• Journal of Radiation Protection and Research
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• 제40권3호
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• pp.147-154
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• 2015

The scatter photons and photoneutrons from high energy photon beams (more than 10 MV) will increase the undesired dose to the patient and the staff working in linear accelerator room. This undesired dose which is found at out-of-field area can increase the probability of secondary malignancy. The purpose of this study is to determine the equivalent dose of scatter photons and neutrons generated by 3 different treatment techniques: 3D-conformal, intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). The measurement was performed using two types of the optically stimulation luminescence detectors (OSL and OSLN) in the Alderson Rando phantom that was irradiated by 3 different treatment techniques following the actual prostate cancer treatment plans. The scatter photon and neutron equivalent dose were compared among the 3 treatments techniques at the surface in the out-of-field area and the critical organs. Maximum equivalent dose of scatter photons and neutrons was found when using the IMRT technique. The scatter neutrons showed average equivalent doses of 0.26, 0.63 and $0.31mSv{\cdot}Gy^{-1}$ at abdominal surface region which was 20 cm from isocenter for 3D, IMRT and VMAT, respectively. The scattered photons equivalent doses were 6.94, 10.17 and $6.56mSv{\cdot}Gy^{-1}$ for 3D, IMRT and VMAT, respectively. For the 5 organ dose measurements, the scattered neutron and photon equivalent doses in out of field from the IMRT plan were highest. The result revealed that the scatter equivalent doses for neutron and photon were higher for IMRT. So the suitable treatment techniques should be selected to benefit the patient and the treatment room staff.

• Journal of Radiation Protection and Research
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• 제26권3호
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• pp.291-298
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• 2001

The designed release rate of liquid effluents from radwaste treatment system should be calculated and evaluated during normal operation, including anticipated operational occurrence and be assured that the release concentration and off-site dose at unrestricted area do not exceed the limits of regulation. The expected annual release rate and off-site dose for the currently operating nuclear power plants in Korea had been calculated and evaluated using PWR-GALE and LADTAP-II which was based on USNRC Regulatory Guide 1.109. Recently, the MOST Notice 2001-2 related to release concentration and off-site dose at unrestricted area was revised to reflect the concept of ICRP-60. It is necessary for KORI 3&4 to re-calculate the release concentration and off-site dose and to compare these results with the limits of regulation. As the results of assessment, we confirmed that the release concentrations were less than its limits of MOST Notice 2001-2 and the off-site dose at unrestricted area using K-DOSE60 was 3.61E-03 mSv/yr to the age of five for the effective dose, and 4.10E-2 mSv/yr to thyroid of the age of five for the organ equivalent dose. We also confirmed the off-site dose was within the limits of MOST Notice 2001-2. Therefore, the release concentration and off-site dose re-evaluated at unrestricted area in KORI 3&4 were well below the regulation limits of MOST Notice 2001-2.

• Journal of Radiation Protection and Research
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• 제43권3호
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• pp.107-113
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• 2018

Background: The purpose of our study was to compare the dosimetric advantages of Flattening filter free (FFF) beams for trigeminal neuralgia patients using 4 mm conical collimators over previously treated patients with 6 MV SRS beam. Materials and Methods: A retrospective study was conducted for 5 TN patients who had been previously treated at our institution using frame-based, LINAC-based stereotactic radiosurgery (SRS) on Novalis Tx using 6 MV SRS beam were replanned on 6X FFF beams on Edge Linear accelerator with same beam angles and dose constraints using 4 mm conical collimator. The total number of monitor units along with the beam on time was compared for both Edge and Novalis Tx by redelivering the plans in QA mode of LINAC to compare the delivery efficiency. Plan quality was evaluated by homogeneity index (HI) and Paddick gradient index (GI) for each plan. We also analyzed the doses to brainstem and organ at risks (OARs). Results and Discussion: A 28% beam-on time reduction was achieved using 6X FFF when compared with 6X SRS beam of Novalis Tx. A sharp dose fall off with gradient index value of $3.4{\pm}0.27$ for 4 mm Varian conical collimator while $4.17{\pm}0.20$ with BrainLab cone. Among the 5 patients treated with a 4 mm cone, average maximum brainstem dose was 10.24 Gy for Edge using 6X FFF and 14.28 Gy for Novalis Tx using 6X SRS beam. Conclusion: The use of FFF beams improves delivery efficiency and conical collimator reduces dose to OAR's for TN radiosurgery. Further investigation is warranted with larger sample patient data.

