• Journal of mucopolysaccharidosis and rare diseases
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• v.3 no.1
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• pp.14-19
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• 2017

Lysosomal storage diseases (LSDs) are a group of rare inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes and subsequent accumulation of substrates. Enzyme deficiency leads to progressive intra-lysosomal accumulation of the incompletely degraded substances, which cause dysfunction and destruction of the cell and eventually multiple organ damage. Patients have a broad spectrum of clinical phenotypes which are generally not specific for some LSDs, leading to missed or delayed diagnosis. Due to the availability of treatment including enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation for some LSDs, early diagnosis is important. ERT products have been approved with optimal outcomes for some LSDs in the recent decades, including Gaucher, Fabry, mucopolysaccharidosis (MPS) I, Pompe, MPS VI, MPS II, and MPS IVA diseases. ERT can stabilize the clinical condition, prevent disease progression, and improve the long-term outcome of these diseases, especially if started prior to irreversible organ damage. Based on the availability of therapy and suitable screening methods in the recent years, some LSDs, including Pompe, Fabry, Gaucher, MPS I, MPS II, and MPS VI diseases have been incorporated into nationwide newborn screening panels in Taiwan.

• Korean Journal of Computational Design and Engineering
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• v.13 no.1
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• pp.58-66
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• 2008

The artificial discs have recently used to preserve the motion of the treated segment in lumbar spine surgery. However, there have been lack of biomechanical information of the artificial discs to explain current clinical controversies such as long-term results of implant wear and excessive facet contact forces. In this study, we investigated the biomechanical effects of three artificial implants on the lumbar spinal segments by finite element analysis. The finite element model of intact lumbar spine(L1-S) was developed and the three implants were inserted in L4-L5 segment of the spine model. 5 Nm of flexion and extension moments were applied on the superior plate of L1 with 400 N of compressive load. Excessive motions and high facet contact forces at the surgical level were generated in the all three implanted models. In the flexion, the peak von-Mises stresses in the semi-constrained type implant was higher than those in the un-constrained type implant which would cause wear on the polyethylene core. The results of the study would provide a biomechanical guideline for selecting optimal surgical approach or evaluating the current design of the implants, or developing a new implant.

• Journal of the Korean Society of Food Culture
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• v.32 no.1
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• pp.58-65
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• 2017

This study was conducted to optimize the conditions of a sweet rice paste as a replacement of red bean paste recipe using the central composite design of response surface methodology (RSM). Ten experimental recipes with two reference points (rice flour and sugar), were selected, and the physical and sensory characteristics of a sweet rice paste were measured. In the Rapid Visco Analyzer test, breakdown value was the highest in rice flour (105.73 RVU). Sweetness significantly increased with addition of sugar contents (p<0.0002) and viscosity increased with addition of rice flour contents (p<0.0185). Moisture contents decreased with increasing contents of rice flour and sugar, whereas yellowness and redness tend to increase. In the sensory evaluation test, quadratic models for color (p<0.01865), sweetness (p<0.0399), thickness (p<0.0073), and overall acceptability (p<0.0249) were approved as independent for the rice flour and sugar contents. In conclusion, the optimal mixing ratio of sweet rice paste was determined to be 45.38 g of rice flour and 77.95 g of sugar.

• International Journal of Concrete Structures and Materials
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• v.11 no.2
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• pp.391-401
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• 2017

In this study, the effects of water-to-binder (W/B) ratio and replacement ratio of blast furnace slag (BFS) on the compressive strength of concrete were first investigated to determine an optimized mixture. Then, using the optimized high-strength concrete (HSC) mixture, hooked steel fibers with various aspect ratios and volume fractions were used as additives and the resulting mechanical properties under compression and flexure were evaluated. Test results indicated that replacement ratios of BFS from 50 to 60% were optimal in maximizing the compressive strength of steam-cured HSCs with various W/B ratios. The use of hooked steel fibers with the aspect ratio of 80 led to better mechanical performance under both compression and flexure than those with the aspect ratio of 65. By increasing the fiber aspect ratio from 65 to 80, the hooked steel fiber volume content could be reduced by 0.25% without any significant deterioration of energy absorption capacity. Lastly, complete material models of steel-fiber-reinforced HSCs were proposed for structural design from Lee's model and the RILEM TC 162-TDF recommendations.

