• KSCE Journal of Civil and Environmental Engineering Research
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• v.3 no.4
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• pp.21-31
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• 1983

Circulation phenamena in open channel with abrupt variation in flow section are studied by solving numerically two dimensional Navier-Stokes equations integrated over depth. Galerkin type finite element method is used as numerical scheme. Numerical results by both implicit and explicit schemes tested in one-demensional rectangular channel agree closely with the known solution. The numerical experiments carded out in the open channel with a pool indicate the expected flow pattern and the center of the circulation coincides with the geometrical center, but the vectors of velocity appear father small, and it remains to be further investigated. Numerically simulated flow profiles along the channel with constrictions such as bridge piers and abutments are shown to be close to hydraulic experimental results. Thus further refined numerical technique is expected to be able to serve as a tool to evaluate the effect of bridge backwater.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.2
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• pp.193-200
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• 2016

Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been reported to lead to cardiac toxicity even at therapeutic doses including sudden cardiac death and ventricular arrhythmia. And in a SSRI-independent manner, sertraline has been known to inhibit various voltage-dependent channels, which play an important role in regulation of cardiovascular system. In the present study, we investigated the action of sertraline on Kv1.5, which is one of cardiac ion channels. The effect of sertraline on the cloned neuronal rat Kv1.5 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Sertraline reduced Kv1.5 whole-cell currents in a reversible concentration-dependent manner, with an $IC_{50}$ value and a Hill coefficient of $0.71{\mu}M$ and 1.29, respectively. Sertraline accelerated the decay rate of inactivation of Kv1.5 currents without modifying the kinetics of current activation. The inhibition increased steeply between -20 and 0 mV, which corresponded with the voltage range for channel opening. In the voltage range positive to +10 mV, inhibition displayed a weak voltage dependence, consistent with an electrical distance ${\delta}$ of 0.16. Sertraline slowed the deactivation time course, resulting in a tail crossover phenomenon when the tail currents, recorded in the presence and absence of sertraline, were superimposed. Inhibition of Kv1.5 by sertraline was use-dependent. The present results suggest that sertraline acts on Kv1.5 currents as an open-channel blocker.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.75-82
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• 2016

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a SSRI-independent manner. These results suggest that paroxetine may cause side effects on cardiac system. In this study, we investigated the effect of paroxetine on Kv1.5, which is one of cardiac ion channels. The action of paroxetine on the cloned neuronal rat Kv1.5 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Paroxetine reduced Kv1.5 whole-cell currents in a reversible concentration-dependent manner, with an $IC_{50}$ value and a Hill coefficient of $4.11{\mu}M$ and 0.98, respectively. Paroxetine accelerated the decay rate of inactivation of Kv1.5 currents without modifying the kinetics of current activation. The inhibition increased steeply between -30 and 0 mV, which corresponded with the voltage range for channel opening. In the voltage range positive to 0 mV, inhibition displayed a weak voltage dependence, consistent with an electrical distance ${\delta}$ of 0.32. The binding ($k_{+1}$) and unbinding ($k_{-1}$) rate constants for paroxetine-induced block of Kv1.5 were $4.9{\mu}M^{-1}s^{-1}$ and $16.1s^{-1}$, respectively. The theoretical $K_D$ value derived by $k_{-1}/k_{+1}$ yielded $3.3{\mu}M$. Paroxetine slowed the deactivation time course, resulting in a tail crossover phenomenon when the tail currents, recorded in the presence and absence of paroxetine, were superimposed. Inhibition of Kv1.5 by paroxetine was use-dependent. The present results suggest that paroxetine acts on Kv1.5 currents as an open-channel blocker.

• Water for future
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• v.21 no.1
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• pp.67-76
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• 1988

Analyzed was the circulation phenomena in the open channel with sudden expansion, by applying the Galerkin's finite element method to the depth-averaged 2-dimensional continuity and momentum equations. Wave tests were done in the simplified channel in order to review the validity of this newly developed model and the computed results were within 0.5% of $L_2$-norm error, and application of this model to the simulation of simplified dam-break gave very close results compared with the analytical solution, thus, it can be concluded that this model is valid and efficient. The main flow in the expanded channel was defined as a new initial condition with given velocity and the flow in the expanded portion was at rest in simulating the circulation, and besides the Neumann's condition the slip boundary condition for lateral wall was found to be proper condition than the no-slip condition. It can be concluded, from the numerical tests in the sudden expension, that the circulating phenomena depend mainly on the convective inertia and the effect of turbulence due to bottom shear and lateral shear is insignificant.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.5B
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• pp.449-458
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• 2008

This study is investigating experimentally the effect of upstream Froude number, weir height, weir length, and main channel width on the discharge coefficient of rectangular sharp crested side-weirs under subcritical flow conditions in a relatively wide rectangular open channel based on the De Marchi discharge coefficient $C_M$. The effects of four main influential parameters found by dimensional analysis, $Fr_1$, $h/y_1$, L/B, and $L/y_1$ are examined by the flume tests. New estimated equations for the discharge coefficients of sharp-crested side-weir are suggested based on the experimental results. The effect of $Fr_1$ for the discharge coefficient of sharp crested side weir is decreased in wide open channel and the relative importance of other influential parameters like $h/y_1$, L/B, and $L/y_1$ are increased. Also, the experimental results are compared with the results of other studies to extend the applicability of pre-suggested formulas for sharp-crested side-weir discharge coefficient.

