• Title/Summary/Keyword: Optical Bio-sensors

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Optical waveguide sensors using optical birefringence of evanescent fields (소산파의 복굴절을 이용한 광 도파관 센서)

  • Son, K.S.;Lee, H.Y.;Kim, W.K.;Lee, S.S.;Park, S.S.;Kwon, S.W.;Lee, E.C.;Park, J.W.;Ju, H.
    • Proceedings of the Optical Society of Korea Conference
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    • 2008.07a
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    • pp.309-310
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    • 2008
  • Polymer optical waveguides are fabricated with high-index materials deposited to strengthen exciations of evanescent field whose birefringence is utilized for optical sensing. Optical sensing properties are examined as a function of time, using different types of analyte solutions to extract noise-free signal induced by evanescent field birefringence. It is observed that sensing signal can be free of initial noise that may obscure real signal recognition, when glycerol is used for sensing characterization, due to slow accumulation process following adsorption of analyte material onto the sensing surface of the waveguide.

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Implementation of Optical Sensor based on Block Surface Wave and Diffraction Grating Profile (Block 표면파와 회절 격자구조에 기초한 광학 센서의 구현)

  • Ho, Kwang-Chun
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.21 no.4
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    • pp.143-148
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    • 2021
  • A systematic study of Bloch surface wave (BSW), which is created by guided mode resonance (GMR) of dielectric multilayer structures with a grating profile, is presented to analyze the sensing performance of bio-sensors. The effect of structural parameters on optical behavior is evaluated by using Babinet's principle and modal transmission-line theory. The sensitivity of designed bio-sensors is proportional to the grating constant at wavelength spectrum, and inversely proportional to the normal wave vector of incident electromagnetic wave at angular spectrum. Numerical results for two devices with SiO/SiO2 and TiO2/SiO2 multilayer dielectric stacks are presented, showing that BSW can be exploited for the realization of efficient diffraction-based bio-sensors from infrared to visible-band range.

Nano-porous Silicon Microcavity Sensors for Determination of Organic Fuel Mixtures

  • Pham, Van Hoi;Bui, Huy;Hoang, Le Ha;Nguyen, Thuy Van;Nguyen, The Anh;Pham, Thanh Son;Ngo, Quang Minh
    • Journal of the Optical Society of Korea
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    • v.17 no.5
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    • pp.423-427
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    • 2013
  • We present the preparation and characteristics of liquid-phase sensors based on nano-porous silicon multilayer structures for determination of organic content in gasoline. The principle of the sensor is a determination of the cavity-resonant wavelength shift caused by refractive index change of the nano-porous silicon multilayer cavity due to the interaction with liquids. We use the transfer matrix method (TMM) for the design and prediction of characteristics of microcavity sensors based on nano-porous silicon multilayer structures. The preparation process of the nano-porous silicon microcavity is based on electrochemical etching of single-crystal silicon substrates, which can exactly control the porosity and thickness of the porous silicon layers. The basic characteristics of sensors obtained by experimental measurements of the different liquids with known refractive indices are in good agreement with simulation calculations. The reversibility of liquid-phase sensors is confirmed by fast complete evaporation of organic solvents using a low vacuum pump. The nano-porous silicon microcavity sensors can be used to determine different kinds of organic fuel mixtures such as bio-fuel (E5), A92 added ethanol and methanol of different concentrations up to 15%.

Fabrication of Optical Sheet for LED Lighting with Integrated Environment Monitoring Sensors (환경모니터링 센서가 집적된 LED 조명용 광학시트 제작)

  • Choi, Yong Joon;Lee, Young Tae
    • Journal of the Semiconductor & Display Technology
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    • v.12 no.3
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    • pp.35-39
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    • 2013
  • In this paper, we developed an optical sheet for LED lighting with integrated $CO_2$ gas and temperature sensor which can monitor at the indoor environment. The optical sheet for LED lighting is fabricated through PMMA(Polymethyl methacrylate) injection process using mold. This research enables to fabricate the reflective sheet, light-guide plate and the prism sheet in a optical sheet. The fabricated sheet demonstrates higher intensity of optical efficiency compared with single-sided sheets. The $CO_2$ sensor was fabricated using NDIR(NON-Dispersive Infrared) method and it has $0.0235mV/V{\cdot}PPM$ sensitivity. The temperature sensor was fabricated using RTD(Resistance temperature detector) method and it has $0.563{\Omega}/^{\circ}C $sensitivity.

Polymeric Waveguide Bio Sensors with Bragg Gratings (브래그 격자 광도파로형 바이오 센서)

  • Lee, Jae-Hyun;Kim, Gyeong-Jo;Oh, Min-Choel
    • Korean Journal of Optics and Photonics
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    • v.17 no.1
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    • pp.54-59
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    • 2006
  • Biophotonic sensors based on polymer waveguide with Bragg reflection grating are demonstrated in this work. Waveguide Bragg reflectors were designed by using the effective index method and the transmission matrix method. The grating pattern was formed by exposing the laser interference pattern on a photoresist. On top of the inverted rib waveguide, the Bragg reflection grating was inscribed by the O2 plasma etching. In order to perform the bio-molecule detection experiment, a calixarene molecule was self-assembled on top of thin Au film deposited on the waveguide Bragg reflector. To measure the response of the sensor, several PBS solutions with different concentrations of potassium ion from 1 pM to $100\;{\mu}M$ were dropped on the sensor surface. The shift of Bragg reflection wavelength was observed from the fabricated sensor device, which was proportional to the concentration of potassium ion ranging from 1 pM to 108 pM.

