• 보존과학연구
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• s.29
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• pp.19-44
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• 2008

Sam-jon-bul or Three Buddha Image Carved on rock surface which is called Sam-jon-bul in Taean, state-designated national treasure No. 307, made in Baek-je Period, has two Buddha images and one Bodhisattva. The detached part of the Sam-jon-bul from wall rock has been attached through conservation treatment in 1995. Few study has been done on weathering condition of petrological point of view and damage while the surface of the Sam-jon-bul has been under serious weathering (relief) of loosing stone particles, and discoloration. In this study, it was made weathering damage maps, which show physical property of the material and state of damage of Sam-jon-bul, in order to dialogize how far the weathering has been done. It has been considered continuing on-site monitoring as necessity when Sam-jon-bul was covered with dew, which may have been caused by change in weather in and out of the protect building. It is necessary to set up detailed conservation plan for it by doing regular diagnosis on the influence of the protect building and weathering of Sam-jon-bul.

• Journal of Interdisciplinary Genomics
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• v.4 no.1
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• pp.15-18
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• 2022

Hemophilia A is a rare X-linked congenital deficiency of clotting factor VIII (FVIII) that is traditionally diagnosed by measuring FVIII activity. Various mutations of the FVIII gene have been reported and they influence on the FVIII protein structure. A deficiency of or reduction in FVIII protein manifests as spontaneous or induced bleeding depending on the disease severity. Mutations of the FVIII gene provide important information on the severity of disease and inhibitor development. FVIII mutations also affect the discrepant activities found using different FVIII assays. FVIII activity is affected differently depending on the mutation site. Long-range PCR is commonly used to detect intron 22 inversion, the most common mutation in severe hemophilia. However, point mutations are also common in patients with hemophilia, and direct Sanger sequencing and copy number variant analysis are being used to screen for full mutations in the FVIII gene. Advances in molecular genetic methods, such as next-generation sequencing, may enable accurate analysis of mutations in the factor VIII gene, which may be useful in the diagnosis of mild to moderate hemophilia. Genetic analysis is also useful in diagnosing carriers and managing bleeding control. This review discusses the current knowledge about mutations in hemophilia and focuses on the clinical aspects associated with these mutations and the importance of genetic analysis.

• Economic and Environmental Geology
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• v.54 no.3
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• pp.311-330
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• 2021

The Sinseongri site contains at least eleven theropod trackways, three sauropod trackways, and one or more ornithopod walkways of dinosaur footprints. The host rock at the site is primarily siltstone and mudstone, but thermal alterations have metamorphosed it into hornfels. Except for micro cracks and exfoliations, joint systems in various directions appeared on the surface of the fossils site and showed a low share of all damage factors. The host rocks in the fossils site demonstrated relatively high physical properties as a result of ultrasonic velocity and were classified as stable. More than half of the fossils required reinforcement to control the progression of cracks if the type of conservation treatment was subdivided according to the damage type of dinosaur footprint fossils. The white paint used to visualize the footprints seems to deteriorate, allowing rock debris to spill out and causing damage to the fossil site, and alternative visualization schemes should be considered.

• 한국문화재보존과학회:학술대회논문집
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• 2004.10a
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• pp.1-14
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• 2004

World state of the arts of the conservation of stone monuments is reviewed and the modern conservation program based on conservation science is proposed for the scientific conservation of stone monuments in Korea. The conservation program suggests that the site environment diagnosis, decay diagnosis, petrophysical property analysis, and conservation experiment should always be carefully studied before conservation treatment. It is an up-to-date widely accepted concept in the world of stone conservation science. Our urgent national tasks that should be accomplished for the scientific conservation of stone monuments in Korea are proposed in the following: 1) The stone monument conservation projects should be planned in accordance with 'Conservation Concept of Stone Cultural Properties' and executed in accordance with the proposed 'Conservation Program for Stone Cultural Property' based on conservation science. 2) It is proposed that 'National Institute of Conservation Science for Cultural Properties' be established for systematic conservation research on the tangible cultural properties. 3) The conservation projects of stone monuments should be executed under the control of stone conservation specialist for their quality control. 4) Special national budget should be prepared for quick development of researches on conservation science in Korea.

