• 대한약침학회지
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• 제25권2호
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• pp.71-78
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• 2022

Objectives: Post-term pregnancy is a condition associated with increased maternal and fetal complications. Administration of castor oil causes cervical stimulation by increasing the production of prostaglandins. We examined the effects of castor oil on cervical ripening and labor induction through a systematic review and meta-analysis. Methods: The search process was performed to obtain relevant articles from databases including Pubmed, Cochrane library, Scopus, Science direct, SID, Iran Medex, and Google Scholar using the English keywords of cervical ripening, post-term, castor oil, labor induction, Bishop score, and pregnancy considering all possible combinations without time constraints and their Persian equivalents from national databases. Results: A total of eight related articles from the 19 primary studies were extracted and systematically reviewed. According to a cumulative chart, the difference in the post-intervention Bishop score was statistically significant (standard mean difference [SMD]: 1.64, 95% confidence interval [CI]: 1.67-2.11, p = 0.001), indicating an effect of castor oil on increasing the Bishop score. In addition, the difference in labor induction was statistically significant after the intervention (odds ratio: 11.67, 95% CI: 3.34-40.81, p = 0.001), indicating an effect of castor oil on increasing the odds ratio of labor induction (experience of vaginal delivery). Conclusion: This meta-analysis showed that oral administration of castor oil is effective for cervical ripening and labor induction. Midwives should closely monitor pregnant women with prolonged labor and collaborate with obstetricians to employ castor oil as a safe intervention to induce cervical ripening and labor to prevent undue caesarean surgery.

• 근관절건강학회지
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• 제30권3호
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• pp.230-241
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• 2023

Purpose: This study aimed to verify the effects of a swallowing training program on swallowing function and depression for nursing home residents with dysphagia after stroke. Methods: This is a quasi-experimental study with non-equivalent control group pre-post test design. The program (oro-facial muscle strengthening exercises, swallowing exercises, expiratory muscle strengthening exercises, and brain stimulation exercises) applied to the experimental group three times per week for eight weeks, 40-45 minutes for each intervention. The final data from 42 people (21 experimental and 21 control) were analyzed by SPSS/WIN 25.0 using descriptive statistics. 𝜒² test, t-test, Wilcoxon rank sum test, and Friedman test. Results: The experimental group was significantly improved than control group in oro-facial muscle strength, swallowing symptoms (Z=-2.22, p=.026), and oral intake function level (Z=-2.00, p=.046). However, there was no significant difference between two groups in depression. Conclusion: This study is meaningful in that it reorganized and mediated a swallowing training program as a safe, non-invasive exercise that nurses can implement in a nursing facility with limited medical personnel and it could be easily followed by older adults.

• International Journal of Oral Biology
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• 제31권2호
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• pp.33-43
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• 2006

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs)on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injected control animals. Field potential recordings were used to monitor amplitude and numbers of population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5 mg/kg; phenytoin 40, 60 mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320 mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

• 대한감각통합치료학회지
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• 제19권1호
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• pp.39-53
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• 2021

목적 : 체계적 문헌고찰을 통해 섭식장애가 있는 아동의 질환에 따른 연하장애를 증상별로 세분화하고 증상에 따른 치료방법을 알아보고자 한다. 연구방법 : 데이터베이스는 PubMed, Medline, CINAHL을 통해 검색하였다. PRISMA, PICOS를 이용하여 연구를 선정하고 체계적 고찰을 시행하였다. 최종적으로 연구에 사용한 문헌은 총 13개로 연구의 질적수준, 질환군, 평가도구, 중재방법, 중재 후 효과에 대해서 분석하였다. 결과 : 총 13편의 연구를 분석한 결과 섭식장애가 있는 아동의 질환군은 자폐스펙트럼장애(Autism Spectrum Disorder; ASD)는 6편(46.15%), 뇌성마비(Cerebral Palsy; CP)는 7편(53.85%)으로 나타났다. 섭식장애 중재를 받은 아동의 연령대는 ASD는 2-8세, CP는 12개월-18세까지로 확인하였다. 평가영역에서 ASD는 행동평가, CP는 구강과 삼킴기능 평가영역이 가장 많았다. 중재방법에서 ASD는 행동수정이 가장 많았고, CP는 구강감각운동, 음식질감조절, 전기자극치료가 각각 동일한 빈도로 적용된 것으로 나타났다. 중재 후 치료효과에서는 모두 효과가 있었다. 결론 : 본 연구에서 섭식장애가 있는 아동의 질환군, 적용되는 평가도구, 중재방법을 고찰을 통해 알아보았다. 본 연구가 질환에 따른 평가와 중재 선택 시 임상가들이 시행착오를 거치지 않고 효율적인 섭식장애 중재를 적용할 수 있는 프로토콜 개발을 하는데 기초자료로 활용될 수 있을 것으로 기대한다.

