• Journal of the Korean Society for information Management
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• v.27 no.4
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• pp.33-47
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• 2010

The growth of IT technology and the popularity of network based information sharing increase the number of digital contents in military area. Thus, there arise issues of finding suitable public information with the growing number of long-term preservation of digital public information. According to the source of raw data and the time of compilation may be variable and there can be existed in many correlations about digital contents. The business service ontology makes knowledge explicit and allows for knowledge sharing among information provider and information consumer for public digital archive engaged in improving the searching ability of digital public information. The business service ontology is at the interface as a bridge between information provider and information consumer. However, according to the difficulty of semantic knowledge extraction for the business process analysis, it is hard to realize the automation of constructing business service ontology for mapping from unformed activities to a unit of business service. To solve the problem, we propose a new business service auto-acquisition method for the first step of constructing a business service ontology based on Enterprise Architecture.

• Journal of Korean Philosophical Society
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• v.147
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• pp.239-260
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• 2018

Is an artificial intelligence robot, a non-human beings newly emerging in the age of technology, a threat to human beings, or a mutual cooperation or ensemble with human beings? The desire to control nature through the use of the power of science and technology is manifested in the fear that humans can annihilate themselves. This study attempts to identify the problems of Cartesian epistemology underlying these questions and fears and to answer these questions based on Merleau - Ponty 's ontological ontology using the Ontology and Latour' s ontology and technological philosophy. The cogito derived from the Cartesian philosophy became the basis of the structure of dichotomous epistemology of 'subjectivity and objectivity' based on human - reason. In the human-centered world, all non-human beings were tools or controls for humans. The problem of the modern people is not only to get help from the natural scientific methods to control the nature including man, but also to think that scientific method is the only way to understand the world. In criticizing this, Merleau-Ponty shows that the body mediates between human beings and non-human beings, and provides a possible ontological basis for the ontology. Merleau - Ponty 's phenomenological methodology and ontology are newly developed by Simondon under the influence of phenomenological philosopher and phenomenology. The relationship between human beings and nonhuman beings by Simondon appears as an ensemble of human and technical objects or a mutual co - operation of human and technical objects. In particular, Latour goes a step further in Simondon and defines all the bodies living in the world as actor-network theory, denying the core concept of modernity. Merleau - Ponty 's phenomenological view can be a new possible basis for the philosophical discussion of the technological age. We will see that the problem itself can be solved by shifting modern fear to a phenomenological attitude.

• Proceedings of the Korean Information Science Society Conference
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• 2008.06a
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• pp.41-42
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• 2008

• Genomics & Informatics
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• v.3 no.2
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• pp.47-51
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• 2005

Molecular mechanisms of biological processes are typically represented as 'pathways' that have a graph­analogical network structure. However, due to the diversity of topics that pathways cover, their constituent biological entities are highly diverse and the semantics is embedded implicitly. The kinds of interactions that connect biological entities are likewise diverse. Consequently, how to model or process pathway data is not a trivial issue. In this review article, we give an overview of the challenges in pathway database development by taking the INOH project as an example.

• Genomics & Informatics
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• v.19 no.1
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• pp.4.1-4.9
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• 2021

Lip and oral cavity cancer, which can occur in any part of the mouth, is the 11th most common type of cancer worldwide. The major obstacles to patients' survival are the poor prognosis, lack of specific biomarkers, and expensive therapeutic alternatives. This study aimed to identify the main genes and pathways associated with lip and oral cavity carcinoma using network analysis and to analyze its molecular mechanism and prognostic significance further. In this study, 472 genes causing lip and oral cavity carcinoma were retrieved from the DisGeNET database. A protein-protein interaction network was developed for network analysis using the STRING database. VEGFA, IL6, MAPK3, INS, TNF, MAPK8, MMP9, CXCL8, EGF, and PTGS2 were recognized as network hub genes using the maximum clique centrality algorithm available in cytoHubba, and nine potential drug candidates (ranibizumab, siltuximab, sulindac, pomalidomide, dexrazoxane, endostatin, pamidronic acid, cetuximab, and apricoxib) for lip and oral cavity cancer were identified from the DGIdb database. Gene enrichment analysis was also performed to identify the gene ontology categorization of cellular components, biological processes, molecular functions, and biological pathways. The genes identified in this study could furnish a new understanding of the underlying molecular mechanisms of carcinogenesis and provide more reliable biomarkers for early diagnosis, prognostication, and treatment of lip and oral cavity cancer.

