• 사물인터넷융복합논문지
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• 제4권2호
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• pp.21-28
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• 2018

본 연구에서는 ALK receptor tyrosine kinase (ALK) 유전자의 단일염기다형성이 뇌출혈의 발병에 관여하는 지를 연구하였다. 156명의 뇌출혈 환자와 425명의 정상인를 모집하였으며 네 개의 단일염기다형성에 대하여 상관성을 살펴보았다. 통계분석에서는 SNPstats, SPSS22.0, Haploview 프로그램을 활용하였다. Odd ratio, 95% 신뢰구간에서는 genotype 모델 및 allele 모델에서 계산하였다. 통계분석결과, rs1881421, rs1881420, rs3795850, rs2246745 의 단일염기다형성이 뇌출혈과 관련하여 유의성을 보였다. (rs1881421, OR=2.02, 95% CI=1.54-2.64, p<0.001; rs1881420, OR=0.53, 95% CI=1.16-2.01, p=0.003; rs3795850, OR=1.54, 95% CI=1.17-2.02, p=0.002; rs2246745, OR=1.95, 95% CI=1.46-2.60, p<0.001 in each allele analysis). CC, GT, and GC haplotypes 빈도 역시 유의성을 보였다. 네 개의 단일염기다형성의 minor allele 가 뇌출혈의 발병을 증가시키는데 기여하였다. 이러한 연구 결과는 ALK 유전자가 뇌출혈의 위험성과 관련 있음을 시사한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.847-853
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• 2014

There is a lot of debate on the relationship between vitamin D receptor polymorphisms and risk of breast cancer. Herein, we quantitatively analyzed the published case-control studies on this relationship by meta-analysis, performing a bibliographic search from Pubmed and CNKI up to July 31, 2013. The included case-control studies for Fok1, Bsm1, Taq1, Apa1, Cdx2 and Poly-A were 16, 19, 20, 10, 4, 6, respectively. Crude and adjusted odd ratios and 95% confidence intervals were calculated to present and compare the strength of any associations. The results of combined analyses indicated that Fok1, Bsm1, Apa1, Cdx2 and Poly-A were not significantly associated with the risk of breast cancer. In contrast, the tt genotype of Taq1 was a modest risk factor for breast cancer development (tt vs. TT: OR = 1.21, 95% CI: 1.01-1.44). To further confirm the above results, adjusted effects for the six polymorphisms were pooled based on adjusted ORs reported in the original studies. Adjusted ORs of Fok1, Apa1, Cdx2 and Poly-A were similar to the crude ORs. However, Bsm1 and Taq1 showed inconsistent results. For Bsm1, OR for BB vs. bb was 0.85, 95% CI: 0.74-0.98; for Taq1, OR for tt vs. TT was 1.03, 95% CI: 0.92-1.15, and not associated with risk. Subgroup analyses for crude ORs showed some association between Bsm1, Taq1 and breast cancer in Caucasians only, but for adjusted ORs, no associations were found. This meta-analysis suggests that the roles that Fok1, Apa1, Cdx2 and Poly-A polymorphisms play in breast cancer risk are negligible, with Bsm1 and Taq1 as possible exceptions. To be conservative, we still assumed that they may play a modest role in determining breast cancer risk. Further studies are needed to validate our findings.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3335-3340
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• 2016

Background: Oral submucous fibrosis (OSF) is a precancerous condition with a 4 to13% malignant transformation rate. Related to the habit of areca nut chewing it is mainly prevalent in South-east Asian countries where the habit of betel quid chewing is frequently practised. On chewing, alkaloids and polyphenols are released which undergo nitrosation and give rise to N-nitrosamines which are cytotoxic agents. CYP450 is a microsomal enzyme group which metabolizes various endogenous and exogenous chemicals including those released by areca nut chewing. CYP1A1 plays a central role in metabolic activation of these xenobiotics, whereas CYP2E1 metabolizes nitrosamines and tannins. Polymorphisms in genes that code for these enzymes may alter their expression or function and may therefore affect an individuals susceptibility regarding OSF and oral cancer. The present study was therefore undertaken to investigate the association of polymorphisms in CYP1A1 m2 and CYP2E1 (RsaI/PstI) sites with risk of OSF among areca nut chewers in the Northern India population. A total of 95 histopathologically confirmed cases of OSF with history of areca nut chewing not less than 1 year and 80, age and sex matched controls without any clinical signs and symptoms of OSF with areca nut chewing habit not less than 1 year were enrolled. DNA was extracted from peripheral blood samples and polymorphisms were analyzed by PCR-RFLP method. Gene polymorphism of CYP1A1 at NcoI site was observed to be significantly higher (p = 0.016) in cases of OSF when compared to controls. Association of CYP1A1 gene polymorphism at NcoI site and the risk of OSF (Odd's Ratio = 2.275) was also observed to be significant. However, no such association was observed for the CYP2E1 gene polymorphism (Odd's Ratio = 0.815). Our results suggest that the CYP1A1 gene polymorphism at the NcoI site confers an increased risk for OSF.

