• Bulletin of the Korean Chemical Society
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• v.33 no.9
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• pp.2890-2896
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• 2012

A simple regioselective synthesis of cinnoline derivatives was achieved by a one-pot three component synthetic methodology. New substituted 7,8-dihydrocinnolin-5(6H)-ones are prepared via one-pot three component reaction of arylglyoxals with 1,3-cyclohexanedione and dimedone in the presence of hydrazine hydrate in moderate to good yields.

• Journal of the Korean Chemical Society
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• v.55 no.4
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• pp.662-665
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• 2011

Highly efficient, three-component condensation of aromatic aldehyde, malononitrile and 4-hydroxycoumarin promoted by neat silica gel at room temperature is described. The method offers an excellent alternative to the synthesis of 3,4-dihydropyrano[c]chromenes. The reactions are fast and clean, and the products are obtained with good yield and purity.

• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.2887-2889
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• 2009

An efficient and easy method for one-pot three-component synthesis of amidoalkyl naphthols by the condensation of aromatic/heteroaromatic/aliphatic aldehydes, 2-naphthol and amides or urea under thermal condition at $60^{\circ}C$ in the presence of acidic ionic liquid 1-butyl-3-methylimidazolium hydrogen sulphate ([bmim]$HSO_4$) has been described.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1556-1560
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• 2012

A simple highly versatile and efficient method has been developed for the three-component coupling of aldehydes, amines and alkynes to prepare propargylamines, in the presence of a catalytic amount of $BiCl_3$. The advantages of methods are high yield, mild reaction conditions, no environmental pollution and easy work up procedure.

• Bulletin of the Korean Chemical Society
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• v.30 no.3
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• pp.551-555
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• 2009

The ytterbium catalyst immobilized on the cross-linked poly(4-vinylpyridine/styrene) copolymer (P/S-Yb) was applied in the Mannich-type, three component one-pot synthesis of $\beta$-aminoketones. This catalytic system showed excellent catalytic activity and selectivity which resulted in the exclusive formation of $\beta$-aminoketone. The applicability of this immobilized catalyst system was shown by the reusability test and again highlighted by the synthesis of a $\beta$-aminoketone library using a broad range of substrates.

• Bulletin of the Korean Chemical Society
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• v.29 no.12
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• pp.2445-2448
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• 2008

• Journal of the Korean Chemical Society
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• v.59 no.4
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• pp.280-283
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• 2015

Hydrated ferric sulfate can be used as an efficient and reusable catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives via one-pot three-component condensation reaction of phthalhydrazide, aromatic aldehydes and cyclic-1,3-diketones in ethanol under reflux conditions.

• Bulletin of the Korean Chemical Society
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• v.32 no.7
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• pp.2203-2206
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• 2011

A mild and efficient procedure has been developed for the one-pot, three-component reaction of aldehydes, benzyl carbamate and allyltrimethylsilane in the presence of 3 mol % of magnesium bistrifluoromethanesulfonimide at room temperature to afford the corresponding protected homoallylic amines in high yields.

• Journal of the Korean Chemical Society
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• v.53 no.1
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• pp.90-94
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• 2009

• Journal of the Korean Chemical Society
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• v.63 no.6
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• pp.435-439
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• 2019

An efficient one pot multicomponent synthesis of pyrimidinone derivatives of Biginelli type is described. 4-amino-6-aryl-pyrimidine-5-carbonitrile molecules were synthesized efficiently via three-component Biginelli-type condensation of aldehyde, malononitrile, and semicarbazone as urea substituent in the presence of a catalytic amount of PEG-400 as green medium under microwave irradiation. The reactions proceeded efficiently in the presence of microwave radiation to afford the desired products in good to excellent yields. Products have been confirmed by IR, and NMR spectral analysis. All the molecules were tested for their antimicrobial activity against E. coli, S. aureus, P. aeruginosa and C. tropicalis. Some of the compounds have shown moderate to good inhibition efficiency against both gram-positive and gram-negative bacteria. The potent activity was observed against the fungal species with minimum inhibition concentration 12.5 ㎍/mL.