• Title/Summary/Keyword: Order Releasing

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Short-term Sustained Release Formulation of KC-6620 with Porous Carrier (다공성 증량제를 이용한 KC-6620 단기용출지연입제의 제제)

  • Yu, Ju-Hyun;Park, Chang-Kyu;Lee, Byung-Hoi;Cho, Kwang-Yun
    • Korean Journal of Environmental Agriculture
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    • v.11 no.2
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    • pp.155-162
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    • 1992
  • In order to extend the releasing period of granular formulation to approximately 20 days, the KC-6620-adsorbed granules were formulated with carriers and polyethylene glycol as adjuvant. The releasing rates of active ingredient from the formulations were evaluated in aqueous medium. The baked bentonite was found most effective carrier to sustain the release of KC-6620. Due to, however, low releasing rate of active ingredient after 20 days, bentonite formulation appeared to be of no practical for the short-term sustained release of KC-6620. The increased pore volume of bentonite granular formulation by adding pyrophyllite increased remarkably the released amount of KC-6620 from bentonite-pyrophyllite(4 : 6) granule up to 85% of total active ingredient incorporated. Addition of polyethylene glycol to the bentonite-pyrophyllite granule further increased the releasing rate of KC-6620. With KC-6620 content in the bentonite-pyrophyllite(4 : 6) granule, the releasing rate of active ingredient was markedly reduced.

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A Study on Anaerobic Release Characteristics of Marine Sediment and Effect of CaO2, an Oxygen Releasing Compound (해양 퇴적물의 혐기적 용출특성과 이에 미치는 산소발생제 CaO2의 영향에 대한 연구)

  • Kwon, Sung-Hyun;Cho, Dae-Chul
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.10
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    • pp.4047-4054
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    • 2010
  • We studied the release characteristics of the marine sediment which could facilitate sea eutrophication through some lab-scale simulation experiments. Environmental indicators such as pH, ORP(oxidation reduction potential), nitrogens, and phosphates were measured in order to calculate the corresponding release rates. $CaO_2$, an oxygen releasing compound was used to determine how it would effect on the natural process of sedimental release. COD, ammonia nitrogen, phosphorous compounds were less released under the oxic environment caused by $CaO_2$. This basic data will help developing methodology for reducing marine eutrophication which may be initiated by the sedimental release.

Enzymatic Degradation and Stabilization of Thyrotropin Releasing Hormone in Various Rabbit Mucosa Extracts (점막 추출액중 치로트로핀 유리호르몬의 효소적 분해 및 안정화)

  • Chun, In-Koo;Shin, Dong-Won
    • Journal of Pharmaceutical Investigation
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    • v.27 no.2
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    • pp.99-108
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    • 1997
  • To evaluate the feasibility of mucosal delivery of thyrotropin releasing hormone (TRH) through various mucosae, enzymatic degradation and stabilization of TRH in the nasal, rectal and duodenal extracts of rabbits were studied. TRH in the extracts was assayed by HPLC and its degradation was found to follow apparent first-order kinetics. The residual concentrations of TRH in the mucosal extracts of nasal, rectal and duodenal segments after 24 hr of incubation were found to be $65.1({\pm}1.1),\;19.7({\pm}2.7)$ and 0%, and in the serosal extracts, $65.6({\pm}5.5),\;75.2({\pm}1.1)$ and $68.7({\pm}1.4)%$, respectively. This result suggests that there is a significant difference in the activity of TRH-degrading enzymes among the sites of administration. The inhibition of TRH degradation in the mucosa extracts was kinetically investigated using various additives such as thimerosal, benzalkonium chloride, disodium edetate, ${\sigma}-phenanthroline$, dithiothreitol and dithioerythritol, and $IC_{50}$ values of inhibitors were calculated. The results obtained showed that thimerosal (0.5 mM) and benzalkonium chloride (0.141 mM) protected TRH from the enzymatic degradation in all the mucosa extracts more than 95% after 24 hr of incubation.

