• Clinical and Experimental Reproductive Medicine
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• 제47권3호
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• pp.155-160
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• 2020

Objective: The genes Bcl-2 and Bax play important roles in apoptosis. Many studies have shown that formalin has a strong deleterious effect on male fertility and can induce apoptosis. L-carnitine has been reported to potentially reverse the negative effects of formalin, leading to improved spermatogenesis. In this study, we examined the levels of expression of Bcl-2 and Bax in mice treated with formalin and L-carnitine. Methods: Thirty adult BALB/c mice were categorized into three groups. The mice in the control group (n = 10) were not injected with any substance. The mice in the second group (n = 10) received 10 mg/kg of formalin daily via an intraperitoneal injection, while those in the final group (n = 10) were intraperitoneally injected daily with a dose of 10 mg/kg of formalin and 100 mg/kg of L-carnitine. All mice were kept in isolated cages for 31 days. Results: The expression of Bax was significantly higher in the formalin-treated mice than in the mice of the control group, while the expression of Bcl-2 was significantly lower in the formalin-treated mice than in the control mice. Additionally, relative to control mice, Bcl-2 expression increased and Bax expression decreased in the mice administered both formalin and L-carnitine. Conclusion: In this study, L-carnitine was shown to augment Bcl-2 expression and to reduce Bax expression, indicating that this compound may inhibit apoptosis. Due to its positive effects, L-carnitine can be used as a prophylactic treatment for people who routinely come into direct contact with formalin as an occupational hazard.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6613-6618
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• 2013

To evaluate the relationship between alcohol drinking, XRCC1 codon 194 and 399 polymorphisms and risk of colorectal cancer, we conducted a case-control study with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. The XRCC1 codon 194 and 399 genotypes were identified using polymerase chain reaction and restrictrion fragment length polymorphism methods (PCR-RFLP). A structured questionnaire was used to elicit detailed information. Odds ratios (ORs) were estimated with an unconditional logistic model. In this study no significant differences were observed among the studied groups with regard to the genotype distribution of the XRCC1 codons 194 and 399 and the risk of colorectal cancer did not appear to be significantly influenced by genotype alone, whereas alcohol consumption showed a positive association (P for trend <0.01). When combined effects of XRCC1 polymorphisms and alcohol consumption were analyzed, we found that the 194Trp or 399Gln alleles further increased the colorectal cancer risk due to high alcohol intake. These findings support the conclusion that colorectal cancer susceptibility may be altered by gene-environment interactions.

• 대한인간공학회지
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• 제31권6호
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• pp.773-783
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• 2012

Objective: The aim of this study is to identify foot shapes of Korean male farmers by classifying their foot types using 3D scan data and analyzing the characteristics of each type. Background: The increasing demands for anthropometric information for the design of machinery and personal protective equipment to prevent occupational injuries has necessitated an understanding of the anthropometric differences to be found among occupations. Static stooped posture and squatting posture are so common in Korean farmers that anthropometric deformation in foot especially seems to occur easily. Method: 366 Korean male farmers volunteered for this study from 16 different farming villages nationwide from 2009 to 2011. Subjects were categorized into 4 age groups from 40s to 70s. Their right feet were measured by using 3D foot scanner, the anthropometric dimensions were composed of 40 items. Results: The 8 major factors affecting the foot shapes were extracted. From these factors the foot shape of Korean male farmers was classified into 3 Foot types. Foot type 1 showed severe deformation in toe 1, type 2 had a narrow shape and type 3 had a wider width for its length. Conclusion: There were some differences in foot shape and types between farmers and the public. The most characteristic foot type in Korean male farmers was type 3. Application: The results of identifying foot shapes of Korean male farmers might provide the useful information for designing ergonomic farm work shoes.

• 보건행정학회지
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• 제17권2호
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• pp.33-51
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• 2007

The disabled population is a vulnerable group, having very complex medical conditions, but little is known about differences in the level of access by type of disability. This study was performed to investigate the differences of health care utilization by the type of disability. The database was constructed from registry of the disabled and health insurance and medical aid claims data submitted to the Korea Health Insurance Cooperation during in the year 2003. The disability classified three groups according to the Disabled Welfare Act; physically disability with external dysfunction, physically disability with organic disease, and mentally disability. There were huge differences in health care utilization by the type of disability. For the inpatient care, those with a mental disability were more likely to utilize health care services in terms of average visit number of medical facilities and visit days per case, but the treatment amount per case was the highest in physically disabled with organic disease. For the outpatient care, those who the physically disabled with organic disease were more likely to utilize health care services in terms of average visit number of medical facilities, treatment amount per case, and the treatment days per case. Also, those who physically disabled with organic disease were more likely to utilize general hospital for both inpatient and outpatient care, and spent more out-of-pocket expenditure. As the number of persons with disabilities rises, the need to consider new approaches to protecting their health grows increasingly. Especially, Korean health care system should be refined to be more responsive to the needs of the type of disability.