Diffraction Characteristics for Optical Bio-Sensor of Bi-level Grating with Mushroom Profile (버섯형 이중 격자구조의 광 바이오센서에 대한 회절 특성)

  • Ho, Kwang-Chun
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.22 no.2
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    • pp.129-134
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    • 2022
  • The resonant bio-sensor of bi-level grating structure with mushroom profile has been designed for operating in the near-infrared (NIR) wavelength range under transverse electric (TE) polarization. The rigorous modal transmission-line theory (MTLT) is applied to determine the optical characteristics, and the reflection resonance of the grating structure is analyzed by varying their geometrical parameters. The numerical result shows that an excited sharp Fano resonance (FR), which does not occur in single layer grating, is demonstrated. The relationship between structure parameters of bi-level grating and the reflectance spectrum in order to guarantee the appearance of FR in the designed structure is fully investigated. An optical bio-sensor with a potential sensitivity of 112.9~214.3 deg/RIU and 447 nm/RIU is designed based on the proposed structure. The proposed mushroom profile may serve as a powerful sample for the design of optical bio-sensors with a wide range of applications.

Imaging the Enzymatic Reaction of Urease Using Liquid Crystal-Based pH Sensor

  • Hu, Qiong-Zheng;Jang, Chang-Hyun
    • Bulletin of the Korean Chemical Society
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    • v.32 no.12
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    • pp.4377-4381
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    • 2011
  • In this study, real-time and label-free methods for monitoring the enzymatic reaction of urease, which releases ammonia through the hydrolysis of urea in an aqueous solution, were developed using a liquid crystal (LC)-based pH sensor. Nematic liquid crystal 4-cyano-4'-pentylbiphenyl (5CB), doped with 4'-pentyl-biphenyl-4-carboxylic acid (PBA), exhibited a shift in optical appearance from bright to dark when it was in contact with ammonia generated from the enzymatic reaction between urease and urea. This optical change was attributed to the anchoring transitions of LCs caused by hydrophobic interactions between the tails of deprotonted PBA ($PBA^-$) molecules and the LCs at the aqueous/LC interface. This novel technique holds great promise for the sensitive detection of urease along with its substrates and inhibitors.

High-Performance Plasmon Bio-Sensor with Grating Profile based on Metallic Layer (금속층에 기반한 격자구조형 고성능 플라즈마 바이오센서)

  • Ho, Kwang-Chun
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.22 no.3
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    • pp.145-150
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    • 2022
  • An analytical model based on a modal transmission-line theory (MTLT) is developed to investigate the optical transmission through metal gratings. This model gives well physical meanings for the transmission as well as for the dispersion relations of the modes responsible for high transmission. These concepts provide accurate information even for real metals used in the visible~near-infrared wavelength range, where surface plasmon polaritons (SPP's) are excited. Furthermore, the dispersion relations allow the nature of the propagation modes to be assessed. The propagation modes are hybrid between Fabry-Pérot like modes and SPP's. It is important to consider different period and aspect ratio of metal gratings in order to determine the nature of the hybrid modes. In this paper, the sensing characteristics and mode propagation phenomena of high-performance plasma bio-sensors that depend on these variables were clearly analyzed.

X-ray grayscale lithography for sub-micron lines with cross sectional hemisphere for Bio-MEMS application (엑스선 그레이 스케일 리소그래피를 활용한 반원형 단면의 서브 마이크로 선 패턴의 바이오멤스 플랫폼 응용)

  • Kim, Kanghyun;Kim, Jong Hyun;Nam, Hyoryung;Kim, Suhyeon;Lim, Geunbae
    • Journal of Sensor Science and Technology
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    • v.30 no.3
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    • pp.170-174
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    • 2021
  • As the rising attention to the medical and healthcare issue, Bio-MEMS (Micro electro mechanical systems) platform such as bio sensor, cell culture system, and microfluidics device has been studied extensively. Bio-MEMS platform mostly has high resolution structure made by biocompatible material such as polydimethylsiloxane (PDMS). In addition, three dimension structure has been applied to the bio-MEMS. Lithography can be used to fabricate complex structure by multiple process, however, non-rectangular cross section can be implemented by introducing optical apparatus to lithography technic. X-ray lithography can be used even for sub-micron scale. Here in, we demonstrated lines with round shape cross section using the tilted gold absorber which was deposited on the oblique structure as the X-ray mask. This structure was used as a mold for PDMS. Molded PDMS was applied to the cell culture platform. Moreover, molded PDMS was bonded to flat PDMS to utilize to the sub-micro channel. This work has potential to the large area bio-MEMS.