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Conditions for Reintroduction of Captive-Bred Endangered Birds: A Review

  • Kim, Sooil;Park, Heonwoo;Cheong, Seokwan
    • Proceedings of the National Institute of Ecology of the Republic of Korea
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    • v.3 no.3
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    • pp.129-138
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    • 2022
  • Reintroduction programs have been promoted across the world to recover and rehabilitate endangered birds through ex situ captive breeding and releasing to the nature. The ultimate aims of these reintroduction programs are recovery of sustainable populations in natural habitats. To ensure the success of the reintroduction programs, it is necessary to examine the followings in order to increase the success rate of releasing along with the development of captive breeding techniques: 1) Adequate habitat provision, 2) adaptability of captive-bred individuals, 3) survivability of released individuals, and 4) social interest and will. Before releasing captive-bred individuals, it should be reviewed whether there are habitats in which the limiting factor is removed, and assessed their long-term safety. The quantity and quality of the released individuals must be considered to increase the chances for mate selection, maintain genetic diversity, and acquire the ability to adapt to the wild. The release method must be decided in consideration of characteristics of the target habitats and individuals, and rational means such as careful observation, evaluation, and feedback must be provided throughout the release process. For the long-term success of recovery projects, social awareness, sustainable support, and related experts are needed. Satisfying these criteria can help to increase the success rates of reintroduction programs. For the bird reintroduction program in the future, the feasibility of the methods and procedures must be closely reviewed before starting.

Effects of the Slow-releasing Fertilizer and Sowing Date on Waxy Corn "Mibaek 2" Propagated through Double Cropping without Tillage in the Middle Region of Korea

  • Lee, Jae-Wung;Hwang, Se-Gu;Moon, Hye-Rim;Kim, Ik-Jei;Kim, Young-Ho
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.65 no.4
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    • pp.477-484
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    • 2020
  • This study was conducted to investigate the effects of slow-releasing fertilizer and sowing date on waxy corn propagated through double cropping without tillage. "Mibaek 2" was sown for first cropping on March 25th, April 5th, and April 15th, and for second cropping on July 5th, July 15th, and July 25th in 2018-2019. In order to save labor, slow-releasing fertilizer was utilized only one time before sowing. The accumulated temperature from sowing to silking was about 590-700℃. It took 65-77 days when "Mibaek 2" was sown in early April, but the one sown in early July took 42-52 days. In the first cropping, the culm length and ear length caused by the sowing date had no statistical significance, but the kernel set length was the highest at 123 cm in the sowing district on April 5th. The weight of marketable ears was the highest at 100%, in addition to soil testing-based recommended fertilization. Meanwhile, in the second cropping, culm length, ear length, and yield were less compared to the first cropping. The culm length, kernel set length, ear length, and seed set length decreased as sowing date was delayed. The number and yield of marketable ears were the highest at 100%, in addition to soil testing-based recommended fertilization like in the first cropping. It has been found that securing yield by July 15th to finish the second seeding of the crop in the central part of Korea is advantageous. These results of this study will be helpful to farmers for the double cropping of waxy corn cultivation and management.

Molecular characterization of gonadotropin-releasing hormone (GnRH) genes and their role in reproductive system of Pangasius species

  • Amirah Syafiqah Zamri;Fatin Nabilah Sahadan;Zarirah Zulperi;Fadhil Syukri;Yuzine Esa
    • Fisheries and Aquatic Sciences
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    • v.27 no.6
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    • pp.366-378
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    • 2024
  • Application of commercial hormone failed to promote breeding in certain Pangasius species due to the differences of gonadotropin-releasing hormone specific peptide with species-specific bioactivities. Gonadotropin-releasing hormone (GnRH) is a hypothalamic decapeptide in the reproductive system that plays a crucial role in the regulation of reproductive processes. This study was performed to determine and analyse the GnRH genes from commercially important Pangasius sp., Pangasianodon hypophthalmus and Pangasius nasutus. The GnRH1 and GnRH2 genes were amplified and cloned into TOPO vector, followed by phylogenetic analysis of a complete open reading frame (ORF) of GnRH genes. The GnRH1 and GnRH2 genes of P. hypophthalmus and P. nasutus were detected at 300 bp and 360 bp, encoded for 81 and 87 amino acids, respectively. Amino acid sequence identities revealed high homology of P. hypophthalmus and P. nasutus GnRH1 and GnRH2 genes in comparison with other fish and vertebrates. Phylogenetic tree showed that fish from various families were aggregated into a group of the same order due to their highest identity similarities. It revealed that the vertebrate formed clusters and are grouped according to their GnRH decapeptide and GnRH-associated peptide (GAP) region, indicating a close relationship among GnRH decapeptide and GAP in different vertebrate species.

