• Environmental Analysis Health and Toxicology
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• 제30권
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• pp.5.1-5.8
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• 2015

Objectives We aimed to assess the radiation exposure for epidemiologic investigation in residents exposed to radiation from roads that were accidentally found to be contaminated with radioactive cesium-137 ($^{137}Cs$) in Seoul. Methods Using information regarding the frequency and duration of passing via the $^{137}Cs$ contaminated roads or residing/working near the roads from the questionnaires that were obtained from 8875 residents and the measured radiation doses reported by the Nuclear Safety and Security Commission, we calculated the total cumulative dose of radiation exposure for each person. Results Sixty-three percent of the residents who responded to the questionnaire were considered as ever-exposed and 1% of them had a total cumulative dose of more than 10 mSv. The mean (minimum, maximum) duration of radiation exposure was 4.75 years (0.08, 11.98) and the geometric mean (minimum, maximum) of the total cumulative dose was 0.049 mSv (<0.001, 35.35) in the exposed. Conclusions An individual exposure assessment was performed for an epidemiological study to estimate the health risk among residents living in the vicinity of $^{137}Cs$ contaminated roads. The average exposure dose in the exposed people was less than 5% of the current guideline.

• Safety and Health at Work
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• 제8권2호
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• pp.169-174
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• 2017

Background: We assessed the cancer risks of four different Finnish asbestos-exposed cohorts. We also explored if the cohorts with varying profiles of asbestos exposure exhibited varying relative risks of cancer. Methods: The incident cancer cases for the asbestos-exposed worker cohorts were updated to the end of 2012 using the files of the Finnish Cancer Registry. The previously formed cohorts consisted of asbestos mine workers, asbestosis patients, asbestos sprayers, and workers who had taken part in a screening study based on asbestos exposure at work. Results: The standardized incidence ratio (SIR) for mesothelioma varied from about threefold to > 100-fold in the different cohorts. In the screening cohort the SIR for mesothelioma was highest in 2003-2007, In other cohorts it was more constant in 5-year period inspection. The SIR for lung cancer was about twofold to tenfold in all except the screening cohort. Asbestos sprayers were at the highest risk of mesothelioma and lung cancer. Conclusion: The SIR for mesothelioma is high in all of the cohorts that represent different kinds of asbestos exposure. The smaller SIR for mesothelioma in the screening cohort with lowest level of asbestos exposure might suggest dose-responsiveness between asbestos exposure and mesothelioma. It does seem that the highest risk of lung cancer in these cohorts except in the youngest of the cohorts, the screening cohort, is over. The highest SIR for lung cancer of the asbestosis patient and sprayers cohort is explained by their heavy asbestos exposure.

• 약학회지
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• 제55권2호
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• pp.81-90
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• 2011

Most antineoplastic agents are nonselective in their mechanism of action, affecting noncancerous as well as cancerous cells, and resulting in acute effects such as irritation of mucous membranes and chronic effects such as genotoxicity, teratogenicity, and carcinogenicity. Healthcare workers occupationally exposed to antineoplastic agents are at risk. The present study aimed to develop and apply methods to monitor occupational exposure to antineoplastic agents, using cyclophosphamide (CP) as the model compound. To monitor environmental and biological exposure, potentially contaminated surfaces were wiped and 24 hour urine samples were collected from workers. Liquid chromatography combined with tandem mass spectrometry was performed, with a limit of detection of 0.05 ng/ml. Measurable amounts of CP were detected on 92% of the sampled surfaces, with a geometric mean of 175.22 $ng/m^2$. Despite the environmental contamination of the model compound, CP was below the detection limit in all urine samples. If workplace contamination cannot be completely avoided, it is importance to reduce exposure to the lowest possible levels. To this aim, efforts to minimize occupational exposure along with biological and environmental monitoring are required. The standardized sampling techniques, and specific and sensitive analytical methods reported in this study may be helpful in assessing occupational exposure and devising strategies to reduce exposure.

• 한국산업보건학회지
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• 제28권3호
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• pp.319-329
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• 2018

Objectives: The object of this paper is to analyze difference of general and occupational characters, risk exposure and ill health symptom depending on the special type of employment. Methods: 50,007 participants from Fourth Korean Working Condition Survey conducted in 2014 was analyzed. Cross-tabulation analysis was conducted for deriving difference in general and occupational characters, mulitvariate logistic regression analysis was conducted after controlling general and occupational characters for deriving difference in risk exposure and ill health symptom depending on the special type of employment. Results: In the special type of employment, female, ages of 50, education levels of high school, monthly income of 2,000-3,000 thousand won, job types of sales person, enterprises of less than 100 workers, working duration of 2-10 years and long working hours worker's proportion was higher than general employment. Physical(OR: 0.84, 95% CI: 0.76-0.94) and ergonomic (OR: 0.48, 95% CI: 0.42-0.55) risk exposure was lower, psychological(OR: 1.77, 95% CI: 1.54-2.04) risk exposure was higher than general employment, and there was no significant difference between the special type of employment and general employment in chemical/biological risk exposure(OR: 1.06, 95% CI: 0.94-1.20) and ill health symptom(OR: 0.98, 95% CI: 0.89-1.09). Conclusions: This article offers the analysing difference between the special type of employment and general employment using huge size cross sectional data represent Korean employees.

