• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.310-315
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• 2017

Although studies evaluating the effects of the blasting vibration on the adjacent structures from various angles have continued, cases of securing the safety of the adjacent buildings and researching the proper blasting method for the field condition by analyzing the vibration waveform of the measuring field while performing the open pit blasting are poor. Therefore, it is necessary to present a remedy for blasting pattern selection through test blasting that is appropriate for field conditions, and is economical and efficient. In this study, open pit blasting work was conducted based on the separation distance applied according to the standard blasting method by test blasting and the vibration regulation standard in the road expansion construction site to measure the blasting vibration value, and the vibration prediction equation by blasting methods was examined using a regression analysis computer program to calculate K, N, and R of the confidence level 95%. By setting the blasting allowed vibration standard of the test blasting target area to 0.3cm/sec, and the charring weight and blasting method by the separation distances according to the blasting vibration estimation equation of the open pit blasting guideline and the blasting vibration estimation equation of the test blasting were compared/analyzed, it was possible to identify the factors that increased the working expenses. In addition, the measurement and analysis of the adjacent structures during open pit blasting and the blasting vibration were performed after selecting the most adjacent structure to the open pit blasting spot to analyze the problems on the test blasting procedure and analysis method in the open pit blasting design/construction guidelines, which appeared in the process of completing open pit blasting construction, and a remedy is presented.

• Journal of Oriental Neuropsychiatry
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• v.15 no.2
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• pp.53-70
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• 2004

Objective : This study was designed to assess the protective effects of Bambusae caulis and St. John's Wort on the animal model of depression, induced by chronic mild stress(CMS) Method : Male Wistar rats were used for this experiment. The subjects were divided into 4 groups ( 1. CMS-drugs: Bambusae caulis administered during CMS treatment, 2. CMS-drugs: St. John's Wort administered during CMS treatment, 3. CMS-vehicle: Water administered during CMS treatment, 4. normal control group without CMS treatment ). After 3 weeks of CMS treatment, they were executed open field test and weight, sucrose intake were measured. Result : 1. CMS Bambusae caulis group showed significant difference of locomotor activities and marginal difference of start latency in comparison with other groups in open field test. 2. There was no change of weights between CMS Bambusae caulis, St. John's Wort groups and CMS control group. 3. CMS St. John's Wort group showed upper level of sucrose intake than CMS Bambusae caulis group and CMS control group. Conclusion : These results suggest that Bambusae caulis may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated locomotor activities in open field test.

• Food Science and Preservation
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• v.19 no.5
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• pp.767-773
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• 2012

The purpose of this study was to investigate the anxiolytic-like effect of the methanol extract of Sophorae fructus (MESF) using elevated plus-maze (EPM), open field test, and horizontal wire test in mice. MESF was orally administered at doses of 50, 100, 200, or 400 mg/kg to ICR mice 1 h before behavioral evaluation. The control group was given an equal volume of 10% Tween 80, and the positive control group was given diazepam (1 mg/kg, i.p.). The administration of MESF significantly increased the percentage of time spent in open arms and the entries into the open arms of the EPM compared with the 10% Tween 80-treated control group (p < 0.05). In addition, the anxiolytic-like activities of MESF were antagonized by flumazenil (a GABAA antagonist, 10 mg/kg) but not by WAY-100635 (a 5-HT1A antagonist, 0.3 mg/kg). Futhermore, there were no changes in the locomotor activity and myorelaxant effects of the experimental group, as opposed to the 10% Tween 80-treated control group. Therefore, these findings suggest that MESF promotes the anxiolytic-like activity mediated by the GABAergic nervous system in mice.

• Architectural research
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• v.8 no.2
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• pp.11-16
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• 2006

The purpose of this study is to scrutinize the effect of office layouts and ambient office sounds on the performance of office workers involved with a proof-reading test (simple task). Twenty subjects, who were professional researchers and computer programmers, were from three different office layouts: 1) Nine subjects from a combined office type with open meeting places and closed individual offices; 2) five from an open office with rectangular individual workstations, and 3) six from an open office with triangular individual workstations. Architects and consultants working in the field of office have reported from interviews and their own observations that occupants' satisfaction differs as their office layouts vary although the sizes are the same. This finding leads to the hypothesis of this experiment. Proof-reading test results were obtained from three different office layouts (combined office type, rectangular and triangular individual workstations in open offices) under two different sound conditions (quiet background sound and ambient sound of their own workplace) for 10 minutes. The test analysis shows the mean test score of subjects from the triangular individual workstations in open offices is significantly different from the mean test scores of subjects from the combined office type and the rectangular individual workstations in open offices.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.261-269
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• 2008

This experiment was performed to investigate the anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen (CFAZ), by using the experimental paradigms of anxiety, and compared with those of a known anxiolytic, diazepam. CFAZ (8.0 mg/kg, p.o.) increased the percentage of time spent on the open arms and the number of open arms entries in the elevated plus-maze test, increased the number of head dips in the hole-board test, and increased the percentage of center zone ambulatory time in the open-field box. However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, $GABA_A$ receptors $\gamma$-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by $GABA_A$ receptors.