Fabrication of Mineral Coating for Slow-releasing Action and Characteristic (완효성을 위한 광물질 피복의 제조와 용출특성연구)

  • Kim, Byoung-Gon;Lee, Gye-Seung;Park, Chong-Lyuck;Jeon, Ho-Seok;Choi, Jong-Myung;Kim, Lee-Yul
    • Korean Journal of Soil Science and Fertilizer
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    • v.40 no.5
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    • pp.377-382
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    • 2007
  • Porous mineral coating have been fabricated and applied for basic research on their slow release action to a fertilizer. Feldspar was selected as raw mineral for the coating and two different particle sizes of powder were prepared. Slow-release action was estimated by using a potassium sulfate fertilizer. Spherical pellets were prepared with a pan-type pelletizer and then screened into sizes ranging 1.4 to 2.35mm. While the fertilizer pellets were rotated in the pelletizer again, the feldspar powder and 0.5% polyvinyl alcohol solution were simultaneously sprayed on the pellets. The fertilizer pellets coated with feldspar powder were fabricated. The pellets were heated to increase their strength and screened to sort by coating thickness. Potassium releasing tests were conducted for 40 days and the performance for slow-release action was estimated as functions of the heating temperature, coating thickness and raw mineral powder size. The Burst effect caused high initial releasing rate. Releasing kinetics was proportional to concentration of potassium in pellets. The pellet that was fabricated with $27.4{\mu}m$-sized feldspar and heated at $1050^{\circ}C$ showed a releasing rate of 43% on the 40th day.

NMR Studies of Metal-binding Luteinizing Hormone Releasing Hormone

  • Won, Ho-Shik
    • Bulletin of the Korean Chemical Society
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    • v.32 no.11
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    • pp.4021-4026
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    • 2011
  • Functions of the luteinizing hormone releasing hormone (LHRH) and its induced release by divalent metal ions have received great attention because this neurotransmitter subsequently regulates the secretion of luteinizing hormone (LH). Metal-LHRH complexes were synthesized by addition of various Cu(II),Ni(II),Zn(II) ions into LHRH in order to understand how the induced release of LHRH is possible. The degree of complexation was monitored by $^1H$, $^{13}C$-NMR chemical shifts, and final products were identified by Mass spectrometry. Solutionstate structure determination of Zn(II)-LHRH out of metal-complexes was accomplished by using NMR and NMR-based distance geometry (DG). Interproton distance information from nuclear Overhauser effect spectroscopy was utilized for structure determination. Structure obtained in this study has a cyclic conformation exhibiting a specific ${\alpha}$-helical turn with residue numbers His[2]-Leu[7] out of 10 amino acids. Comparison of chemical shifts and EPR studies of Ni(II),Cu(II)-LHRH complexes exhibit that these metal complexes have 4-coordination geometry.

An experimental study on adhesion of concrete form release agent (콘크리트 거푸집 박리제의 부착력에 대한 실험적 연구)

  • Seo, Hyun-Jae;Park, Jong-Pil;Nam, Sun-Hwa;Gong, Min-Ho;Sng, Jae-Young;Oh, Sang-Keun
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2018.11a
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    • pp.77-78
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    • 2018
  • Form-work is a must for construction work. In order to secure the best condition of the form surface and to increase the number of times, the form releasing agent is applied during the process of the form-work. The base oil of the form release agent which has been used already uses the oil which directly or indirectly affects the natural environment and the concrete. In this study, the basic study on the form release agent for concrete was carried out only for the effect of adhesion. The adhesive force of the tile is measured by the mortar to determine the change of the releasing agent and the adhesive strength.

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An Order Releasing Algorithm for a Semiconductor Wafer Manufacturer (주문형반도체 제조회사의 작업하달 논리의 개발)

  • Kim, Ki-Young;Kang, Chang-Ho;Kim, Kap-Hwan
    • IE interfaces
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    • v.19 no.2
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    • pp.97-105
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    • 2006
  • In this paper, based on the process analysis of a semiconductor company, a lot order release procedure (input regulation) is developed for a semiconductor company. The major characteristic of the order release procedure in this paper is to consider the workloads of machines which are obtained from a virtual lot flows by the dispatching rule at machines in the shop of the semiconductor company. The objective is to minimize the cycle time and to obtain other good performances. A simulation is performed in order to evaluate the order release procedure in this paper.