• Journal of Preventive Medicine and Public Health
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• 제24권2호
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• pp.195-210
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• 1991

Fatty liver is caused by derangement of fat metabolism and can be reversed by removal of contributing factors. The contributing factors of fatty liver is known to be overweight, chronic alcoholism, diabetes mellitus, malnutrition, and drug abuse such as tetracycline. This study was carried out on 1335 persons who visited 'Soon Chun Hyang Human Dock Center' from March to June 1990. In analysis of the data, prevalence of fatty liver diagnosed by ultrasonogram by age and sex, laboratory finding between fatty liver group and normal group, and odds ratio of known contributing factors, were compared. The results obtained are as following ; 1) The prevalence rate of fatty liver diagnosed by ultrasonogram is 29.6% in male and 11.5% in female. 2) Age groups with high prevalences are $40{\sim}50's$ in male (32.0%) and 50's in female (24.5%). 3) The fatty liver shows significant association with style (p<0.05), whereas not with hepatitis B-virus surface antigen (p>0.05). 4) All laboratory values except alkaline phosphatase and bilirubin are elevated significantly in accordance with the degree of fatty liver (p<0.01). 5) Fatty liver diagnosed by ultrasonogram showed so strong associations with body index, triglycerides and gamma-glutamyl transferase for males, and body index and fasting blood sugar for females that these factors may be used as supplementary data in establishing diagnosis of fatty liver. 6) Odds ratio of contributing factors are as follows ; If the odds ratio of below 29 year of age is 1.0 then that of $30{\sim}39$ is 1.74 (p=0.33), $40{\sim}49$ is 2.47 (p=0.10), $50{\sim}59$ is 2.86 (p=0.0570), over 60 is 1.81 (p=0.34). If the odds ratio of female is 1.0 then that of male is 5.67 (p<0.01). If the odds ratio of body index below zero is 1.0 then that of $0{\sim}9$ is 5.08 (p<0.01), $10{\sim}19$ is 12.37 (p<0.01), $20{\sim}29$ is 29.19 (p<0.01), 30 above is 154.02 (p<0.01). If the odds ratio of below 99 mg/dl FBS is 1.0 then that of $100{\sim}120$ is 106 (p=0.76), over 120 is 1.91 (p=0.02). If the odds ratio of below $29{\mu}/1{\gamma}-GT$ is 1.0 then that of $30{\sim}s59$ is 2.11 (p<0.01), $60{\sim}90$ is 1.87 (p<0.05), 90 above is 1.69 (p=0.15). If the odds ratio of below 149 mg/dl TG is 1.0 then $150{\sim}199$ is 1.49 (p=0.05), $200{\sim}250$ is 1.09 (P=0.77), 250 above is 2.53 (p<0.01). In summary, early diagnosis of fatty liver could be made by ultrasonogram supplemented with body index and nm triglyceride. The fatty liver could be preventive by avoiding contributing factors such as obesity, alcohol intake, high blood sugar appropriately.

• 생명과학회지
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• 제21권12호
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• pp.1795-1803
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• 2011