• 한국산업보건학회지
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• 제4권2호
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• pp.240-247
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• 1994

To identify normal levels of ethanol, acetaldehyde and alcohol dehydrogenase(ADH) activity in blood of Koreans, ethanol and acetaldehyde levels, activity of ADH in blood of Koreans, ethanol and acetaldehyde levels, activity of ADH in blood were measured in 97 subjects(male : 36, female : 61), 45 subjects(male : 21, female : 24) were not exposed to organic solvents and any other chemicals. Fifty two subjects(male : 15, female : 37) were exposed to organic solvents including toluene and xylene. The results were summerized as follows : 1. The blood ADH was not detected in exposed and non-exposed group. 2. The average blood ethanol level of non-exposed group was 0.0490 mg/dl, and exposed group was 0.0363 mg/dl. They were statistically significant(p<0.05). 3. The blood acetaldehyde levels in exposed group were significantly higher than that of non-exposed group was not statistically significant (p>0.05). 4. The average blood ethanol level of males in both groups was significantly higher than that of females, however, they were not statistically significant (p>0.05).

• 한국산업보건학회지
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• 제3권2호
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• pp.227-239
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• 1993

The author selected 77 dust emissing processes from 71 types of industries which placed in Sasang Industrial Complex in Pusan. The level of total dust was measured as areal concentration and personal exposure concentration by low volume air sampler and personal air sampler, respectively. Collected samples were classified into 5 groups (chemicals and rubber product, metal product, sawmills and wood, foundries and others). Respirable particulate and total dust of areal and personal exposure were analyzed. The results were as follows; 1. All of the respirable dust concentration and total dust of areal and personal concentration were log-normally distributed. 2. Geometric mean of respirable particulate of personal exposure concentration measured $0.55mg/m^3$ in the first group, $0.86mg/m^3$ in the second group, $0.39mg/m^3$ in the third group, $0.81mg/m^3$ in the forth group and $0.52mg/m^3$ in the fifith group. The exceed rates over TLV (thehold limit values) of total dust were 31.3% in the first group, 31.3% in the second group, 70% in the third group, 80% in the forth group and 13.3% in the fifth group. 3. There were singnificant difference between areal and personal exposure concentration and personal exposure concentration was higher than that of area. 4. In the case of high ratio of respirable particulate to total dust, pneumoconiosis incidence was high even though the workshop was opened and emissing dust concentration was low. These findings suggest that it is desirable to measure respirable particulate in environmental assessment of dust emissing workshops.

• Journal of Preventive Medicine and Public Health
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• 제20권1호
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• pp.120-128
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• 1987

To assess the proportion of spectacles-wearing and an aspect of familial aggregation of myoptic spectacles-wearing and to observe the birth cohort for myoptic spectacles-wearing, a nationwide self-administered questionnaire survey was conducted from March 11 to September 19, 1985 A probability sample of 13,346 persons was taken from 180 enumerated districts designated by the fifth nationwide tuberculosis prevalence survey from Korean Institute of Tuberculosis. The major findings of this survey are as follows: 1) Total of 62.5% of the study population lived in urban area whereas 37.5% lived in Eup-Myun area. There was statistically significant difference in age and sex distribution between two residential area. 2) The percentage of spectacles-wearing was 8.3% and among these, myoptic and hyperoptic spectacles were 6.0%, 2.3%, respectively. A total of 8.5% of the male study population wore spectacles and this was slightly higher than the female (8.0%). 3) Among the occupational groups, students were the highest myoptic spectacles-wearing group whereas professionals were the highest hyperoptic spectacles-wearing group. 4) The proportion of myoptic spectacles-wearing was higher in female students than in male students respectively 11.6%, 8.7%. There was an increasing tendency of spectacles-wearing as age increased. 5) The age-sex adjusted prevalence rate of myoptic spectacles-wearing by residential areas was 2 times higher in urban area than Eup-Myun area 6) A wearing of the myoptic spectacles in early age was observed in recent birth cohort than remote birth cohort. 7) There was a tendency of familial aggregation for myoptic spectacles-wearing. The proportion of myoptic spectacles-wearing was 6 times higher for those who had parents wearing spectacles. 8) 60.9% of the total myoptic spectacles-wearing persons received the eye-specialist's order and 44. 9% for the hyperoptic spectacles wearing.