• Architectural research
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• v.20 no.4
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• pp.137-145
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• 2018

The nondestructive test is widely used in the field of diagnosis and maintenance to evaluate the degree of damaging of structures caused by aging, and the demand for this test method is expected to continue increasing. However, there is a lack of standards related to the nondestructive test, and South Korea is relying heavily on developed nations for original technologies related to diagnosis. It is an urgent task to establish a nondestructive test method appropriate for the circumstance of South Korea. The purpose of this study is to compare and analyze estimated error of compressive strength in single-story structures comprised of vertical and horizontal reinforced concrete members using the impact testing method and rebound hardness method, which are nondestructive test methods, and to review on-site applicability of these methods. Based on compressive strength of the structures estimated, overall mean error was 21.2% for the impact testing method and 15.6% for the rebound hardness method. The necessity of a reliable diagnostic method based on compound nondestructive test methods to increase accuracy of estimation was confirmed.

• Korean Journal of Ecology and Environment
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• v.40 no.4
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• pp.495-502
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• 2007

Species biotic index (SBI), based on a fish assemblage, was applied to a stream assessment using long-term ecological fish data set (1996 to 2001) in Boryong dam area, which is located in the mainstream of Ungchun Stream of Chungnam province, Korea. According to the methods of Hilsenhoff (1988), the scores of tolerance guild assigned 10 classes to each species by its habitat and feeding guild, but modified current 7 criteria to 5 scoring standards due to unclear borderline among species. Relative abundance in the species number of upper stream guilds was only 7% of the total, whereas the abundance in the species number of middle to downstream upper stream guilds was 64%. Mean SBI, based on dataset in Site 1 during 1995-2001 averaged 5.10, which was judged as a "good" condition by the rank criteria of SBI. Before the dam construction, mean SBI in the Site 1 was 4.61, indicating a "good" condition, but after the dam construction, mean SBI was 5.60, indicating a "fair" condition. Trajectory analysis in the Site 1 showed significantly (One-way ANOVA, $F_{6,21}=3.26$, p=0.02) different among years, reflecting the changes of fish composition and population density by the dam construction, whereas Site 2 showed no significant changes ($F_{6,21}=1.00$, P =0.45) difference among years. Mean SBI prior to the dam construction in the Site 3 was 4.52 but after the construction, the value was 6.30, indicating a distinct difference between the pre- and post-dam construction. Trajectory analysis at the Site 3 supported this fact: Values of SBI showed significantly ($F_{6,21}$=14.37, p<0.01) different. Mean SBI was 4.67 in the Site 4, indicating a "good" condition in the health and the health rank was same as the sampling sites 1, 2, and 4. Trajectory in the Site 4 showed no significant ($F_{6,21}=2.35$, p=0.07) difference among the years. Overall, our trajectory analysis indicated that three of four sampling sites (sites 1, 3, 4) showed significant decreases (n=7, p<0.05) and that the proportions of sensitive species declined evidently in the sites 1 and 2 and the tolerant species increased in the dam sites. Our outcomes may be used as a key data for diagnosis of the long-term ecological impact in the future in the watershed.

• Journal of Life Science
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• v.14 no.5
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• pp.732-740
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• 2004

MCM proteins are essential for eukaryotic DNA replication, playing roles in the initiation and elongation of DNA replication. MCM proteins expression is much higher in malignant tissues than normal tissues. Several reports have indicated the usefulness of MCM proteins as markers of cancer cells in histopathological diagnosis. However, the cause of enhanced expression of MCM proteins in cancer cells remain to be clarified. The purpose of this study is to examine the relative transcriptional activities of human mcm gene promoters in cancer and normal cells. The minimal promoter region required for transcription of a luciferase reporter gene was contained an E-box and one E2F site. In addition, luciferase activities from mcm7 and mcm2 promoter/luciferase gene reporter constructs were significantly increased in cancer cells at 8 times compared with normal cells. E-box and E2F binding site in the promoter of mcm genes are responsible for different mechanism of transcription regulation on the cellular environment.