• 산업융합연구
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• 제21권5호
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• pp.77-85
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• 2023

자살은 한국 청소년의 주요 사망 원인입니다. 자살 생각과 우울 증상의 위험 요인으로서 외로움의 역할에 대한 관심이 높아지고 있다. 그러나 한국 상황에 대해서는 알려진 바가 거의 없다. 본 연구는 2020년과 2021년 한국청소년건강행태조사에 참가한 총 109,796명의 응답자를 분석하였다. 외로움과 자살 생각 및 우울감 사이의 연관성을 시험하기 위해 다중 로지스틱 회귀 모델을 이용하였다. 공변량으로는 인구학적 특성, 학교, 가계 소득, 생활 방식, 자가 평가 건강, 및 폭력으로 인한 치료 횟수가 포함되었다. 보정 오즈비(OR) 및 95% 신뢰 구간(CI)을 산출하였다. 청소년의 12.0%는 자주, 3.0%는 항상 외로움을 느낀다고 보고하였다. 자살생각과 우울감의 유병률은 각각 11.8%과 26.0%이었다. 자살생각의 유병률은 자주 외로운 청소년(35.1%)보다 항상 외로운 청소년(52.6%)에서 더 높았다. 전혀 외로움을 느끼지 않은 청소년에 비해서 항상 외로운 청소년은 자살 생각(OR=30.7; 95% CI, 27.1 - 34.8)과 우울함(OR=32.5; 95% CI, 29.2 - 36.4)을 가질 위험이 훨씬 더 높았다. 결론적으로 외로움은 한국 청소년의 자살생각과 우울감의 주요 위험요인이다. 외로움의 상태를 모니터링하고 해결하는 것이 자살생각과 우울감을 줄이는데 도움이 될 수도 있다.

• 복식
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• 제50권7호
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• pp.181-193
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• 2000

The purpose of this study was to establish the marketing strategy, that strengthens the brand royalty of their own in apparel industry and that can induce consumer's brand switching against competitive brand. This might be done by suggesting influencing factors on the brand switching for fashion goods. This study was classified into theoretical and experimental study Experimental study was done, using the survey to prove the models for consumers' responses to brand switching by the theoretical study. The survey was conducted through two preliminary questionnaires. It was used as a criterion to prove the validity of the main survey and analyse the reliability. It analyzed at last five hundred ninety-two women in the age of twenty to thirty years odd who live in Seoul and the suburban of Seoul. Followings are the summary of the results revealed through the experimental study. First, brand switching behavior of consumers far formal dress was attributed to two extremes the inner motivation of variety seeking tendency and communication contact, complex variety seeking group, true variety seeking group, derived variety seeking group, and variety avoiding group. Second, the structure of low dimension related fashion according to factor analysis, which affects brand switching, was composed to involvement in 5-dimension, information search in 3-dimension. Based on the results of this study the types of brand switching in fashion goods can be classified by the variety seeking tendency. as inner motivation, and level of contact communication as a outside stimuli. In addition this study showed a correlation among the factors for brand switching related to variables of fashion.

• 한국융합학회논문지
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• 제9권8호
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• pp.71-76
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• 2018

본 연구의 목적은 우리나라 성인의 비만과 치주질환간의 관련성을 평가하고자 하였다. 2015년 국민건강영양조사자료를 사용하였으며, 최종 분석대상자는 4,827명이다. 치주질환은 지역사회치주지수로 평가하였다. 비만은 체질량지수로 측정하였다. 오즈비는 이분형로지스틱회귀분석을 이용하여 분석하였다. 층화변수는 흡연과 당뇨이며, 성별, 연령, 교육수준을 공변수로 보정하였다. 본 연구 결과는 비만인 경우에서 치주질환 위험이 1.29배(95% CI=1.11-1.49)로 나타났으며, 비흡연군과 당뇨가 없는군을 동시에 고려한 하위분석에서는 정상에 비해 비만군에서 치주질환 위험이 1.20배(CI=1.02-1.48) 유의하게 높게 나타났다. 본 연구는 비만이 치주질환의 독립적인 위험요인임을 파악할 수 있었다. 국민의 구강건강수준 향상을 위해 치주질환 관리하고자 할 때 비만도 함께 고려되어야 할 것이다.

• Journal of Radiation Protection and Research
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• 제18권1호
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• pp.53-61
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• 1993

홀수 핵종인 $^{75}As$의 핵 구조를 분광학적 방법으로 연구하기 위하여 $^{75}Se$의 전자 포획에 의하여 방출되는 감마선에 대해 단일 감마선 측정과 감마-감마 동시측정 실험을 하였다. 본 실험에서 구한 각 상관관계 계수는 $A_{22}=-0.452{\pm}0.017,\;A_{44}=0$이고 279.5keV 전이 감마선에 대한 혼합비는 ${\delta}=-0.586{\pm}0.017$을 얻었다. 또한 낮은 준위에서의 에너지의 상대 강도를 정확히 측정한 후 이를 이용하여 환산 행렬 요소들을 계산한 후 단일 입자 모형의 관점에서 hindrance factor를 구했다. 그 결과 279.5 keV 감마 전이의 다중극도는 74.44%의 Ml 전이와 25.56%의 E2 전이를 포함한 혼합 전이이며 5/2 준위의 밴드구조를 $f_{5/2}$ proton준위에 바탕을 둔 1/2 [310]으로 결정하였다.

