• 대한두경부종양학회지
• /
• 제7권2호
• /
• pp.114-119
• /
• 1991

Malignant oncocytoma(oxyphil cell adenoma) is a extremely rare malignant tumor of the salivary glands and almost occurs in the parotid gland. A case of malignant oncocytoma of the parotid gland occurring in a 63 year old man is reported. Establishing a diagnosis of malignant oncocytoma essentially requires the application of two sets of criteria to the tumor under examination. First, the tumor cells must be identified as oncocyte and second, malignancy must be determined. Histochemical stains are not as useful as generally believed. Electron microscopy confirms the diagnosis by demonstrating an abundance of mitochondria. The diagnosis of malignant oncocytoma depends on several additional criteria in addition to cellular and nuclear pleomorphism, including lack of encapsulation, local infiltration, perineural and intravascular growth, and regional and/or distant metastasis. Satisfactory results from surgical resection and postoperative radiotherapy in our patient serve as additional experience in the treatment of this rare malignancy.

• 대한수의학회지
• /
• 제59권1호
• /
• pp.47-49
• /
• 2019

A renal oncocytoma was diagnosed in an 8-year-old female Maltese dog with a history of renal cysts. Tumor cells were not detected until six months after observation of renal cysts. Nephrectomy was performed to treat the neoplasia. Tumor-like masses with numerous nodules were observed in the inner surface of cysts present in the caudal part of the left kidney. Histologically, the tumor consisted of cells with abundant eosinophilic cytoplasm. The diagnosis was based on histological features, periodic acid-Schiff reaction, and immunohistochemical cytokeratin staining. Based on a literature review, this is the first canine renal oncocytoma case reported in Korea.

• 대한세포병리학회지
• /
• 제7권1호
• /
• pp.31-37
• /
• 1996

It is well known that fine needle aspiration biopsy(FNAB) is very useful and has a high accuracy rate in the diagnosis of renal neoplasms. Although there is some indecision to perform the FNAB for a rare possibility of tumor seeding along the biopsy needle tract, it tends to be used increasingly. As in the cytologic diagnosis of metastatic lesion through-out the body, renal cell carcinoma should nearly always be considered in the differential diagnosis, the precise understanding of cytologic features of renal cell carcinoma with various cell types and architectural patterns is necessarily required. In this report, we present three cases of primary renal cell tumors, two of renal cell carcinomas and one of oncocytoma, preponderantly emphasizing the cytologic differential points in the FNAB specimen.

• Journal of Yeungnam Medical Science
• /
• 제26권1호
• /
• pp.30-37
• /
• 2009

RO는 경계가 좋은 고형종괴로써, 석회화를 포함할 수 있다. 조영전 CT 영상에서 신실질과 유사한 밀도의 균일한 종괴로 보인다. 조영 후 영상에서는 불균일하게 조영증강되는데, 역동적 조영증강 검사의 동맥강조기에서 주변부는 강하게 조영증강되었다가 시간에 따라 점차 조영이 약해지고, 중앙부는 시간에 따라 점차 조영이 증강되어 시간에 따른 조영증강의 부분적 역전현상이 관찰되었다. 이러한 영상의학적 특징이 관찰되는 경우에는 RO의 가능성을 시사할 수 있으며 이를 통해 환자의 예후를 예측하고 수술 방법을 술전에 결정하는데 도움을 줄 수 있으리라 생각한다.

• Toxicological Research
• /
• 제11권1호
• /
• pp.127-131
• /
• 1995

Sequential changes in cell proliferation during the development of epitherial kidney tumors induced in rats were investigated by autoradiographic determination of the $^3H$-thymidine-labeling index. Renal cell tumors were induced in male Sprague-Dawley rats by oral administration of N-nitrosomorpholine at the concentration of 120 mg/l in the drinking water for 7 weeks. At different times between 12 and 34 weeks after withdrawal of the carcinogen (stop model) animals were sacrificed. According to cytological criteria, neoplastic lesions were classified into clear cell, acidophilic cell, basophilic cell and oncocytic tumors. The labeling index was found to be increased in all types of preneoplastic tubules as compared to their corresponding original tubules. A much stronger elevation of cell proliferation was ocurred during the development of renal cell tumors from preneoplastic tubules. Of four tumor types, acidophilic cell tumor showed the highest labeling index while oncocytoma exhibited the lowest proliferative activity. These findings are in good accordance with the clinical observations that acidophilic cell tumors have a worse prognosis than oncocytoma. The data presented in this study suggest that the individual proliferation rates may be an objective biological marker of kidney tumor aggressiveness.

• Journal of Chest Surgery
• /
• 제26권7호
• /
• pp.560-563
• /
• 1993

Oncocytic carcinoid is a very rare tumor composed of epithelial cells that have abundant eosinophilic granular cytoplasm. Ultrastructurally, this tumor corresponds to mitochondrial hyperplasia. Therefore, the elctronmicroscopic study is an essential for the diagnosis of oncocytic carcinoid. Fechner and Bentinck first described a pulmonary oncocytoma/oncocytic carcinoid with ultrastructural confirmation in 1973. A case of pulmonary oncocytic carcinoid in the fifty year old male was diagnosed by immunohistochemical and elecronmicroscopic study is presented.