• Genomics & Informatics
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• v.19 no.2
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• pp.16.1-16.14
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• 2021

Even in the current age of advanced medicine, the prognosis of malignant peritoneal mesothelioma (MPM) remains abysmal. Molecular mechanisms responsible for the initiation and progression of MPM are still largely not understood. Adopting an integrated bioinformatics approach, this study aims to identify the key genes and pathways responsible for MPM. Genes that are differentially expressed in MPM in comparison with the peritoneum of healthy controls have been identified by analyzing a microarray gene expression dataset. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of these differentially expressed genes (DEG) were conducted to gain a better insight. A protein-protein interaction (PPI) network of the proteins encoded by the DEGs was constructed using STRING and hub genes were detected analyzing this network. Next, the transcription factors and miRNAs that have possible regulatory roles on the hub genes were detected. Finally, survival analyses based on the hub genes were conducted using the GEPIA2 web server. Six hundred six genes were found to be differentially expressed in MPM; 133 are upregulated and 473 are downregulated. Analyzing the STRING generated PPI network, six dense modules and 12 hub genes were identified. Fifteen transcription factors and 10 miRNAs were identified to have the most extensive regulatory functions on the DEGs. Through bioinformatics analyses, this work provides an insight into the potential genes and pathways involved in MPM.

• The Journal of the Korea Contents Association
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• v.6 no.9
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• pp.152-163
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• 2006

The development of Semantic Web basically requires knowledge induced from the formalization and semantization of information, and thus ontology should be introduced as a knowledgization tool. URI(Universal Resource Identifier) is an indispensible scheme to uniquely indicate individuals on ontology. However, it is difficult to find the use cases of URI in real data including science and technology papers. This paper describes the method to construct internal and external human resource information based on URI from the papers. We use co-authors, e-mails, publication date, and affiliation for discriminating authors with the same strings. HRST(Human Resources devoted to Science and Technology) is referred to acquire URIs for human resource. We expect the internal and external human resource information would be adopted to outcome analysis applications such as researcher network analysis and outcome statistics.

• Journal of KIISE
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• v.42 no.3
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• pp.295-306
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• 2015

MOnCa2 is a framework for building intelligent smartphone applications based on smartphone sensors and ontology reasoning. In previous studies, MOnCa determined and inferred user situations based on sensor values represented by ontology instances. When this approach is applied, recognizing user space information or objects in user surroundings is possible, whereas determining the user's physical context (travel behavior, travel destination) is impossible. In this paper, MOnCa2 is used to build recognition models for travel behavior and routes using smartphone sensors to analyze the user's physical context, infer basic context regarding the user's travel behavior and routes by adapting these models, and generate high-level context by applying ontology reasoning to the basic context for creating intelligent applications. This paper is focused on approaches that are able to recognize the user's travel behavior using smartphone accelerometers, predict personal routes and destinations using GPS signals, and infer high-level context by applying realization.

• Journal of Pharmacopuncture
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• v.16 no.3
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• pp.30-38
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• 2013

Objectives: Modified regular ginseng extract (MRGX) has stronger anti-cancer activity-possessing gensenoside profiles. Methods: To investigate changes in gene expression in the MRGX-treated lung cancer cells (A549), we examined genomic data with cDNA microarray results. After completing the gene-ontology-based analysis, we grouped the genes into up-and down-regulated profiles and into ontology-related regulated genes and proteins through their interaction network. Results: One hundred nine proteins that were up- and down-regulated by MRGX were queried by using IPA. IL8, MMP7 and PLAUR and were found to play a major role in the anti-cancer activity in MRGX-treated lung cancer cells. These results were validated using a Western blot analysis and a semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis. Conclusions: Most MRGX-responsive genes are up-regulated transiently in A549 cells, but down-regulated in a sustained manner in lung cancer cells.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.6
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• pp.2707-2712
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• 2012

Desktop-based computing environment is changed into mobile computing using smart phone and cloud computing providing common behavior and big data by network. Because of this transformation software development and operating environment is changed into heterogeneous distributed environment. As a result, dynamic service composition or changement is required. However, there is few research of techniques supporting service composition or changement dynamically in this situation. This paper suggests a technique for customizing services dynamically of mobile applications based on android platform. Especially we propose a customization technique of service by applying ontology technique to improve sharing and reuse of service. We applied proposed technique into meeting notification system, and obtain that it can be customized into various services such as email, sms, twitter service, and so on.