• Safety and Health at Work
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• 제9권3호
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• pp.356-359
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• 2018

This case report attempts to present a case of acute toxic hepatitis in fire extinguisher manufacturing workers exposed to 2,2-dichloro-1,1,1-trifluoro-ethane (HCFC-123) in August 2017 in Korea. Twenty-two-year-old male workers were exposed to HCFC-123 for 1.5 hours one day and for 2.5 hours the other day, after which one worker died, and the other recovered after treatment. The workers were diagnosed with acute toxicity of hepatitis. However, exposure levels of HCFC-123 were not known with no work environment measurement done. Therefore, this study was conducted to estimate the exposure concentration of HCFC-123 via a job simulation experiment. In the simulation, the HCFC-123 exposure concentration was measured with the same working practice and working time as with the workers aforementioned. As a result, the workers who infused HCFC-123 into storage tanks were estimated to be exposed to HCFC-123 at a concentration of $20.65{\pm}10.81ppm$, and a mean concentration of area samples within a working radius were estimated as $70.30{\pm}18.10ppm$. Valve assembly workers working on valves of a fire extinguisher filled with HCFC-123 were exposed to HCFC-123 at concentrations of $91.65{\pm}4.03ppm$ and $115.55{\pm}7.28ppm$, respectively, in the simulation, and area samples simulated within the working radius were also found to be high with concentrations of $122.75{\pm}91.15ppm$ and $126.80{\pm}60.25ppm$, respectively. Nitrogen gas packing workers, who did not handle HCFC-123 directly, were exposed to the agent at a concentration of $71.80{\pm}8.49ppm$. These results suggest that exposure to HCFC-123 at high concentrations for 1.5-2.5 hours caused acute toxic hepatitis in two workers.

• Safety and Health at Work
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• 제2권3호
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• pp.243-249
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• 2011

Objectives: Cement contains hexavalent chromium, which is a human carcinogen. However, its effect on cancer seems inconclusive in epidemiologic studies. The aim of this retrospective cohort study was to elucidate the association between dust exposure in the cement industry and cancer occurrence. Methods: The cohorts consisted of male workers in 6 Portland cement factories in Korea. Study subjects were classified into five groups by job: quarry, production, maintenance, laboratory, and office work. Cancer mortality and incidence in workers were observed from 1992 to 2007 and 1997-2005, respectively. Standardized mortality ratios and standardized incidence ratios were calculated according to the five job classifications. Results: There was an increased standardized incidence ratio for stomach cancer of 1.56 (27/17.36, 95% confidence interval: 1.02-2.26) in production workers. The standardized mortality ratio for lung cancer increased in production workers. However, was not statistically significant. Conclusion: Our result suggests a potential association between cement exposure and stomach cancer. Hexavalent chromium contained in cement might be a causative carcinogen.

• 한국산업보건학회지
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• 제26권1호
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• pp.11-19
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• 2016

Objectives: Exposure to volatile organic compounds such as trichloroethylene(TCE) and perchloroethylene(PCE), along with Agent Orange, that were issued around Camp Carroll US Army Base situated in Waegwan, Chilgok-gun, Gyeongsangbuk-do Province, Korea. The main objective of this study was to assess the exposure to TCE and PCE of residents of the area surrounding Camp Carroll. Methods: The TCE, PCE and trichloroethanol(TCEOH) concentrations in blood and trichlroroacetic acid(TCA) and TCEOH concentrations in urine were measured and analyzed in a total of 1,033 residents around Camp Carroll. TCA and TCEOH are metabolites of TCE and PCE, respectively. The information on demographic characteristics and exposure variables in relation to underground water were obtained through a questionnaire completed by the subjects. Results: TCE, PCE and TCEOH concentrations were not detected in blood. Detection rates of TCA and TECOH concentrations in urine were 98.5% and 36.6%, respectively. Creatinine-corrected average TCA and TCEOH concentrations were $12.23{\pm}23.81{\mu}g/g$ and $0.66{\pm}4.31{\mu}g/g$, respectively. A significant difference was not shown between the drinking group and no drinking group for underground water, which was assumed as a potential route of exposure to TCE and PCE through the consumption of ground water. However, females drinking ground water showed a significantly higher mean level of TCA in urine than did males. There was no significant difference according to drinking ground water as a potential source of exposure to TCE and PCE in residents around Camp Carroll. Conclusions: Considering the statistical analysis of factors affecting exposure to TCE and PCE in ground water along with previous reports, TCA in urine as exposure to TCE and PCE might not be appropriate because it is found in chlorinated drinking water. Therefore, TCA concentration in urine may be the result of drinking of chlorinated water.

