• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.787-792
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• 2015

Background: Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies, originating in the lymphatic organs, whose incidence is increasing in developed as well as developing countries. Epidemiological evidence suggests that aspirin may reduce the incidence and mortality of several cancers. The main objective of this study was to evaluate the potential relationship between using aspirin and development of NHL with a meta-analysis. Materials and Methods: A total of 7 studies were included. Outcome was calculated and reported as odds ratios (ORs). Heterogeneity was assessed with Cochrane Q and $I^2$ statistics. Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis. Results: Our analysis showed OR of developing NHL overall of 1(95% CI: 0.87-1.16, p=0.9), and in females this was 0.81 (95%CI: 0.72-.92, p=0.001) and in males 1.01 (95%CI: 0.82-1.26, p=0.86). The odds ratio (OR) of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) was 0.85 (95%CI: 0.75-0.97, p=0.02), The ORs of follicular lymphoma (FL) and large B-cell lymphoma (DLBCL) in individuals exposed to aspirin were 1.12 (95%CI: 0.86-1.45, p=0.37) and 1.03 (95%CI: 0.9-1.19, p=0.6) respectively. Conclusions: In conclusion, individuals taking aspirin do not demonstrate any change in risk of Non-Hodgkins lymphoma.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.675-678
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• 2015

Background: There are several validated risk factors for breast cancer. However the legitimacy of elevated fasting blood glucose (FBG) is not well established. This study was designed to assess this parameter as a risk factor for breast cancer among pre- and post-menopausal women. Materials and Methods: This case-control study was conducted at Department of Biochemistry, University of Karachi from June 2010 to August 2014. Simple random sampling technique was used to collect data of study subjects comprising 175 diagnosed breast cancer patients with positive histopathology from Breast Clinic, surgical unit-1, Civil Hospital, Karachi and 175 healthy controls from various screening programs. Blood samples were analyzed for FBG and serum insulin. Results: FBG, HOMA-IR, systolic and diastolic blood pressure were significantly raised in breast cancer cases when compared to control subjects. Cases and controls were further categorized in to two groups using cutoff value of 110mg/dl to distinguish subjects into normal fasting glucose (<110mg/dl) and having impaired fasting glucose (${\geq}110-{\leq}125mg/dl$) or diabetes (${\geq}126mg/dl$). Odds ratios were found to be 1.57, 2.15 and 1.17 in overall, pre-menopausal and post-menopausal groups, respectively. (all p < 0.05). Conclusions: A statistically significant risk of breast cancer exists in women having elevated fasting blood glucose levels, corresponding to prediabetes and diabetes, among pre and postmenopausal ages, with comparatively greater effects in the premenopausal group.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1931-1935
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• 2013

Background: This study was undertaken to identify the socio-demographic determinants of quit attempts among smokers and smokeless tobacco users to identify correlates of tobacco cessation behaviour in India Materials and Methods: This was a cross-sectional study for the outcome of quit attempts made by current tobacco users in last 12 months in twelve districts in two states. Simple and multivariable logistic regression analysis was used to obtain the odds ratios (ORs) of socio-demographic variables (age, gender, education, occupation, socio-economic status, community, area, type of family) and tobacco user status (smoker/smokeless). Results: In the combined analysis, a smoker had higher predicted probability of attempting quitting (OR-1.41,CI 1.14-1.90), in comparison to a smokeless tobacco user and a tobacco user in the state of Gujarat was less likely to attempt quitting than a user in Andhra Pradesh (OR-0.60, CI 0.47-0.78). The probability of making a quit attempt was higher among tobacco users who were more educated (OR-1.40, CI 1.04-1.94), having a higher socio-economic status (SES) (OR-2.39, CI 1.54-3.69), and belonging to non-agricultural labourer occupational group (OR-1.90, CI 1.29-2.78). The effects were maintained even after adjusting for all other variables. In disaggregated analysis, findings were similar except in smokeless as a separate group, education level was not significantly associated with quit attempts and with lower odds (OR-0.91, CI 0.58-1.42). Conclusions: This is one of the first studies to provide useful insight into potential determinants for quit attempts of tobacco users in India including smokeless tobacco users, exploring the socio-demographic patterning of correlates of quit attempts.