• Journal of Korea Multimedia Society
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• v.12 no.2
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• pp.219-230
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• 2009

With the development of broadcasting technology from analogue to interactive digital, the number of TV channels and TV contents provided to audiences is increasing in a rapid speed. In this multi-channel world, it is difficult to adapt to the increase of the TV channel numbers and their contents merely using remote controller to search channels. For these reasons, the EPG system, one of the essential services providing convenience to audiences, is proposed in this paper. Collaborative filtering method with multi-step filtering is used in EPG to recommend contents according to the preference of audience groups with similar preference. To implement our designed TV contents recommendation EPG, we prefer DiTV and use JavaXlet programming based on MHP. The European DVB-MHP specification will be also our domestic standard in DiTV. Finally, the result is verified by OpenMHP emulator.

• Journal of Navigation and Port Research
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• v.29 no.7
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• pp.627-634
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• 2005

Gunsan-Janghang Harbor is located at the mouth of Gum River, on the central west coast of Korea The harbor and coastal boundaries are protected from the effects of the open ocean by natural coastal islands and shoals due to depositions from the river, and two breakwaters. The navigation channel commences at the gap formed by the outer breakwater and extends through a bay via a long channel formed by an isolated jetty. For better understanding and analysis of wave transformation process where a wide coastline changes appear due to on-going reclamation works, we applied the spectral wave model including wind effect to the related site, together with the energy balance models. This paper summarizes comparisons of coastal responses predicted by several numerical wave predictions obtained at the coastal waters near Gunsan-Janghang Harbor. Field and numerical model investigations were initially conducted for the original navigation channel management project. We hope to contribute from this study that coastal engineers are able to use safety the numerical models in the area of port and navigational channel design.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.11
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• pp.1134-1142
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• 2003

This paper presents a hardware implementation of the STS diversity system, utilizing FPGAs and introduces the function and the design method of each of the modules of the system. In order to improve the performance of the implemented STS system which is an open loop transmit diversity system under fading environment, the exact estimation of the communication channel is essential. Therefore, we propose the optimal forgetting factor to estimate pilot channel in this paper, It is shown in this paper that the pilot channel is estimated using the forgetting factor of 0.7 without increasing the integration range of the pilot channel even when the power of pilot channel is not sufficiently large in CDMA 2000 1x signal environment.

• Journal of Communications and Networks
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• v.14 no.1
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• pp.51-62
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• 2012

The exponential growth in wireless services has resulted in an overly crowded spectrum. The current state of spectrum allocation indicates that most usable frequencies have already been occupied. This makes one pessimistic about the feasibility of integrating emerging wireless services such as large-scale sensor networks into the existing communication infrastructure. Cognitive radio is an emerging dynamic spectrum access technology that can be used for flexibly and efficiently achieving open spectrum sharing. Cognitive radio is an intelligent wireless communication system that is aware of its radio environment and that is capable of adapting its operation to statistical variations of the radio frequency. In ad hoc cognitive radio networks, a common control channel (CCC) is usually used for supporting transmission coordination and spectrum-related information exchange. Determining a CCC in distributed networks is a challenging research issue because the spectrum availability at each ad hoc node is quite different and dynamic due to the interference between and coexistence of primary users. In this paper, we propose a novel CCC selection protocol that is implemented in a distributed way according to the appearance patterns of primary systems and connectivity among nodes. The proposed protocol minimizes the possibility of CCC disruption by primary user activities and maximizes node connectivity when the control channel is set up. It also facilitates adaptive recovery of the control channel when the primary user is detected on that channel.

• Nuclear Engineering and Technology
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• v.51 no.5
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• pp.1218-1230
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• 2019

A sub-channel solver, named ${\underline{S}}teady$ and ${\underline{T}}ransient$ ${\underline{A}}nalyzer$ for ${\underline{R}}eactor$ ${\underline{T}}hermal$ hydraulics (START), has been developed using the homogenous model for two-phase conditions of light water reactors. The code is developed as a fast and accurate TH-solver for coupled and multi-physics calculations. START has been validated against the NUPEC PWR Sub-channel and Bundle Test (PSBT) database. Tests like single-channel quality and void-fraction for steady state, outlet fluid temperature for steady state, rod-bundle quality and void-fraction for both steady state and transient conditions have been analyzed and compared with experimental values. Results reveal a good accuracy of solution for both steady state and transient scenarios. Axially different values for turbulent mixing coefficient are used based on different grid-spacer types. This provides better results as compared to using a single value of turbulent mixing coefficient. Code-to-code evaluation of PSBT results by the START code compares well with other industrial codes. The START code has been parallelized with the OpenMP algorithm and its numerical performance is evaluated with a large whole PWR core. Scaling study of START shows a good parallel performance.