• Neonatal Medicine
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• 제17권2호
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• pp.193-200
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• 2010

목적: 초극소 저체중 출생아는 경구수유를 진행하는데 여러가지 어려움을 겪어, 경구수유로의 이행이 늦어진다. 본 연구에 서는 초극소 저체중 출생아 중, 수유 시 산소포화도 저하가 발생하는 군과 산소포화도 저하가 없는 군 사이의 특징을 비교하고, 초극소 저체중 출생아의 경구수유 이행 및 입원기간에 미치는 영향에 대해 알아보았다. 또한 초극소 저체중 출생아에서 구강자극요법을 시행하는 경우, 수유 시 산소포화도 저하와 경구수유 능력의 발달, 입원기간에 미치는 효과를 알아보았다. 방법: 제 1상 연구에서는 2003년 10월부터 2009년 1월까지 서울아산병원 신생아 중환자실에 입원한 125명의 초극소 저체중 출생아를 대상으로 차트 분석을 통한 후향적 연구를 실시하여, 수유 시 산소포화도 저하 여부에 따른 특성, 산소포화도 저하가 경구수유 능력 발달 및 입원기간에 미치는 영향에 대해 알아보았다. 제 2상 연구에서는 2009년 3월부터 2010년 5월까지 29명의 초극소 저체중 출생아에게 구강자극요법을 시행하며 전향적으로 자료를 수집하였고, 81명의 초극소 저체중 출생아에서 후향적 코호트 연구를 통해 두 그룹을 비교 분석하였다. 결과: 초극소 저체중 출생아의 72.8%에서 수유 시 산소포화도 저하를 보였고. 그 중 37.4%에서 서맥을 동반하였다. 수유 시산소포화도 저하가 발생하는 시점은 평균 58.2일이었고, 당시 평균 175.4 mL의 수유를 하고 있었으며, 대부분 위관영양과 경구수유를 병행하고 있었지만, 36.3%에서는 위관영양만 시행하고 있었다. 수유 시 산소포화도 저하가 발생한 군은 정상군 보다 출생 시 재태연령이 낮고, 5분 아프가 점수가 낮았으며, 위식도 역류 및 상인두 부조화가 유의하게 많았다. 또한 기관지폐이형성이 있는 초극소 저체중 출생아에서 수유 시 산소포화도의 저하가 발생할 확률은 19배 증가하였다. 수유 시 산소포화도 저하가 있는 군은 경구수유로 완전히 이행하는 시기가 늦었으며, 입원기간도 길었다. 위 결과를 토대로, 초극소 저체중 출생아에서 구강자극요법을 시행하였을 때 대조군에 비해 경구수유 시작시기 및 경구수유로 완전히 이행한 시기가 빨랐으며, 입원기간이 단축되었다. 결론: 초극소 저체중 출생아에서 구강자극요법은 경구수유능력 발달에 긍정적인 효과가 있으며 입원기간을 단축하는데 도움이 된다.

• 한국치위생학회지
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• 제16권3호
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• pp.463-469
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• 2016

Objectives: The purpose of the study is to investigate the effect of chewing gum containing Prunus mume extract(PME) on the change of saliva ingredients. On the basis of the biological background of molecules and diagnostic indices in the use of saliva, the mastication effect of chewing gum containing PME was demonstrated in terms of secretory IgA concentration and total protein concentration in stimulated saliva. Methods: This study is an experimental research on the use of a research design before and after applying a randomized control group. Participants were distributed randomly to the experimental group and the control group, respectively. The experiment group was instructed to masticate the chewing gum containing PME for 10 minutes for one month after each meal within 30 minutes. Salivary secretion was collected by the participants between 8 and 10 a.m in the morning in the research office. For the measurement of secretory IgA and total protein concentrations in the saliva, indirect enzyme-linked immunosorbent assay(ELISA) was used. Results: The salivation stimulation rate was significantly increased after four weeks of masticating chewing gum containing PME after each meal(p<0.001). Mastication of chewing gum containing PME for four weeks decreased the concentration of secretory IgA much more significantly than that after mastication for one week(p=0.003). The concentration of total protein in the saliva was decreased after four weeks in the experimental and control groups. Conclusions: Mastication of chewing gum containing PME stimulated salivary secretion and led to oral disease prevention in patients with xerostomia. Furthermore, it seems to be urgent to seek measures that can be utilized in intervention for patients with xerostomia.