현대인의 고지방 식습관과 당뇨와 비만인구 증가로 인한 비 알코올성 지방간(nonalcoholic fatty liver)의 유병률(prevalence rate)은 나날이 증가하고 있는 추세이며, 특히 남성과 폐경기 여성에게서 두드러진다. 이런 성 특이적(sex-specific) 간질환의 차이는 여성 호르몬인 에스트로겐(estrogen)의 보호 역할 때문일 것으로 추정되고 있으나, 에스트로겐의 보호 기작을 포함한 지방간의 만성 간질환으로의 진행 메커니즘이 규명되어 있지 않기 때문에 간질환의 효과적인 예방 및 치료책이 없는 실정이다. 그런데 최근에 간 섬유화(fibrosis)를 포함한 만성 간질환의 진행에서 헤지호그(hedgehog) 신호전달계가 주요한 역할을 함이 보고되면서 손상된 간의 회복과 간질환 진행메커니즘 조절을 위한 연구대상으로서 주목 받고 있다. 헤지호그는 발생 및 분화를 조절하는 모포젠(morphogen)으로 성인의 건강한 간에서는 발현되지 않으나, 손상된 간에서 손상 정도에 비례하게 재 발현되며, 섬유화 유발세포인 근섬유아세포(myofibroblasts) 및 간 줄기세포(hepatic progenitor cells)의 활성 및 증식인자로 작용하여 지나친 간 섬유화를 일으킨다. 이에 반해, 에스트로겐은 간 성상세포(hepatic stellate cells)가 근섬유아세포로 활성화되는 것을 억제함으로써 간 섬유화를 막는 것으로 보고되고 있다. 간 섬유화에 대한 헤지호그와 에스트로겐의 상반된 역할 사이의 관련성은 아직 밝혀지지 않고 있으나, 간 섬유화 유발 물질인 오스테오폰틴(osteopontin) 발현에 대한 에스트로겐의 억제효과와 헤지호그에 의한 오스테오폰틴 발현 유도는 오스테오폰틴에 의해 매개되는 에스트로겐과 헤지호그 신호전달계 사이의 연관성을 시사한다. 따라서, 에스트로겐에 의한 헤지호그 신호전달계 조절 메커니즘을 규명하는 것은 간질환 환자에서의 간 섬유화 및 만성 질환으로의 진행을 억제할 수 있는 치료제 개발에 대한 기초 지식을 제공할 수 있다. 이를 위해 간 섬유화에 대한 헤지호그와 에스트로겐의 역할을 확실하게 이해하고, 상호 관련성 및 조절 기작을 밝히는 연구가 선행되어야 할 것이다.

• 한국생활과학회지
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• 제16권4호
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• pp.849-854
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• 2007

Body fat proportion is a major issue in health. The prevalence of obesity in childhood has been increasing on thesedays. A series of indirect estimates of body fat have been developed. There are hydrodensitometry, BIA and anthropometry equation for body fat. Hydrodensitometry has been regarded as a common criterion method. BIA made it possible to analyze body fat mass more related to hydrodensitometry than anthropometry. The purpose of this unvestigation were to compare body fat and other body composition between boys & girls and to know which anthropometry equation for body fat was most closely associated with BIA in boys & girls respectively. The subjects were 148 4th grade elementary school students(male:70, female:78). They underwent BIA(InBody 3.0, Biospace Korea)to determine body fat and other body composition. Anthropometric measurements were taken of height, weight, skinfolds and circumferences. The results obtained are summarized as follow: 1) Weight, BMI and Rohrer index were $39.9{\pm}7.2kg$, $20.5{\pm}8.0$, $138.2{\pm}17.0$ for boys and $35.9{\pm}6.7kg$, $18.2{\pm}2.6$, $96.6{\pm}13.6$ for girls. 2) Total body fat and percent body fat determined by BIA were $10.3{\pm}4.3kg$, $25.4{\pm}6.6%$ for the boys group and $9.3{\pm}3.8kg$, $25.1{\pm}6.0%$ for girls. 3) Mean triceps skinfold thickness was $20.5{\pm}6.1mm$ in boys, $17.0{\pm}5.1mm$ in girls and mean WHR was $0.88{\pm}0.4$ in bodys, $0.82{\pm}0.4$ in female and the values were significantly different by sex. 4) Correlational nanlyses showed that estimation of body fat by BIA measurement seemed to be closely associated with Rohere index(boys r=0.854, girls r=0.909). Kim's equation was highly correlated with the body fat in girls(r=0.910) but less correlated in boys(r=0.710). We need to develop specific anthropometric equations based on age and sex to determine body fat for children.