• Journal of Acupuncture Research
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• 제31권4호
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• pp.71-79
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• 2014

Objectives : The aim of this study is to evaluate the safety of acupuncture therapy when applied to patients who are undergoing anticoagulants / antiplatelet medication therapy combined with herbal medicine using a retrospective, case-control study. Methods : 428 charts of patients were reviewed in this study. Odds ratio between case of bleeding-related adverse event and control was calculated as main analysis. Exposures were anticoagulants / antiplatelet medication, Hwalhyeolgeoeo herbal medicine and combination of both drugs. Additionally, odds ratios were calculated according to the severity of bleeding-related adverse events. Results : The results were as following: 1. Analysis of all bleeding-related adverse events showed there was no increased risk of combined therapy compared with other exposures and control group. 2. Analysis of only clinically significant adverse events showed there was no increased risk of combined therapy compared with other exposure and control group. 3. Hwalhyeolgeoeo herbal medicine group showed a tendency of increased risk of bleeding-related adverse events in all analysis but was not statistically significant. Conclusions : The results suggest that Hwalhyeolgeoeo herbal medicine-anticoagulant / antiplatelet medication combined therapy may not increase risk of bleeding-related adverse events in acupuncture therapy. By executing various modules of analysis, it was possible to acquire useful data for possible future studies. Further research is needed to confirm such results.

• Journal of the Korean Data and Information Science Society
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• 제20권5호
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• pp.819-827
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• 2009

국립축산과학원에서 수집한 한우 관능 평가 데이터에 대해 사회 인구학적 요인과 한국 소비자들의 맛 평가에 대한 연관성을 연구하고자 한다. 소비자 거주지역, 연령, 성별, 직업, 월수입과 쇠고기 부위를 설명변수로 맛등급 평가를 반응변수로 이항 다중 로지스틱 모형과 다항 다중 로지스틱 모형을 적합하고 회귀계수별 유의성 검정과 적합도 검정을 실시하였다. 단계별 변수 선택으로 최종 모형을 선택하고 반응변수 범주에 대한 오즈비를 계산하여 관련성을 파악한다. 그 결과 거주 지역, 연령, 월수입과 쇠고기 부위 변수들이 선택되었다. 영남에서 맛을 비교적 높게 평가하는 경향이 있으며 수입이 많고 연령이 높을수록 맛을 까다롭게 평가하는 경향을 보인다. 쇠고기 부위별로는 우둔에 비해서 등심이 다른 부위들 중 맛에 대한 차이가 크다고 볼 수 있다.

• 응용통계연구
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• 제23권5호
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• pp.857-870
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• 2010

국립축산과학원에서는 2006년 부터 2008년 까지 전국 소비자들을 대상으로 한우 거세우 표본 시료에 대한 관능 평가 조사를 실시하여 데이터를 수집하였으며 본 연구에서는 한우 관능 평가 데이터에 대해 사회 인구학적 요인과 한국 소비자들의 맛 평가에 대한 연관성을 탐구하고자 한다. 소비자 거주지역, 연령, 성별, 직업, 월수입과 쇠고기 부위를 설명변수로 맛등급 평가를 반응변수로 이항 다중 로지스틱 모형과 다항 다중 로지스틱 모형을 적합하고 회귀계수별 유의성 검정과 적합도 검정을 실시한다. 단계별 변수 선택으로 최종 모형을 선택하고 반응변수 범주에 대한 오즈비를 계산하여 맛등급과 설명변수들 간의 관련성을 파악한다. 또한 맛과 관련 있는 연속형 변수를 설명변수로 포함한 경우에 대해서도 이항 다중 로지스틱 모형과 다항 다중 로지스틱 모형을 적합하고 비교한다. 그 결과 거주 지역, 연령, 월수입과 쇠고기 부위 변수들이 선택되었으며 영남지역에서 맛에 대한 오즈가 큰 편이며 수입이 많고 연령이 높을수록 맛에 대한 오즈가 작은 편이었다. 요리법으로는 탕에 대한 구이의 오즈비가 큰 편이며 쇠고기 부위별로는 우둔에 비해서 등심이 다른 부위들 보다 맛에 대한 차이가 크다고 볼 수 있다. 연속형 변수로는 연도가 맛등급에 큰 영향을 미치는 변수로 나타났다.

• 한국산업보건학회지
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• 제27권3호
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• pp.201-209
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• 2017

Objectives: This study was conducted to assess the association between level of physical activity and depressive symptoms among Korean male workers. Methods: A self-administered questionnaire was distributed and anthropometric measurements were conducted with 1,379 male workers during a general health check. From this data, we identified the general characteristics, levels of physical activity(IPAQ), and depressive symptoms(CES-D) of the study population. We conducted univariate logistic regression to verify the variables that affect depressive symptoms and multivariate logistic regression to calculate odds ratios. Results: Among the 1,379 male workers, 43.4% were in the insufficiently active group(IPAQ category 1) and 22.8% were in the depressive symptom group($CES-D{\geq}16$). The odds ratio(OR) for depressive symptoms was statistically higher in the insufficiently active group, workers aged over 30, the shift work group, and the unmarried group. Adjusted for those variables, the ORs for depressive symptoms were found to be 1.45(95% CI=1.25-2.11), 1.15(OR=1.15, 95% CI=1.08-1.99) and 1.75(95% CI=1.48-2.02), for the insufficiently active group, workers aged over 30, and the shift work group, respectively. Conclusions: We found physical inactivity, age, marital status, and shift work to be associated with depressive symptoms among male workers. This study supports the suggestion that physical activity can be helpful to reduce depressive symptoms among workers.