• Journal of Advanced Marine Engineering and Technology
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• v.32 no.6
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• pp.989-996
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• 2008

Recently, a few types of fish-cage in open sea are researched. This fish-cage has to operate monitoring system for keeping an optimum living condition for fish. The most efficient monitoring system is WVMS(Wireless Vision Monitoring System) for fish-cage in open sea. WVMS should be able to transmit video signal and communicate with each controller. So. it needs to be based on WLAN(Wireless LAN) which has characteristic of higher transfer-rate, In this paper, we propose a structure of WVMS using WLAN equipments for maritime environment and prove its effectiveness. We present the propagation loss model of WVMS's communication channel. measured by field test, and discuss its validity compared with the predictive value based on the Friss propagation model and Plane earth reflection model. We present the number of frames that is received from WLAN modem connecting with underwater-camera in field test spots. As a result, we confirmed that proposed WVMS is suitable for maritime environment and it is possible to be applied to fish-cage in open sea on 'seogwipo'.

• Progress in Superconductivity and Cryogenics
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• v.3 no.2
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• pp.32-38
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• 2001

A 30[kVA] superconducting generator (SCG) is built and tested at Korea Electrotechnology Research Institute (KERI) in Korea. This superconducting generator has an air-gap winding instead of the typical steel teeth structure. The rotor has 4 field coils of race-track type with NbTi superconducting wired. The rotor is composed of two dampers and a liquid helium composed of two dampers and a liquid helium container in which the field poles reside. The space between the outermost damper and the container is vacuum insulated. A ferrofluid seal is used between the stationary part connected to the couping and the rotor. A helium transfer coupling(HTC) has 3 passages of the recovered heilum gas and a gas flow control system. The open circuit test and sustained short circuit test are preformed to obtain the open circuit characteristics (OCC) and short circuit characteristics (SCC) Also. the test results usder the light load (up to 3.6[kW]) are given. The structure, manufacturing and basis test of the 30[kVA]SCG are discussed.

• Journal of Life Science
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• v.25 no.2
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• pp.151-157
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• 2015

Zebrafish (Danio rerio) has been more widely used to study pharmacology. Oxytectracycline (OTC) is a broad-spectrum antibiotic and works by interfering with the ability to produce essential proteins of bacteria. The aim of this study was to identify the effects of exposure to OTC on behavioral changes or endocrine response in zebrafish. The behavioral effects of exposure to OTC (50, 100 or 200 mg/l) were characterized in several novelty-based paradigms such as the novel tank or open field test in zebrafish. Moreover, to investigate effects of exposure to OTC on endocrine response, we measured whole-body cortisol level using cortisol ELISA kit. As results of novel tank test, duration in top and immobile duration were significantly increased by the exposure to OTC in a concentration-dependent manner (p<0.05). In addition, moving distance, highly mobile, velocity and zone transition were significantly decreased by the exposure to OTC in a concentration-dependent manner (p<0.05). As results of open field test, the exposure to OTC increased immobile duration significantly (p<0.05). However, moving distance, mobile duration and velocity were significantly decreased by the exposure to OTC in a concentration-dependent manner (p<0.05). Besides, the exposure to OTC elevated whole-body cortisol levels in zebrafish. These results suggest that the exposure to OTC may induce chemical stress in zebrafish.

• Journal of Oriental Neuropsychiatry
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• v.14 no.1
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• pp.1-16
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• 2003

Objective : This study was designed to assess the protective effects of Hwangryeonhaedoktang on the animal model of depression, induced by chronic mild stress(CMS). Method : Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Hwangryeonhaedoktang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed forced swimming test(FST), open field test and c-Fos in paraventricular nucleus(PVN) were measured. Result : 1. In FST, immobility behavior decreased significantly in CMS-drug group. 2. There was no difference in the open field test between 3 groups 3. c-Fos expressed cell bodies in PVN were significantly less in CMS-drug than in CMS-vehicle group. Conclusion : These results suggest that Hwangryeonhaedoktang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus.

• Biomolecules & Therapeutics
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• v.26 no.5
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• pp.432-438
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• 2018

Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This study investigates whether treatment with the Evodia rutaecarpa aqueous extract (ERAE) from berries and its major molecular component, evodiamine, can reduce the adverse caffeine-induced sleep-related and excitation effects. We combined measurements from the pentobarbital-induced sleep test, the open field test, and the locomotor activity test in mice that had been dosed with caffeine. We found that ERAE and evodiamine administration reduced the degree of caffeine-induced sleep disruption during the sleep test. Additionally, we found that evodiamine significantly inhibits caffeine-induced excitation during the open field test, as well as decreasing hyperlocomotion in the locomotor activity test. Additional in vitro experiments showed that caffeine administration decreased the expression of ${\gamma}$-aminobutyric acid $(GABA)_A$ receptor subunits in the mouse hypothalamus. However, evodiamine treatment significantly reversed this expression reduction. Taken together, our results demonstrate that ERAE and its major compound, evodiamine, provide an excellent candidate for the treatment or prevention of caffeine-induced sleep disturbances and excitatory states, and that the mechanism of these beneficial effects acts, at least in part, through the $GABA_A$-ergic system.