• 한국안광학회지
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• 제18권1호
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• pp.61-65
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• 2013

목적: 40세 이상의 한국 성인 남녀에서 녹내장 발병과 식사패턴과의 관련성을 알아보고자 하였다. 방법: 국민건강영양조사 자료를 이용하여 40세 이상의 성인남녀 총 6,453명(남자 2,759명, 여자 3,694명)을 대상으로 하였다. 녹내장은 의사로부터 진단받았던 경우를 기준으로 하였다. 일차적으로 녹내장과 비만지수와 관련성을 확인하기 위해서 녹내장과 정상군에서 허리둘레와 체질량지수를 비교하였다. 두 번째로 등푸른 생선(고등어), 해조류(김, 미역), 콩류(콩류, 두유), 야채(시금치, 콩나물, 오이, 당근, 양배추, 고추, 토마토, 호박), 과일(귤, 사과, 딸기, 배, 포도, 복숭아)에 대해서 요인분석을 이용하여 식사패턴을 분석하였다. 마지막으로 추출된 식사패턴요인과 녹내장과의 회귀분석을 실시하였다. 결과: 녹내장과 정상군에서 허리둘레와 체질량지수는 각각 $82.25{\pm}9.96cm$와 $23.27{\pm}2.84kg/m^2$, 그리고 $75.79{\pm}13.79cm$와 $22.39{\pm}4.0kg/m^2$로 유의한 차이를 확인할 수 있었다(p<0.05). 요인분석에 의해 조사된 섭취식품은 총3개의 요인으로 추출되었으며, 이때의 요인 1은 콩나물, 시금치, 당근, 양배추, 미역, 오이, 고등어, 김으로 묶여졌다. 식사패턴요인 1은 녹내장의 발병 위험도를 줄이는 경향을 보였고(OR: 0.697, 95%CI: 0.496-0.980, p=0.038), 성별과 연령을 보정한 후에도(OR: 0.698, 95%CI: 0.497-0.982, p=0.039) 마찬가지로 나타났다. 결론: 한국성인을 대상으로 녹내장과 식사패턴요인과의 관련성을 처음 분석한 연구로서 야채, 김과 고등어는 녹내장의 위험도를 감소시키는 관계가 있었다.

• 대한지역사회영양학회지
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• 제17권5호
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• pp.603-622
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• 2012

The population aged 95 years and older in Seoul approximately increased to five-fold over the past 10 years, while nationwide rates increased to three-fold. In order to examine the dietary habit and nutritional status of oldest-old population living in Seoul, we recruited 87 subjects (25 males and 62 females) aged 95 years and older. The prevalence of underweight (BMI < 18.5 $kg/m^2$) and obesity (BMI ${\geq}25kg/m^2$) were 18.2% and 18.2% in males, and 20.8% and 9.4% in females, respectively. In self-assessment of health, only 25.3% answered to be unhealthy. More males exercised regularly and reported a wide range of activities than females. The average of %Kcal from carbohydrate, protein and fat (C : P : F) was 64.9 : 13.8 : 21.2 in males and 68.1 : 14.2 : 17.7 in females. The average daily energy intake was 1,307 kcal in males and 1,304 kcal in females. More than 75% of subjects were taking under estimated average requirements (EAR) for vitamin $B_1$, $B_2$ & C and Ca. The average of mean adequacy ratio (MAR) was 0.66 in males and 0.70 in females, and 28.8% of males and 12.9% of females were in MAR < 0.50. Based on MAR, 32.0% of males and 14.5% females were classified as normal and 16.0% of males and 25.8% of females were classified as malnourished. Our subjects were taking more animal food, especially milk and its products, compared to those living, in rural areas. However, a significant proportion did not meet the EAR for vitamin $B_1$, $B_2$ & C and Ca.

• 한국생활과학회지
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• 제21권5호
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• pp.947-956
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• 2012

