• 한국양식학회지
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• 제22권1호
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• pp.56-62
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• 2009

Effects of Korean mistletoe extracts (KM-110), Viscum album coloratum on the specific and non-specific immune responses of Japanese eel Anguilla japonica were examined. The optimal concentration not showing toxicity of KM-110 was determined to $30-40{\mu}g/ml$ in vitro and $100{\mu}g$/100 g of fish in vivo. Even $1000{\mu}g$ of KM-110/100 g of fish did not show any clinical problem in fish though the levels of toxic parameters were slightly increased. In terms of antibody production, KM-110 significantly elicited more antibody production than FCA or $\beta$-glucan. $\beta$-glucan plus KM-110 group synergistically enhanced antibody production. There was no significant difference between KM-110 and KM-110 plus $\beta$-glucan group. The ROI production by head kidney (HK) leucocytes of eel injected with 500 or $1000{\mu}g$ KM-110 was significantly (P<0.05) enhanced than the control and FCA-treated group. Maximum increase in the NBT reduction value was observed in $1000{\mu}g$ KM-110 group but no significant difference was found between 500 and $1000{\mu}g$ KM group. The level of serum lysozyme activity was significantly (P<0.05) higher in the 500 and $1000{\mu}g$ KM-110- or FCA-treated group than in the control and $200{\mu}g$ KM-110 group. The phagocytic activities of HK leucocytes isolated from eel injected with 500 and $1000{\mu}g$ KM-110 were significantly (P<0.05) higher than $200{\mu}g$ KM-110 and PBS-injected control group. Korean mistletoe appeared to be a good activator of the specific and non-specific immune responses of Japanese eel.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2018년도 추계학술대회
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• pp.373-376
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• 2018

기존의 파프리카 스마트팜 시스템의 경우 여러 센서 값을 기준 값에 추종하도록 설정 되어 있기 때문에 다른 외란의 값이 들어오면 시스템이 최적의 판단을 하지 못하는 경우가 많아 파프리카 생장에 유해한 경우가 발생한다. 이를 의사결정 나무 기법을 활용하여 파프리카 스마트팜용 전문가 시스템을 설계하여 주변 환경에 따라 달라지는 요소들에 의해 생성되는 데이터를 사용하여 농민의 경험치와 유사한 의사결정 구조를 가진 제어 알고리즘을 구축한다. 현재의 스마트팜 제어시스템의 경우 농민이 설정해둔 기준 값에 센서 값들을 추종하도록 시스템화 되어 있기 때문에 주변 환경의 외란에 대한 사용자의 개입이 필수적이다. 파프리카 스마트팜 장비를 제어하기 전 여러 환경 요소 중 가장 영향력을 미치는 것을 선정한 후 농민들의 경험치와 표준 의사결정 기준이 반영된 복합 환경제어를 위한 전문가 시스템을 모델링하였다. 설계된 모델은 내외부 환경 데이터에 의해 학습된 의사결정트리 기반의 파프리카용 전문가시스템으로 서, 사용자의 간섭을 최소화한 제어기를 설계할 수 있도록 지원한다. 이번 연구를 통해 여러 데이터를 복합 시키면서 각 환경 요소들이 상호관계를 갖고 있으며, 나아가 여러 주변 환경 요소들이 생장에 영향을 미치고 있기에 전문가용 파프리카 스마트팜을 만들 때 표준이 될 수 있는 제어 알고리즘이 될 것으로 기대한다.

• 한국전문물리치료학회지
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• 제12권2호
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• pp.1-10
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• 2005

Pressure ulcers are serious complications of tissue damage that can develop in patients with diminished pain sensation and diminished mobility. Pressure ulcers can result in irreversible tissue damage caused by ischemia resulting from external loading. There are many intrinsic and extrinsic contributors to the problem, including interface tissue pressure, shear, temperature, moisture, hygiene, nutrition, tissue tolerance, sensory and motor dysfunction, disease and infection, posture, and body support systems. The purposes of this study were to investigate the relationship between buttock interface pressure and seating position, wheelchair propulsion speed. Seated-interface pressure was measured using the Force Sensing Array pressure mapping system. Twenty subjects propelled wheelchair handrim on a motor-driven treadmill at different velocities (40, 60, 80 m/min) and seating position used recline ($100^{\circ}$, $110^{\circ}$, $120^{\circ}$) with a wheelchair simulator. Interface pressure consists of average (mean of the pressure sensor values) and maximum pressure (highest individual sensor value). The results of this study were as follows; No significant correlation in maximum/average pressure was found between a static position and a 40 m/min wheelchair propulsion (p>.05). However, a significant increase in maximum/average pressure were identified between conditions of a static position and 60 m/min, and 80 m/min wheelchair propulsion (p<.05). No significant correlation in maximum pressure were found between a $90^{\circ}$ recline (neutral position) and a $100^{\circ}$, $110^{\circ}$, or $120^{\circ}$ recline of the wheelchair back (p>.05). No significant difference in average pressure was found between conditions of a $90^{\circ}$ recline and both a $100^{\circ}$ and $110^{\circ}$ recline of wheelchair back. However, a significant reduction in average pressure was identified between conditions of a $90^{\circ}$ and $120^{\circ}$ recline of wheelchair back (p<.05). This study has shown some interesting results that reclining the seat by $120^{\circ}$ reduced average interface pressure, including the reduction or prevention in edema. And interface pressure was greater during dynamic wheelchair propulsion compared with static seating. Therefore, the optimal seating position and seating system ought to provide postural control and pressure relief. We need an education on optimal seating position and a suitable propulsion speeds for wheelchair users.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.93-102
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• 2018

