• 약학회지
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• 제44권6호
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• pp.578-587
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• 2000

The purpose of the present study was to design and prepare the optimum formulation for the oral administration of titrated extract of the unsaponifiable fraction of Zea mays L. (ETIZM). For this purpose, we simulated the blood concentration of ETIZM after its oral administration, changing the dissolution rate constants $(0.05{\sim}20\;hr^{-1})$. In vivo parameters, such as absorption rate constant $(k_a)$, elimination rate constant (k) and volume of distribution (Vd), were incorporated in the simulation on the basis of the experiments and literatures. When the dissolution rate constant $(k_r)$ is over $5\;hr^{-1}$, the absorption process appears to be the rate limiting step for the transport of ETIZM from the G.I. ract to the blood circulation. While less than $5\;hr^{-1}$, the dissolution rate considered to be the rate limiting step. Moreover, the optimum blood concentration was shown in the range from 1 to $5\;hr^{-1}$ of $k_r$ in the simulation. To design and prepare the tablets on the basis of the above results, 7 formula containing HPMC, PEG 4000 and PEG 6000 (1-5%, respectively) were prepared and evaluated. The tablets containing PEG 4000 (1%), PEG 6000 (1%) or PEG 4000 (5%) satisfy the optimum $k_r$ range ($1-5\;hr^{-1}$). These formulations, therefore, will be able to show the more effective blood concentration, compared with the commercial products after the oral administration.

• 한국건설관리학회논문집
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• 제6권2호
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• pp.111-119
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• 2005

일반적으로 공동주택의 수명은 50년이지만, 보통 20년이 경과하면 철거되거나 재건축되어 경제적인 낭비를 초래하고 있다. 이에 본 연구는 LCC이론을 기초로 초기투자비와 경과년수에 따른 유지관리비용의 합이 최소가 되는 시점을 추정 $\cdot$ 분석하여 공동주택의 적정 리모델링 시기를 도출함을 목적으로 하였다. 본 연구의 결과를 보면 내용년수 50년까지의 건축물의 생애 총유지관리비용의 합은 초기투자비의약 4.69배가 되고, 공동주택의 적정 리모델링 시기는 할인율 $4.17\%$를 적용했을 경우 30년으로 파악되었으며 서울시에서 발표한 법정허용년수인 40년이 경제수명으로 설정되려면 할인율은 $6.122\%$가 설정되어야 한다. 또한 할인율 변동에 따른 민감도 분석결과 할인율이 감소할 경우 적정 리모델링 시기는 연장되며, 증가할 경우 단축되는 것으로 나타났다. 이에 본 연구의 결과는 공동주택의 철거 또는 재건축 시기를 예측할 수 있으며, 보수 및 대수선의 적절한 시기를 예측하여 공동주택의 수명을 최대한 연장시킬 수 있는 기초자료로 활용될 수 있을 것으로 기대한다.

• Korean Journal of Acupuncture
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• 제27권2호
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• pp.107-120
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• 2010

Objectives : The aim of this study is to measure pulse waveforms by applying 5-level graded pressure, and selecting optimum pulse waveforms. Also to proposing the possibility of using AW(Area of the 1/3 upper height of h1) rate in respect to AT(Total Area) for risk assessment of hypertension or arteriosclerosis is another aim of the study. Methods : Pulse waveforms of normotensive were measured by 5-level graded pressure. The pulse waveforms well reflecting properties of blood vessel(having the largest h1) were selected for optimum pulse waveforms. Various parameters(h-parameter, t-parameter, and others) of optimum pulse waveforms were analyzed. AIx(Augmentation index) was calculated by height-parameters to assess arterial stiffness. The area rate of the 1/3 upper height for h1 in respect to total area was analyzed according to aging. Results : According to aging 1. in height-parameter, h2 and h3 were increased but h5 was decreased. 2. In time-parameter, t2, t3, and t5 were getting short. 3. Area of systolic period was increased, and that of diastolic period decreased. 4. AIx rose by aging. 5. AW was significantly increased despite no changes in AT. Conclusions : By analyzing optimum pulse waveforms of 5-level graded pressure method, we could complement weakness of single graded pressure method. Also, possibility of applying the AW rate to risk assessment of hypertension or arteriosclerosis was confirmed in normotensive population which might not be assessed by AIx.