• The Journal of the Korean dental association
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• v.58 no.6
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• pp.336-345
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• 2020

Peri-apical implant lesion, also known as 'retrograde peri-implantitis' can occur with multifactorial etiological factors. The purpose of this case report is to demonstrate resolution of periapical implant lesion by removal of causative factors and saving implant by regenerative therapy. A 54-year old male patient with mild dull pain around implant on the right mandibular second premolar area due to persistent peri-apical infection of the adjacent first premolar was treated. Extraction of tooth with symptomatic apical periodontitis and regenerative therapy on the buccal fenestration area of the implant and extraction site were performed. After 6-month reentry, notable regenerated bone tissue around implant was found, and implant placement on the previous extraction site was performed. After 14-month follow-up from the regenerative therapy, neither biological nor mechanical complication could be found around the implant, evidenced by high implant stability, normal clinical probing depth, and absence of discomfort spontaneously and during masticatory function. In conclusion, surgical intervention including regenerative therapy using bone graft and barrier membrane on periapical implant lesion can be suggested as one of the treatment options considering the extent of periapical lesion.

• Parasites, Hosts and Diseases
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• v.48 no.3
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• pp.263-265
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• 2010

Echinococcosis is a multisystem disease and has propensity to involve any organ, an unusual anatomical site, and can mimic any disease process. Primary peritoneal echinococcosis is known to occur secondary to hepatic involvement but occasional cases of primary peritoneal hydatid disease including pelvic involvement have also been reported. We report here 1 such case of primary pelvic hydatidosis mimicking a malignant multicystic ovarian tumor where there was no evidence of involvement of the liver or spleen. Our patient, a 27-year-old female, was detected to have a large right cystic adnexal mass on per vaginal examination which was confirmed by ultrasonography. Her biochemical parameters were normal and CA-125 levels, though mildly raised, were below the cut off point. She underwent surgery and on exploratory laparotomy, another cystic mass was found attached to the mesentery of the small gut. The resected cysts were processed histopathologically. On cut sections both large cysts revealed numerous daughter cysts. Microscopic examination of fluid from the cysts revealed free scolices with hooklets and the cyst wall had a typical laminated membrane with inner germinal layer containing degenerated protoplasmic mass. The diagnosis of pelvic hydatid disease was confirmed and patient was managed accordingly. Hydatid disease must be considered while making the differential diagnosis of pelvic cystic masses, especially in endemic areas.

• Journal of Biomedical Engineering Research
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• v.20 no.4
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• pp.451-459
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• 1999

During the electromyographic evaluation for the diagnosis of neuropathy, presence for site of lesion could be predicted by a detection of denervation potentials such as fibrillation potentials or positive sharp waves in a group of muscles. Unfortunately, since denervation potentials are distinguished by examiner's experience, it is possible to make mistake identifying endplate spikes as a denervation potential. The aim of the study was to extract parameters to make an algorithm for quantitative distinction between denervation potentials and endplate spikes. It will help to minimize the examiner's bias and to localize the site of lesion thus increase the reliability on EMG diagnosis. There types of signals, endplate spike, fibrillation potential and positive sharp wave were obtained from the EDB(extensor digitorum brevis) muscle using then neuropathic patients. Eight parameters such as duration, area, slope, peak-to-peak amplitude, positive peak negative peak amplitude, ratio of positive to negative peak amplitude, and number of phase were extracted and compared. As a results, peak-to-peak amplitude, positive peak amplitude, ratio of positive to negative peak amplitude showed statistically significant differences between endplate spikes and denervation potentials. It was concluded that those parameters could be used to establish an algorithm which will improve the accuracies in automated quantitative EMG diagnosis.