• Title/Summary/Keyword: Observational methods

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Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study

  • Jung-Ho Yang;Ji-An Jeong;Sun-Seog Kweon;Young-Hoon Lee;Seong-Woo Choi;So-Yeon Ryu;Hae-Sung Nam;Kyeong-Soo Park;Hye-Yeon Kim;Min-Ho Shin
    • Korean Circulation Journal
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    • v.52 no.3
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    • pp.220-230
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    • 2022
  • Background and Objectives: Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is the genetic variant with the most potent effect on drinking behavior. Methods: A total of 8,964 participants from the Dong-gu Study were included in the present study. The causal association between alcohol consumption and AF was evaluated through a Mendelian randomization (MR) analysis using the ALDH2 rs671 polymorphism as an instrumental variable. Results: No significant relationship between alcohol consumption and AF was found in the observational analysis. However, the genetic analysis using the ALDH2 polymorphism showed a significant association in men. In the MR analysis, genetically predicted daily alcohol consumption was positively related to AF. Conclusions: MR analysis revealed a significant association between the amount of alcohol consumption and AF, which suggests that the association may be causal.

Improving Satellite Derived Soil Moisture Data Using Data Assimilation Methods (자료동화 기법을 이용한 위성영상 추출 토양수분 자료 개선)

  • Hwang, Soonho;Ryu, Jeong Hoon;Kang, Moon Seong
    • Proceedings of the Korea Water Resources Association Conference
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    • 2018.05a
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    • pp.152-152
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    • 2018
  • Soil moisture is a important factor in hydrologic analysis. So, if we have spatially distributed soil moisture data, it can help to study much research in a various field. Recently, there are a lot of satellite derived soil moisture data, and it can be served through web freely. Especially, NASA (National Aeronautics and Space Administration) launched the Soil Moisture Aperture Passive (SMAP) satellite for mapping global soil moisture on 31 January 2015. SMAP data have many advantages for study, for example, SMAP data has higher spatial resolution than other satellited derived data. However, becuase many satellited derived soil moisture data have a limitation to data accuracy, if we have ancillary materials for improving data accuracy, it can be used. So, in this study, after applying the alogorithm, which is data assimilation methods, applicability of satellite derived soil moisture data was analyzed. Among the various data assimilation methods, in this study, Model Output Statistics (MOS) technique was used for improving satellite derived soil moisture data. Model Output Statistics (MOS) is a type of statistical post-processing, a class of techniques used to improve numerical weather models' ability to forecast by relating model outputs to observational or additional model data.

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Influencing Factors of Nutritional Status among Liver Cancer Patients Receiving Transcatheter Arterial Chemoembolization(TACE) (간동맥 화학색전술을 받은 간암환자의 영양상태에 미치는 영향요인)

  • Sohn, Young-Sil;Kang, In-Soon
    • The Korean Journal of Health Service Management
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    • v.11 no.1
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    • pp.159-169
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    • 2017
  • Objectives : The purpose of this descriptive observational study was to identify the factors influencing the nutritional status of patients with liver cancer receiving transarterial chemoembolization(TACE) Methods : A total of 100 participants were enrolled in this study. Data were collected and descriptive statistics and logistic regression were performed. Results : Among participants, 41.0% had a risk of malnutrition and 59.0% had a normal nutritional status. Statistically significant differences between the normal and risk groups were found for the following factors: occupation; economical status; regular exercise; underlying disease; adverse events right after TACE; current adverse events; duration after TACE; depression; and self-care performance. Underlying disease(OR=5.134, p=.005) and self-care performance(OR=0.931, p=.032) had statistically associated with nutritional status. Conclusions : The findings suggest that underlying disease and self-care performance influence the nutritional status among liver cancer patients receiving transcatheter arterial chemoembolization(TACE).

The impact of malnutrition on survival in patients with gynecologic cancer undergoing chemotherapy

  • Nho, Ju-Hee;Kwon, Yong Soon;Jo, Seongil
    • Journal of Nutrition and Health
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    • v.50 no.6
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    • pp.595-602
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    • 2017
  • Purpose: Malnutrition is a major concern in patients with gynecologic cancer receiving chemotherapy. The aim of this study was to evaluate the prognostic significance of malnutrition in patients with gynecologic cancer undergoing chemotherapy. Methods: A prospective, observational study was conducted on a total of 99 subjects who were treated at a tertiary hospital in Korea. Data regarding demographic, clinical, nutritional, and psychological characteristics at baseline and survival were obtained. Results: Performance status, nutritional status, depression, and annual income were significantly different between survivors and non-survivors. Multivariate Cox modeling after adjusting for other factors showed that a malnourished status in patients with gynecologic cancer undergoing chemotherapy was a significant and independent negative influencing factor for survival. Conclusion: These findings provide evidence that adequate nutritional assessment and intervention may assist in improving survival in patients with gynecologic cancer undergoing chemotherapy.

A Study on the Clinical Study of Periodic Treatment of Endometriosis (자궁내막증의 주기요법 임상 연구에 대한 고찰)

  • Park, Jang-Kyung
    • The Journal of Korean Obstetrics and Gynecology
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    • v.33 no.2
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    • pp.112-123
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    • 2020
  • Objectives: The purpose of this study is to review the research in the cyclic treatment of endometriosis in traditional Korean medicine. Methods: By October 2019, the relevant studies on the periodic therapy of endometriosis were searched using the Chinese National Knowledge Infrastructure Database (CNKI) and Oriental Medicine Advanced Searching Integrated System (OASIS). Results: Finally, three Randomized controlled trials, one case study, two clinical observational studies were selected. In all studies, herbal medicine periodic therapy has been effective in improving symptoms of endometriosis. Blood-activating and stasis-dispelling medicinal were the most commonly used before menstruation and during menstruation, and tonifying and replenishing medicinal were the most commonly used after menstruation. According to the one study, which reported safety, herbal medicine was safe. Conclusions: Although limited due to a lack of literature, periodic therapy is effective in improving endometriosis related symptoms and preventing recurrence. A well-designed study and experimental studies for the identification of the mechanism are needed.