• 한국학교보건학회지
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• 제19권2호
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• pp.105-115
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• 2006

Purpose：This thesis was performed to evaluate the effect of the experience safety education on the safety behavior and standard of habit to the middle school students of one islands. Methods：The participants of this study included 43, located in the adjoining region in S county. While one of the class, composed of 19 students was designated as an experimental group, and the other class, composed of 24 students, was compared as a control group. Used program in this study was safety education program, 'Safe School, Safe Life' which was developed by Korea Occupational Safety & Health Agency. This program has emphasis on the virtual case rather than lecture style education. Results：The findings in this research were as follows. Indoor safety behavior was significant difference between the two groups. On the other hand, the effect on outdoor safety behavior was not difference. In playground case, active strength was needed without continuous attention. The effect of the experience safety behavior education was not shown in the area of traffic rules, pedestrian safety, and vehicle safety. But home safety behavior was effective. Education program on the manners of standard life habit gives positive results. But in the area of rules, this program was not effective, since students had tendency to emphasize the rigid scale rather than manners. Conclusion：These findings in the study give us the necessity of experience safety education program to prepare various situations of everyday life and to reinforce safety behavior and improve standard life habit.

• 대한감각통합치료학회지
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• 제5권1호
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• pp.1-20
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• 2007

Objective : The purposes of this study were two-fold; First it investigated self-esteem, stress and coping behaviors of mothers with handicapped children as a function of their and their children's characteristics; Second it examined the relationship among these variables. Method : The subjects were 294 mothers of handicapped children who were receiving treatment in one of the sixteen special therapy institutions in Seoul, Gyeonggi-do, and Gangwon-do. Rosenberg's(1965) Self-Esteem Scale translated by Jeon Byung-Jea(1974) was used to measure the degree of mothers' self-esteem. Mothers' stress was assessed using the Support Burden Scale revised by Seong Jong-sook(2000) and their coping behavior was examined using Folkman's(1986) Coping Scale translated by Jeon Sung-hye. The data were analyzed with descriptive statistics, t-test, one-way ANOVA and Pearson's Correlation. Result : The major results of this study were as follows; First, working mothers of handicapped children showed higher self-esteem and problem solving coping behavior more than non-working mothers. Self-esteem was found higher with high-income mothers than with low-income ones. Stress was shown more intense to low- and middle-income mothers than to high-income ones. Problem solving coping behavior was preferred more by high-and middle-income mothers than by low-income ones. Second, mothers with the mild-handicap children showed higher self-esteem than those with the first-degree handicap ones. Mothers of children with first-, second- and third-degree handicap perceived more stress than those with mild handicap. Coping behavior was significantly different depending on the severity of children's handicap, but no significant difference was found among the groups. Third, the higher the self-esteem of mothers was, the less they perceived stress and used more of problem solving coping behavior. When mothers perceived a great deal of stress, they used more of emotion-oriented coping behaviors.

• 한국안전학회지
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• 제26권2호
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• pp.70-76
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• 2011

Industrial accident frequency in small- and medium-sized ship-building plants is much higher than that of large-sized ones so that safety management activities should be different. In that sense, voluntary hazard assessment would be helpful for small- and medium-sized plants. However, conventional hazard assessment items and methods had some problems that discouraged voluntary participation of plants concerned. This study aimed to develop a new model for small- and medium-sized ship-building plants that can promote and encourage voluntary hazard assessment activities. For that purpose, ship-building process was assumed as a sequence of phases, and accident characteristics were compared with them. From that result, relative weights of accident factors including ship-building phases, accident types, occupational category, accident-induced objects, and hazardous items were determined with accident frequency data and with the help of expert groups. Therefore, for web-based integrative computer programming, a plain but accident data-dependent model was developed, with an additive function for related agencies that want to collect assessment results. It is expected that this model would help small- and medium-sized ship-building plants that wanted not only simple checklists but also effective assessment and management guidelines.