• Parasites, Hosts and Diseases
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• 제52권4호
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• pp.391-397
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• 2014

We evaluated the status of Clonorchis sinensis infection and potential risk factors among residents of riverside areas (Geumgang) in Muju-gun, Jeollabuk-do (Province), Korea. From January to February 2010, a total of 349 (171 males, 178 females) stool samples were collected and examined by the formalin-ether concentration technique. Also, village residents were interviewed using questionnaires to obtain information about C. sinensis infection-related risk factors. Overall egg-positive rate of C. sinensis was 13.2%. Egg-positive rates were significantly higher in males, farmers, and residents who had lived there more than 20 years, and in residents who had eaten raw freshwater fish than in opposite groups, respectively. However, there was no significant difference between age groups, education levels, cigarette smoking, alcohol drinking, health status, past history of infection, and experience of clonorchiasis medication and examination. Logistic regression analysis was performed to determine risk factors for clonorchiasis. On univariate analysis, the odds ratios for males, farmers, those who had lived there more than 20 years, and who had eaten raw freshwater fish were 2.41, 4.44, 3.16, and 4.88 times higher than those of the opposites, respectively. On multivariate analysis, the odds ratio of residents who had eaten raw freshwater fish was 3.2-fold higher than that of those who had not. These results indicate that residents living in Muju-gun, along the Geum River, Korea, have relatively high C. sinensis egg-positive rates, and the habit of eating raw freshwater fish was the major factor for the maintenance of clonorchiasis.

• Journal of Preventive Medicine and Public Health
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• 제41권6호
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• pp.427-433
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• 2008

Objectives: This study was performed to assess the association between physical activity and the clustering of metabolic abnormalities among Korean children. The effect of substituting moderate to vigorous physical activity for the time spent in inactivity was examined as well. Methods: The study subjects were comprised of 692 (354 boys, 338 girls) 4th grade elementary school students. We used a modified form of the physical activity questionnaire that was developed in the Five-City Project. The subjects with clustering of metabolic abnormalities were defined as having two or more of the following five characteristics: waist circumference ${\geq}90\;%$, systolic or diastolic blood pressure ${\geq}90\;%$, fasting glucose ${\geq}110\;mg/dl$, triglycerides ${\geq}110\;mg/dl$ and HDL cholesterol ${\geq}40\;mg/dl$. We calculated the odds ratios to assess the effect of substituting moderate to vigorous physical activity for time spent in inactivity. Results: The risk of clustered metabolic abnormalities was inversely correlated with the increased time spent on moderate to vigorous physical activity, but the correlation was not significant. The odds ratio for clustering of metabolic abnormalities that represented the effect of substituting moderate to vigorous physical activity for 30minutes of sedentary activity was 0.87(95% Cl=0.76-1.01). Conclusions: These findings suggest that substituting moderate to vigorous physical activity for sedentary activity could decrease the risk of clustered metabolic abnormalities.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.522-529
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• 2013

Background Despite advances in surgical techniques, sterile protocols, and perioperative antibiotic regimens, surgical site infections (SSIs) remain a significant problem. We investigated the relationship between wound classification (i.e., clean, clean/contaminated, contaminated, dirty) and SSI rates in plastic surgery. Methods We performed a retrospective review of a multi-institutional, surgical outcomes database for all patients undergoing plastic surgery procedures from 2006-2010. Patient demographics, wound classification, and 30-day outcomes were recorded and analyzed by multivariate logistic regression. Results A total of 15,289 plastic surgery cases were analyzed. The overall SSI rate was 3.00%, with superficial SSIs occurring at comparable rates across wound classes. There were similar rates of deep SSIs in the clean and clean/contaminated groups (0.64%), while rates reached over 2% in contaminated and dirty cases. Organ/space SSIs occurred in less than 1% of each wound classification. Contaminated and dirty cases were at an increased risk for deep SSIs (odds ratios, 2.81 and 2.74, respectively); however, wound classification did not appear to be a significant predictor of superficial or organ/space SSIs. Clean/contaminated, contaminated, and dirty cases were at increased risk for a postoperative complication, and contaminated and dirty cases also had higher odds of reoperation and 30-day mortality. Conclusions Analyzing a multi-center database, we found that wound classification was a significant predictor of overall complications, reoperation, and mortality, but not an adequate predictor of surgical site infections. When comparing infections for a given wound classification, plastic surgery had lower overall rates than the surgical population at large.