• Title/Summary/Keyword: Optimum Dosage

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The study of analysis of mutagen in drinking water (음용수 중 변이원성 물질(MX)에 관한 연구)

  • Yoo, Eun-Ah;Won, Jung-In
    • Analytical Science and Technology
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    • v.19 no.4
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    • pp.290-300
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    • 2006
  • Disinfection by-products(DBPs), such as volatile trihalomethanes and the nonvolatile organochlorine acids, created by chlorination have been extensively studied. However MX which contributes 20-50% of the mutagenic activity in drinking water began to people's attention since 1990. Its chemical name is 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone. According to WHO guidelines its concentration should be controlled, but its value has not been set up. Due to analytical difficulties in measuring this compound at such a low concentrations and lack of information on toxicity to human. Because concentration (ng/L) of MX in drinking water is low traditional testing methods are ineffective. Therefore this study compared LLE and SPE and have chosen SPE to improve preconcentration. MX has been identified in chlorinated drinking water samples in several countries but not in korea Therefore this study analyzed concentration of MX in different water sources and in spring water. This study examined the causes of changing MX content. Chlorine dosage, seasons, water temperature and distance from the source was all discoverd to be relavant. MX was analyzed in various treatment to find optimum disinfection methods. The outcome was that the concentration of MX was minimized when using biological activated carbon-O3 and granular activated carbon.

Gamma-ray Irradiation on Radio Sensitivity in Yacon (Samallanthus sonchifolius (Poepp. & Endl.) H. Robinson) Breeding (돌연변이 육종을 위한 야콘의 최적 감마선 조사량)

  • Su Jeong Kim;Hwang Bae Sohn;Yul Ho Kim;Jung Hwan Nam;Jong Nam Lee;Dong Chil Chang;Jong Taek Suh
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2021.04a
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    • pp.27-27
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    • 2021
  • Yacon [Samallanthus sonchifolius (Poepp. & Endl.) H. Robinson], a member of Compositae plants, has sweet taste and crisp texture. Unlike other Andean root crops such as potato and sweet potato, the cultivation area of yacon has increased recently, since it is known to have large content of fructooligosaccharides (FOS). Since there are no yacon varieties bred in Korea, we have been trying to create new genetic resources using gamma-ray. The optimal gamma-ray dosage for mutation breeding in yacon was investigated. Crown bud and green bud of yacon were exposed to doses of gamma rays from 20 Gy to 80 Gy, and subsequently planted in a greenhouse. After 50 days of sowing, the survival rates and growth decreased rapidly at doses above 40 Gy, while all of crown bud individuals died above 60 Gy. The median lethal dose (LD50) of crown bud and green bud was 22.4 and 36.6 Gy, and the median reduction doses (RD50) for plant height, fresh weights, and tuberous root weight were 20-40 Gy, respectively. A dose of 20-40 Gy was found to be optimal for mutation breeding in yacon. Considering the growth factors, the optimum doses were determined to be within the range of 20-40 Gy for the selection of useful mutant lines. M2-M3 mutant lines were obtained from 20-60 Gy gamma-ray-irradiated M1 plants through clonal propagation. These mutant lines will be used for the development of a new variety of yacon plant with high FOS and no crack tuberous root.

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Fertility and Rate of Fertilizer Application for Orchard Soils of Apple and Pear (사과 및 배 과수토양(果樹土壤)의 비옥도구분(肥沃度區分)에 의한 시비기준(施肥基準) 설정(設定))

  • Lee, Choon-Soo;Lee, Ju-Young;Lee, Yong-Jae;Shin, Jae-Sung;Han, Ki-Hak;Kim, Dong-Soo
    • Korean Journal of Soil Science and Fertilizer
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    • v.26 no.2
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    • pp.103-110
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    • 1993
  • This study was made to evaluate the chemical properties of 481 farmers' orchard fields in An-Seong area. And the reasonable ferilizer rates were recommended utilizing the result of soil analysis. The results are summarized as follows : 1. As the soil fertility status of collected soil samples were evaluated on the basis of temporary optimal range for each soil chemical properties, 12.7 to 49.6% of the total 481 farmers' fields were range for soil improvement. 2. The contents of chemical component have a tendancy to decrease with depth gradually from surface to subsoil. 3. According to the relationship between the contents of soil component in subsoil and those in surface soil, the fertility condition of subsoil could be estimated on the basis of analysis data of surface soil. 4. The multiple regression equation for pear yield prediction to the organic matter and exchangable calcium contents in the soil were obtained. 5. Referring the average value, distribution ratio compared to the optimum level for each soil chemical properties and standard fertilizer rate, the soil fertility status could be categorized as "High" "Medium" and "Low". For each category, the recommended amounts for NPK and organic matter application were established. 6. The recommended rates through soul fertility diagnosis were less than farmer's dosage in the range 7.1~7.7 kg/10a for N, 0.8~11.5 kg/10a for $P_2O_5$, 7.1~19.9 kg/10a for $K_2O$ and 90~116 kg/10a for lime.