• 한국농공학회논문집
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• 제62권6호
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• pp.51-62
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• 2020

The objective of this study was to estimate an optimum ecological flow rate in the Banbyeon stream based on the two representative fish species. Hydraulic stream environment was simulated with HEC-RAS for two water flow regimes and used for the PHABSIM hydraulic simulation. A dominant species of Zacco platypus and an endemic species of Squalidus chankaensis tsuchigae were selected as the representative fishes whose habitat conditions were evaluated for the spawning and adult stages. Weighted usable area (WUA) was estimated based on habitat suitability index (HSI) and PHABSIM habitat simulation. Overall deep water zone in the stream demonstrated greater WUA which implies better habitat status. The estimated WUA for Zacco platypus as the dominant species was about five times greater than Squalidus chankaensis tsuchigae at the stream flow of 12 ㎥/s. The optimum ecological flow rates were 15 ㎥/s and 25 ㎥/s for the respective spawning and adult stages of Zacco platypus, while 5 ㎥/s was estimated for both the life cycles of Squalidus chankaensis tsuchigae. Assuming that the dominant species may survive better in wider flow regimes, the optimum ecological flow rate should be determined rater based on the endemic species and flow rate of 5 ㎥/s was suggested for the Banbyeon stream.

• 한국항해학회지
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• 제25권4호
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• pp.461-469
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• 2001

The purpose of this paper is the optimum modification of dynamic characteristics of stiffened plate structure including the number of stiffener. This paper shows the optimum structural modification method by dynamic sensitivity analysis and quasi-least squares method and considers it's validity. In the method of the optimization, finite element method, sensitivity analysis and optimum structural modification method are used. The change of natural frequency and total weight are made to be an objective function. Thickness of plate, the number of stiffener and cross section moment of stiffener become a design variable. The dynamic characteristics of stiffened plate structure is analyzed using finite element method. Next, rate of change of dynamic characteristics by the change of design variable is calculated using the sensitivity analysis. Then, amount of change of design variable is calculated using optimum structural modification method. It is shown that the results are effective in the optimum modification for dynamic characteristics of the stiffened plate structure including the number of stiffener.

• International Journal of Air-Conditioning and Refrigeration
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• 제13권3호
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• pp.145-151
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• 2005

A thermally asymmetric straight rectangular fin is analysed and optimized using the two-dimensional separation of variables method. The optimum heat loss is presented as a function of bottom to top Biot number ratio, fin base length and top Biot number. Decreasing rate of the optimum fin length with the increase of the fin base length is listed. The optimum fin tip length is shown as a function of bottom to top Biot number ratio, fin base length and tip to top Biot number ratio. One of the results shows that the optimum heat loss and the actual optimum fin length decrease while the optimum fin tip length increases as the fin base length increases.

• 한국자동차공학회논문집
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• 제1권2호
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• pp.1-16
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• 1993

It is widely recognized that exhaust emissions, fuel economy and engine torque are affected by engine temperature, and logic would suggest that a cooling system offering a better compromise of engine temperature would improve both overall engine performance and economy. Author measured coolant temperature of some parts and flow rate which are necessary to heat transfer in a engine. And Author determined parameters necessary for the optimum design of a thermostat to keep the best engine performance ; determined the optimum operating temperature of electric cooling fan. A summary of this study is followed. 1. Study of the effects of cooling condition to combustion character in a engine. 2. Analyze of heat transfer surrounding engine cylinders. 3. Study of the effects of cooling character to engine heat rejection, determination of the optimum collant temperature for keeping the optimum engine performance and determination of the optimum design of a thermostat for keeping that temperature.

• 상하수도학회지
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• 제18권3호
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• pp.312-319
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• 2004

The optimum dosage control is presumably the goal of every water treatment plant. However it is difficult to determine the dosage rate of coagulant, due to nonlinearity, multivariables and slow response characteristics, etc. To deal with this difficulty, the real number genetic-fuzzy system was used in determining the dosage rate of the coagulant. The genetic algorithms are excellently robust in complex optimization problems. Since it uses randomized operators and searches for the best chromosome without auxiliary informations from a population which consists of codings of parameter set. To apply this algorithms, we made the real number rule table and membership function from the actual operation data of the water treatment plant. We determined optimum dosages of coagulant(LAS) using the fuzzy operation and compared them with the dosage rate of the actual operation data.

• Plant Resources
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• 제7권3호
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• pp.181-186
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• 2004

To find out the optimum fertilizer level for high yielding variety, Paldanghomil, experiment was conducted with 15 compositions of fertilizer levels at the experiment field of forage rye in Sunchon National University from Sep. 1998 to Aug. 1999. The effects of nitrogen fertilizer on plant growth were large significant but increasing rate of application in potassium and phosphate fertilizers above 10kg/10a had negligible effects on plant growth. Raising nitrogen application rate of fertilizers turned out to be 18-10-10kg/l0a of N-P$_2$O$_{5}$-K$_2$O. Content of crude protein was the highest and that of crude fiber such as NDF, ADF, cellulose and lignin were lowest at this rate. Furthermore, IVDMD was high and dry matter yield were the highest at the optimum rate.e.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1994년도 춘계학술대회 논문집
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• pp.30-33
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• 1994

This paper studies on the effect of DSC(Differential Scanning Calorimeter) analysis condition on the glass transition temperature of silica filled epoxy network polymer used for ultra-high voltage apparatus. The effects of temperature scanning rate specimen size and gas flow rate on measured glass transition temperature have been studied in order to select optimum thermal analysis condition.