• 대한후두음성언어의학회지
• /
• 제17권2호
• /
• pp.143-145
• /
• 2006

Oncocytic hyperplasia is uncommon in the practice of otolaryngology. Oncocytic hyperplasia usually arises in the major salivary gland, especially parotid gland. We have recently experienced a case of oncocytic hyperplasia arising in the larynx of 58 year old female patient. The mass was removed under the general anesthesia using laryngeal micro-surgery and confirmed as oncocytic hyperplasia of larynx on histopathological examination.

• 대한두경부종양학회지
• /
• 제17권2호
• /
• pp.210-215
• /
• 2001

저자들은 약 4년에 걸친 주타액선 종양에 대한 치료 경험을 통하여, 성공적인 치료를 위한 필요조건으로 다음과 같은 내용들을 고려하여야 할 것으로 생각하였다. 즉 타액선 종양은 다양한 조직학적 특징과 임상 경과를 보이는 질환군이므로 수술 전 세침흡인생검 등에 의한 정확한 병리조직학적 진단의 뒷받침이 필수적이라는 점이다. 또한 악성 종양의 경우, 질병분류 및 병기설정 방식이 완전히 통일되어 있지 아니한 상황에서 특정 질환의 특정 병기에 한 가지 치료방법을 고집하기보다는 다양한 종류의 치료를 복합적으로 사용하는 데에 적극적일 필요가 있다고 생각하였다. 특히 예후에 부정적인 영향을 미치는 요소를 가지고 있을 경우에는 적극적인 외과적 절제 및 수술 후 방사선 치료 등을 통하여 생존율을 높이는데 관심을 기울여야 할 것으로 생각되었다. 더 나아가 절개선 등 수술흔이 가지는 미용적 문제점 등도 고려하여 전체적인 치료의 만족도를 향상시키는데 기여해야 할 것으로 생각하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권5호
• /
• pp.2303-2307
• /
• 2014

Background: Renal cancer is a serious public health problem which may be under reported and registered in our setup, since the Karachi cancer registry documented only 43 cases out of 4,268 incident cancer cases over 3 year duration. Therefore we aimed to determine the clinicopathologic characteristics of adult renal tumors in our setup. Materials and Methods: The study was conducted in histopathology department, Liaquat National Hospital and included total of 68 cases of adult renal tumors over 4 years. Detailed histopathologic characteristics of tumors were analyzed. Results: Mean age of patients was 56.4 (18-84) years. Renal cell carcinoma (RCC) was the most common cell type (78%) cases; followed by transitional/urothelial carcinoma (12.5%), leiomyosarcoma (4.7%), oncocytoma (1.6%), squamous cell carcinoma (1.6%) and high grade pleomorphic undifferentiated sarcoma (1.6%). Among 50 RCC cases; 62% were conventional/clear cell RCC (CCRCC) type followed by papillary RCC(PRCC), 24%; chromophobe RCC(CRCC), 6% and sarcomatoid RCC(SRCC), 8%. Mean tumor size for RCC was 7.2 cm. Most RCCs were intermediate to high grade (60% and 40% respectively). Capsular invasion, renal sinus invasion, adrenal gland involvement and renal vein invasion was seen in 40%, 18%, 2% and 10% of cases respectively. Conclusions: We found that RCC presents at an earlier age in our setup compared to Western populations. Tumor size was significantly larger and most of the tumors were of intermediate to high grade. This reflects late presentation of patients after disease progression which necessitates effective measures to be taken in primary care setup to diagnose this disease at an early stage.

• Journal of Yeungnam Medical Science
• /
• 제16권1호
• /
• pp.94-100
• /
• 1999

본 연구는 신보존수술의 임상적 가치를 알아보기 위해, 반대측 신장이 기능적으로 정상인 작은 크기의 고형 신종양 환자를 대상으로 신보존수술을 이용한 환자의 임상 경과를 후향적인 조사를 통하여 알아보고자 하였다. 21례의 환자중 술전 방사선 영상 소견상 신세포암으로 추정된 15례의 환자는 술후 병리조직학적 검사 결과 14례에서 신세포암($T_1N_0M_0$ : 14례)으로, 1례에서 호산성과립세포종으로 진단되었다. 신혈관지방종으로 추정된 4례는 역시 신혈관지방종으로 진단되었고, 또한 신세포암과 구별하기 어려웠던 2례는 선혈관지방종 및 해면상혈관종으로 각각 밝혀졌다. 신세포암의 재발, 원격 전이 및 신세포암으로 인한 사망 등은 추척 관찰 기간(평균 18.6개월, 1-103개월) 중 관찰되지 않았고 양성 신종양 환자군에서도 종양의 재발은 관찰되지 않았다(평균 추척 관찰 기간 : 43.8개월, 7-97개월). 신보존수술의 합병증으로는 1례의 신세포암에서 wedge resection을 시행한 후 술후 10일에 신출혈로 인한 육안적 혈뇨 및 혈압 저하의 소견이 나타나 근치적 신적출술을 시행하였고, 그 외 다른 환자에서는 요낭종, 후복막혈종 및 폐 색전증 등과 갈은 합병증은 관찰되지 않았다. 이상의 결과에서, 대측 신장의 기능이 정상인 작은 표기(4cm 이하)의 단일 고형 신종양 환자일 경우 신기능을 보존하기 위하여 신보존수술은 좋은 치료법으로 생각되며 일차적인 치료법으로 사용되어도 유익하리라 기대되나, 향후 보다 장기적인 추적 관찰이 필요하리라 생각된다.