• 복식
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• 제64권7호
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• pp.97-113
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• 2014

The study aims to determine the significance and characteristics of self-similarity inherent in natural objects or phenomena, the existence of self-similarity in design created by fashion designers, and the traits and internal significance implied in self-similarity and their effects on fashion. The subject of the study is Viktor & Rolf, and the scope of the study is the collections created from 2001 to 2014, which include designs implemented in their early years and those unveiled in the media. Self-similarity means attributes of a fractal structure appearing without change in the original form, even after modification of scale or direction in terms of shape or phenomena. As self-similarity is applied to the arts and design sectors, it leads people to pay attention to fundamental characteristics and intrinsic forms as a factor of expressing a unique creative world. Analysis of Viktor & Rolf collections generated ribbons, overlapping/juxtaposition, side decorations and exaggerated design elements as basic units of self-similarity. These factors had self-similarity rates as high as 84%. Self-similarity was established as design elements formed in the incipient stage were repeated in a certain form, and continued for a long period of time. It served as an element that recognizes design and a fashion designer at the same time. Characteristics of self-similarity appearing in Viktor & Rolf collections can be summarized as homeostasis based on an equivalent relationship, balance based on self-organization, reducibility into essential elements, and uniqueness based on odd shapes. These characteristics influenced the pursuit of consistent brand image, the maintenance of a fashion designer's creative world, the formation of styles and the expression of a fashion designer's identity.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7507-7512
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• 2015

Background: In the low incoming country Bangladesh, breast cancer is second most common neoplasm and is increasing at an alarming rate among females. Lack of awareness and illiteracy are contributory factors for late presentation and therefore mortality. Purpose: To examine associations of different factors with breast cancer mortality and to raise awareness among the women of society in Bangladesh. Materials and Methods: This descriptive case-control study was conducted on 160 participants from April 2011 till July 2014. Through a valid questionnaire covering personal and family history, data were collected by face to face interview. For analyzing correlations among factors with breast cancer data, binary logistic regression, Pearson's ${\chi}^2$-value, odd ratios and p-value tests were conducted with SPSS version 20. Results: The mean age of the patients was 43.0 ($SD={\pm}11.12$). In ascending order the leading significant factors were hormone therapy (p<0.0000, OR=4.897), abortion (p<0.0001, OR=3.452), early start menarche (p<0.0002, OR=3.500), family history (p<0.0022, OR=3.235), and late menopause (p<0.0093, OR=3.674) with both ${\chi}^2$ test and logistic regression analyses. Non-significant factors were cancer experience, fatty food habits, marital status and taking alcohol. Conclusions: Regarding the investigation of this study, significant and insignificant factor's correlation visualization with breast cancer will be helpful to increase awareness among Bangladeshi women as well as all over the world.

• 대한의생명과학회지
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• 제7권3호
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• pp.117-125
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• 2001

This study was performed in order to evaluate the risk factors for nosocomial urinary tract infection and the frequencies of organisms isolated, and to provide the epidemiologic and basic data of hospital acquired urinary tract infection in intensive care unit. A prospective analysis was performed with 1,235 urine samples following urinary bladder catheterization in 569 patients, who had no evidence of UTI at the time of catheter insertion, admitted to intensive care unit in Pusan P hospital between June 1997 and May 1998. To identify risk factors for UTI, clinical characteristics of infected patients were analyzed. We analyzed these data by percentage, chi-square and odd ratio. Obtained results were as follows: A total of 569 patients (male 341 and female 228) were an average age of 50.8 years and catheterization of 8.04 days. Incidence of UTI was 16.1% (199/1,235) and The risk factors of UTI were duration of catheterization over 7 days, no use of systemic antibiotics, summer and female, and During the first 7 days these risk factors were no use of systemic antibiotics, summer, place of first catheter insertion (ICU) and type of intensive care unit (NSICU). A total of 220 the isolated strains were Gram negative rod 83 (37.7%), yeast like fungi 74 (33.6%) and Gram positive cocci 63 (28.6%). The common organisms isolated were Enterococcus faecalis 23 (10.5%), Serratia marcescens 19 (8.6%), Pseudomonu spp.17 (7.7%), E. ooh 16 (7.3%), Staphylococcus epidemidis 11 (5.0%) mdklebsiellapneumoniae 8 (3.6%). Therefore, in these results 199 of 569 (35%) patients in ICU with indwelling urinary catheter developed UTI. The risk factors for UTI are prolonged duration of catheterization, no use of systemic antibiotics, summer, and female.