• Archives of Pharmacal Research
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• 제25권4호
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• pp.493-499
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• 2002

We investigated the antitumor activity of oregonin, a diarylheptanoid derivative purified from Alnus hirsuta Turcz, Betulaceae. Oregonin is a potential novel immunomodulator, which augments the activation of natural killer (NK) cells, and thereby leads to a powerful antitumor activity. To evaluate the cytotoxicity of oregonin against tumor cells, we examined the effectiveness of NK cells and determined that oregonin could increase NK cell cytotoxicity. This was confirmed by MTT assay. In addition, the survival time of C57BL/6 mice were measured by inoculating 816-F10 melanoma cells to mice via intra muscular (i.m.) injection. Oregonin treatment after 10 hours of inoculation at 10 mg/kg dosage showed a significant extension of survival time by up to 51.32%, when compared to the control group. Moreover, oregonin significantly reduced the incidence of pulmonary metastasis, which may be developed from 816-F10 melanoma cells. These findings suggest that oregon in may be classified as a new and novel immunomodulator due to its potential antitumor activity.

• 보존과학회지
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• 제35권1호
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• pp.51-60
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• 2019

This paper provides quantitative data that describes the evolution of the air quality in the Whale and Sea Museum, located in the Iwate prefecture, collected after the 2011 Great East Japan Earthquake and tsunami. The museum was damaged significantly by the disaster, and restoration works continued for over six years. The air quality in the temporary storage facility and museum was monitored during the rehabilitation process. Evaluation of air quality is carried out by gas chromatography- mass spectrometry, ion chromatography and high-performance liquid chromatography. The results showed that the characteristics of the chemical components differed depending on the measurement locations inside the building. The museum atmosphere tended to be alkaline as the airtightness increased because of the maintenance works at the entrance. It was also determined that it was necessary to study the intake/exhaust routes and to clean them according to the contamination degree. In Japan, there are recommended museum air quality standards for acetic acid, formic acid, alkali, and aldehydes. The results indicated that these standards should not be used as a reference for damaged museums. Furthermore, at the temporary storage facilities for to store the collections during the rehabilitation of the museum, solvents such as ethyl benzene, toluene, and xylene are initially abundant, although they can be reduced by ventilation, while other components such as 2E1H was confirmed in this case are likely to remain.

• Acta Via Serica
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• 제6권2호
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• pp.61-90
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• 2021

Recent excavations in Qinghai Province, China, have disclosed textiles and artworks from Tuyuhun-Tubo (Tibetan) tombs, dated to the 7^th-9^th centuries, that suggest artistic and cultural exchanges along an external southern branch of the main Silk Road, between Gansu and Sichuan Provinces, across the Qinghai-Tibetan plateau toward the Himalayas. Many similar textiles, possibly from this area, have appeared lately on the art market and ended in private collections. Although these textiles, dated to the early Tibetan period, follow a popular prototype established in Central Asia in the 6^th century, the technical features, colors, and other indigenous elements suggest that they were woven in workshops different from those established between Sogdiana and Gansu. The exhibition "Cultural Exchange Along the Silk Road - Masterpieces of the Tubo Period," organized by the Dunhuang Research Academy and the Pritzker Collaborative Art between July and October 2019 in Dunhuang, Gansu, was a groundbreaking event that gathered scholarly attention on early Tibetan material culture, but a relevant publication is still forthcoming. In my previous work, I briefly discussed a group of silk textiles, possibly from Qinghai or Sichuan, that I analyzed in 2014 in the China National Silk Museum in Hangzhou, Zhejiang. In light of the recent material excavated, published online, or displayed in Dunhuang, in this article, I reevaluate the data previously collected, and discuss in detail the technical and iconographic features of one of the fragments held in Hangzhou. Eventually, the piece was recognized as the ending part of a large panel, which is now in the Abegg Stiftung in Riggisberg, Switzerland.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.334-334
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• 2023