본 논문은 뇌격전류에 따른 저압 배전계통의 전자식 전력량계 및 배전 패널의 통신설비와 전원장치를 보호할 목적으로 사용하는 서지보호장치(SPD)에 관한 것이다. 서지보호장치(SPD)는 접속방식에 따라 1-포트 서지보호장치(SPD)와 감결합 요소를 포함한 2-포트 서지보호장치(SPD)로 구분된다. 뇌격전류에 대한 내부 시스템의 보호는 협조된 서지 보호체계를 이루는 계통적인 접근이 필요하다. 이에 대응하기 위해 이론적인 검토를 통해 피뢰구역(LPZ) 정의에 대한 고찰 및 해석을 진행하였다. 뇌서지에 의한 뇌격전류는 상당히 크기 때문에 하나의 서지보호장치(SPD)로 방호하기에는 한계가 발생하며, 이를 해결하기 위해 다단의 종속적으로 서지보호장치(SPD)를 설치하게 된다. 본 논문에서는 전력계통에 있어 한전계통에 연계되는 Incoming side가 아닌 건물 내에 설치되는 분기형 배전패널 내부의 전자식 전력량계 및 각종 통신(제어)설비를 보호할 목적으로 한전계통이 연계되는 MOF 단에 설치되는 LPZ0에 해당하는 피뢰기(LA, SA)와 보호협조를 이루는 LPZ1과 LPZ2의 경계영역에 설치하는 저압 배전계통용 II등급 서지보호장치(SPD)에 대해 설계를 하였다. 또한 감결합 요소가 없고, 부하 전류를 흘릴 수 있는 직렬 접속 방식의 1-포트 서지보호장치(SPD)에 대한 최적의 설계 방안을 도출하고 실험을 통해 기존의 방식과 비교하여 성능 개선과 관련한 검증을 실시하였다.

• 한국전산구조공학회논문집
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• 제27권5호
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• pp.337-343
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• 2014

본 논문에서는 재생 커널 기법을 사용하여 혼합모드 균열진전 문제에 대한 연속체 기반의 형상 설계민감도 해석을 수행하였다. 재생 커널 기법은 기존의 유한요소법과 달리 요소망을 재구성할 필요가 없어, 커널 함수의 연속성을 증가시켰을 때 높은 정밀도의 형상함수를 얻을 수 있다는 장점을 가지고 있다. 균열선단 주변에서 J-적분을 수행하기 위해 선형탄성 조건이 고려되었다. 변위장과 응력 확대 계수의 설계변수에 대한 감도해석을 위하여 물질도함수를 도입하였으며 직접 미분법보다 효율적인 애조인 방법을 사용하여 설계민감도를 유도하였다. 수치 예제들을 통해서 재생 커널 기법을 이용한 균열진전 해석결과의 타당성을 확인하였으며 애조인 방법을 이용한 형상 설계민감도 해석 결과를 유한차분법과 비교하여 매우 정확하고 효율적인 결과를 얻을 수 있음을 알 수 있었다. 이를 바탕으로 간단한 모델에 대하여 형상 최적설계를 수행하여 균열이 발생될 수 있는 구조물에 대해서 균열에 의한 피해를 최소화할 수 있도록 균열을 제어할 수 있는 최적의 형상을 도출하였다.

• 한국환경농학회:학술대회논문집
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• 한국환경농학회 2009년도 정기총회 및 국제심포지엄
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• pp.3-18
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• 2009

