• Title/Summary/Keyword: Occupational disease

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Biomarkers available in workplaces

  • Maeng, Eung-Hee
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.05a
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    • pp.31-34
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    • 2003

  • The monitoring of genotoxic effect or oxidative DNA damage in workers exposed to hazardous materials is increasingly applied for hazard identification or risk assessment purposes in workplaces. The current generation of biomarkers has the potential to allow for the earlier detection of occupational disease, for the reduction of misclassification of exposure and outcome. (omitted)

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MSDSs Reliability Evaluation in Workplaces Manufacturing Aromatic Hydrocarbon (방향족 탄화수소 화학물질 제조사업장의 MSDS 신뢰성 평가 연구)

  • Lee, Kwon Seob;Choi, Jin Hee;Jo, Jihoon;Choi, Sung Bong;Lee, Jong Han;Yang, Jeong Sun
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.19 no.4
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    • pp.370-380
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    • 2009

  • Reliable hazard and risk communication is needed to prevent the safety accident & occupational disease through right use of chemicals and MSDS(Material Safety Data Sheet) is mainly used as such a tool of communication. MSDS policy has been put into effect in order to prevent the safety accident & occupational disease through right use of chemicals and fulfill workers' right to know. If information on MSDS lacks reliability due to its inaccuracy, prevention of the various effects related with environmental safety & health in advance is not possible to achieve. The most essential thing regarding authoring MSDS is to exactly evaluate the composition and ingredients of the chemical and include reliability-guaranteed information. Therefore, in this study reliability was evaluated on MSDSs in 15 aromatic hydrocarbons(benzene, toluene, xylene, etc.) manufacturers and ways to secure reliability of MSDS were suggested. The results showed 93.5% of composition agreement rate and 89% of reliability on each section in MSDSs. In order to curb MSDSs with low reliability, examination on CBI(confidential business information) in MSDS, certification of MSDS, collection and verification of MSDS are suggested.

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Malondialdehyde and 3-Nitrotyrosine in Exhaled Breath Condensate in Retired Elderly Coal Miners with Chronic Obstructive Pulmonary Disease

  • Lee, Jong Seong;Shin, Jae Hoon;Hwang, Ju-Hwan;Baek, Jin Ee;Choi, Byung-Soon
    • Safety and Health at Work
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    • v.5 no.2
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    • pp.91-96
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    • 2014

  • Background: Chronic obstructive pulmonary disease (COPD) is an important cause of occupational mortality in miners exposed to coal mine dust. Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD. Methods: To investigate the relevance of exhaled biomarkers of oxidative and nitrosative stress in participants with COPD, we determined the levels of hydrogen peroxide, malondialdehyde (MDA), and 3-nitrotyrosine (3-NT) in exhaled breath condensate (EBC) in 90 retired elderly coal miners (53 non-COPD and 37 COPD participants). Results: Mean levels of MDA (4.64 nMvs. 6.46 nM, p = 0.005) and 3-NT (3.51 nMvs. 5.50 nM, p = 0.039) in EBC were significantly higher in participants with COPD. The median level of MDA did show statistical difference among the COPD severities (p = 0.017), and the area under the receiver operating characteristic curve forMDA (0.67) for the diagnostic discrimination of COPD indicated the biomarker. The optimal cutoff values were 5.34 nM (64.9% sensitivity and 64.2% specificity) and 5.58 nM (62.2% sensitivity and 62.3% specificity) forMDA and 3-NT, respectively. The results suggest that high levels ofMDA and 3-NT in EBC are associated with COPD in retired elderly miners. Conclusion: These results showed that the elevated levels of EBC MDA and EBC 3-NT in individuals with COPD are biomarkers of oxidative or nitrosative stress.

  • https://doi.org/10.1016/j.shaw.2014.03.001 인용 PDF