도시침수는 사회 기반시설에 파괴적인 영향을 끼치고, 재산 및 인명 피해의 원인이 되므로, 고해상도 고정확도 예측 정보를 활용한 선제적 대응이 중요하다. 하지만, 기후변화로 인한 강수 강도의 증가, 도시의 확장 및 고밀화 등 토지피복 변화, 홍수방어시설의 노후화 등 여러 요인들의 복합적인 영향으로 인해 도시침수의 정확한 재현 및 예측은 여전히 난제로 남아 있다. 천수 방정식(Shallow Water Equations)을 기반으로 하는 물리과정 모형은 신뢰도 높은 예측 결과를 제공할 수 있지만, Courant-Friedrichs-Lewy 조건 등의 제약으로 인해 대규모 도시 지역의 고해상도 실시간 예측에는 적합하지 않은 한계가 있다. 본 연구에서는 상대적으로 간단한 연산 규칙의 중첩을 통해 복잡계 물리 시스템을 모의하는 셀룰러 오토마타(Cellular Automata; CA) 기술에 기반한 도시침수 해석 모형인 CA-Urban을 개발하고, 미국 Oregon 주 북서쪽에 위치한 Portland시의 도심지역에 대해 침수해석의 적용성을 평가한다. 세부적으로는, 기존 셀룰러 오토마타 기반 침수해석알고리즘의 수치 진동(Oscillation) 문제에 대한 원인을 분석하고, 안정성 향상 방법인 셀 간 최대유량 제한, 가중치 적용 기법, 모형의 계산 효율성 향상을 위한 최적 적응 시간 단계 기법(Adaptive time step)의 적용 결과를 소개한다. 또한, 침투 및 증발산 등 물순환 요소 해석 모듈의 개발 성과 및 방향에 대해서 토의한다.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.36-41
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• 2013

With the increased interest in green buildings, the building industry has been experiencing a fast-growing demand for LEED (Leadership in Energy and Environmental Design) certification for the last decade. Still, it is not unusual to see various barriers and issues during its implementation, and experience tells that they can result in harming the overall project performance with reworks, lower productivity, schedule delays, and cost overruns. In order to better understand the industry's observation on issues and their consequences during LEED implementation, we distributed an online survey, and a total of 53 responses were received. The survey results indicate that (1) both designers and non-designers (e.g., contractors) select 'added costs to design and construction' as the biggest barrier; (2) both designers and non-designers select 'decision made too late in the design process' as the most frequently observed issue; and (3) non-designers indicate higher perceived severity in every consequence criteria than designers. The statistical analyses reveal that cost overruns are the most severe impact observed and have a statistically significant relationship with responses in regard to the barrier to LEED implementation.

• 한국과학교육학회지
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• 제28권7호
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• pp.697-712
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• 2008

The purpose of this study was to seek strengths and weaknesses from analyzing Korea and U.S. science textbooks in terms of general structural features, contents, cognitive levels of questions and the purpose of questions used in science textbooks. This provided insight into improvement of textbooks that can effectively assist teaching and learning. To investigate organization of unit in textbooks in-depth, the evolution unit was selected and scrutinized as one example. The results showed that the number of pages, activities, vocabulary words, and vocabulary lists are considerably different between Korean and the U.S. Commonly, U.S. textbooks were more laden with information and lacking in coherence than those of the Korean textbooks. The findings on the cognitive levels of questions showed that the majority of questions in both nations are concerned with knowledge. However, the difference between the two nations is great in the ratios of analysis, synthesis, and evaluation questions. Questions are concentrated in review section (45% of Korean and 60.6% of U.S.) in textbooks. It suggested that well-planned questions in a review section can provide the basic guidance for strength in a science classroom.

• 기본간호학회지
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• 제14권3호
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• pp.371-381
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• 2007

Purpose: This study was done to investigate the relationship of family function, self-esteem, life satisfaction, and general characteristics to loneliness in community dwelling Korean elders and identify factors affecting loneliness. Method: With a cross-sectional causal-relationship design and a convenience sample, 205 elders residing in three districts of the city of Seoul, S. Korea were recruited. Participants were assessed using the Family APGAR Score, Self-Esteem Scale, Life-Satisfaction Scale, and Revised UCLA Loneliness Scale. Results: The mean score for degree of loneliness (Mean=39.61, SD=10.09) was just below the mean for the scale (Possible range 20-80). Loneliness had significant negative correlations with family function (r= -.400, p<.001), self-esteem (r= -.399, p<.001), and life satisfaction (r= -.644, p<.001). Other general characteristics that had significant or nearly significant relationships with loneliness were perceived current financial and health status, whether doing any exercise or physical activities, degree of close relationship with family members, and length of living in current residence. Among variables, life satisfaction (Standardized ${\beta}\;=\;-.589$, p<.001) and length of living in current residence (Standardized ${\beta}\;=\;-.136$, p<.05) significantly predicted degree of loneliness. Conclusion: Findings of this study allow a comprehensive understanding of loneliness and related factors among community dwelling elders in Korea. However, further studies with a larger random sample from various living environments are necessary.