It is difficult for consumers to satisfy high safety request with post-management method such as inspection and surveillance, as various changes in-and-out of the country associated with food safety. In terms of food safety problems related to foods, it is crucial to recognize public health and consumer protection and construct pre-preventive Food Control System. A joint committee, FAO/WHO made the following consultations to the National Food Safety System. ${\circ}$ Approach entirely from farm to table ${\circ}$ Get ready for Risk Analysis System ${\circ}$ Secure transparency ${\circ}$ Establish the optimal policy by evaluating the effect of regulation When it comes to summarizing the consultation, it would be accumulated as two key words; "Efficiency" and "Credibility". Whereas the problem of efficiency focuses on precaution rather than post-management, it requires policy option to maximize consumer's benefit by evaluating the cost for the Food Safety Management and its benefit. Also, analyzing risk's character and amount, demanding an optimal means, and introducing scientific analysis system put much value on the stakeholder's communications are procedure's security which can satisfy both "Efficiency" and "Credibility" simultaneously. Especially, it is emphasized here that Risk Assessment need to be separated from Risk Management. This action is a valid means of credibility security throughout improving transparency. A number of nations and organizations have reformed the method of food management passing through reflection and examination of the prior National Food Safety Management since BSE occurred in Britain, 1996. FSA; Food Standard Agency, AFFSA, EFSA, BfR, and FSC are Risk Assessment Organization functionally separated from Risk Management Organization, JECFA, JMCFA, JMPR, JEMRA in Codex charge Risk Assessment internationally. In case of advanced countries excluding several those such as The U.S. and so forth, though these Risk Assessment Organizations are either separated functionally within Risk Management Organization or operated as apart organ, common factors are in which it has independence as Science Base. While securing independence of Risk Assessment Function, it is a tendency Risk Management should be functionally unified into efficiency as well. Though Germany constructs integral Risk Management System of diverse ways according to social and political conditions of each country such as GFOCP, DVFA, SNFA, CFIS and AQIS, there is a key word in the center, "Securing efficiency of Food Safety Management". However our nation has a representative plural；diversified system with The U.S., we took a step forward for unification as empowering policy's generalization；adjustment and Risk Assessment Function by means of enacting the "Food Safety Fundamental Law" in 2008 and establishing the "Food Safety Policy Commission" with private and governmental sectors in the Prime Minister's office. Even though the unification of Risk Management hereby increased, there is the lack of strengthening function of Risk Assessment and securing independence. It needs to be required for the professional committee in Food Safety Policy Commission to develop as a exclusive office of Risk Assessment by separating from a policy decision. Administrative Branches should reinforce feeble functions such as fundamental investigation；research for carrying out Risk Assessment with securing efficiency throughout reassessment of prior Risk Management Means.

• International Journal of Advanced Culture Technology
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• 제5권1호
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• pp.58-63
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• 2017

Emergencies and disasters can happen any time without any warning, and things can change and escalate very quickly, and often it is swift and decisive actions that make all the difference. It is a responsibility of the building facility management to ensure that a proven evacuation plan in place to cover various worst scenario to handled automatically inside the facility. To mapping out optimal safe escape routes is a straightforward undertaking, but does not necessarily guarantee residents the highest level of protection. The emergency evacuation navigation approach is a state-of-the-art that designed to evacuate human livings during an emergencies based on real-time decisions using live sensory data with pre-defined optimum path finding algorithm. The poor decision on causalities and guidance may apparently end the evacuation process and cannot then be remedied. This paper propose a cloud connected emergency evacuation system model to react dynamically to changes in the environment in emergency for safest emergency evacuation using IoT based emergency exit sign system. In the previous researches shows that the performance of optimal routing algorithms for evacuation purposes are more sensitive to the initial distribution of evacuees, the occupancy levels, and the type and level of emergency situations. The heuristic-based evacuees routing algorithms have a problem with the choice of certain parameters which causes evacuation process in real-time. Therefore, this paper proposes an evacuee routing algorithm that optimizes evacuation by making using high computational power of cloud servers. The proposed algorithm is evaluated via a cloud-based simulator with different "simulated casualties" are then re-routed using a Dijkstra's algorithm to obtain new safe emergency evacuation paths against guiding evacuees with a predetermined routing algorithm for them to emergency exits. The performance of proposed approach can be iterated as long as corrective action is still possible and give safe evacuation paths and dynamically configure the emergency exit signs to react for real-time instantaneous safe evacuation guidance.

• 한국식품영양과학회지
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• 제42권7호
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• pp.1125-1132
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• 2013