• 한국환경보건학회지
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• 제38권1호
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• pp.18-30
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• 2012

Objectives: The purpose of this study was to estimate the exposure level to extremely low frequency-magnetic fields (ELF-MF) among a selected Korean population using 24-hour personal exposure measurement. Methods: Participants were randomly selected for the measurement of MF exposure under the assumption that the subjects are representative of the overall Korean population. Levels of personal exposure to MF were measured according to the subject's daily activities. Results: The 24-hour time-weighted average (TWA) of 250 participants was $1.56{\pm}4.56$ mG (GM, GSD: 0.79, 2.46 mG). Personal exposure levels for females were higher than for males. The highest personal exposure level was shown in the age group between 20-60 years old. Personal exposure levels according to job category were higher for the non-occupational group than for the occupational group. Conclusions: Our results showed MF exposure exceeding 2 mG per day among 11.3% of the Korean population, indicating a somewhat higher percentage compared to the EMF RAPID Program's results for the U.S population.

• 한국산업보건학회지
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• 제25권2호
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• pp.146-155
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• 2015

Objectives: The aims of this study were to set up benzene exposure matrices according to industry and process and to assess the risk of those occupational exposure to benzene. Methods: The benzene exposure matrices were assembled depending on industry and process, based on an exposure database provided by KOSHA(the Korean Occupational Safety and Health Agency), which was gathered from a workplace hazards evaluation program in Korea. These exposure matrices were assessed by Hallmark Risk Assessment tool. Results: The benzene was treated 412 industries sector(36%), 2,747 business places, and 471 industrial processes according to database. The arithmetic mean of past decade 8 hours time-weighted average of airborne benzene concentrations in the workplace was 0.10722 ppm. 1.07% of the total sample were greater than OEL, and 59.8% were showed less than the limit of detection. The highest risk values(Danger Value) were seen 36 industries including manufacture of general paints and similar product and 12 processes, such as other painting of manufacture of metal fabricated members. Exposure matrices based on employee exposure data base may provide exposure histories and can be used in epidemiological studies. Conclusions: It was found that more attentions should be paid to 36 among 412 industries and 12 of 471 processes, with a higher risk value.

• 한국산업보건학회지
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• 제33권4호
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• pp.517-527
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• 2023

Objectives: We examine cases of chemical poisoning that occurred in the cleaning of metal parts and the regulations on halogenated solvents in other countries and propose regulations necessary to prevent chemical poisoning from halogenated solvents. Methods: We collected cases of chemical poisoning through the website of the Korea Occupational Safety and Health Agency. A review of the literature was conducted focusing on regulations related to halogenated solvents in the United States and the European Union, particularly for cleaning metal parts. Among the Material Safety Data Sheets submitted to the government, MSDS containing eleven substances were extracted to confirm the composition and product use. We investigated cleaning methods for metal parts used in South Korea. For the hazard classification, the European Chemicals Agency or Japan's NITE's website was used. Results: In the case of poisoning, the cleaning methods involving trichloromethane were dipping and dry, which was not found in the literature. It was confirmed that many halogenated solvents and dimethyl carbonate were used for metal cleaning in South Korea. In vapor degreasing using TCE in the USA, even if the facility is strictly managed, such as by installing cooling coils in open cleaning facilities, the risk of exposure to TCE is considered to be not only carcinogenic but also a concern for acute and chronic effects. In comparison, exposure through Korean work methods such as dipping and drying operations is inevitably much higher. Conclusions: The transition to water-based cleaning with low-hazard chemicals should be a priority in the cleaning process. In the case of metal parts that require precise cleaning, if the use of a halogenated solvent is inevitable, a closed degreasing facility should be used to minimize exposure. The current regulations in the Occupational Safety and Health Act, the Chemical Substances Control Act, and the Air Environment Conservation Act do not require cleaning facilities to minimize emissions. To protect the health of workers using halogenated solvents to clean metal parts, regulations that require a fundamental reduction in exposure will be necessary.