• The Korean Journal of Physiology and Pharmacology
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• 제10권1호
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• pp.39-44
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• 2006

Type I diabetes (T1D) is an organ-specific autoimmune disease caused by the T cell-mediated destruction of the insulin-producing ${\beta}$ cells in the pancreatic islets. The onset of T1D is the consequence of a progressive destruction of islet ${\beta}$ cells mediated by an imbalance between effector $CD4^+$ T helper (Th)1 and regulatory $CD4^+$ Th2 cell function. Since interferon-alpha (IFN-${\alpha}$) has been known to modulate immune function and autoimmunity, we investigated whether administration of adenoviralmediated IFN-${\alpha}$ gene would inhibit the diabetic process in NOD mice. The development of diabetes was significantly inhibited by a single injection of adenoviral-mediated IFN-${\alpha}$ gene before 8 weeks of age. Next, we examined the hypothesis that Th2-type cytokines are associated with host protection against autoimmune diabetes, whereas Th1-type cytokines are associated with pathogenesis of T1D. The expression of IFN-${\alpha}$ induced increase of serum IL-4 and IL-6 (Th2 cytokines) levels and decrease of serum IL-12 and IFN-${\gamma}$ (Th1 cytokines) levels. Therefore, overexpression of IFN-${\alpha}$ by adenoviralmediated delivery provides modulation of pathogenic progression and protection of NOD mice from T1D.

• Journal of Radiation Protection and Research
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• 제35권1호
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• pp.1-5
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• 2010

This study concerning the surface dose of eye and thyroid from panoramagraphy used thermoluminescent dosimeter (TLD) and photoluminescent dosimeter (PLD) to take measurements at ten hospitals in the Gwangju metropolitan area. The recommendations from ICRP 60 and ICRP 73 on the allowance standard for eye are 15 mSv and for thyroid is 1 mSv. The left eye TLD and PLD values are 0.19 mSv and 0.24 mSv respectively. The right eye TLD and PLD values are 0.23 mSv and 0.25 mSv respectively. Thyroid TLD and PLD values are 0.08 mSv and 0.25 mSv respectively and did not exceed the allowance standards(p<0.001). Also comparisons are made between TLD and PLD for each organ and PLD has higher dose measurements than TLD. There are statistically significant differences in left eye measurements and thyroid measurements (p<0.01). There is no significant difference in measurements for the right eye (p>0.05). The TLD and PLD measured dose from panoramagraphy instruments on eyes and thyroid from each hospital did not exceed the recommended dose from ICRP 60 for surface dose measurements. However, due to the probability of influence, consideration should be made for all levels of dose.

• 대한안전경영과학회지
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• 제14권1호
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• pp.43-51
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• 2012

This study was carried out to observe the impacts of a mouse's inhalation of toxic gas SO2 generated from combustion on its organs by different concentrations. As for research methods: First, after concentrations of SO2 generation from combustion had been set to three: low (10.4 ppm), middle (24.9 ppm) and high (122 ppm) through Gas Toxicity Testing Method (KS F 2271) and SO2 combustion gas was exposed to eight mice in each concentration. Five mice that were able to move based on LD50, a criterion, which sets the down time of a mouse's average behaviors to over 9 minutes, were randomly selected in each concentration, and they were set up as the subjects of the study on toxicity bio-markers. Second, tissues were taken from heart, liver, lungs, spleen and the thymus gland of the mice selected in each concentration and a pathological examination of them was carried out. As a result, microvascular congestion appeared in the heart, and cell necrosis, cortex congestion and tubule medulla congestion, etc. in each concentration were observed in addition to vascular congestion in liver, lungs, spleen and the thymus gland. Also, it was found that the higher the concentrations of SO2 exposure is, the greater, the changes in the organs get. Through this study, SO2 of various toxic gases generated from fire turned out to affect the tissues of each organ of a mouse, it is expected that the toxic gases may greatly affect human body in case of actual fire, and this study is evaluated as having a significance as a basic data on inhalation toxicity assessment of toxic substances generated in combustion.

