• The Journal of Korean Medicine
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• v.32 no.1
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• pp.121-129
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• 2011

Objective: The propose of this study is to build a conceptual framework for representing clinical findings in Traditional East Asian Medicine(TEAM). As the existing standard models have been developed without considering features of Traditional Medicine, in this study we introduced unique characteristics for the TEAM. Method: This study was composed of three steps. First, we analyzed whether the existing clinical information models are suitable for representing clinical findings. Second, we analyzed ISO/TS 22789 model which is a ISO medical informatics standard, to find out the problem by applying clinical findings of TEAM into the model. Finally, we defined semantic links and a concept hierarchy in our model based on the analyzed results. The model includes the concepts for clinical findings and terms, and the semantic links can be regarded as relations between concepts, so that the representating clinical findings are completed by connecting concepts with other concepts. Results: Our framework was developed by removing unnecessary semantic links, and adding some necessary ones based on ISO/TS 22789 model. The ISO/TS 22789 model has a simple concept hierarchy, but in this study we subdivided the hierarchy and also considered interoperability with other terminological systems and standard models. Conclusions: This research needs more discussions, but is meaningful as proposing a way how to develop Traditional Medicine terminological systems. This study shows the limitations of existing models in describing clinical findings for TEAM, and what should be considered to represent Traditional Medicine knowledge, and propose a solution to improve the problem.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.8
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• pp.1861-1867
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• 2010

A datawarehouse is generally used in organizations for decision and policy making. And In a distribute environment when a new system is added, there needs considerable amount of time and cost due to the difference between the systems. Therefore, to solve this matter. Firstly, heterogeneous data structures can be handled by creating abstract queries according to the standard schema and by separating the queries using XMDR. Secondly, metadata dictionary which defines synonyms of metadata and methods for data expression is used to overcome difference of definition and expression of data. Especially, work presented in this thesis provides standardized information for data integration and minimizing the effects of integration on local systems in discrete environments using XMDR to create information of data warehouse in realtime.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.6
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• pp.1087-1094
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• 2008

Recently, XML has been widely used as a standard for a data exchange, and there has emerged the tendency that the size of XML document becomes larger. The data transfer can cause problems due to the increase in traffic, especially when a massive data such as Data Warehouse is being collected and analyzed. Therefore, an XMDR wrapper can solve this problem since it analyzes the tree structures of XML Schema, regenerates XML Schema using the analyzed tree structures, and sends it to each station with an XMDR Query. XML documents which are returned as an outcome encode XML tags according to XML Schema, and send standardized messages. As the formalized XML documents decrease network traffic and comprise XML class information, they are efficient for extraction, conversion, and alignment of data. In addition, they are efficient for the conversion process through XSLT, too, as they have standardized forms. In this paper we profuse a method in which XML Schema and XMDR_Query sent to each station are generated through XMDR(extended Meta-Data Registry) and the generation of products and XML conversion occur in each station wrapper.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.1
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• pp.56-65
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• 2007

Existing application systems of enterprises can process and collect a lot of information within enterprises, but it could be difficult to share validated information with partners and other system in the process of contacting to other legacy systems required in cooperation environment. For solving these problems, EAI systems are introduced in cooperation environment so that data sharing and integration can be achieved. The integration based on EAI is not limited to particular business system but all systems of an enterprise so that standard of suitable metadata level is needed for forwarding consistently between each business of systems. Therefore this paper maintains consistency of data sharing and integrating among legacy systems in cooperative environment for proposing message exchanging based on bridge XMDR.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.10
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• pp.1957-1967
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• 2007

User can be offered various information form internet and reserve. However this operation is hard to be satisfied with user's requirement. Because it offer the alternative by self-mediation and the place where offer the information is distributed and a form or stored f[nm of data would be different. These cases occurred in change of enterprise recently. In a process of M&A, outsourcing or cooperation. necessity of new strategy become a pressing issue for ensuring interoperability on application, database of each enterprise and integration information management. Thus, interoperability of distributed data is a base condition for cooperation of legacy system, it will solve a problem such as available or clarity of data, problem of cooperation system. This paper use a XMDR for integration of distributed system and ensuring interoperability. By using XMDR, integrate a traveling information system and it will be solve the problem of interoperability and variety data problem that be occurred in integration of data by suggesting a technique of transaction management.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.9
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• pp.1771-1780
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• 2007

The necessity of Information integration has emphasized by advancement of internet and change of enterprise environment. In enterprises, it usually integrates the multi-database constructing by M&A. For this integration of information it must guarantee interpretation and integration which is stabilized with solving heterogeneous characteristic problem. In this paper, we propose the method that change the global XML query to local XML query for interpretation. It is based on XMDR(eXtended Meta-Data Registry) which expresses the connection between the standard and the local for solve the interoperability problem in heterogeneous environment. Thus, we propose the legacy model that can search and modify by one Query with creating global XML Query by XMDR. and for his, we use the 2PC technique which is the distributed transaction control technique of existing.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.6
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• pp.757-765
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• 2021

To carry out multi-domain operations included in the U.S. Department of Defense's national security strategy in 2018, timely data sharing between C4I systems is critical. Several studies of the Korean military have also raised the problems of interface and standardization between C4I systems, and it is necessary to establish a new plan to solve this problem. In this study, a solution to the problem was derived through case analysis that the U.S. Department of Defense has been pursuing for about 20 years to implement the data strategy after establishing the data strategy in 2003. and by establishing a data strategy suitable for the ROK military C4I system operating environment, developing a data model, selecting a standard for data sharing, and proposing a shared data development procedure, we intend to improve the data sharing capability between ROK military C4I systems.