Medical Management of Drug-Resistant Tuberculosis

  • Jeon, Doosoo
    • Tuberculosis and Respiratory Diseases
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    • v.78 no.3
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    • pp.168-174
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    • 2015
  • Drug-resistant tuberculosis (TB) is still a major threat worldwide. However, recent scientific advances in diagnostic and therapeutic tools have improved the management of drug-resistant TB. The development of rapid molecular testing methods allows for the early detection of drug resistance and prompt initiation of an appropriate treatment. In addition, there has been growing supportive evidence for shorter treatment regimens in multidrug-resistant TB; and for the first time in over 50 years, new anti-TB drugs have been developed. The World Health Organization has recently revised their guidelines, primarily based on evidence from a meta-analysis of individual patient data (n=9,153) derived from 32 observational studies, and outlined the recommended combination and correct use of available anti-TB drugs. This review summarizes the updated guidelines with a focus on the medical management of drug-resistant TB.

Resicential Chair Design for Physically Handicapped Children (지체부자유아동을 위한 주거용 의자설계에 관한 연구)

  • 박영순
    • Journal of the Korean Home Economics Association
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    • v.30 no.1
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    • pp.115-131
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    • 1992
  • The purpose of this study is the investigation of the physically handicapped childrens' residentical life, using furniture and opinion of auxiliary furniture ot find out alternative forms of desirable furniture. This study consists of two parts: a survey of residential life and furniture usage and a new chair design based on the survey. Documentary research, observational investigation and questionaire survey methods were used. According to the survey, a chair was chosen as the most needed piece of furniture. The alternative chair was designed to accomodate to the individual physical needs of each child. The structural charasteristics of the chair form consist of four parts: 1) basic seat 2) supporting metal frame 3) detachable chair legs 4) detachable table top. Auxilliary options include adjustable parts such as a head rest, seat belt, arm rest and pedestal.

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Clinical study about 62 cases of psoriasis patient using pyretotherapy (피레토세라피를 이용(利用)한 건선환자(乾癬患者) 62명(名)에 대(對)한 임상보고(臨床報告))

  • Kang, Jae-Chun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.25 no.4
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    • pp.35-44
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    • 2012
  • Objectives : This study was aimed to evaluate the treatment effect of psoriasis patient using pyretotherapy. Methods : The clinical study was performed using retrospective observational research method. Treatment method was pyretotherapy that optimized core temperature through herbs therapy, food therapy, excercise and life style change. In other aspects, pyretotherapy is skin cure therapy that rise core temperature, down skin temperature and open sweat gland. Results : 1. 40s years showed the most coming of clinic in the distribution of age of psoriasis patient. 2. Board type showed the most number in the classification of psoriasis. 3. Pyretotherapy was very effective results in psoriasis patient treatment. 4. Pyretotherapy showed effects of rising axillary temperature and moving facial high skin temperature toward abdominal portion. Conclusions : The author is able to say that it is possible for pyretotherapy to become new skin therapy for many skin disease, especially psoriasis.

The study of correlation between forward head posture and shoulder pain: A STROBE-compliant cross-sectional study

  • Kim, Hyun-Joong;Lee, DongJin
    • Physical Therapy Rehabilitation Science
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    • v.10 no.3
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    • pp.251-256
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    • 2021
  • Objective: The forward head posture (FHP) is strongly related to the rounded shoulder posture (RSP), which is associated with shoulder pain. Design: Observational cross sectional study design Methods: A total of 37 were enrolled in the study, 22 individuals with FHP(experimental group) and 15 healthy adults(control group). Correlation with differences between groups was analysed through craniovertebral angle (CVA) representing FHP for both groups, neck disability index (NDI) indicating neck pain, disability of the arm, shoulder and hand (DASH) indicating shoulder pain. Results: There was a significant difference in the results of CVA, NDI, and DASH in FHP and healthy adults (p<0.05). Significant correlations were found between DASH and CVA in FHP participants (r = -0.656, p = 0.001). Also, in the regression analysis results of DASH and CVA, the regression model was found to be suitable and the variation in DASH could be explained by 43% (F = 15.118, p = 0.001). Conclusions: Shoulder pain and neck discomfort are potentially related, and an increase in shoulder pain can increase FHP.

Effects of Action Observation Training and Motor Image Training on Brain Activity (동작관찰 훈련과 운동 상상훈련이 뇌 활성상태에 미치는 효과)

  • Yang, Byung-Il;Park, Hyeong-Ki
    • The Journal of Korean Society for Neurotherapy
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    • v.22 no.3
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    • pp.7-10
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    • 2018
  • Purpose The purpose of this study was to investigate the difference of brain activity during action observation training and image training throughout EEG. Methods This study was participated 1 healthy college student without mental illness or cognitive impairment. The subject was randomly selected from university students and was interested in participating in the experiment. The purpose of this study was to investigate the visual and auditory stimuli (action observation) and brain image training. Results The results of our study, EEG value measured o.1 during resting. But brain activity changed to 0.3 during action observation. Finally, it changed to .05 after brain image training. Conclusion EEG measurement results were showed that after watching the Ball squat video, Brain activity increased.