• Computers and Concrete
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• v.13 no.4
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• pp.423-436
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• 2014

Ground Granulated Blast Furnace Slag (GGBFS) is widely used as an effective partial cement replacement material. GGBFS inclusion has already been proven to improve several performance characteristics of concrete. GGBFS provides enhanced durability, including high resistance to chloride penetration and protection against alkali silica reaction. In this paper results of an experimental research work on influence of low-reactivity GGBFS (which is largely available in Iran) on the properties of mortars and concretes are reported. In the first stage, influence of GGBFS replacement level and fineness on the compressive strength of mortars was investigated using Taguchi method. The analysis of mean (ANOM) statistical approach was also adopted to develop the optimal conditions. Next, based on the obtained results, concrete mixtures were designed and water penetration, capillary absorption, surface resistivity, and compressive strength tests were carried out on highstrength concrete specimens at different ages up to 90 days. The results indicated that 7-day compressive strength is adversely affected by GGBFS inclusion, while the negative effect is less evident at later ages. Also, it was inferred that use of low-reactivity GGBFS (at moderate levels such as 20% and 30%) can enhance the impermeability of high-strength concrete since 28 days age.

• International Journal of Computer Science & Network Security
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• v.24 no.3
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• pp.12-22
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• 2024

The travelling salesman problem is very famous and very difficult combinatorial optimization problem that has several applications in operations research, computer science and industrial engineering. As the problem is difficult, finding its optimal solution is computationally very difficult. Thus, several researchers have developed heuristic/metaheuristic algorithms for finding heuristic solutions to the problem instances. In this present study, a new hybrid genetic algorithm (HGA) is suggested to find heuristic solution to the problem. In our HGA we used comprehensive sequential constructive crossover, adaptive mutation, 2-opt search and a new local search algorithm along with a replacement method, then executed our HGA on some standard TSPLIB problem instances, and finally, we compared our HGA with simple genetic algorithm and an existing state-of-the-art method. The experimental studies show the effectiveness of our proposed HGA for the problem.

• Computers and Concrete
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• v.11 no.2
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• pp.93-104
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• 2013

The use of rock wool waste, an industrial by-product, in cement-based composites has positive effects on the environment because it reduces the problems associated rock wool disposal. The experiments in this study tested cement-based composites using various rock wool waste contents (10, 20, 30 and 40% by weight of cement) as a partial replacement for Portland cement in mortars. The pozzolanic strength activity test, flow test, compressive strength test, dry shrinkage test, absorption test, initial surface absorption test and scanning electron microscope observations were conducted to evaluate the properties of cement-based composites. Test results demonstrate that the pozzolanic strength activity index for rock wool waste specimens is 103% after 91 days. The inclusion of rock wool waste in cement-based composites decreases its dry shrinkage and initial surface absorption, and increases its compressive strength. These improved properties are the result of the dense structure achieved by the filling effect and pozzolanic reactions of the rock wool waste. The addition of 30% and 10% rock wool wastes to cement is the optimal amount based on the results of compressive strength and initial surface absorption for a w/cm of 0.35 and 0.55, respectively. Therefore, it is feasible to utilize rock wool waste as a partial replacement of cement in cement-based composites.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.1
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• pp.71-78
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• 2015

This paper presents a method for analyzing the size and economic sensitivity of a new renewable hybrid generation system according to changes in the component replacement costs based on HOMER (Hybrid Optimization Model for Electric Renewables). The design of a hybrid system can be optimized by reducing the size of a sensitive component based on sensitivity analysis using the change in cost of a component. Sensitivity analysis can also provide information on what combinations are necessary for the optimal hybrid system. As an example, sensitivity analysis was performed on the residential load provided by HOMER, and the effects of component replacement costs on the system size and cost were quantitatively analyzed.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.6
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• pp.781-787
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• 2010

Forecasting possible failure characteristics is very important in maintenance planning because it helps in predicting any future failures and determining the optimum replacement interval. This paper examines the time.to-failure distribution of the transfer gearbox of a J79 engine by using a probability plotting technique which is one of the most convenient techniques for reliability analysis. Various probability distributions are evaluated for determining the suitable probability distribution of the failure data of the transfer gearbox, and the resulting correlation coefficient indicates that failure data have a lognormal distribution. The expected number of unscheduled maintenance actions and the optimum replacement interval for various values of cost ratios are determined.

• Journal of Chest Surgery
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• v.38 no.7 s.252
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• pp.507-509
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• 2005

Open heart surgery via right thoracotomy can be accomplished in atrial septal defects, and mitral valve diseases. Recently, thoracoscopic atrial septal defect closure, mitral valve repair, Maze operation, and minimal invasive direct coronary artery bypass (MIDCAB) are accomplished with AESOP 3000. However, there is no report of thoracoscopic aortic valve replacement in Korea. We report a successful thoracospic aortic valve replacement assisted with AESOP 3000 in a 31-year-old female patient.