• 한국보건간호학회지
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• 제29권1호
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• pp.29-39
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• 2015

Purpose: The purpose of this study was to investigate the aging anxiety, factors of successful aging, and preparation for aging in early and late middle-aged people. Methods: The study subjects were 140 middle-aged people aged from 40 to 59. Data were collected using a self-administered questionnaire from August 16 to September 30, 2013. The collected data were analyzed with descriptive statistics, t-test, ${\chi}^2$-test and Pearson correlation coefficient using IBM SPSS 21.0 program. Results: Between early and late middle age, there were statistically significant differences in the subcategories of aging anxiety: fear of loss (t=2.93, p=.004), fear of old people (t=-2.33, p=.021), physical appearance (t=2.32, p=.022), and psychological concerns (t=2.04, p=.043). A statistically significant difference was found between two groups in one subscale of preparation for aging: physical preparation (t=-2.02, p=.045). In early midlife, significant associations were observed between preparation for aging and both aging anxiety (r=.56, p<.001) and factors of successful aging (r=.54, p<.001). In late midlife, preparation for aging and factors of successful aging showed positive correlation (r=.50, p<.001) Conclusion: Results of this study indicate that programs for successful transition to old age in middle-aged people should consider their aging anxiety level and preparation for aging at their stage of life.

• BMB Reports
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• 제48권11호
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• pp.595-596
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• 2015

Skeletal muscle exhibits a loss of muscle mass and function with age. Decreased regenerative potential of muscle stem/progenitor cells is a major underlying cause of sarcopenia. We analyzed microRNAs (miRNA) that are differentially expressed in young and old myoblasts, to identify novel intrinsic factors that play a degenerative role in aged skeletal muscle. miR-431, one of decreasing miRNAs in old myoblasts, improved the myogenic differentiation when overexpressed in old myoblast, but suppressed their myogenic capability in knockdowned young myoblasts. We found that miR-431 directly binds to 3` untranslated regions (UTR) of Smad4 mRNA, and decreases its expression. Given that SMAD4 is one of the downstream effectors of TGF-β, a well-known degenerative signaling pathway in myogenesis, the decreased miR-431 in old myoblast causes SMAD4 elevation, thus resulting in defective myogenesis. Exogenous expression of miR-431 greatly improved the muscle regeneration in the cardiotoxin-injured hindlimb muscle of old mice by reducing SMAD4 levels. Since the miR-431 seed sequence is conserved in human SMAD4 3'UTR, miR-431 regulates the myogenic capacity of human skeletal myoblasts in the same manner. Our results suggest that age-associated miR-431 is required for the maintenance of the myogenic capability in myoblasts, thus underscoring its potential as a therapeutic target to slow down muscle aging.

• 디지털융복합연구
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• 제11권12호
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• pp.121-144
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• 2013

본 연구는 중년층의 성공적 노화인식이 노후준비에 미치는 영향을 규명하기 위한 것이다. 이를 위하여 서울 경기지역의 35-65세 미만 중년층 350명을 대상으로 데이터를 수집하였고 위계적 회귀분석을 이용하여 분석하였다. 연구결과는 첫째, 중년층의 노후준비도는 평균 보통보다 약간 높은 수준으로 정서적 준비도가 가장 높았고 가장 준비도가 낮은 변인은 경제적 준비로 나타났다. 성공적 노화 인식수준은 상당히 긍정적인 인식수준을 보였으며 일상의 안녕에 대한 인식수준이 가장 높게 나타났다. 둘째, 노후준비에 영향을 주는 개인적 특성은 성별, 연령, 결혼상태, 종교유무, 직업, 월 가구소득, 건강상태, 노후계획정도, 사회활동 정도로 나타났다. 셋째, 성공적 노화인식은 노후준비에 정적인 영향을 미치는 것으로 나타나 성공적 노화 인식수준이 높을수록 성공적인 노후를 위한 준비를 보다 적극적으로 함을 알 수 있다. 성공적 노화의 하위변인 중 심리사회적 안녕과 자기효능감이 높을수록 신체적 준비를 잘 하고 있으며 심리사회적 안녕, 일상의 안녕, 자기효능감의 순으로 정서적 준비에 정적인 영향을 주는 것으로 나타났다.

