웨어의 개발에 자주 사용되는 자산을 분리하여 관리한다면 개발시간과 비용을 절감할 수 있다. 본 논문에서는 Tiny OS 기반에서 임베디드 센서 네트워크 소프트웨어 개발 시 프로덕트라인 방법을 적용하여 공통적인 자산과 가변적인 자산을 구별하고 재사용성을 높이며 개발 효율을 증대하는 방안을 제시한다. 이러한 연구는 이종의 임베디드 소프트웨어 개발에도 적용되어 늘어나는 임베디드 소프트웨어의 양적, 질적 수요를 충족시켜주는데 도움이 될 것이다.