This study aims to investigate both general dietary behaviors and clinical symptoms of diet related effects among fifth grade students at an elementary school in Ulsan Metropolitan City, and to categorize those relationships in terms of their comparative differences. The findings of this study are as follows. 1. Out of 694 students polled, 53.7% were of boys and 46.2% were girls with average age of $11.9{\pm}0.3$, average height of $145.1{\pm}6.8cm$, and average weight of $39.7{\pm}9.7kg$. Obesity in boys (5.5%) exceeded girls (3.9%) whereas children categorized as underweight showed girls (14.6%) slightly exceeded boys (10.4%). 2. Dietary behaviors were largely the result of four factors - unbalanced diet, balanced diet, protein and fruits and healthy dietary habits. Of these factors, protein and fruits ($4.04{\pm}1.03$) ranked first, balanced diet ($3.38{\pm}1.04$) second, healthy dietary habits ($3.04{\pm}1.01$) third and unbalanced diet ($2.23{\pm}0.6$) ranked last. 3. When Dietary behaviors were classified with four low ranking factors, they were divided into four types such as convenience (22.4%), good diet (24.7%), busy contemporary modern man (24.3%) and healthy dietary habits (26%). 4. Clinical symptoms include colds ($2.27{\pm}1.15$) followed by headaches ($2.17{\pm}1.19$), stomachaches ($2.16{\pm}1.15$), dizziness ($2.02{\pm}1.15$), atopic allergy ($1.95{\pm}1.30$), prevalence for cold sores ($1.86{\pm}1.07$), allergy ($1.65{\pm}1.05$), and constipation ($1.54{\pm}0.87$). 5. According to the results, clinical symptoms were divided into two groups - unhealthy (40.1%) and healthy (59.9%). 6. By analyzing the relationship between dietary behavior types and clinical symptom types, the convenience factor included slightly more of the unhealthy group (56.3%), whereas the good diet (71.1%), busy contemporary modern person (55.8%) and healthy dietary habits (69.7%) included more of healthy group (p<.001). Since the majority of students belonging to the unhealthy group had convenience dietary behavior, education about desirable dietary activities is needed for these students. In addition, nutrition information and information on possible clinical symptoms caused by nutritional imbalance should be provided for students and their households.

• Clinical and Experimental Pediatrics
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• 제52권10호
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• pp.1103-1108
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• 2009

목 적:만성질환자가 아닌 일반 학동기 아동을 대상으로 보완대체요법 이용실태를 파악하며 소아청소년과 의사로서 대처 방향을 모색하고자 연구를 실시하였다. 방 법:3개 초등학교 1학년부터 6학년 1,688명의 학부모를 대상으로 설문조사를 시행하였다. 그중 설문지가 회수된 794명(47%)을 분석하였다. 결 과:일반적인 학동기 아동에서 보완대체요법의 이용률은 278명(35%)이었고, 보완대체요법의 종류는 한약제 62.6%, 보조식품 31.3%, 비타민 30.2%, 선식 11.2%, 침술 11.2%, 체 냄, 수지침 순이었다. 보완대체요법의 이용률은 어머니의 학력이 대학 이상 일 때, 종교가 있을 때, 가정 월 총수입이 100만 원 이상일 때 의미 있게 높았으며 이용하게 된 동기는 질병예방목적이 가장 많았고, 주로 주변 사람이나 매체를 통해 이용하였다. 보완대체요법에 대한 만족하지 못하는 경우는 16%였고, 재사용 의향이 없는 경우는 20.5%였고, 환아가 건강할 때 주로 사용하는 경향을 보였다. 환아가 영양결핍, 아토피 피부염, 관절통증, 알레르기비염, 비만, 천식 때 주로 이용하는 경향을 보였다. 결 론:보완대체 의학의 사용이 아이의 건강상태와는 밀접하지 않으며 사용 경로 또한 주변 사람의 권유나 방송 매체 등을 통해 이루어지고, 병원치료와 병행 시 좋을 것이라는 막연한 기대감으로 사용되고 있는 경우가 많아 보완대체요법에 대한 부작용, 효과, 안전성에 대한 연구가 필요하며 만성질환 및 알레르기 질환의 경우 소아청소년과 의사로서 현대의학의 적극적인 치료 및 교육이 필요할 것으로 사료된다.