• 대한한방내과학회지
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• 제26권2호
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• pp.379-389
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• 2005

Objectives: It is well known that aging and aging-related diseases are linked to the increased level of oxidative stress caused by reactive oxygen species(ROS) and reactive nitrogen species(RNS). Nonprotein-SH decreases during aging, while substances such as ROS, nitric oxide(NO), peroxynitrite($ONOO^-$), myeloperoxidase(MPO), and dityrosine show a significant increase. This study investigated the effect of Ichungwhan on the aging process by examining its effect on the generation of the above-mentioned substances. Methods: Four comparison groups of SD rats were used. They were 6 month-old rats, 24 month-old rats, and 24 month-old rats fed with food containing 0.1% and 0.3% of Ichungwhan extract. The amount of NO, $ONOO^-$, and ROS in the rats' kidneys were examined using a fluorescence microplate reader. The reagents used for this purpose include: dihydrorhodamine 123 (DHR 123), 2',7' -dichlorodihydrofluorescein, diacetate(DCFDA), and 4,5-diaminofluorescein(DAF-2). A spectrophotometer was used to investigate the reactivity of nonprotein-SH and myeioperoxidase(MPO), using reagents such as trichloroacetic acid(TCA) and tetramethylbenzidine(TMB). The amounts of MPO protein and dityrosine were measued by western blot. Results: The observed effects of Ichungwhan on rats were as follows: increase of nonprotein-SH; effective decrease of RNS level by suppression of the generation system of $ONOO^-$ and NO; decrease of ROS level; decrease of the MPO reactivity and the subsequent reduction of amount of MPO protein; retardation of dityrosine formation. It can be hypothesized, therefore, that Ichungwhan affects both the earlier and later phases of the molecular inflammatory process, and retards the aging process. Conclusions: Empirical evidence in this study supports a role for Ichungwhan in generation mechanisms of aging process-linked substances ROS, NO, $ONOO^-$, nonprotein-SH, MPO and dityrosine. Affects contrary to the aging process observed in rats beg further empiricism to investigate potential application of Ichungwhan as a medication for age-related diseases in humans.

• 방사선산업학회지
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• 제4권3호
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• pp.203-207
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• 2010

Radiation-induced late injury to normal tissue is a primary area of radiation biology research. The present study was undertaken to investigate whether the late effect of the ionizing radiation appears as an age-related oxidative status in the brain. Three groups of 4-month old C57BL/6 mice that were exposed to $^{137}Cs$ ${\gamma}-rays$ at a single dose (5 Gy) or fractionated doses ($1Gy{\times}5times$, or $0.2Gy{\times}25times$) at 2 months old were investigated for the oxidative status of their brains with both young (2-month) and old (24-month) mice. A significant (p<0.05) decrease in superoxide dismutase (SOD) activity was observed in old mice brains compared with that of the young mice. malondialdehyde (MDA) content was significantly (p<0.05) increased in the old mice brain. However, any significant difference in SOD activity and MDA contents of the irradiated brain was not observed compared to age-matched control group mice. SOD activity and MDA content were observed within good parameters of brain aging and there were no late effects on the age-related oxidative level in the ${\gamma}-ray$ irradiated mice brains.