종균용 김치를 제조를 하기 위해서는 김치 공장에서 저가로 종균이 대량배양 되어야 한다. 그러나 현재의 유산균배지는 종균 생산용으로 사용하기에는 비용이 많이 든다. 이를 해결하기 위해서는 새로운 배지를 개발해야 하는데 새로운 배지를 개발하기 위한 기본적인 요소에는 배추 추출액, 탄소원, 질소원, 무기염류가 있다. 선정된 최적배지 조성은 배추 추출액 잎 30%, maltose 2%, yeast extract 0.25%, $2{\times}$ salt stock(2% sodium acetate trihydrate, 0.8% disodium hydrogen phosphate, 0.8% sodium citrate, 0.8% ammonium sulfate, 0.04% magnesium sulfate, 0.02% manganese sulfate)으로 나타났다. 그리고 새롭게 개발된 배지의 이름은 MFL로 명명하였다. Leuconostoc(Leuc.) citreum GR1을 $30^{\circ}C$에서 24시간 배양하면 MRS 배지에서는 $3.41{\times}10^9$ CFU/mL, MFL 배지에서는 $7.49{\times}10^9$ CFU/mL의 생균수로 MFL 배지에서 배양하면 MRS 배지에서 배양했을 때보다 2.2배 더 높은 성장을 보였다. 또한 최적화 배지의 scale-up을 위해 5 L 발효조를 이용하여 2 L의 working volume으로 Leuc. citreum GR1을 배양하였다. 교반속도는 50 rpm에서 생균수 $8.60{\times}10^9$ CFU/mL를 얻었다. 발효조의 pH 조절은 pH-stat mode로 하였으며, 균체 성장의 최적 pH는 수산화나트륨 수용액을 이용한 pH 6.8이었고, 이 조건으로 20시간 배양 후 $11.42{\times}10^9(1.14{\times}10^{10})$ CFU/mL의 균체를 얻을 수 있었다. 이는 MRS 배지로 사용하여 얻은 생균수의 3.34배에 해당하는 높은 값으로, 본 연구에서 개발된 MFL 배지는 김치 종균용 Leuc. citreum GR1 배양을 위한 배지로 배지 단가 절감, 높은 균체 수율 등 충분한 경제적 장점을 기대할 수 있다.

• 정보처리학회논문지B
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• 제15B권1호
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• pp.45-52
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• 2008

최근 IT 서비스 발달과 함께 고장제어, 고장의 원인분석 등의 복잡한 문제에 대하여 적합한 해결책을 제시할 수 있는 효과적인 진단시스템의 필요성이 커지고 있다. 따라서 본 논문에서는 지능형 진단 시스템분야에서의 시스템의 성능을 향상시키고, 최적의 진단을 수행하고자 사례기반추론과 인공신경망을 혼합한 지능형 진단 시스템을 제안 한다. 사례기반추론은 과거의 사례(경험)를 통해 현재의 제시된 문제를 해결하는 추론방식으로, 지식 획득이 덜 복잡하고, 정형화되기 어려운 규칙이나 문제영역이 불분명한 분야를 효율적으로 추론할 수 있다. 하지만 사례기반추론만을 이용해 추론된 사례는 증상에 대해 다수의 원인을 추론하게 된다. 이때 추론된 증상에 따른 다수의 원인은 동일한 가중치를 가져 불필요한 원인까지 진단해야 하는 문제점이 있다. 이러한 문제를 해결하고자 인공신경망의 오류역전파 학습 알고리즘을 이용하여 증상에 대한 원인들의 쌍을 학습 시킨 후 각각의 증상에 대한 원인의 가중치를 구해 제시된 증상에 대해 가장 발생 가능성이 높은 원인을 찾아내어, 보다 명확하고 신뢰성 있는 진단을 하는 데 그 목적이 있다.

• 대한의용생체공학회:의공학회지
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• 제40권5호
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• pp.215-221
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• 2019

The respiratory medical device is a medical device that delivers optimal oxygen or a certain amount of humidification to a patient by delivering artificial respiration to a patient through a machine when the patient has lost the ability to breathe spontaneously. These include respirators for use in chronic obstructive pulmonary disease and anesthesia or emergency situations, and positive airway pressure devices for treating sleep apnea, and as the population of COPD (chronic obstructive pulmonary disease) and elderly people worldwide surge, the market for the respiratory medical devices it is getting bigger. As the demand for both airway pressure devices, there is a problem that the ventilator standard is applied because the reference standard has not been established. Therefore, the boundaries between the items are blurred due to the purpose, intended use, and method of use overlapping similar items in a respiratory medical device. In addition, for both airway pressure devices, there is a problem that the ventilator standard is applied because the reference standard has not been established. Therefore, in this study, we propose clear classification criteria for the respiratory medical devices according to the purpose, intended use, and method of use and provide safety and performance evaluation guidelines for those items to help quality control of the medical devices. And to contribute to the rapid regulating and improvement of public health. This study investigated the safety and performance test methods through the principles of the respiratory medical device, national and international standards, domestic and international licensing status, and related literature surveys. The results of this study are derived from the safety and performance test items in the individual ventilator(ISO 80601-2-72), the International Standard for positive airway pressure device (ISO 80601-2-70), The safety and performance of humidifiers (ISO 80601-2-74) and the safety evaluation items related to home healthcare environment (IEC 60601-1-11), In addition, after reviewing the guidelines drawn up through expert consultation bodies including manufacturers and importers, certified test inspection institutions, academia, etc., the final guidelines were established through revision and supplementation. Therefore, in this study, we propose guidelines for evaluating the safety and performance of the respiratory medical device in accordance with growing technology development.