• Nutrition Research and Practice
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• 제12권5호
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• pp.387-395
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• 2018

BACKGROUND/OBJECTIVE: Recent studies showed vitamin D deficiency is linked to chronic diseases in addition to skeletal metabolism which could threaten the elderly. We analyzed health conditions and socio-demographic factors associated with vitamin D deficiency in community dwelling people aged 65 years and older. SUBJECTS/METHOD: Data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010 to 2012 were obtained. A total of 2,687 subjects aged 65 years and older were participated. The cutoff value of the Vitamin D deficiency was considered as serum 25-hydroxyvitamin D [25(OH)D] ${\leq}20ng/mL$ (50 nmol/L). RESULTS: The overall prevalence rate of vitamin D deficiency in the elderly was 62.1%. The factors such as female, obesity, metabolic syndrome, current smoker, and skipping breakfast were positively associated with vitamin D deficiency, but high intensity of physical activity and more than 9 hours of sleep duration were negatively associated with vitamin D deficiency (all P < 0.05). CONCLUSIONS: It is important that health professions know that the factors proved in this study are connected to vitamin D deficiency thus provide information and intervention strategies of vitamin D deficiency to old aged people.

• Clinical and Experimental Reproductive Medicine
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• 제36권1호
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• pp.71-80
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• 2009

목 적: 다낭성 난소 증후군은 생식기 여성에서 나타나는 가장 흔한 내분비 질환 중 하나이며 다양한 임상 양상을 보이고 있다. 본 연구에서는 한국인 다낭성 난소 증후군 환자 특유의 임상 양상 및 혈액학적 소견을 밝히고자 하였으며 그 결과를 터키와 미국의 다낭성 난소 증후군 환자와 비교 분석하였다. 연구방법: 2000년 1월부터 2008년 4월까지 경북대학교 병원 불임치료실을 찾은 88명의 다낭성 난소 증후군 환자를 대상으로 하여 후향적으로 임상 양상 및 혈액학적 소견을 연구하였다. 결 과: 한국인 다낭성 난소 증후군 환자군 내에서는 통계학적으로 유의한 연령에 따른 임상 양상의 차이가 없었으나 터키와 미국의 다낭성 난소 증후군 환자와 비교했을 때 고안드로겐혈증의 빈도는 유의하게 낮았다. 결 론: 다낭성 난소 증후군 환자 내에서도 인종간의 임상 양상 및 혈액학 소견의 차이가 있다고 생각되며 유전 및 생활 습관의 차이 등이 그 원인을 설명할 수 있을 것이다. 그러나 연구 대상인 환자의 수가 적고 연령군의 분포가 좁아 향후 좀 더 큰 규모의 연구가 필요하다.

• 한국식품영양학회지
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• 제29권5호
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• pp.724-734
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• 2016

The purpose of this study was to determine the health behaviors and nutritional status related to dyslipidemia in Korean middle-aged adults (between 50 and 64 years old) from the Korean National Health and Nutrition Examinations Survey data (2007~2010). A total of 4,721 subjects were analyzed in this study. The subjects were divided into three groups (normal, borderline, and dyslipidemia) according to serum lipid levels. Parameters included in this study were drinking and smoking, anthropometric parameters, blood and nutritional parameters. The latter parameter included food/nutrients intake. All data was adjusted by sex, region, education level, and age. General linear model and logistic regression model were used for statistical analysis. The dyslipidemia group was comprised of more men than women. By contrast, the borderline group was comprised of more women than men (p<0.001). No significant differences were observed for other general characteristics. There were more smokers and drinkers(drinking per time) in the dyslipidemia group (p<0.05). Anthropometric data showed significant difference, ie, height (p<0.05), weight, body mass index, waist circumference, percent body fat, and blood pressure were higher in the dyslipidemia group (p<0.001). Only blood urea nitrogen showed no significant difference among groups. The HbA1c (p<0.01), fasting blood glucose, GOT, GPT, creatinine levels were higher in the dyslipidemia group (p<0.001). So it is required for the management of obesity in dyslipidemia group. The dyslipidemia group ate less sea food (p<0.05). The nutrients intake of energy and protein, thiamin, riboflavin, niacin, calcium, phosphorus were lower in the dyslipidemia group (p<0.05). Therefore, to lower dyslipidemia prevalence rates, it is necessary to increase the intake of foods containing ${\omega}-3$ fatty acids. We also suggest a meal management program and nutritional education to recognize the risk of dyslipidemia, especially for people such as the individual in the borderline and dyslipidemia study groups.