• 한국노년학
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• 제38권2호
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• pp.309-327
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• 2018

본 연구의 목적은 중 노년의 노화불안에 미치는 변인들을 통합적으로 살펴보기 위하여 2007년 2월부터 2017년 3월까지 국내에서 보고된 34편의 연구에 대한 메타분석을 실시하였다. 노화불안 관련 변인들을 6개의 변인군으로 나누고 각각 변인군에 대하여 하위변인별로 효과크기를 산출하였으며 결과는 다음과 같다. 첫째, 전체효과크기는 중간효과크기를 보였고, 변인군에 따른 효과크기는 부정심리적변인군이 가장 높게 나타났으며, 긍정심리적변인군, 사회적변인군, 신체적변인군, 가족적변인군, 인구통계적변인군의 순으로 나타났다. 둘째, 하위변인들 중에서는 심리적 안녕감, 죽음불안의 효과크기가 가장 높게 나타났다. 상기와 같이 노화불안과 관련된 변인들 중 심리적변인군에 속한 심리적 안녕감과 죽음불안의 효과크기가 높게 나타남에 따라 이러한 변인들이 노화불안 중재에 영향력이 클 수 있음을 시사하였다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.713-716
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• 2002

Aging effect on the cardiovascular circulation is simulated by lumped parameter model. Aging phenomena can be hemodynamically explained as (1) the increase of flow resistance induced by remodeling of artery vessels and increased viscosity of blood and (2) the reduction of the vessel capacitance caused by arteriosclerosis. Appropriate physiological parameters are evaluated from the clinical data of adults and old men. Simulation results well explain the hypertension with aging of cardiovascular system.

• 대한안전경영과학회지
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• 제11권2호
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• pp.159-165
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• 2009

Through the understanding of the change of productivity and the ability of error recovery according to aging and the assessment and analysis of them, we may take this research to contribute to make a design for the road-map to help set up the policy of employment for old generation. For this we have taken an experiment of the coordination tester for 100 person who are chosen randomly and analysed the collected data using SAS, which is one of widely used statistical analysis packages. The main results are as follow: $\circledcirc$ The result of regression between the working speed and the length of the correction of error shows independence. (pr>0.2029). $\circledcirc$ The regression between age and working speed is statistically significant. (pr<0.0001) $\circledcirc$ The relation between age and the length of the correction of error is not significant. (pr>0.9123).

• 한국주거학회논문집
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• 제18권1호
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• pp.95-102
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• 2007

As the aging of this society, instead of growing numbers old protective functions of families decreased according to increasing tendency of nuclear families, increasing rates of females' participation of economic activities. Now, the problem of supporting the old is in need of social supporting system the cope with this situation. Thus it needs that welfare service for the elderly who stay at home that have local basis. The results are based on these factors are like this: 1) It is necessarily the instruction of medical welfare service. 2) The overlapped service is avoided and the service of specialized. 3) Most of the welfare service institution is Seoul and local city hall, so it needs the institution is transferred. 4) It needs the increase the number of home helper. 5) When the service is offered, the government must considers finance, elderly health condition and preference. 6) It needs the department for the welfare service for the old who stay at home.

• 한방안이비인후피부과학회지
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• 제23권1호
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• pp.253-259
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• 2010

Objectives: We investigated $L^*a^*b^*$ and $ITA^{\circ}$ value on the face to correlate the complexion of Korean female with aging theory of Neijing(內經) in Suwen-Shanggutianzhenlun(素問,上古天眞論). Methods: Three hundreds and thirty one Korean females, aged 22-64 years($39.36{\pm}9.71$ years) were participated in this study. We measured the skin properties of the face with Spectrophotometer CM2600d(Minolta, Japan). Trisimulus $L^*a^*b^*$ color and $ITA^{\circ}$ value divided on 7 years were and analyzed by regression analysis method. Results: $L^*$, ITA value decreased and $a^*$, $b^*$ increased as the age increases. Among these, we found out that ITA value is most related to aging. $L^*$ value decreased among the group of 28 to 35 years old. ITA value decreased among the group of 35 to 42 years old. $a^*$ value decreased among the group of 42 to 49 years old. Conclusions: Unique aging pattern by 7 years of female in Oriental medicine is reflected to complexion.