• 한국약용작물학회지
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• 제28권4호
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• pp.298-309
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• 2020

Background: Safflower (Carthamus tinctorius L.) is a useful medicinal and oil crop in Korea. However, when safflower is cultivated, the flowering period overlaps with the rainy season, and seed maturation is poor. Therefore, this study aimed to use basic research data to develop superior varieties using agronomic characteristics and crossing method. Methods and Results: A total of 34 safflower germplasms were sown and their agronomic characteristics were investigated. Based on these investigations, the cultivar 'ui-san-hong-hwa' was selected as the mother plant, and 'Myanmar safflower' (Hsu Pan) was selected as the father plant. In addition, we developed a floret-protecting cap to cover florets after emasculation during the artificial crossing. When florets were protected by the cap, the seed setting rate increased in comparison to that in the non-covered florets. Conclusions: Agronomic characteristics can contribute to developing suitable varieties. The results suggest that the protection cap will be helpful in breeding without the floral organ drying. This study contributes an efficient breeding method to develop new safflower varieties.

• Journal of Radiation Protection and Research
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• 제13권2호
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• pp.41-51
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• 1988

우리나라의 환경특성에 적합한 섭식경로 내부피폭 해석코드를 확립하기 위한 준비과정으로서 FOOD III 코드를 부분적으로 보완하여 한국 성인 남자에 대한 선량평가 결과를 보완전의 결과와 비교하고 앞으로의 개선방안을 논의 하였다. 평가예제로는 1984년도 고리 원전 1호기에서의 Mn-54, Co-58, Co-60, I-131, I-132의 방출량 자료와 부지경계선상 대기확산인자(X/Q)의 최대값을 사용하였다. 보완된 코드로 계산한 결과, 장기별 선량은 보완 전에 비해 $20{\sim}70%$ 정도 낮아졌으며 예탁실효선량당량은 ICRP 제한치의 0.16%인 $7.935{\times}10^{-6}Sv/y$로 계산되어 보완전의 $1.32{\times}10^{-5}Sv/y$에 비해 40% 정도 낮게 평가되었다.

• Journal of Radiation Protection and Research
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• 제47권2호
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• pp.93-98
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• 2022

Background: This study aims to derive the characteristics of each work type for industrial radiography based on empirical evidence through expert advice and a survey of radiation workers of various types of industrial radiography. Materials and Methods: According to a Korean report, work types of industrial radiography are classified into indoor tests, underground pipe tests, tests in a shielded room (radiographic testing [RT] room test), outdoor field tests, and outdoor large structure tests. For each work type, exposure geometry and radiation sources were mainly identified through the expert advice and workers' survey as reliable empirical evidence. Results and Discussion: The expert advice and survey results were consistent as the proportion of the work types were high in the order of RT room test, outdoor large structure test, underground pipe test, outdoor field test, and indoor test. The outdoor large structure test is the highest exposure risk work type in the industrial radiography. In most types of industrial radiography, radiation workers generally used ¹⁹²Ir as the main source. In the results of the survey, the portion of sources was high in the order of ¹⁹²Ir, X-ray generator, ⁶⁰Co, and ⁷⁵Se. As the exposure geometry, the antero-posterior geometry is dominant, and the rotational and isotropic geometry should be also considered with the work type. Conclusion: In this study, through expert advice and a survey, the external exposure characteristics for each work type of industrial radiography workers were derived. This information will be used in the reconstruction of organ dose for health effects assessment of Korean radiation workers.

• 대한방사선기술학회지:방사선기술과학
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• 제47권3호
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• pp.213-218
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• 2024

The myocardial nuclear medicine examination is widely performed to diagnose myocardium disease using various radionuclides. Although image quality according to radionuclides has improved, the radiation exposure for target organ as well as peripheral organs should be considered. Here, the aim of this study was to evaluate absorbed dose (Gy) for peripheral organs in myocardial nuclear medicine scan from myocardium according to various scan environments based on Monte Carlo simulation. The simulation environment was modeled 5 cases, which were considered by radionuclides, number of injections, and radiodosage. In addition, the each radionuclide simulation such as distribution fraction was considered by recommended standard protocol, and the mesh computational female phantom, which is provided by International Commission on Radiological Protection (ICRP) 145, was used using the particle and heavy ion transport code system (PHITS) version 3.33. Based on the results, the closer to the myocardium, the higher the absorbed dose values. In addition, application for dual injection for radionuclides leaded to high absorbed dose compared with single injection for radionuclide. Consequently, there is difference for absorbed dose according to radionuclides, number of injections, and radiodosage. To detect the accurate diseased area, acquisition for improved image quality is crucial process by injecting radionuclides, however, we need to consider absorbed dose both target and peripheral inner organs from radionuclides in terms radiation protection for patient.