• Asian-Australasian Journal of Animal Sciences
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• 제5권3호
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• pp.481-485
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• 1992

In order to upgrade native sheep, Rambouillet (R) rams were mated to Kaghani (K) ewes to generate F1 ($R{\times}K$) crossbred ewes. Crossbred ewes were backcrossed to Rambouillet rams to produce B1 ($R{\times}F1$), B2 ($R{\times}B1$) and B3 ($R{\times}B2$) genotypes. Weaning weight of 2605 lambs and wool weight of 2378 mature ewe records, representing R, K, F1, B1, B2 and B3 genotypes, were analyzed to compare genetic variation among genotypes produced during upgrading process and identify genotypes of the highest performance. Performance of Rambouillets was also evaluated under semi-temperate climate. Data were adjusted for yearly variation considering Rambouillet as a control. Genotypes influenced lambs weaning weight (p<.01). B1 lambs were heaviest (18.4 kg) followed in order by B2, F1, B3, R and K lambs (18.3, 17.9, 16.9, 16.8 and 13.2 kg, respectively). The highest wool production was 2.5 kg from R ewes followed by B2 (2.3), B3 (2.3), F1 (2.0) and K (1.2) ewes (p < .01). Ewe mating weight, reproduction, growth and wool production of Rambouillets deteriorated significantly after the first decade of their importation. Compared with the first phase (1959-1971), ewe mating weight, litter size, birth weight, lamb weaning weight and wool production declined by 20, 23, 32 and 36%, respectively, in the second phase (1972-1988).

• Imaging Science in Dentistry
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• 제50권2호
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• pp.141-151
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• 2020

Purpose: This study aimed to quantify the influence of tooth position within the field-of-view (FOV) on cone-beam computed tomography (CBCT) imaging artifacts' intensity when assessing teeth restored with various intracanal materials. Materials and Methods: Seventy single-rooted teeth were divided into 7 groups (10 teeth per group): NiCr post (NC), AgPd post (AP), metal core fiberglass post (MCFG), fiberglass post (FG), anatomical fiberglass post (AFG), fiberglass post cemented with core build-up cement (FGCo), and anatomical fiberglass post cemented with core build-up cement (AFGCo). All posts were cemented using a regular dual-curing resin cement (Allcem), except FGCo and AFGCo which were cemented with a core build-up dual-curing resin cement (AllcemCore). Each tooth was scanned on a CS9000 in 5 positions within the FOV: a central position, anterior horizontal peripheral, peripheral superior, peripheral inferior, and posterior horizontal peripheral position. Hyperdense, hypodense, remaining teeth areas and ROI areas were quantitatively analyzed using ImageJ software. Results: Posterior horizontal peripheral position increased the intensity of artifacts on FGCo and AFGCo post groups (P<0.05), and specifically the hypodense artifact intensity on FG and AFG post groups (P<0.05). NC and AP groups presented greater intensity of artifacts than any other post groups(P<0.05). Conclusion: Artifact intensity increases in the presence of high atomic number materials and when the object is not centered within the FOV. The impact of positioning within the FOV on artifact was greater for fiberglass posts cemented with core build-up dual-curing cement than for metal posts and fiberglass posts cemented with regular dual-curing cement.

• 대한화학회지
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• 제55권5호
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• pp.875-881
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• 2011

이 연구에서는 자연과학을 전공하는 대학생과 고등학교 과학교사를 대상으로 대학에서의 과학 학습에 영향을 주는 요인과 고등학교 과학교육 개선 방향에 대한 인식을 알아보았다. 대학생들은 전공별로 대학에서의 과학 학습에 주는 영향을 주는 요인에 대해 다른 양상을 보이는 것으로 나타났다. 물리학과의 경우에는 수학 능력과 논리적 사고력, 화학과와 생물학과의 경우에는 영어 능력과 기초 과학 지식이 대학에서 공부하는 데 큰 영향을 준다고 인식하는 경향이 있었다. 대학생과 과학 교사 두 집단 모두 기초 과학 지식과 수학 능력이 대학에서의 과학 학습에 크게 영향을 준다고 인식하는 것으로 나타났다. 대학에서의 성공적인 과학 학습을 위한 과학교육 개선 방안으로, 대학생들은 탐구 기회 확대, 과학교사들은 선택과목의 필수 이수 확대라고 각각 응답하여 두 집단 간 다른 양상을 나타내었다.