• Genes and Genomics
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• v.40 no.12
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• pp.1351-1361
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• 2018

A new cold tolerant germplasm resource named glutinous rice 89-1 (Gr89-1, Oryza sativa L.) can overwinter using axillary buds, with these buds being ratooned the following year. The overwintering seedling rate (OSR) is an important factor for evaluating cold tolerance. Many quantitative trait loci (QTLs) controlling cold tolerance at different growth stages in rice have been identified, with some of these QTLs being successfully cloned. However, no QTLs conferring to the OSR trait have been located in the perennial O. sativa L. To identify QTLs associated with OSR and to evaluate cold tolerance. 286 $F_{12}$ recombinant inbred lines (RILs) derived from a cross between the cold tolerant variety Gr89-1 and cold sensitive variety Shuhui527 (SH527) were used. A total of 198 polymorphic simple sequence repeat (SSR) markers that were distributed uniformly on 12 chromosomes were used to construct the linkage map. The gene ontology (GO) annotation of the major QTL was performed through the rice genome annotation project system. Three main-effect QTLs (qOSR2, qOSR3, and qOSR8) were detected and mapped on chromosomes 2, 3, and 8, respectively. These QTLs were located in the interval of RM14208 (35,160,202 base pairs (bp))-RM208 (35,520,147 bp), RM218 (8,375,236 bp)-RM232 (9,755,778 bp), and RM5891 (24,626,930 bp)-RM23608 (25,355,519 bp), and explained 19.6%, 9.3%, and 11.8% of the phenotypic variations, respectively. The qOSR2 QTL displayed the largest effect, with a logarithm of odds score (LOD) of 5.5. A total of 47 candidate genes on the qOSR2 locus were associated with 219 GO terms. Among these candidate genes, 11 were related to cell membrane, 7 were associated with cold stress, and 3 were involved in response to stress and biotic stimulus. OsPIP1;3 was the only one candidate gene related to stress, biotic stimulus, cold stress, and encoding a cell membrane protein. After QTL mapping, a total of three main-effect QTLs-qOSR2, qOSR3, and qOSR8-were detected on chromosomes 2, 3, and 8, respectively. Among these, qOSR2 explained the highest phenotypic variance. All the QTLs elite traits come from the cold resistance parent Gr89-1. OsPIP1;3 might be a candidate gene of qOSR2.

• Mycobiology
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• v.50 no.1
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• pp.66-78
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• 2022

The identification of oleaginous yeast species capable of simultaneously utilizing xylose and glucose as substrates to generate value-added biological products is an area of key economic interest. We have previously demonstrated that the Cutaneotrichosporon dermatis NICC30027 yeast strain is capable of simultaneously assimilating both xylose and glucose, resulting in considerable lipid accumulation. However, as no high-quality genome sequencing data or associated annotations for this strain are available at present, it remains challenging to study the metabolic mechanisms underlying this phenotype. Herein, we report a 39,305,439 bp draft genome assembly for C. dermatis NICC30027 comprised of 37 scaffolds, with 60.15% GC content. Within this genome, we identified 524 tRNAs, 142 sRNAs, 53 miRNAs, 28 snRNAs, and eight rRNA clusters. Moreover, repeat sequences totaling 1,032,129 bp in length were identified (2.63% of the genome), as were 14,238 unigenes that were 1,789.35 bp in length on average (64.82% of the genome). The NCBI non-redundant protein sequences (NR) database was employed to successfully annotate 11,795 of these unigenes, while 3,621 and 11,902 were annotated with the Swiss-Prot and TrEMBL databases, respectively. Unigenes were additionally subjected to pathway enrichment analyses using the Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Cluster of Orthologous Groups of proteins (COG), Clusters of orthologous groups for eukaryotic complete genomes (KOG), and Non-supervised Orthologous Groups (eggNOG) databases. Together, these results provide a foundation for future studies aimed at clarifying the mechanistic basis for the ability of C. dermatis NICC30027 to simultaneously utilize glucose and xylose to synthesize lipids.

• Journal of Veterinary Science
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• v.23 no.6
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• pp.90.01-90.13
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• 2022

Background: Insulin regulates glucose homeostasis and has important effects on metabolism, cell growth, and differentiation. Depending on the cell type and physiological context, insulin signal has specific pathways and biological outcomes in different tissues and cells. For studying the signal pathway of insulin on glycolipid metabolism in porcine embryonic fibroblast (PEF), we used high-throughput sequencing to monitor gene expression patterns regulated by insulin. Objectives: The goal of our research was to see how insulin affected glucose and lipid metabolism in PEFs. Methods: We cultured the PEFs with the addition of insulin and sampled them at 0, 48, and 72 h for RNA-Seq analysis in triplicate for each time point. Results: At 48 and 72 h, 801 and 1,176 genes were differentially expressed, respectively. Of these, 272 up-regulated genes and 264 down-regulated genes were common to both time points. Gene Ontology analysis was used to annotate the functions of the differentially expressed genes (DEGs), the biological processes related to lipid metabolism and cell cycle were dominant. And the DEGs were significantly enriched in interleukin-17 signaling pathway, phosphatidylinositol-3-kinase-protein kinase B signaling pathway, pyruvate metabolism, and others pathways related to lipid metabolism by Kyoto Encyclopedia of Genes and Genomes enrichment analysis. Conclusions: These results elucidate the transcriptomic response to insulin in PEF. The genes and pathways involved in the transcriptome mechanisms provide useful information for further research into the complicated molecular processes of insulin in PEF.