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Study on Tumor Control Probability and Normal Tissue Complication Probability in 3D Conformal Radiotherapy (방사선 입체조형치료에 대한 종양치유확율과 정상조직손상확율에 관한 연구)

  • 추성실
    • Progress in Medical Physics
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    • v.9 no.4
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    • pp.227-245
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    • 1998
  • A most appropriate model of 3-D conformal radiotherapy has been induced by clinical evaluation and animal study, and therapeutic gains were evaluated by numerical equation of tumor control probability(TCP) and normal tissue complication probability (NTCP). The radiation dose to the tumor and the adjacent normal organs was accurately evaluated and compared using the dose volume histogram(DVH). The TCP and NTCP was derived from the distribution of given dosage and irradiated volume, and these numbers were used as the biological index for the assessment of the treatment effects. Ten patients with liver disease have been evaluated and 3 dogs were sacrificed for this study. Based on the 3-D images of the tumor and adjacent organs, the optimum radiation dose and the projection direction which could maximize the radiation effect while minimizing the effects to the adjacent organs could be decided. 3). The most effective collimation for the normal adjacent organs was made through the beams eye view with the use of multileaf collimator. When the dose was increased from 50Gy to 70Gy, the TCP for the conventional 2-port radiation and the 5-port multidimensional therapy was 0.982 and 0.995 respectively, while the NTCP was 0.725 and 0.142 respectively, suggesting that the 3-D conformal radiotherapy might be the appropriate therapy to apply sufficient radiation dose to the tumor while minimizing the damages to the normal areas of the liver. Positive correlation was observed between the NTCP and the actual complication of the normal liver in the animal study. The present study suggest that the use of 3-D conformal radiotherapy and the application of the mathematical models of TCP and NTCP may provide the improvements in the treatment of hepatoma with enhanced results.

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Studies on Properties of Superplasticized Fly Ash Concrete (고류동화제(高流動化劑)를 사용한 플라이애쉬 콘크리트의 제성질(諸性質)에 관한 연구(硏究))

  • Kim, Seong Wan;Sung, Chan Yong;Cho, Il Ho
    • Korean Journal of Agricultural Science
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    • v.16 no.2
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    • pp.212-224
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    • 1989
  • This paper reports results of an investigation to determine properties of superplasticizered fly ash concrete. The mixture proportions of fly ash were 0, 10, 20 and 30%, by weight of cement, and superplasticizer was added as a percentage of fly ash, 0, 0.6, 12 and 1.8%. To investigate the effective use of the superplasticized fly ash concrete, the basic data were analyzed. The results obtained were summarized as follows : 1. The unit water content was decreased by 1%, 6% and increased by 2% to the ratio of addition of fly ash 10%, 20%, 30%, respectively, but in case of the superplasticized fly ash concrete, it was decreased by 3~16%, 4~14% and 10~17%, at 0.6, 12, and 1.8% dosage of superplasticizer, respectively. 2. In the properties of the fresh fly ash concrete, the slump loss was reduced with the ratio of replacement of fly ash increased, and with times went by. When using superplasticizer in fly ash substituting concrete, the fludity in the concrete was not decreased. 3. The compressive strength of fly ash concrete at early ages was lower than that of ordinary concrete. At the later age of 28 days, the compressive strength with 20% addition of fly ash was increased than that of ordinary concrete. In cased of 10%, 30% addition of fly ash, the compressive strength were reduced. From this, it was proved that the optimum amount of fly ash appears to be about 20%. The compressive strength at all ages of superplasticized fly ash concrete was significantly higher than that of fly ash concrete, with increasing fly ash content. 4. In case of the tensile strength, the effects of the increasing strength with the ages were similar to those of the compressive strtength, and at the later ages was seen a decreasing tendency of strengths. 5. The correlation between compressive and tensile strength of superplasticized fly ash concrete was highly significant. The multiple regression equations of compressive and tensile strength were obtained on a function of the mixture proportion of fly ash and the addition of superplasticizer. The relation between compressive and tensile strength is higher than for ordinary concrete. The strength ratio is 7~11, and it is higher than that of ordinary concrete, 8~10. 6. Bulk density was decreased by 1~3% compared with ordinary concrete with the mixture proportion of fly ash increased, 10~30%, and decreased by 1~2% with the superplasticizer added 0.6~1.8%.

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